LOCUS       NM_011890               3733 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus sarcoglycan, beta (dystrophin-associated glycoprotein)
            (Sgcb), mRNA.
ACCESSION   NM_011890
VERSION     NM_011890.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3733)
  AUTHORS   Gloriani,M., Cheli,B., D'Ercole,C., Ruggieri,V., Cosentino,M.,
            Serrat Pineda,M., Lozanoska-Ochser,B., Grassi,F., Bouche,M.,
            Madaro,L. and Sanchez Riera,C.
  TITLE     Sarcoglycans are enriched at the neuromuscular junction in a
            nerve-dependent manner
  JOURNAL   Cell Death Dis 16 (1), 37 (2025)
   PUBMED   39843456
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3733)
  AUTHORS   Zaren,P. and Gawlik,K.I.
  TITLE     Thrombospondin-4 deletion does not exacerbate muscular dystrophy in
            beta-sarcoglycan-deficient and laminin alpha2 chain-deficient mice
  JOURNAL   Sci Rep 14 (1), 14757 (2024)
   PUBMED   38926599
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3733)
  AUTHORS   Baumann,C.W., Lindsay,A., Sidky,S.R., Ervasti,J.M., Warren,G.L. and
            Lowe,D.A.
  TITLE     Contraction-Induced Loss of Plasmalemmal Electrophysiological
            Function Is Dependent on the Dystrophin Glycoprotein Complex
  JOURNAL   Front Physiol 12, 757121 (2021)
   PUBMED   34764884
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3733)
  AUTHORS   Camps,J., Breuls,N., Sifrim,A., Giarratana,N., Corvelyn,M.,
            Danti,L., Grosemans,H., Vanuytven,S., Thiry,I., Belicchi,M.,
            Meregalli,M., Platko,K., MacDonald,M.E., Austin,R.C., Gijsbers,R.,
            Cossu,G., Torrente,Y., Voet,T. and Sampaolesi,M.
  TITLE     Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in
            Dystrophic Muscles
  JOURNAL   Cell Rep 31 (5), 107597 (2020)
   PUBMED   32375047
REFERENCE   5  (bases 1 to 3733)
  AUTHORS   Randazzo,D., Khalique,U., Belanto,J.J., Kenea,A., Talsness,D.M.,
            Olthoff,J.T., Tran,M.D., Zaal,K.J., Pak,K., Pinal-Fernandez,I.,
            Mammen,A.L., Sackett,D., Ervasti,J.M. and Ralston,E.
  TITLE     Persistent upregulation of the beta-tubulin tubb6, linked to muscle
            regeneration, is a source of microtubule disorganization in
            dystrophic muscle
  JOURNAL   Hum Mol Genet 28 (7), 1117-1135 (2019)
   PUBMED   30535187
  REMARK    Erratum:[Hum Mol Genet. 2019 Jun 1;28(11):1930. doi:
            10.1093/hmg/ddz035. PMID: 30753428]
REFERENCE   6  (bases 1 to 3733)
  AUTHORS   Araishi,K., Sasaoka,T., Imamura,M., Noguchi,S., Hama,H.,
            Wakabayashi,E., Yoshida,M., Hori,T. and Ozawa,E.
  TITLE     Loss of the sarcoglycan complex and sarcospan leads to muscular
            dystrophy in beta-sarcoglycan-deficient mice
  JOURNAL   Hum Mol Genet 8 (9), 1589-1598 (1999)
   PUBMED   10441321
REFERENCE   7  (bases 1 to 3733)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
REFERENCE   8  (bases 1 to 3733)
  AUTHORS   Noguchi,S., Wakabayashi,E., Imamura,M., Yoshida,M. and Ozawa,E.
  TITLE     Developmental expression of sarcoglycan gene products in cultured
            myocytes
  JOURNAL   Biochem Biophys Res Commun 262 (1), 88-93 (1999)
   PUBMED   10448073
REFERENCE   9  (bases 1 to 3733)
  AUTHORS   Chan,Y.M., Bonnemann,C.G., Lidov,H.G. and Kunkel,L.M.
  TITLE     Molecular organization of sarcoglycan complex in mouse myotubes in
            culture
  JOURNAL   J Cell Biol 143 (7), 2033-2044 (1998)
   PUBMED   9864373
REFERENCE   10 (bases 1 to 3733)
  AUTHORS   Matsumura,K., Ervasti,J.M., Ohlendieck,K., Kahl,S.D. and
            Campbell,K.P.
  TITLE     Association of dystrophin-related protein with
            dystrophin-associated proteins in mdx mouse muscle
  JOURNAL   Nature 360 (6404), 588-591 (1992)
   PUBMED   1461282
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY133708.1 and AK169403.1.
            
            On May 12, 2018 this sequence version replaced NM_011890.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169403.1, AK132306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY133708.1         2-7
            7-3733              AK169403.1         2-3728
FEATURES             Location/Qualifiers
     source          1..3733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.89 cM"
     gene            1..3733
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /note="sarcoglycan, beta (dystrophin-associated
                     glycoprotein)"
                     /db_xref="GeneID:24051"
                     /db_xref="MGI:MGI:1346523"
     exon            1..63
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..987
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /note="43 kDa dystrophin-associated glycoprotein;
                     sarcoglycan, beta (43kD dystrophin-associated
                     glycoprotein)"
                     /codon_start=1
                     /product="beta-sarcoglycan"
                     /protein_id="NP_036020.1"
                     /db_xref="CCDS:CCDS19344.1"
                     /db_xref="GeneID:24051"
                     /db_xref="MGI:MGI:1346523"
                     /translation="MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKA
                     GYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSM
                     EFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKN
                     KTSITSDIGMQFFDPRTHNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDL
                     NIKVDGRAIVRGNEGVFIMGKTIEFHMGGDVELKAENSIILNGTVMVSPTRLPSSSSG
                     DQSGSGDWVRYKLCMCADGTLFKVQVTGHNMGCQVSDNPCGNTH"
     exon            64..273
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            274..459
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            460..651
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            652..783
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            784..3733
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2854..2859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /note="hexamer: AATAAA"
     polyA_site      2876
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
     regulatory      3712..3717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /note="hexamer: AATAAA"
     polyA_site      3732
                     /gene="Sgcb"
                     /gene_synonym="43DAG; beta-SG"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcgggc tgcggcgggc caagatggcg gcagcggcgg cggcggcggc agcgaccgag
       61 cagcaagggt ccaacgggcc agtgaagaaa tccatgcggg agaaggctgt ggagcggagg
      121 aatgttaaca aagagcacaa cagcaatttc aaagctggat atatccccat cgatgaggac
      181 cggctccata agactgggct gagggggcga aagggcaact tagccatctg cgtgatcgtc
      241 ctcctgttta tcctggccgt catcaatcta ctcattacac ttgtcatctg ggcggtgatc
      301 cgcattgggc caaatgggtg tgatagcatg gagttccacg agagcggtct gctgaggttc
      361 aagcaagtgt ctgacatggg cgtcatccac ccgctttata agagcacggt gggaggacgg
      421 cggaatgaaa acctggtcat cactggcaac aaccagccaa ttgtcttcca gcaagggacg
      481 accaagctga gtgttgaaaa gaacaagacc tccatcacca gcgacatcgg gatgcagttt
      541 tttgacccaa ggacacacaa tatcctgttc agcacggact atgagacgca cgagtttcat
      601 ctgccaagtg gggtgaaaag tttgaacgtt cagaaagcat cgactgaaag gattaccagc
      661 aatgctacca gtgacttaaa catcaaagtc gatgggcgtg caattgtgcg aggcaacgaa
      721 ggcgtcttca tcatgggcaa aaccattgaa tttcacatgg gaggagatgt ggagttaaaa
      781 gctgaaaaca gcatcatcct caacggcacg gtgatggtca gccctacgcg cctgcccagt
      841 tcctccagcg gggaccagtc agggagtggt gactgggtgc gctacaagct ctgcatgtgt
      901 gcagatggca cactcttcaa agtacaagta acaggtcaca acatgggctg ccaggtctca
      961 gacaaccctt gtgggaacac tcattagacg gtgcatccgc agggctcagc gcgctcagat
     1021 ctgacttgac cttccccttt ttaagaatgc atgtgaacca tgtttgtaca gcgtttgcca
     1081 taacttgtaa ttattttacc tggggagcac cactgtgtct attatgtact ctccatattt
     1141 aagggatctt gagtgcctac attctaatac attttagtaa gttgcactga tactcaacag
     1201 ttctctaaaa caatgatgag aaattaataa aataaaatta atctttgaag tgtttttaac
     1261 attctactat atcttgtcct agaggacaaa gggctgaagt ggttgagaca ctccatcagt
     1321 aagccttggt cattctaagg gagagatcca ctagagatgt ttggagagac agggacactg
     1381 tgctctgtct ttggttttta aaagggaagg cacagatttt taatgcatta acccaaagct
     1441 acattttcac aaacaagtca ttaaggagct ttccatatat aagcttgtaa gaaactatgt
     1501 ttccttagtt ttgcactaaa gaaaatactg tcatggtatg tttacttgaa ataatgatac
     1561 atgtatttac ggtgtgtgga cgttaaacgc aatcacagtt ctcactctcg tgagcaacag
     1621 aagccatcat catcaggcct cttcttgctg agcactgtcc tgggtgcgat acacttgatc
     1681 tctctgactc ccactgcacc tctctaagca agggcttcga tcccagcttt acccatcagg
     1741 aaactgaagg tcagcgaggt tcaggatgct gccccatact atacagggtt gggagtcaag
     1801 tacaattcca acccaggtaa acctgattcc aaatgtgttt ctgccttttt tactatctac
     1861 actgaatttt caactattta aaactctcaa agaatgggaa aaacctaatc ctaattcacc
     1921 taacaggtaa aaaaacaagc atgtgtgcta ctctagttaa aatgccaatg ctagaaaaac
     1981 atgaccaatc actgtcagac tttaaactct cttgagccag ttctaagatg tcattcaata
     2041 gacagaccag cttggtctgc ttgtcatgtg ggagtacctg aatgagttat agagaagctg
     2101 gcatactttt ccctaaaccc tggggaagct cagtggaaag gggggaagct aggcctcagt
     2161 aggtcctgct gtccagaggt tgttcctcct gtgtcccata ccagcatcac cctttagaag
     2221 aattctgtgt gtgcctagaa attaatatac acgagaataa agggtgctaa ctggaaagat
     2281 gacgcaggtc attttagcta ggtataaaac cttgatctct gctcctcacc tcagtctcat
     2341 tttaattaat tacagccctc aagccagttg attcttagta cagtttatac ttgatttaaa
     2401 aggaatttct tggtattact aagaaacatg ggattgggga tgaagaataa tgcatagctc
     2461 caaagcagac agtagggagg caccatgggc ctagctacag agaaggatgt tggtactctg
     2521 tcatggtcac ttagaactgt gtgggtaaaa aatgagcaca taaaacaatt cgtgttcact
     2581 gttgtcacaa ttctgtcaaa tgaaaaaatg aaatacctta tagactgtga actcaggcta
     2641 aggtgagagt tgactggaga ccagacacta agtgcagatt ttagatgtaa agaaagagag
     2701 caatttatac ctctggatat attcaagtat tgtttaataa ctaaataatg ctcagaaaaa
     2761 tcacgcttgg aattctcatg tccatgctca gtgtattttt aaattgtaca tttgtttcat
     2821 gttctattta aatttgtttt gagaatttct ttaaataaat atttttacta aatccacaga
     2881 accctatatt acaaagtatt atttactgaa tacaattcat gagaaaaaag tgtattttta
     2941 cgtctgtggg aaacacttgt gttttgatac atctccattg agcactttga agtttgagca
     3001 tatcctgctg ctctgtaaag cgcgtggtta ctaggtatgc tattttagac tgcattttgg
     3061 gtagaccctc tgacacactg acctgaaagc agagaagcgg agcttggtgc acagtgaagc
     3121 ggcactgtta aatctggcca ccagggggcg tatgccttct catgtgttca tttcttcggt
     3181 tttgaacata gcacactgag aggacttact gcagcgctgg ggaaggtagg tgcaggaagg
     3241 acccagggag gaaagcaaac acacatttaa cagacagtat tcgagaggtg aatatcaatg
     3301 caaagagata gaaataaaaa gaagacccct tccagactgt ccagtgagag gttggggggt
     3361 gggggataca caacacaaag caggagctac ctgccgactc ggcaaccttt taaaatattc
     3421 ttcggtggca atcttcttgc actgtgacag aagcaaaata aactttgtgt gatagttttg
     3481 gtgatgaaag gtagaatttc tacctgtttt tgatgagtgg tttgtgtttt cttgtttgtt
     3541 tgttttttgc ttttttaaag gagttaaaaa cttgttttta acttgatgaa gaggagacca
     3601 ctaaagtgct gctcatggta atcttttgaa cgacatcaag aggggcaaag tttacaagtt
     3661 atgccacaca aaaatatacc tatgtatttc agattgatga cctctgttta caataaagct
     3721 ctgtgaactt ggc
//
