LOCUS       NM_009161               1738 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sarcoglycan, alpha (dystrophin-associated
            glycoprotein) (Sgca), mRNA.
ACCESSION   NM_009161 NM_001136080
VERSION     NM_009161.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Angelini,G., Capra,E., Rossi,F., Mura,G., Saclier,M., Taglietti,V.,
            Rovetta,G., Epis,R., Careccia,G., Bonfanti,C. and Messina,G.
  TITLE     MEK-inhibitors decrease Nfix in muscular dystrophy but induce
            unexpected calcifications, partially rescued with Cyanidin diet
  JOURNAL   iScience 27 (1), 108696 (2023)
   PUBMED   38205246
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Careccia,G., Saclier,M., Tirone,M., Ruggieri,E., Principi,E.,
            Raffaghello,L., Torchio,S., Recchia,D., Canepari,M., Gorzanelli,A.,
            Ferrara,M., Castellani,P., Rubartelli,A., Rovere-Querini,P.,
            Casalgrandi,M., Preti,A., Lorenzetti,I., Bruno,C., Bottinelli,R.,
            Brunelli,S., Previtali,S.C., Bianchi,M.E., Messina,G. and
            Venereau,E.
  TITLE     Rebalancing expression of HMGB1 redox isoforms to counteract
            muscular dystrophy
  JOURNAL   Sci Transl Med 13 (596) (2021)
   PUBMED   34078746
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Levoux,J., Prola,A., Lafuste,P., Gervais,M., Chevallier,N.,
            Koumaiha,Z., Kefi,K., Braud,L., Schmitt,A., Yacia,A., Schirmann,A.,
            Hersant,B., Sid-Ahmed,M., Ben Larbi,S., Komrskova,K., Rohlena,J.,
            Relaix,F., Neuzil,J. and Rodriguez,A.M.
  TITLE     Platelets Facilitate the Wound-Healing Capability of Mesenchymal
            Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming
  JOURNAL   Cell Metab 33 (2), 283-299 (2021)
   PUBMED   33400911
  REMARK    Erratum:[Cell Metab. 2021 Mar 2;33(3):688-690. doi:
            10.1016/j.cmet.2021.02.003.. PMID: 33657394]
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Guha,T.K., Pichavant,C. and Calos,M.P.
  TITLE     Plasmid-Mediated Gene Therapy in Mouse Models of Limb Girdle
            Muscular Dystrophy
  JOURNAL   Mol Ther Methods Clin Dev 15, 294-304 (2019)
   PUBMED   31890729
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Verhaart,I.E.C., Putker,K., van de Vijver,D., Tanganyika-de
            Winter,C.L., Pasteuning-Vuhman,S., Plomp,J.J., Aartsma-Rus,A.M. and
            van Putten,M.
  TITLE     Cross-sectional study into age-related pathology of mouse models
            for limb girdle muscular dystrophy types 2D and 2F
  JOURNAL   PLoS One 14 (8), e0220665 (2019)
   PUBMED   31430305
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   Liu,L., Vachon,P.H., Kuang,W., Xu,H., Wewer,U.M., Kylsten,P. and
            Engvall,E.
  TITLE     Mouse adhalin: primary structure and expression during late stages
            of muscle differentiation in vitro
  JOURNAL   Biochem Biophys Res Commun 235 (1), 227-235 (1997)
   PUBMED   9196068
REFERENCE   7  (bases 1 to 1738)
  AUTHORS   Song,K.S., Scherer,P.E., Tang,Z., Okamoto,T., Li,S., Chafel,M.,
            Chu,C., Kohtz,D.S. and Lisanti,M.P.
  TITLE     Expression of caveolin-3 in skeletal, cardiac, and smooth muscle
            cells. Caveolin-3 is a component of the sarcolemma and
            co-fractionates with dystrophin and dystrophin-associated
            glycoproteins
  JOURNAL   J Biol Chem 271 (25), 15160-15165 (1996)
   PUBMED   8663016
REFERENCE   8  (bases 1 to 1738)
  AUTHORS   Madhavan,R. and Jarrett,H.W.
  TITLE     Interactions between dystrophin glycoprotein complex proteins
  JOURNAL   Biochemistry 34 (38), 12204-12209 (1995)
   PUBMED   7547961
REFERENCE   9  (bases 1 to 1738)
  AUTHORS   Roberds,S.L., Anderson,R.D., Ibraghimov-Beskrovnaya,O. and
            Campbell,K.P.
  TITLE     Primary structure and muscle-specific expression of the 50-kDa
            dystrophin-associated glycoprotein (adhalin)
  JOURNAL   J Biol Chem 268 (32), 23739-23742 (1993)
   PUBMED   8226900
REFERENCE   10 (bases 1 to 1738)
  AUTHORS   Matsumura,K., Ervasti,J.M., Ohlendieck,K., Kahl,S.D. and
            Campbell,K.P.
  TITLE     Association of dystrophin-related protein with
            dystrophin-associated proteins in mdx mouse muscle
  JOURNAL   Nature 360 (6404), 588-591 (1992)
   PUBMED   1461282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606480.11 and AK075915.1.
            
            On or before Dec 14, 2012 this sequence version replaced
            NM_001136080.1, NM_009161.3.
            
            Summary: This gene encodes a member of the sarcoglycan
            alpha/epsilon family of transmembrane proteins. The encoded protein
            is part of the dystrophin-glycoprotein complex which links the
            extracellular matrix to the cytoskeleton in muscle fibers.
            Disruption of this gene results in progressive muscular dystrophy
            and is associated with the development of embryonal
            rhabdomysarcoma. [provided by RefSeq, Dec 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data. The combination of the 5' and 3' non-coding exons
            is inferred from available partial transcript data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.35801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AL606480.11        30035-30247         c
            214-228             AL606480.11        27384-27398         c
            229-1693            AK075915.1         1-1465
            1694-1738           AL606480.11        16697-16741         c
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..1738
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /note="sarcoglycan, alpha (dystrophin-associated
                     glycoprotein)"
                     /db_xref="GeneID:20391"
                     /db_xref="MGI:MGI:894698"
     exon            1..213
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            214..290
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1417
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /note="alpha-sarcoglycan; alpha-SG; 50 kDa
                     dystrophin-associated glycoprotein; adhalin"
                     /codon_start=1
                     /product="alpha-sarcoglycan precursor"
                     /protein_id="NP_033187.1"
                     /db_xref="CCDS:CCDS25266.1"
                     /db_xref="GeneID:20391"
                     /db_xref="MGI:MGI:894698"
                     /translation="MAAAVTWIPLLAGLLAGLRDTKAQQTTLHLLVGRVFVHPLEHAT
                     FLRLPEHVAVPPTVRLTYHAHLQGHPDLPRWLHYTQRSPYNPGFLYGSPTPEDRGYQV
                     IEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPTTPANRFLTA
                     LGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDS
                     YARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPFFC
                     PPTEATDRDFLTDALVTLLVPLLVALLLTLLLAYIMCFRREGRLKRDMATSDIQMFHH
                     CSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH"
     exon            291..410
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            411..565
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            566..638
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            639..837
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1000
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1209
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1236
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1434
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1738
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="Sgca"
                     /gene_synonym="50DAG; Asg"
                     /note="major polyA site"
ORIGIN      
        1 caggagatat caaggtgatc tgggcacaaa tgcctgtctg tgagcctgag tggaggctga
       61 ctctggagat tctgtgactc tcaggggaca cccagggtgg tcaggtggga agcacgaagg
      121 caaagggaca aggacaaagt aacttgccca gtcgtcacct gaatggaaac ctgaactgag
      181 acatctttgc ttggacattc aaggtgtggg gagcccctgt ccctgtcact cactggctag
      241 gccccgggca actatggcag cagcagtaac ttggatacct ctcctggcag gtctcctggc
      301 aggactgagg gacaccaagg cccagcagac aactttacac ctacttgtgg gtcgtgtgtt
      361 tgtgcatcct ttggaacatg ccaccttcct gcgccttcca gaacacgttg cggtgccacc
      421 cactgtccga ctcacctacc acgctcacct ccagggacat ccagacctgc ccaggtggct
      481 gcactacaca cagcgcagtc cctataaccc tggcttcctc tacggctccc ccactccaga
      541 agatcgtggg taccaagtca tcgaggtcac agcctacaat cgagacagtt ttgacaccac
      601 tagacagagg ctgctgctgc tgattgggga ccccgaaggt ccccggttgc cataccaagc
      661 tgagttcctg gtgcgcagcc atgatgtgga ggaggtgctg cccaccacac ctgccaaccg
      721 cttcctcacc gccttggggg gactgtggga gccaggagag cttcagctgc tcaacatcac
      781 ttccgccttg gaccggggag gccgagtccc tcttcctatt gagggacgga aggaaggggt
      841 atacattaag gtaggctctg ccacaccctt ctccacctgc ctgaagatgg tggcgtcgcc
      901 cgacagctat gcccgttgtg cccagggaca gcctccacta ctgtcctgct acgacacttt
      961 ggcaccccac ttccgcgttg actggtgcaa tgtgtctctg gtagacaagt cagtacccga
     1021 gcccctggat gaggtaccta ctccaggcga tgggatcttg gagcacgacc cgttcttctg
     1081 cccacccact gaagccacag accgagactt cctgacagat gccttggtga ccctcttggt
     1141 gcctttgttg gtggctctgc tgcttactct gttgctggct tacatcatgt gctttcggcg
     1201 tgaaggacgg ctgaagagag acatggccac ctctgacatc cagatgtttc accactgttc
     1261 catccatggg aatacagaag agcttcggca gatggcagcc agccgagagg tgccccggcc
     1321 tctttccacc ttgcccatgt ttaatgttcg tacaggagag cggttacctc cccgagtaga
     1381 cagcgcacag atgcctctta tcctggacca gcactgaaag ccctgccaag atgggtgctc
     1441 acagtactgg aactgtgcca caactgccaa ccagtcaggg ctggagggtc aggataaggg
     1501 agagaggatt ctggaacctc ccactctgtc ctctacatga ccttgtagct ccagctccag
     1561 ctgcaccact cagagatgct gacctgtgaa tatgtctaca actgactcca gctcctagcc
     1621 tacttggacc tccggctcca caaaggcaga cagatggtgt agggagggct gagggcattt
     1681 ggagtcagca cccaaaaata aaaaaaatac ctgctgcttc tgcttatcgt ttctagtg
//
