LOCUS       NM_178639               3654 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sideroflexin 5 (Sfxn5), mRNA.
ACCESSION   NM_178639 XM_903757
VERSION     NM_178639.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3654)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3654)
  AUTHORS   Xiao,H., Bozi,L.H.M., Sun,Y., Riley,C.L., Philip,V.M., Chen,M.,
            Li,J., Zhang,T., Mills,E.L., Emont,M.P., Sun,W., Reddy,A.,
            Garrity,R., Long,J., Becher,T., Vitas,L.P., Laznik-Bogoslavski,D.,
            Ordonez,M., Liu,X., Chen,X., Wang,Y., Liu,W., Tran,N., Liu,Y.,
            Zhang,Y., Cypess,A.M., White,A.P., He,Y., Deng,R., Schoder,H.,
            Paulo,J.A., Jedrychowski,M.P., Banks,A.S., Tseng,Y.H., Cohen,P.,
            Tsai,L.T., Rosen,E.D., Klein,S., Chondronikola,M., McAllister,F.E.,
            Van Bruggen,N., Huttlin,E.L., Spiegelman,B.M., Churchill,G.A.,
            Gygi,S.P. and Chouchani,E.T.
  TITLE     Architecture of the outbred brown fat proteome defines regulators
            of metabolic physiology
  JOURNAL   Cell 185 (24), 4654-4673 (2022)
   PUBMED   36334589
REFERENCE   3  (bases 1 to 3654)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3654)
  AUTHORS   Plouhinec,J.L., Granier,C., Le Mentec,C., Lawson,K.A.,
            Saberan-Djoneidi,D., Aghion,J., Shi,D.L., Collignon,J. and Mazan,S.
  TITLE     Identification of the mammalian Not gene via a phylogenomic
            approach
  JOURNAL   Gene Expr Patterns 5 (1), 11-22 (2004)
   PUBMED   15533813
REFERENCE   5  (bases 1 to 3654)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (bases 1 to 3654)
  AUTHORS   Demangel,C., Bertolino,P. and Britton,W.J.
  TITLE     Autocrine IL-10 impairs dendritic cell (DC)-derived immune
            responses to mycobacterial infection by suppressing DC trafficking
            to draining lymph nodes and local IL-12 production
  JOURNAL   Eur J Immunol 32 (4), 994-1002 (2002)
   PUBMED   11920565
REFERENCE   7  (bases 1 to 3654)
  AUTHORS   Lockhart,P.J., Holtom,B., Lincoln,S., Hussey,J., Zimprich,A.,
            Gasser,T., Wszolek,Z.K., Hardy,J. and Farrer,M.J.
  TITLE     The human sideroflexin 5 (SFXN5) gene: sequence, expression
            analysis and exclusion as a candidate for PARK3
  JOURNAL   Gene 285 (1-2), 229-237 (2002)
   PUBMED   12039050
REFERENCE   8  (bases 1 to 3654)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB628882.1, AK036285.1, AK082073.1 and BC099507.1.
            
            On Jan 8, 2010 this sequence version replaced NM_178639.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082073.1, SRR7652917.1240698.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB628882.1         2-4
            4-1176              AK036285.1         2-1174
            1177-1361           AK082073.1         1175-1359
            1362-2796           AK082073.1         1362-2796
            2797-3654           BC099507.1         32-889              c
FEATURES             Location/Qualifiers
     source          1..3654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.23 cM"
     gene            1..3654
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /note="sideroflexin 5"
                     /db_xref="GeneID:94282"
                     /db_xref="MGI:MGI:2137681"
     exon            1..115
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1036
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /codon_start=1
                     /product="sideroflexin-5"
                     /protein_id="NP_848754.1"
                     /db_xref="CCDS:CCDS20291.1"
                     /db_xref="GeneID:94282"
                     /db_xref="MGI:MGI:2137681"
                     /translation="MADTATTASAASAAASAPNASTDAPPFQLGKPRFQQTSFYGRFR
                     HFLDIIDPRTLFVTEKRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTN
                     EKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPS
                     PASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNV
                     VLMRYGELEEGIDVLDADGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSML
                     EKTALLQARPRLLLPVHSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIARATSSR
                     TVVYNKGL"
     exon            116..184
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..262
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            263..289
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..370
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..424
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            425..481
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            482..547
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            548..638
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            639..754
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            755..840
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..958
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            959..3654
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3654
                     /gene="Sfxn5"
                     /gene_synonym="C230001H08Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtggccatg gcggatacag caaccacagc ctcagcggcg tccgcggcgg ccagtgcccc
       61 gaacgcctcc acagatgcgc cccctttcca gctgggcaag ccccgcttcc agcagacatc
      121 cttctacggt cgcttcaggc acttcttgga catcatcgat cctcgaacac tctttgtcac
      181 tgagaaacgt ctcagagagg ctgtgcaact gctggaggat tacaagcatg gcaccctgcg
      241 cccaggagtt acaaatgaac agctctggag tgcacagaaa atcaaacagg ctatcctaca
      301 cccggacacc aacgagaaga tcttcatgcc tttcagaatg tcaggttaca ttcctttcgg
      361 gacgccaatt gtggtgggac ttctcttgcc taaccagacg ctggcatcca ctgtcttctg
      421 gcagtggctg aaccagagcc ataatgcctg tgtcaactat gcaaaccgca atgctaccaa
      481 gccttcacct gcatccaagt tcatccaggg ctacctgggc gctgtcatca gtgctgtttc
      541 cattgctgtg ggccttaatg tgctggttca gaaagcaaac aagttcactc cagctactcg
      601 ccttctcgtg cagagatttg tacccttccc tgcagtagcc agtgccaata tctgcaacgt
      661 ggtcctgatg cgatatgggg agttagagga aggaattgat gtcctggatg ctgatggcaa
      721 cctcgtgggc tcctcaaaga ttgcagccag acacgccctg ctggagacag ctctgacacg
      781 tgtggttctg cctatgccca ttctggtgct tcctccaatc gtcatgtcca tgctggagaa
      841 gacagctctc ttgcaagcac gcccgcggct actcctacct gtgcatagcc tcgtgtgcct
      901 ggcagccttc ggcctggccc tgccgctggc catcagcctt ttcccgcaga tgtcagagat
      961 tgaaacctcc caattggagc ctgagatagc ccgggctacc agcagccgga cagtggtgta
     1021 caataagggg ctgtgagtga agaccagccg gcctgggcac acagcactat ccaggccggg
     1081 cgttcggggt ggggagagaa gtctcttgag ctgtctctgc aaggaggggc tgcctggaaa
     1141 gcagccaacc tccgtcagta gggagactaa ccattcacat tttaacatag gggagaggaa
     1201 ttctgacaca tttcctacac aaaaagaatc aagtgcatct ctgggcctta catggggtca
     1261 gctaaactcc actcagcaca atttcgtgtg agctaaagaa ctgtagagtg cttctggggt
     1321 agaagtagta tccttttata tgttcttttt tttttttttt tcggtttgtt ttaatttttt
     1381 ttttattaga agcaagtctg agccttggtt gcagctgacc aaaagtagca ggacaggtgg
     1441 cgggagccag aggagcatgg gaactggttt gcattgatgg gaggggagta taatggttag
     1501 gcctggtggg cccctcgggt tagagaaggg aagggaaggg aggtggtctg caccccacag
     1561 gatgaaccaa ggtttttggg aattggcttt ctctatcaaa gagcactaga gaccccttgg
     1621 aagattccgg gaacaccagg ctctgaatgt acccagctcc tacccacccc acagctgagg
     1681 gaaagtcaga tgaccccagg cacgggtcat ctttcatgga gctcttattg attccaggtc
     1741 cctgagagta gcccagctct agtcagggat ccccaagaag caacactgtt ctgtgggaac
     1801 aaggagagag gatcctgcct gggctttgca ggagggttct tttccacaag tagctagagt
     1861 ttcctacggg gacaaaggtg ggctgagccc actgtggtcc agtctgcagc cactgaagct
     1921 gtcacaaccc acacctttct gcaatagagg agtctcctgc ctgagggtgc aaggccggat
     1981 cctgagggtg caactgcctg agaggtcgcc tcagcaatgg acaagccacc cacatctccg
     2041 agcttccatt ccctgcctgg aagcgaagga ctgaacttgg gttccccaca agcctggggc
     2101 tcctctctac ctgcttcact cagatgtgca cattccaggc atctcaaagg tggattctgg
     2161 actggaaagt gcatcaggcc attctggaaa tggccagcac ttagcctaca aaagcacctt
     2221 gtccttctgt gtggactccc ctacatccta aaaaaccttg acttgtgcca aacccttcct
     2281 ggctgtggag gaggcagtat ggatgcctga gctgagctta ggggtcacac ggcatgccct
     2341 tcctcactgc tgcagacttg gggcctcttg ctgctggctc catctcgtca cgtgtaggcc
     2401 acagaggaag agatagctct acctaaggag gcagggtctg ggtgagctga acagggtgac
     2461 tcctggtcca aaggacccac agagaggaga tacactgatc tctacacagc cctcatctgt
     2521 ccaccctagg atgggaaccc tggctcatga ccctggaatc tgacacagga ggggtcaggc
     2581 tgaagatcaa catgtatggt tgcagaaaaa ggctggcgcg aggcagcaag gacaaggtca
     2641 caggttccct gccagcatct taaggcaggt gtagctgtag caagatgggc tgagcatggg
     2701 tattgggctc caggccttgg ctggacacta gatctgtttg ctgaagcctc ttttgaaaag
     2761 ttcattctca gctttttttt tttttttttt tttttttttt gtccccactt gtcctggagc
     2821 cttgtcctta tgcatttatc ttgggaccaa aacctccctc ccccaggcct gcctgctcca
     2881 gaggttcttc cagctcgccc tctgtgctgg ctgtccccat ggcctcagta cccctcgtag
     2941 gtgtgttttg tgtgtggagt gatttctgcc atgctccaat acaccctgag cccaggtgag
     3001 ctgagggggc aactcctttg gatttgctgt gacagatggt ccttgtggcc cacagtgatg
     3061 gtggctgagc gtcttgagcc atgctgttaa accctgtttt gacttcataa aaatccataa
     3121 gggaagcttt ctgtgaatgc aaatgtccct atttgctgag gctaggggac agaaagaggc
     3181 ctggaggaaa gggggcaaat tacctctcgt tgggtgtggt ttttccagca gtcagggcaa
     3241 atctacagca ggctctccag ctctgatgtt cctggccaac tctcctctga taacttttaa
     3301 acattccctg aaggatgctc ttccatctct ggaaagcaat ttgggagtac aggaaccaaa
     3361 agtccaagat gccaaatggc caccgaacca agatgtctgc actctgtctc atttcctaat
     3421 tgtggctgtc ttatgaaagt ctctggtctg gggaagggtg gggcactgag gagaggggcc
     3481 agtgggaggc aggtccatgc taagcttcca gccttgggca ggtatgagtg aggctcaaca
     3541 cgtatgcctc agcataccta gggacttcag actttttaac ctcagaaaat gtctcaatgt
     3601 atgtgattta tgtcatacta acgggctgtg ggcaataaac atgaatttaa aaca
//
