LOCUS       NM_053198               2729 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sideroflexin 4 (Sfxn4), transcript variant 1, mRNA.
ACCESSION   NM_053198
VERSION     NM_053198.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102432.9 and AC163019.5.
            
            On Apr 13, 2018 this sequence version replaced NM_053198.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089535.1, AF325263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC102432.9         165056-165185
            131-196             AC102432.9         166390-166455
            197-271             AC102432.9         167746-167820
            272-298             AC102432.9         169108-169134
            299-353             AC102432.9         169220-169274
            354-379             AC102432.9         170632-170657
            380-433             AC102432.9         172424-172477
            434-490             AC102432.9         172564-172620
            491-556             AC102432.9         172732-172797
            557-635             AC102432.9         174394-174472
            636-751             AC102432.9         175410-175525
            752-837             AC163019.5         152298-152383       c
            838-955             AC163019.5         150208-150325       c
            956-2729            AC163019.5         145366-147139       c
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..2729
                     /gene="Sfxn4"
                     /note="sideroflexin 4"
                     /db_xref="GeneID:94281"
                     /db_xref="MGI:MGI:2137680"
     exon            1..130
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1033
                     /gene="Sfxn4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sideroflexin-4 isoform 1"
                     /protein_id="NP_444428.3"
                     /db_xref="CCDS:CCDS29943.1"
                     /db_xref="GeneID:94281"
                     /db_xref="MGI:MGI:2137680"
                     /translation="MEPNLQFWISERQAFFRRFCQWMDLLDPVNMFISIGSIEKSRQL
                     LFTTEDAPKHYLDNQVIKDAWNKSLSTVHPDSSKLIPHLFRPAAFLPVTAPMVFLLMM
                     PDTGIKSIILTQGCLYGYTTAFNITNGNASYSHGPVERTLLGAGVSVSSTFIGLIPHL
                     FQMKYPPNNFWLKRTLPIVFLAQVSGMNVFASRSFENHRGIEVMDKEGHVVGHSRKAG
                     RKAIKDTAKSRAVLFGTSALAPELFIHIFKRTRFYPQTLLSLVILRMSSTFFMMGLMV
                     PVSFSMFPQIGQIQCSQLEEKIQSSTEEKELFYYRGV"
     exon            131..196
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            197..271
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            272..298
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            299..353
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            354..379
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            380..433
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..490
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..556
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..635
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            636..751
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            752..837
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..955
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..2729
                     /gene="Sfxn4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfxn4"
                     /note="hexamer: AATAAA"
     polyA_site      1258
                     /gene="Sfxn4"
                     /note="major polyA site"
ORIGIN      
        1 aaacggggcc tgcatcacac tcgggtttgt tcagagaaga ggaggaggcg cttgctggcg
       61 ttgccaaggg cgtagtggcg ccgctgtcca aatggaaccc aacctgcagt tctggatttc
      121 cgaacgccaa gccttttttc gaagattttg tcagtggatg gatttattag atcctgtaaa
      181 catgtttatt tcaattggaa gcatagaaaa atcacgacag ttgttattta ccactgaaga
      241 tgcacccaaa cactacctgg ataaccaagt gattaaagac gcatggaata agagtctttc
      301 aactgtgcac cctgacagca gcaagttgat cccccatctt tttcgacctg cagctttcct
      361 gcctgtgaca gcacccatgg tatttctgtt gatgatgcca gacactggaa taaagtccat
      421 cattttaact cagggttgct tgtatggata caccacagcc tttaacatca ccaatggaaa
      481 tgccagttat agtcatggac cagtagagag aacattgttg ggagcagggg tgtctgtgtc
      541 ttcaactttc attggattaa ttcctcatct ctttcaaatg aagtatcccc cgaataactt
      601 ttggcttaaa agaaccttgc caatcgtctt tcttgcccaa gtcagtggaa tgaatgtttt
      661 tgcatcccgc agttttgaaa accatcgagg aattgaggtg atggataagg aaggccatgt
      721 cgtaggccat tccagaaaag ctggaagaaa ggctattaaa gatacagcga aatccagagc
      781 agtgctgttt gggacctcag ccttggcccc tgaactcttt atccacatct ttaaaaggac
      841 gaggttttac ccacagactc tgctgtcact cgtgatcctg agaatgagtt ccacattctt
      901 tatgatggga ctgatggtgc cagtgtcatt cagcatgttt ccacagattg gacagatcca
      961 gtgcagtcag cttgaagaga agattcaatc ttctacagaa gaaaaggaac tcttctatta
     1021 cagaggggta taggaacaag tttatctcct gtttggaaat ctttggcccc ttaaagagca
     1081 ctgccatggt cctcagggtt cccagcaaca cttgtgcagc aagctggctt cagtgcctga
     1141 gtctaaccaa aagaagagca gcacccaggg gactgctgag atgaagtaag agtcagcccg
     1201 gggaaggata atgtgaccct gtgaataaac ctgtctggag ttgaatactt gaaagaaatc
     1261 atcaaaaggt ataccttatc tggggtacaa acactacact gatagcctcc agatagatac
     1321 aaaactctgg tgagctcatt aaggcttcta gtccctaagt agtcctgttt ccctacttat
     1381 tttatctgat cccacactgc aagcattctg tctacttccc tggtttctgt tgaaaggacc
     1441 ctgatacttc tatttctaga ataactgagg cccctagcca acaacagctt cctgctcaat
     1501 accagtccag gtctatatat agtcaactct cttagggatc cccatctccc ttcctctggg
     1561 ccttgctctg tagtcactgg ggcatctctg gcttacttct ctctatagac tactcccagg
     1621 agcattgaaa ctgccttaac aaacaaacaa acaaacaaac aaaccatact tcctagccaa
     1681 aatttcttct tccttccttc cttccttcct tccttccttc cttccttcct tccttccttc
     1741 cttccttcct tccttccttc cttccgattc ttcctccttc ttccccagtc ccttcttcaa
     1801 gacagggttt ttctgtgttg gtcacagcct acattctgct gagatggctc tcacctaagc
     1861 cccatccaag gctggactac cattctgcca ggccctcata ccccaaccag ttgctacagt
     1921 gtacttggct ctttggatgc ccccacggga ctcatggttg agtcaaccat gccttatctc
     1981 agctccctag taaccttggg taatggtgac atcatttacc cagctatgtc actcaacctc
     2041 ttatcccaga caggcataat ttcatgtgtt aagaacccaa ggcttcaggt gctgcttcag
     2101 ctcagtgcaa tagcaccccc tgctggcatt gtcttgtggc tttttgcctt gctctggctg
     2161 ctctctgaaa cctcctgctt ctgtctggag acaaagttct gcttcttttt tttttcagat
     2221 ttatttattt attatatgta agtacactgt agctgtcttt agacactcca gaagagggag
     2281 tcagatggtt gtgagccacc atgtggttgc tgggatttga actccagacc tttggaagag
     2341 cagttgggtg ctcttaccca ctgagccatc tcaccagccc caaagttctg attcttaaca
     2401 cccttagaaa acctctatct tattcatctc ttgtcatccc cttctatgtc ccacagaacc
     2461 taacatctgg ttcctcacat tagtttgtgg gcttttctgt ttttttactg caaccgtttc
     2521 ttctctggag gcctagagag ctcacagtat tgagtgaggt accccttcca ctggtttcca
     2581 tagcacccca tttctcttat cagacctgct cccggccaca ctacctcaag acctgttgcc
     2641 tggtcctatt tcgtagcaga ctgtctttag agaagatgca tattgtttgg ttattgtgat
     2701 attttcacat taaactcacc aaaggtgtc
//
