LOCUS       NM_009160               1326 bp    mRNA    linear   ROD 30-DEC-2024
DEFINITION  Mus musculus surfactant associated protein D (Sftpd), mRNA.
ACCESSION   NM_009160
VERSION     NM_009160.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Avcibas,R., Vermul,A., Gluhovic,V., Boback,N., Arroyo,R.,
            Kingma,P., Isasi-Campillo,M., Garcia-Ortega,L., Griese,M.,
            Kuebler,W.M., Ochs,M., Lauster,D. and Lopez-Rodriguez,E.
  TITLE     Multivalent, calcium-independent binding of surfactant protein A
            and D to sulfated glycosaminoglycans of the alveolar epithelial
            glycocalyx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L524-L538 (2024)
   PUBMED   38375572
  REMARK    GeneRIF: Multivalent, calcium-independent binding of surfactant
            protein A and D to sulfated glycosaminoglycans of the alveolar
            epithelial glycocalyx.
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Hata,K., Tsubouchi,K., Suzuki,K., Eto,D., Ando,H., Yanagihara,T.,
            Kan-O,K. and Okamoto,I.
  TITLE     Surfactant protein D prevents mucin overproduction in airway goblet
            cells via SIRPalpha
  JOURNAL   Sci Rep 14 (1), 1799 (2024)
   PUBMED   38245585
  REMARK    GeneRIF: Surfactant protein D prevents mucin overproduction in
            airway goblet cells via SIRPalpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Wan,L., Hu,X., Xia,T., Li,F., Chi,Q., Ma,H., Yan,S., Li,W. and
            Huang,W.
  TITLE     Disruption of Cdyl gene impairs mouse lung epithelium
            differentiation and maturation
  JOURNAL   Gene 853, 147088 (2023)
   PUBMED   36464171
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Ganguly,K., Kishore,U., Metkari,S.M. and Madan,T.
  TITLE     Immunomodulatory Role of Surfactant Protein-D in a Transgenic
            Adenocarcinoma of Mouse Prostate (TRAMP) Model
  JOURNAL   Front Immunol 13, 930449 (2022)
   PUBMED   35874783
  REMARK    GeneRIF: Immunomodulatory Role of Surfactant Protein-D in a
            Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Yang,G., Lu,S., Jiang,J., Weng,J. and Zeng,X.
  TITLE     Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in
            Mice by the FGF Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (11), 6014 (2022)
   PUBMED   35682694
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Botas,C., Poulain,F., Akiyama,J., Brown,C., Allen,L., Goerke,J.,
            Clements,J., Carlson,E., Gillespie,A.M., Epstein,C. and Hawgood,S.
  TITLE     Altered surfactant homeostasis and alveolar type II cell morphology
            in mice lacking surfactant protein D
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 11869-11874 (1998)
   PUBMED   9751757
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Mason,R.J., Greene,K. and Voelker,D.R.
  TITLE     Surfactant protein A and surfactant protein D in health and disease
  JOURNAL   Am J Physiol 275 (1), L1-L13 (1998)
   PUBMED   9688929
  REMARK    Review article
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Wong,C.J., Akiyama,J., Allen,L. and Hawgood,S.
  TITLE     Localization and developmental expression of surfactant proteins D
            and A in the respiratory tract of the mouse
  JOURNAL   Pediatr Res 39 (6), 930-937 (1996)
   PUBMED   8725251
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Wevrick,R., Barker,J.E., Nadeau,J.H., Szpirer,C. and Buchwald,M.
  TITLE     Mapping of the murine and rat Facc genes and assessment of
            flexed-tail as a candidate mouse homolog of Fanconi anemia group C
  JOURNAL   Mamm Genome 4 (8), 440-444 (1993)
   PUBMED   7690622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY116790.1, AC124400.4, BG085186.2, CJ237327.1 and AI573415.1.
            
            On Jan 1, 2009 this sequence version replaced NM_009160.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript from the
            reference strain was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments
            from other mouse strains and orthologous rat and human data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003705.1, BI248935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               BY116790.1         3-327
            326-390             AC124400.4         119316-119380       c
            391-507             AC124400.4         118959-119075       c
            508-561             AC124400.4         118579-118632       c
            562-1214            BG085186.2         1-653
            1215-1323           CJ237327.1         399-507
            1324-1326           AI573415.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..1326
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /note="surfactant associated protein D"
                     /db_xref="GeneID:20390"
                     /db_xref="MGI:MGI:109515"
     exon            1..74
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            75..273
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1202
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /note="pulmonary surfactant-associated protein D; lung
                     surfactant protein D"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein D
                     precursor"
                     /protein_id="NP_033186.1"
                     /db_xref="CCDS:CCDS26962.1"
                     /db_xref="GeneID:20390"
                     /db_xref="MGI:MGI:109515"
                     /translation="MLPFLSMLVLLVQPLGNLGAEMKSLSQRSVPNTCTLVMCSPTEN
                     GLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLQGPTGPVGPKGENGSAGEPGPKGERG
                     LSGPPGLPGIPGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSTGAKGS
                     TGPKGERGAPGVQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGVPGDRGIKGES
                     GLPDSAALRQQMEALKGKLQRLEVAFSHYQKAALFPDGRSVGDKIFRTADSEKPFEDA
                     QEMCKQAGGQLASPRSATENAAIQQLITAHNKAAFLSMTDVGTEGKFTYPTGEPLVYS
                     NWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF"
     exon            274..390
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            391..507
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            508..624
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            625..741
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            742..825
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1326
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /note="hexamer: AATAAA"
     polyA_site      1326
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /note="major polyA site"
ORIGIN      
        1 aggcataaat agccgagcct gacaaacaga ggtgcattta cctggacctc ctggggccaa
       61 caaggaagca atctgacatg ctgccctttc tctccatgct tgtcttgctt gtacagcccc
      121 tgggaaatct gggagcagaa atgaagagcc tctcgcagag atcagtaccc aacacctgca
      181 ccctagtcat gtgtagccca acagagaatg gcctgcctgg tcgtgatgga cgggatggga
      241 gagaaggtcc acggggtgag aagggtgatc caggtttgcc aggacctatg gggctctcag
      301 ggttgcaggg ccctacaggt ccagttggac ccaaaggaga gaatggctct gctggcgaac
      361 ctggaccaaa gggagaacgt ggactaagtg gacctccagg acttccaggt attcctggtc
      421 cagctgggaa agaaggtccc tctgggaagc aggggaacat aggacctcaa ggcaaaccag
      481 gtcctaaagg agaggctggg cccaaaggag aagtaggtgc tcctggcatg caaggatcta
      541 caggggcaaa aggctccaca ggccccaagg gagaaagagg tgcccctggt gtgcaaggag
      601 ccccagggaa tgctggagca gcaggacctg ccggacctgc cggtccacag ggagctccag
      661 gttccagggg gcccccagga ctcaaggggg acagaggtgt tcctggagac agaggaatca
      721 aaggtgaaag cgggcttcca gacagtgctg ctctgaggca gcagatggag gccttaaaag
      781 gaaaactaca gcgtctagag gttgccttct cccactatca gaaagctgca ttgttccctg
      841 atggccgaag tgttggagac aagatcttca ggacagcaga ctctgaaaag ccttttgagg
      901 atgcccagga gatgtgcaaa caggctggag gacagctggc ctccccacgt tctgctactg
      961 agaatgctgc catacagcaa ctcatcacag cccacaacaa ggctgctttc ctgagtatga
     1021 cagatgtggg cacagagggc aagttcactt accccacagg agagcccctg gtctattcta
     1081 attgggctcc aggggagccc aacaacaatg gtggagcaga gaactgtgtg gagatcttca
     1141 ccaatgggca atggaatgat aaggcttgtg gagagcagcg ccttgttatc tgtgagttct
     1201 gagccactgg aggtaaaaaa aaaaaaaaaa aaaaaaacag gacaatattt ggccaggagt
     1261 ttaaccagtg tactatggct cagacctgta tgttgccaac atcctaataa aaggtgtata
     1321 gcttga
//
