LOCUS       NP_033186                374 aa            linear   ROD 25-APR-2025
DEFINITION  pulmonary surfactant-associated protein D precursor [Mus musculus].
ACCESSION   NP_033186
VERSION     NP_033186.1
DBSOURCE    REFSEQ: accession NM_009160.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Avcibas,R., Vermul,A., Gluhovic,V., Boback,N., Arroyo,R.,
            Kingma,P., Isasi-Campillo,M., Garcia-Ortega,L., Griese,M.,
            Kuebler,W.M., Ochs,M., Lauster,D. and Lopez-Rodriguez,E.
  TITLE     Multivalent, calcium-independent binding of surfactant protein A
            and D to sulfated glycosaminoglycans of the alveolar epithelial
            glycocalyx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L524-L538 (2024)
   PUBMED   38375572
  REMARK    GeneRIF: Multivalent, calcium-independent binding of surfactant
            protein A and D to sulfated glycosaminoglycans of the alveolar
            epithelial glycocalyx.
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Hata,K., Tsubouchi,K., Suzuki,K., Eto,D., Ando,H., Yanagihara,T.,
            Kan-O,K. and Okamoto,I.
  TITLE     Surfactant protein D prevents mucin overproduction in airway goblet
            cells via SIRPalpha
  JOURNAL   Sci Rep 14 (1), 1799 (2024)
   PUBMED   38245585
  REMARK    GeneRIF: Surfactant protein D prevents mucin overproduction in
            airway goblet cells via SIRPalpha.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Wan,L., Hu,X., Xia,T., Li,F., Chi,Q., Ma,H., Yan,S., Li,W. and
            Huang,W.
  TITLE     Disruption of Cdyl gene impairs mouse lung epithelium
            differentiation and maturation
  JOURNAL   Gene 853, 147088 (2023)
   PUBMED   36464171
REFERENCE   4  (residues 1 to 374)
  AUTHORS   Ganguly,K., Kishore,U., Metkari,S.M. and Madan,T.
  TITLE     Immunomodulatory Role of Surfactant Protein-D in a Transgenic
            Adenocarcinoma of Mouse Prostate (TRAMP) Model
  JOURNAL   Front Immunol 13, 930449 (2022)
   PUBMED   35874783
  REMARK    GeneRIF: Immunomodulatory Role of Surfactant Protein-D in a
            Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 374)
  AUTHORS   Yang,G., Lu,S., Jiang,J., Weng,J. and Zeng,X.
  TITLE     Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in
            Mice by the FGF Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (11), 6014 (2022)
   PUBMED   35682694
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 374)
  AUTHORS   Botas,C., Poulain,F., Akiyama,J., Brown,C., Allen,L., Goerke,J.,
            Clements,J., Carlson,E., Gillespie,A.M., Epstein,C. and Hawgood,S.
  TITLE     Altered surfactant homeostasis and alveolar type II cell morphology
            in mice lacking surfactant protein D
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 11869-11874 (1998)
   PUBMED   9751757
REFERENCE   7  (residues 1 to 374)
  AUTHORS   Mason,R.J., Greene,K. and Voelker,D.R.
  TITLE     Surfactant protein A and surfactant protein D in health and disease
  JOURNAL   Am J Physiol 275 (1), L1-L13 (1998)
   PUBMED   9688929
  REMARK    Review article
REFERENCE   8  (residues 1 to 374)
  AUTHORS   Wong,C.J., Akiyama,J., Allen,L. and Hawgood,S.
  TITLE     Localization and developmental expression of surfactant proteins D
            and A in the respiratory tract of the mouse
  JOURNAL   Pediatr Res 39 (6), 930-937 (1996)
   PUBMED   8725251
REFERENCE   9  (residues 1 to 374)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   10 (residues 1 to 374)
  AUTHORS   Wevrick,R., Barker,J.E., Nadeau,J.H., Szpirer,C. and Buchwald,M.
  TITLE     Mapping of the murine and rat Facc genes and assessment of
            flexed-tail as a candidate mouse homolog of Fanconi anemia group C
  JOURNAL   Mamm Genome 4 (8), 440-444 (1993)
   PUBMED   7690622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY116790.1, AC124400.4, BG085186.2, CJ237327.1 and AI573415.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript from the
            reference strain was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments
            from other mouse strains and orthologous rat and human data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003705.1, BI248935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     Protein         1..374
                     /product="pulmonary surfactant-associated protein D
                     precursor"
                     /note="pulmonary surfactant-associated protein D; lung
                     surfactant protein D"
                     /calculated_mol_wt=35651
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2056
     mat_peptide     20..374
                     /product="Pulmonary surfactant-associated protein D.
                     /id=PRO_0000017466"
                     /note="propagated from UniProtKB/Swiss-Prot (P50404.1)"
                     /calculated_mol_wt=35651
     Region          38..222
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P50404.1)"
     Region          <60..>219
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50404.1)"
     Region          223..267
                     /region_name="Surfac_D-trimer"
                     /note="Lung surfactant protein D coiled-coil
                     trimerization; pfam09006"
                     /db_xref="CDD:286141"
     Region          261..374
                     /region_name="CLECT_collectin_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in human collectins including lung surfactant proteins A
                     and D, mannose- or mannan binding lectin (MBL), and CL-L1
                     (collectin liver 1); cd03591"
                     /db_xref="CDD:153061"
     Site            order(316,320,343,348..349)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153061"
     Site            order(320,343,349)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153061"
     Site            order(340,342,348,360..361)
                     /site_type="other"
                     /note="carbohydrate binding site [chemical binding]"
                     /db_xref="CDD:153061"
     CDS             1..374
                     /gene="Sftpd"
                     /gene_synonym="PSP-D; Sfpd; Sftp4; SP-D"
                     /coded_by="NM_009160.2:78..1202"
                     /db_xref="CCDS:CCDS26962.1"
                     /db_xref="GeneID:20390"
                     /db_xref="MGI:MGI:109515"
ORIGIN      
        1 mlpflsmlvl lvqplgnlga emkslsqrsv pntctlvmcs ptenglpgrd grdgregprg
       61 ekgdpglpgp mglsglqgpt gpvgpkgeng sagepgpkge rglsgppglp gipgpagkeg
      121 psgkqgnigp qgkpgpkgea gpkgevgapg mqgstgakgs tgpkgergap gvqgapgnag
      181 aagpagpagp qgapgsrgpp glkgdrgvpg drgikgesgl pdsaalrqqm ealkgklqrl
      241 evafshyqka alfpdgrsvg dkifrtadse kpfedaqemc kqaggqlasp rsatenaaiq
      301 qlitahnkaa flsmtdvgte gkftyptgep lvysnwapge pnnnggaenc veiftngqwn
      361 dkacgeqrlv icef
//
