LOCUS       NM_147779               1562 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus surfactant associated protein B (Sftpb), transcript
            variant 1, mRNA.
ACCESSION   NM_147779 XM_974249
VERSION     NM_147779.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Chen,S.Y. and Liu,F.C.
  TITLE     The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497597
REFERENCE   2  (bases 1 to 1562)
  AUTHORS   Wan,L., Hu,X., Xia,T., Li,F., Chi,Q., Ma,H., Yan,S., Li,W. and
            Huang,W.
  TITLE     Disruption of Cdyl gene impairs mouse lung epithelium
            differentiation and maturation
  JOURNAL   Gene 853, 147088 (2023)
   PUBMED   36464171
REFERENCE   3  (bases 1 to 1562)
  AUTHORS   Yang,G., Lu,S., Jiang,J., Weng,J. and Zeng,X.
  TITLE     Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in
            Mice by the FGF Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (11), 6014 (2022)
   PUBMED   35682694
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1562)
  AUTHORS   Xu,H., Nie,G., Yin,T., Shao,C., Ding,D. and Zou,M.
  TITLE     Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant
            Protein B Alleviates Inflammatory Response in Acute Respiratory
            Distress Syndrome by Regulating Macrophage Polarization
  JOURNAL   Balkan Med J 39 (1), 130-139 (2022)
   PUBMED   35330560
  REMARK    GeneRIF: Umbilical Cord-derived Mesenchymal Stem Cells with
            Surfactant Protein B Alleviates Inflammatory Response in Acute
            Respiratory Distress Syndrome by Regulating Macrophage
            Polarization.
REFERENCE   5  (bases 1 to 1562)
  AUTHORS   Morishita,H., Kanda,Y., Kaizuka,T., Chino,H., Nakao,K., Miki,Y.,
            Taketomi,Y., Guan,J.L., Murakami,M., Aiba,A. and Mizushima,N.
  TITLE     Autophagy Is Required for Maturation of Surfactant-Containing
            Lamellar Bodies in the Lung and Swim Bladder
  JOURNAL   Cell Rep 33 (10), 108477 (2020)
   PUBMED   33296658
REFERENCE   6  (bases 1 to 1562)
  AUTHORS   Bachurski,C.J., Pryhuber,G.S., Glasser,S.W., Kelly,S.E. and
            Whitsett,J.A.
  TITLE     Tumor necrosis factor-alpha inhibits surfactant protein C gene
            transcription
  JOURNAL   J Biol Chem 270 (33), 19402-19407 (1995)
   PUBMED   7642621
REFERENCE   7  (bases 1 to 1562)
  AUTHORS   Clark,J.C., Wert,S.E., Bachurski,C.J., Stahlman,M.T., Stripp,B.R.,
            Weaver,T.E. and Whitsett,J.A.
  TITLE     Targeted disruption of the surfactant protein B gene disrupts
            surfactant homeostasis, causing respiratory failure in newborn mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7794-7798 (1995)
   PUBMED   7644495
REFERENCE   8  (bases 1 to 1562)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   9  (bases 1 to 1562)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   10 (bases 1 to 1562)
  AUTHORS   D'Amore-Bruno,M.A., Wikenheiser,K.A., Carter,J.E., Clark,J.C. and
            Whitsett,J.A.
  TITLE     Sequence, ontogeny, and cellular localization of murine surfactant
            protein B mRNA
  JOURNAL   Am J Physiol 262 (1 Pt 1), L40-L47 (1992)
   PUBMED   1733280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116115.11 and FO681326.1.
            
            On Jan 23, 2023 this sequence version replaced NM_147779.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC116115.11        68698-68776
            80-207              AC116115.11        69080-69207
            208-279             AC116115.11        69716-69787
            280-405             AC116115.11        69897-70022
            406-570             AC116115.11        70899-71063
            571-660             AC116115.11        71242-71331
            661-844             FO681326.1         320-503
            845-1005            AC116115.11        74723-74883
            1006-1086           AC116115.11        76441-76521
            1087-1164           AC116115.11        76958-77035
            1165-1562           AC116115.11        78062-78459
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..1562
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /note="surfactant associated protein B"
                     /db_xref="GeneID:20388"
                     /db_xref="MGI:MGI:109516"
     exon            1..79
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1149
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pulmonary surfactant-associated protein B;
                     pulmonary surfactant-associated proteolipid SPL(Phe)"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein B
                     isoform 1 precursor"
                     /protein_id="NP_680088.1"
                     /db_xref="GeneID:20388"
                     /db_xref="MGI:MGI:109516"
                     /translation="MAKSHLLQWLLLLPTLCCPGAAITSASSLECAQGPQFWCQSLEH
                     AVQCRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDIL
                     PLKLLVPRCRQVLDVYLPLVIDYFQSQINPKAICNHVGLCPRGQAKPEQNPGMPDAVP
                     NPLLDKLVLPVLPGALLARPGPHTQDFSEQQLPIPLPFCWLCRTLIKRVQAVIPKGVL
                     AVAVSQVCHVVPLVVGGICQCLAERYTVLLLDALLGRVVPQLVCGLVLRCSTEDAMGP
                     ALPAVEPLIEEWPLQDTECHFCKSVINQAWNTSEQAMPQAMHQACLRFWLDRQKCEQF
                     VEQHMPQLLALVPRSQDAHITCQALGVCEAPASPLQCFQTPHL"
     exon            80..207
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            208..279
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            280..405
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            406..570
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            571..660
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            661..844
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1005
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1086
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1164
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1562
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1542..1547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /note="hexamer: AATAAA"
     polyA_site      1562
                     /gene="Sftpb"
                     /gene_synonym="SF-B; Sftp-3; Sftp3; SP-B"
                     /note="major polyA site"
ORIGIN      
        1 aagcagtagg cagccatggc caagtcgcac ctactgcagt ggctactgct gcttcctacc
       61 ctctgctgcc caggtgcagc tatcacgtcg gcctcatccc tggagtgtgc acaaggccct
      121 caattctggt gccaaagcct ggagcatgca gtgcagtgca gagccctggg gcactgcctg
      181 caggaagtct gggggcatgc aggagctaat gacctgtgcc aagagtgtga ggatattgtc
      241 cacctcctca caaagatgac caaggaagat gctttccagg aagcaatccg gaagttcctg
      301 gaacaagaat gtgatatcct tcccttgaag ctgcttgtgc cccggtgtcg ccaagtgctt
      361 gatgtctacc tgcccctggt tattgactac ttccagagcc agattaaccc caaagccatc
      421 tgcaatcatg tgggcctgtg cccacgtggg caggctaagc cagaacagaa tccagggatg
      481 ccggatgccg ttccaaaccc tctgctggac aagctggtcc tccctgtgct gccaggagcc
      541 ctcttggcaa ggcctgggcc tcacactcag gacttctctg agcaacagct ccccattccc
      601 ctgcccttct gctggctttg cagaactctg atcaagcggg ttcaagccgt gatccccaag
      661 ggtgtgctgg ctgtggctgt gtcccaggtg tgccacgtgg tacccctggt ggtgggtggc
      721 atctgccagt gcctggctga gcgctacaca gttctcctgc tagacgcact gctgggccgt
      781 gtggtgcccc agctagtctg tggccttgtc ctccgatgtt ccactgagga tgccatgggc
      841 cctgccctcc ctgctgtgga gcctctgata gaagaatggc cactacagga cactgagtgc
      901 catttctgca agtctgtgat caaccaggcc tggaacacca gtgaacaggc tatgccacag
      961 gcaatgcacc aggcctgcct tcgcttctgg ctagacaggc aaaagtgtga acagtttgtg
     1021 gaacagcaca tgccccagct gctggccctg gtgcctagga gccaggatgc ccacatcacc
     1081 tgccaggccc ttggcgtatg tgaggccccg gctagccctc tgcagtgctt ccaaacccca
     1141 cacctctgag aacgcggtct ccagcagcct gctccagagg acaagcctca gcctgcaccc
     1201 tcagccctgt gtcagtctgt atgtcccagc tctaactaca gaccaccacc accaccacca
     1261 ccaccaccac caccaccacc accaccacca ccaccaccac caccaccaca gtggtttctg
     1321 gctccccccg gtgatggggg gcggcaggcc cacgtcctct ggaagccttc agaaggggct
     1381 tcgggccttc gcctccacca gagccaagcc agctcccata gctcccacag cccacaggga
     1441 ctgagaagaa ctgttgtggc tccaagaaga catcgggtag aagctgggta tagccacacc
     1501 aaccccttgc taacatttct atgaaatcca aacttgagaa gaataaagaa tgggaacatg
     1561 ga
//
