LOCUS       NM_023134               2775 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus surfactant associated protein A1 (Sftpa1), mRNA.
ACCESSION   NM_023134
VERSION     NM_023134.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Scheffzuk,C., Biedziak,D., Gisch,N., Goldmann,T. and Stamme,C.
  TITLE     Surfactant protein A modulates neuroinflammation in adult mice upon
            pulmonary infection
  JOURNAL   Brain Res 1840, 149108 (2024)
   PUBMED   38964703
  REMARK    GeneRIF: Surfactant protein A modulates neuroinflammation in adult
            mice upon pulmonary infection.
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Avcibas,R., Vermul,A., Gluhovic,V., Boback,N., Arroyo,R.,
            Kingma,P., Isasi-Campillo,M., Garcia-Ortega,L., Griese,M.,
            Kuebler,W.M., Ochs,M., Lauster,D. and Lopez-Rodriguez,E.
  TITLE     Multivalent, calcium-independent binding of surfactant protein A
            and D to sulfated glycosaminoglycans of the alveolar epithelial
            glycocalyx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L524-L538 (2024)
   PUBMED   38375572
  REMARK    GeneRIF: Multivalent, calcium-independent binding of surfactant
            protein A and D to sulfated glycosaminoglycans of the alveolar
            epithelial glycocalyx.
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Guan,Z., Worth,B., Umstead,T.M., Amatya,S., Booth,J. and
            Chroneos,Z.C.
  TITLE     Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs
            gestation and reduces fetal survival during
            lipopolysaccharide-induced parturition in late gestation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L508-L513 (2024)
   PUBMED   38349123
  REMARK    GeneRIF: Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway
            prolongs gestation and reduces fetal survival during
            lipopolysaccharide-induced parturition in late gestation.
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Dare,A., King,S.D. and Chen,S.Y.
  TITLE     Surfactant protein A promotes western diet-induced hepatic
            steatosis and fibrosis in mice
  JOURNAL   Sci Rep 14 (1), 7464 (2024)
   PUBMED   38553537
  REMARK    GeneRIF: Surfactant protein A promotes western diet-induced hepatic
            steatosis and fibrosis in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Araujo,A.P., Oliveira,M.L.S. and Miyaji,E.N.
  TITLE     Negligible role for pneumococcal surface protein A (PspA) and
            pneumococcal surface protein C (PspC) in the nasopharyngeal
            colonization of mice with a serotype 6B pneumococcal strain
  JOURNAL   Microb Pathog 185, 106391 (2023)
   PUBMED   37839762
  REMARK    GeneRIF: Negligible role for pneumococcal surface protein A (PspA)
            and pneumococcal surface protein C (PspC) in the nasopharyngeal
            colonization of mice with a serotype 6B pneumococcal strain.
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Korfhagen,T.R., Bruno,M.D., Glasser,S.W., Ciraolo,P.J.,
            Whitsett,J.A., Lattier,D.L., Wikenheiser,K.A. and Clark,J.C.
  TITLE     Murine pulmonary surfactant SP-A gene: cloning, sequence, and
            transcriptional activity
  JOURNAL   Am J Physiol 263 (5 Pt 1), L546-L554 (1992)
   PUBMED   1443158
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Ten Have-Opbroek,A.A.
  TITLE     Lung development in the mouse embryo
  JOURNAL   Exp Lung Res 17 (2), 111-130 (1991)
   PUBMED   2050021
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124400.4.
            
            On Jan 25, 2019 this sequence version replaced NM_023134.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004788.1, AK004620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC124400.4         73811-73855
            46-78               AC124400.4         74239-74271
            79-273              AC124400.4         74458-74652
            274-393             AC124400.4         74845-74964
            394-471             AC124400.4         75661-75738
            472-2775            AC124400.4         76093-78396
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..2775
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="surfactant associated protein A1"
                     /db_xref="GeneID:20387"
                     /db_xref="MGI:MGI:109518"
     exon            1..45
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            46..78
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            79..273
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..848
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="pulmonary surfactant-associated protein A; PSAP;
                     PSP-A; surfactant pulmonary associated protein A1"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein A
                     precursor"
                     /protein_id="NP_075623.2"
                     /db_xref="CCDS:CCDS26960.1"
                     /db_xref="GeneID:20387"
                     /db_xref="MGI:MGI:109518"
                     /translation="MSLGSLAFTLFLTVVAGIKCNGTEVCAGSPGIPGTPGNHGLPGR
                     DGRDGIKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGEHGDKGEPGERGLPGFPAY
                     LDEELQTALYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIREMCTRAGG
                     HIAAPRNPEENEAIASITKKYNTYPYLGVIEGQTPGDFHYLDGASVNYTNWYPGEPRG
                     RGKEKCVEMYTDGKWNDKGCLQYRLAICEF"
     exon            274..393
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            394..471
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            472..2775
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="hexamer: GATAAA"
     polyA_site      886
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="major polyA site"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
                     /note="major polyA site"
     polyA_site      2626
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
     polyA_site      2735
                     /gene="Sftpa1"
                     /gene_synonym="Sftp-1; Sftp1; SP-A"
ORIGIN      
        1 gactcggagg cagacatcca cacagcttgc aggctctgtg tgcggggatc tgaagttgga
       61 ggcctgcagt gtgattggga gaaaccactg gtacagtagc catgtcacta ggctctttgg
      121 ccttcaccct cttcttgact gttgttgctg gcatcaagtg caatgggaca gaagtttgtg
      181 ccggaagccc tgggatccct ggcactcccg gaaaccatgg tttgcccggc agagatggga
      241 gagatggtat caaaggagac cctggacctc caggtcccat gggccctcct ggaggaatgc
      301 caggtcttcc tgggcgcgat gggctgcctg gagcccctgg tgcacctgga gaacatggag
      361 acaagggaga gcctggagaa agggggcttc cagggtttcc agcttacctg gatgaggagc
      421 ttcagactgc actctacgag atcaaacatc agattctgca aacaatggga gtcctcagct
      481 tgcaaggatc catgctgtca gtgggggata aagtcttttc caccaatggg cagtcagtca
      541 actttgatac cattagagag atgtgtacca gagccggtgg ccacattgct gccccgagga
      601 atcctgagga gaacgaggcc atcgcaagca ttacaaagaa gtacaacacc tatccctact
      661 taggtgtgat tgaaggccag actcctggag acttccacta cctggatggg gcttctgtga
      721 actacaccaa ctggtaccca ggagagccca ggggtcgggg caaagagaaa tgtgtagaaa
      781 tgtatacaga tgggaaatgg aatgataagg gctgcctgca gtaccggctg gccatttgtg
      841 aattttgatc aagcaattag atgaaaagat aaaacttcac actgtcttta agcctctatc
      901 ttgatgatcc atctggtctg taagaccctg taactacctt tcaagcaaat ttacttgtgg
      961 ccatcagaat tataagcatc cttagttacg ccatctccca catggcttct aaactcttct
     1021 ccatattcat tagtaatcct gagtgtcccc ctagagtccc atctgagcat tcaactcaag
     1081 gcagccactg tcaaccttga ttttcatcag gagatcgatg gagacttcct ttttcctcac
     1141 tttgtccagt cttcacttat aaattgtggc catggaagaa ccctctaaat tacatagaaa
     1201 gtgcctgctc ctggaccctt caacccttct tctgcagctc atggtcccaa gatttaaaag
     1261 tccaggttaa atataaaaga tagccatagg gaatttctgg gaaataccta gtatatggat
     1321 gtaggccaca ttgagtgtcc tctgtatacc tgctttcaag gcaaacacgg tgtctaagaa
     1381 gccagagaac caggtagggc cacagcacag tactggggaa acataacctc cctggttggc
     1441 atatatggcc tcttccttgg atctggatct tgacctaata gcagccaccc tgagtttaga
     1501 gagaatcacc tttccagccc agaccctaac tcaagtaatt tcctgctaac aaacataacc
     1561 ttcgtccact ttacatcact gaggcatacc aactgctctc ttttcgcctc tcatgaactc
     1621 aatcaactat tccattaaag tcagcttcat cccagatgtt agtctgtctt ccggtaagct
     1681 ttgagctaac ttttctttga gcttatttct ttactatggt atgcaaataa agtaattatt
     1741 acattttttc tacctaccca aagcattacc tataacaatt cctacaacaa agactgatca
     1801 catgctgcct accaagtact ttgacaagca cagataacat ttgttgttag gtgtcattta
     1861 atctttaaat gggccacaga accagattag gggcgtggga gctaaaaagg tattaagaag
     1921 aacatgacat ttgtgctgat agctggggtc aaggtaactc cagacctgtg cccatatggt
     1981 ccatgttgag gagtgatatt atctttttca tccttcctca actactggga tgctatttac
     2041 tgtgccatga ctggaggtgg gattcaaggt gaggtttcta tgaatcatcc tactctcaaa
     2101 tgcatggaat ggattatggg attcacccta gtctcaacta tgtggaatgc gaccatgacc
     2161 cacactccag gtatccatag gggtgtaact atatgccttg agggggcagc caactataca
     2221 tcttatctct agaagtctcc tgtgctctgc ccacctgaca ctcttcccac atttccatct
     2281 tttcttgggc ataaggaagc ccaggaacag ccagatggaa aattgctact tacacttgca
     2341 agaatgttaa ctgccaagct gacctttcta tctgtgtgat gaggactcaa tgtataagct
     2401 gttgagggtt tgctgagatc aaatgagcaa gaaaaaggca catattctca gttttataga
     2461 tcaacagcct aaagctttaa aagttcacat tgccccattt cctcttgggt ctaatttttt
     2521 atgacattac ttttaattgt aactacattg cttttgaaaa tatttttatt gagctattgc
     2581 tggtttgggg gaaagaatga tttttaaaaa ttgatcttat actcaaccat ctttttggat
     2641 tcatattttt cctttaatac tttcaatgat tcatatatca ttgcatttgt aaatgatgat
     2701 tttttttcct gctcacatat atttatacat atatacatat gtgtcatagg agaatttcta
     2761 atacttcacc agtgg
//
