LOCUS       NM_172276               3319 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus splicing factor SWAP (Sfswap), transcript variant 1,
            mRNA.
ACCESSION   NM_172276
VERSION     NM_172276.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Crisci,A., Raleff,F., Bagdiul,I., Raabe,M., Urlaub,H., Rain,J.C.
            and Kramer,A.
  TITLE     Mammalian splicing factor SF1 interacts with SURP domains of U2
            snRNP-associated proteins
  JOURNAL   Nucleic Acids Res 43 (21), 10456-10473 (2015)
   PUBMED   26420826
REFERENCE   3  (bases 1 to 3319)
  AUTHORS   Roberts,J.M., Ennajdaoui,H., Edmondson,C., Wirth,B., Sanford,J.R.
            and Chen,B.
  TITLE     Splicing factor TRA2B is required for neural progenitor survival
  JOURNAL   J Comp Neurol 522 (2), 372-392 (2014)
   PUBMED   23818142
REFERENCE   4  (bases 1 to 3319)
  AUTHORS   Moayedi,Y., Basch,M.L., Pacheco,N.L., Gao,S.S., Wang,R.,
            Harrison,W., Xiao,N., Oghalai,J.S., Overbeek,P.A., Mardon,G. and
            Groves,A.K.
  TITLE     The candidate splicing factor Sfswap regulates growth and
            patterning of inner ear sensory organs
  JOURNAL   PLoS Genet 10 (1), e1004055 (2014)
   PUBMED   24391519
  REMARK    GeneRIF: We show that Jag1; Sfswap compound mutants have inner ear
            defects that are more severe than expected from simple additive
            effects of the single mutants, indicating a genetic interaction
            between Sfswap and Jag1
REFERENCE   5  (bases 1 to 3319)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   6  (bases 1 to 3319)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3319)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3319)
  AUTHORS   Sarkissian,M., Winne,A. and Lafyatis,R.
  TITLE     The mammalian homolog of suppressor-of-white-apricot regulates
            alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS
  JOURNAL   J Biol Chem 271 (49), 31106-31114 (1996)
   PUBMED   8940107
REFERENCE   9  (bases 1 to 3319)
  AUTHORS   Denhez,F. and Lafyatis,R.
  TITLE     Conservation of regulated alternative splicing and identification
            of functional domains in vertebrate homologs to the Drosophila
            splicing regulator, suppressor-of-white-apricot
  JOURNAL   J Biol Chem 269 (23), 16170-16179 (1994)
   PUBMED   8206918
REFERENCE   10 (bases 1 to 3319)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277733.1, AK140369.1, BC057314.1 and AW121884.1.
            
            On Jul 22, 2006 this sequence version replaced NM_172276.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY277733.1         1-8
            9-2673              AK140369.1         2-2666
            2674-3300           BC057314.1         4501-5127
            3301-3319           AW121884.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.13 cM"
     gene            1..3319
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /note="splicing factor SWAP"
                     /db_xref="GeneID:231769"
                     /db_xref="MGI:MGI:101760"
     exon            1..366
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2986
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 8;
                     serine/arginine-rich splicing factor 8; suppressor of
                     white apricot protein homolog; splicing factor, suppressor
                     of white-apricot homolog"
                     /codon_start=1
                     /product="splicing factor, suppressor of white-apricot
                     homolog isoform 1"
                     /protein_id="NP_758480.2"
                     /db_xref="CCDS:CCDS19694.1"
                     /db_xref="GeneID:231769"
                     /db_xref="MGI:MGI:101760"
                     /translation="MYGAGGGRAKPERKGGVKEEAGPGGTGTGGNRVELLVFGYACKL
                     FRDDERALAQEQGQHLIPWMGDPKILIDRYDGRGHLHDLSAYDAEYATWNRDYQLSEE
                     EARVEALCDEERYLALHTDLLEEEARQEEEYKRLSEALAEDGNYSAVGFTYGSDYYDP
                     SEPTEEEEPSKQREKNEAENLEENEEPFIAPLGLSVPSDVELPPTAKMHAIIERTANF
                     VCKQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKEGRYTVLAESKNEEK
                     KKSGPTSDNEEEDDEEDGSYLHPSLFASKKSSRLEELMKPLKVVDPDHPLAALVRKAQ
                     ADSSAPAPPTADGTPAQPSQVEYTADSTVAAMYYSYYMLPDGTYCLAPPPPGIDVATY
                     YSTLPAGVTVSSSPGVTTTVPPPPGTTPPPPPTTAEPSSGVTSTTTTTSALAPVAIIP
                     PPPDIQPVIDKLAEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQFFLQK
                     EGGGSTQAASTAEEAPTETAVEESGEAGEDGAPEGMAETGGRGSGKKEAGSSKSTVDG
                     KLVKASFAPISFAIKAKENDLLPLEKNRVKLDDDSEEDEESRECQESTSSVANPSPAA
                     APPSVAVEEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKR
                     KAALFLQTLKNPLPEAEVGKLEESTFGVEDTGVMPCPLLVGGRTLPILEGKPPERPSN
                     RCRDPPREEEREKKKKKHKKRSRTRSRSPKYHSSSKPRSRSHSKAKHSLPSAYRTVRR
                     SRSRSRSPRRRAHSPERRREERSVPTAYRMSGSPGVSRKRTRSRSPHEKKKKRRSRSR
                     TKAKARSQSTSPSKQAAQRPSAHSAHSASISPVESRGSSQERSRGVSQEKDGQISSAI
                     VSSVQSKITQDLMAKVRAMLAASKNLQTSAS"
     exon            367..536
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            537..668
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            669..754
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            755..980
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1093
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1229
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1470
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1599
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1693
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1859
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2090
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2281
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2547
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2673
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2847
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2920
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3303
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3270..3275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /note="hexamer: AATAAA"
     polyA_site      3303
                     /gene="Sfswap"
                     /gene_synonym="1190005N23Rik; 6330437E22Rik; Sfrs8; Srsf8;
                     SWAP"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctcca ttttgtggct cgctatggcg gctgtgttga agttgcgaag aggatgcggc
       61 gcctgtgact gagtgggtag gccaggcgag gcatcgggga cgttgttcgg cccagcagca
      121 gaccgtcccg gacgtcgggg acgctgtcat gtacggtgcc ggcgggggcc gtgccaagcc
      181 ggagaggaaa ggcggagtga aggaggaggc cgggccgggc ggcaccggca ctgggggcaa
      241 ccgggtggag cttctggttt tcggctatgc ctgcaagttg ttccgcgacg acgagcgggc
      301 tttggcccag gaacagggac agcacctcat cccctggatg ggggacccca agatcctcat
      361 cgacagatac gacgggcgtg gtcacctgca tgacctctct gcgtacgatg ctgagtacgc
      421 cacgtggaac cgagactacc agctgtctga agaggaggct cgggtagagg cgctgtgtga
      481 tgaagagagg tatttagcct tgcatacgga cttgcttgag gaggaggcaa ggcaagagga
      541 agaatacaaa agattgagtg aagcgctggc ggaggatgga aactacagtg ccgtagggtt
      601 cacttacggc agcgactatt atgacccgtc agagcccacg gaagaggagg agccttcgaa
      661 gcagagagaa aaaaatgagg ctgaaaactt ggaagaaaat gaagaacctt tcatcgcccc
      721 tttaggatta agcgtcccgt ctgatgtgga gctgccacca acagccaaaa tgcatgccat
      781 cattgagcgc acagccaact tcgtatgcaa gcagggagca cagttcgaga tcatgctgaa
      841 ggccaagcaa gctcgaaact cacagttcga cttcctacgg tttgatcact acctcaaccc
      901 ctactataaa ttcatccaga aagccatgaa agaaggacgg tacacggtgc tagctgagag
      961 caagaacgag gagaagaaaa agtctgggcc aacctctgac aacgaagagg aagatgatga
     1021 ggaagatggg agttacctgc acccgtctct ctttgcttcc aagaagagca gccgcctgga
     1081 agagctgatg aagcccttga aggtggtgga cccggatcac cctctagcag cccttgtccg
     1141 gaaagcacaa gctgacagct cagctccagc cccacccact gcagatggca cacctgctca
     1201 gccctcccag gtggagtaca cggcagactc aactgtggca gccatgtact acagctacta
     1261 catgttgcca gatggtacct actgcctggc accaccccca cctgggatcg atgtggccac
     1321 ttactacagc acccttcctg ctggagtgac tgtgtccagc tcacctggtg tgactaccac
     1381 tgtaccaccg cctcctggga ccacacctcc tccaccccca accacagctg aaccaagcag
     1441 cggggttacc tccacaacca ccaccacaag tgcgcttgct cccgtggcca tcataccccc
     1501 gccccccgac atccagcctg tgattgacaa gctggcagag tacgtcgcta gaaacggcct
     1561 taaatttgag accagtgttc gagccaagaa cgatcaaaga tttgaatttc ttcagccctg
     1621 gcaccagtac aacgcctact acgagtttaa gaagcagttc ttcctgcaga aagaaggagg
     1681 cggtagcaca caggcagcat caacagctga agaggctccc acagaaaccg ctgttgaaga
     1741 gtcgggtgaa gctggagagg acggcgctcc tgagggtatg gcagagactg ggggaagagg
     1801 cagcgggaag aaggaggctg ggtccagcaa gagcaccgtg gacgggaagc tggtaaaagc
     1861 ttcttttgct ccaataagct ttgccatcaa agccaaagaa aatgacctcc ttcccttgga
     1921 gaaaaaccgt gtcaagctgg acgatgacag tgaagaggat gaagaaagca gggagtgcca
     1981 ggaaagcaca agcagcgtgg ccaaccccag ccctgctgcc gccccgccct ccgtggctgt
     2041 agaggagaag aaaccacagc ttacccagga ggagctggaa gccaagcaag caaaacaaaa
     2101 gctggaggac cgccttgctg ctgctgcccg ggaaaagcta gcccaggcgt ccaaggaatc
     2161 aaaggagaag cagcttcagg ctgaacgtaa aaggaaagca gcgttgttct tacaaacctt
     2221 aaaaaatcct cttccagaag cagaagttgg aaaacttgag gagagtactt tcggggttga
     2281 ggacactggt gtcatgccct gtcctctgct ggttggtggt agaactctgc ccatattgga
     2341 agggaagcct ccagaaaggc cttcaaacag atgcagagat ccaccaagag aagaagaaag
     2401 agagaaaaag aagaagaagc acaaaaaacg gtctcggaca aggtcccgct ctcccaagta
     2461 ccactcgtct tccaagccca ggtctagatc ccactcaaaa gcaaagcact ccctgcccag
     2521 tgcctaccgg acagtgcggc ggtcaaggtc acggtctcgg tccccaagaa ggagagctca
     2581 ctctcctgag agacggcggg aagaaaggag tgtccctaca gcctaccgga tgagcggcag
     2641 ccctggggtc agcaggaaaa ggacccgttc cagaagtccc cacgagaaga agaagaaacg
     2701 gcgctcacgg tctcgcacca aagccaaggc ccggtcgcag tcaacatccc cgagtaaaca
     2761 ggccgcacag cgtccctcgg cccactcagc ccactcggcc agcatctctc ctgtggagag
     2821 ccgaggttcc tcccaggaac gctccagggg ggtttctcag gaaaaagatg gccagatctc
     2881 ctcagcaatc gtctcctctg tgcagagcaa aataactcag gatctcatgg ccaaagtaag
     2941 agcaatgctc gcagcttcaa aaaacctgca aaccagtgca tcctgagacg gcagccccgg
     3001 agcagccccc ggcgaacagc acggctgtgg ccctggctgt ggccacaggt gctgggctac
     3061 tgctcagagc agccacagtc cagacgtcag aagctgagct gtgagctctg ccgacctaca
     3121 tgcagctatc caggttctcc agcccgactc ctgggtcagt cagtggcttt tgtaaatttt
     3181 tggtgacatt ttctgtttca gatttttgac cagcagtctc tacctgtata tatgtaaata
     3241 tatcatgttt ctgtgaaaat gtattatcaa ataaaatggg aagaacagct tttctagcta
     3301 gcaaaaaaaa aaaaaaaaa
//
