LOCUS       NM_018780               1900 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus secreted frizzled-related sequence protein 5 (Sfrp5),
            mRNA.
ACCESSION   NM_018780
VERSION     NM_018780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Shi,Z., Zhao,T., Li,D., Wang,C., Luo,Y. and Zheng,Y.
  TITLE     Silencing of forkhead box C1 reduces nasal epithelial barrier
            damage in mice with allergic rhinitis via epigenetically
            upregulating secreted frizzled-related protein 5
  JOURNAL   Mol Immunol 168, 51-63 (2024)
   PUBMED   38422887
  REMARK    GeneRIF: Silencing of forkhead box C1 reduces nasal epithelial
            barrier damage in mice with allergic rhinitis via epigenetically
            upregulating secreted frizzled-related protein 5.
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Tang,S., Cope,D.I., Vasquez,Y.M. and Monsivais,D.
  TITLE     BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential
            for Receptivity and Early Pregnancy
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35383354
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Hu,W., Dong,A., Karasaki,K., Sogabe,S., Okamoto,D., Saigo,M.,
            Ishida,M., Yoshizumi,M. and Kokubo,H.
  TITLE     Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac
            differentiation
  JOURNAL   Sci Rep 11 (1), 3588 (2021)
   PUBMED   33574455
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Sun,M., Wang,W., Min,L., Chen,C., Li,Q. and Weng,W.
  TITLE     Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells
            against LPS-induced inflammation and apoptosis via inhibiting
            Wnt5a/JNK pathway
  JOURNAL   J Orthop Surg Res 16 (1), 129 (2021)
   PUBMED   33573682
  REMARK    GeneRIF: Secreted frizzled-related protein 5 (SFRP5) protects ATDC5
            cells against LPS-induced inflammation and apoptosis via inhibiting
            Wnt5a/JNK pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Quwailid,M.M., Hugill,A., Dear,N., Vizor,L., Wells,S., Horner,E.,
            Fuller,S., Weedon,J., McMath,H., Woodman,P., Edwards,D.,
            Campbell,D., Rodger,S., Carey,J., Roberts,A., Glenister,P.,
            Lalanne,Z., Parkinson,N., Coghill,E.L., McKeone,R., Cox,S.,
            Willan,J., Greenfield,A., Keays,D., Brady,S., Spurr,N., Gray,I.,
            Hunter,J., Brown,S.D. and Cox,R.D.
  TITLE     A gene-driven ENU-based approach to generating an allelic series in
            any gene
  JOURNAL   Mamm Genome 15 (8), 585-591 (2004)
   PUBMED   15457338
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Finley,K.R., Tennessen,J. and Shawlot,W.
  TITLE     The mouse secreted frizzled-related protein 5 gene is expressed in
            the anterior visceral endoderm and foregut endoderm during early
            post-implantation development
  JOURNAL   Gene Expr Patterns 3 (5), 681-684 (2003)
   PUBMED   12972006
  REMARK    GeneRIF: Here we report that the Secreted frizzled-related protein
            5 (Sfrp5) gene, which encodes a secreted factor that can antagonize
            Wnt signaling, is expressed in the AVE and foregut endoderm during
            early mouse development
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Pilcher,K.E. and Krieg,P.A.
  TITLE     Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of
            Xenopus
  JOURNAL   Gene Expr Patterns 2 (3-4), 369-372 (2002)
   PUBMED   12617827
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Chang,J.T., Esumi,N., Moore,K., Li,Y., Zhang,S., Chew,C.,
            Goodman,B., Rattner,A., Moody,S., Stetten,G., Campochiaro,P.A. and
            Zack,D.J.
  TITLE     Cloning and characterization of a secreted frizzled-related protein
            that is expressed by the retinal pigment epithelium
  JOURNAL   Hum Mol Genet 8 (4), 575-583 (1999)
   PUBMED   10072424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603804.18.
            
            On Oct 31, 2009 this sequence version replaced NM_018780.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032921.1, AF117759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               AL603804.18        95839-96599
            762-839             AL603804.18        98233-98310
            840-1900            AL603804.18        99060-100120
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.93 cM"
     gene            1..1900
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /note="secreted frizzled-related sequence protein 5"
                     /db_xref="GeneID:54612"
                     /db_xref="MGI:MGI:1860298"
     exon            1..761
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1186
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /note="secreted frizzled-related protein 5; sFRP-5"
                     /codon_start=1
                     /product="secreted frizzled-related protein 5 precursor"
                     /protein_id="NP_061250.2"
                     /db_xref="CCDS:CCDS29826.1"
                     /db_xref="GeneID:54612"
                     /db_xref="MGI:MGI:1860298"
                     /translation="MWVAWSARTAALALLLGALHGAPTRGQEYDYYGWQAEPLHGRSY
                     SKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQ
                     VFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCI
                     AVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLI
                     GAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLT
                     AVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH"
     exon            762..839
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1900
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="Sfrp5"
                     /gene_synonym="SARP3"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggggtg ggaggtgagg gggaccagcg gctgcagatt ggctagggaa cggcgaagcc
       61 tgggctggag ccccgtggtg ggaggcgcct ggatcactcc ggcagcggag cggagcagag
      121 actgccacct acttggacga ccctagtagc agccggcttc agggaacatc ccagccgggg
      181 cgcacgccgg gcagcggggc gccgagcacc gagccgtcgg ggcaggccgc aacatccagc
      241 catgtgggtg gcctggagcg cacggacggc cgcactggcg ttgctgctcg gggcgctgca
      301 tggggcgcca acacgcggcc aggagtacga ctactacggt tggcaggccg agccgctgca
      361 cggccgctcc tactccaagc caccgcagtg cctcgacatc cccgccgatc tgccgctctg
      421 tcacacggtg ggctacaagc gcatgcggct gcccaacctg ctggagcacg agagcctggc
      481 cgaggtgaag cagcaggcaa gcagctggct gccactgctg gccaagcgct gccactcaga
      541 cacccaggtc ttcctctgct cgctcttcgc tcccgtctgc ctggaccgac ccatctaccc
      601 ctgccgctcg ctgtgcgaag ccgtgcgcgc cggctgcgct ccgctcatgg aggcctacgg
      661 tttcccttgg cccgagatgc tgcactgcca caagttcccc ctggacaacg acctctgcat
      721 cgcggtgcag ttcgggcacc tgcctgccac cgcgcctcca gtgaccaaga tctgtgccca
      781 gtgtgagatg gagcacagcg ctgatggcct catggaacag atgtgctcca gtgactttgt
      841 ggtcaagatg cgcattaagg agatcaagat agacaacggg gaccgaaagt tgattggagc
      901 ccagaagaag aagaagctgc tcaaggcagg ccccttaaag cgcaaggaca ccaagaagct
      961 ggtcctgcat atgaagaacg gggcaagctg cccttgccca cagttagaca acctgacggg
     1021 cagcttcctg gtcatgggcc gcaaagtaga gggacagctg ctgctcacgg ccgtctaccg
     1081 ctgggacaag aagaataagg agatgaagtt tgcagtcaaa ttcatgttct cctatccctg
     1141 ttccctctac tacccttttt tctatggggc agctgaaccc cactgaaggg ccccctgctc
     1201 cttgccccaa ccagccagct gtgccttgcc tcgcctctgt ccacgcccac ttggcctcac
     1261 cttcactccc aggctgaccc atcacccccc ccccccaagg atggcttcac gcacctactg
     1321 cacaggctcc aaagcagagg catggggcta ccctctttga ctgaagggtt ctgggatcct
     1381 ggggtctgcc cggggacgcc ccctctccca gtagaaggac tttctcttct gggggaagcc
     1441 ctagtgtctg aaaaaaaaca ggcagaggag gaaaatgtga aggactacgg atacaggata
     1501 cagggcctcc tgcagcctgg ggaggggctt tccagaaagg attgtgggtc tcatcgctaa
     1561 gcgggatccg tacttaggga atagctttcc tcccccatgc ccctttgtgt gtcatcacag
     1621 tcctccaaag agcaagatcc aaggcctcca cgtcttccag ccacgcccac tcctcatctg
     1681 gagccacgat ggactggagt gcaggctcag ctgcttctgc gttcactgcc acacagcctt
     1741 gctccctggc tcttgctctg cctcctcaat ccctgtatcc caacgacgat aaattattgc
     1801 tactgctgtg gggccgctga ttctagacaa caggtttggt ccttaatttt tttaaaaagt
     1861 ttttaattaa ataaaacaac agttgctttg gaccaattaa
//
