LOCUS       NM_016687               1780 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus secreted frizzled-related protein 4 (Sfrp4), mRNA.
ACCESSION   NM_016687
VERSION     NM_016687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1780)
  AUTHORS   Ren,M., Ye,X., Ouyang,C., Da,Q., Xue,W. and Chen,P.
  TITLE     JMJD2A mediates transcriptional activation of SFRP4 and regulates
            oxidative stress and mitochondrial dysfunction in heart failure
  JOURNAL   Pathol Int 74 (4), 210-221 (2024)
   PUBMED   38411359
  REMARK    GeneRIF: JMJD2A mediates transcriptional activation of SFRP4 and
            regulates oxidative stress and mitochondrial dysfunction in heart
            failure.
REFERENCE   2  (bases 1 to 1780)
  AUTHORS   Chen,R., Dong,H., Raval,D., Maridas,D., Baroi,S., Chen,K., Hu,D.,
            Berry,S.R., Baron,R., Greenblatt,M.B. and Gori,F.
  TITLE     Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell
            niche function
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312677120 (2023)
   PUBMED   37931101
  REMARK    GeneRIF: Sfrp4 is required to maintain Ctsk-lineage periosteal stem
            cell niche function.
REFERENCE   3  (bases 1 to 1780)
  AUTHORS   Brommage,R., Liu,J. and Powell,D.R.
  TITLE     Skeletal phenotypes in secreted frizzled-related protein 4 gene
            knockout mice mimic skeletal architectural abnormalities in
            subjects with Pyle's disease from SFRP4 mutations
  JOURNAL   Bone Res 11 (1), 9 (2023)
   PUBMED   36808149
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1780)
  AUTHORS   Takaya,K., Asou,T. and Kishi,K.
  TITLE     Downregulation of senescence-associated secretory phenotype by
            knockdown of secreted frizzled-related protein 4 contributes to the
            prevention of skin aging
  JOURNAL   Aging (Albany NY) 14 (20), 8167-8178 (2022)
   PUBMED   36084952
  REMARK    GeneRIF: Downregulation of senescence-associated secretory
            phenotype by knockdown of secreted frizzled-related protein 4
            contributes to the prevention of skin aging.
REFERENCE   5  (bases 1 to 1780)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   6  (bases 1 to 1780)
  AUTHORS   Martin,N., Jaubert,J., Glaser,P., Szatanik,M. and Guenet,J.L.
  TITLE     Genetic and physical delineation of the region overlapping the
            progressive motor neuropathy (pmn) locus on mouse chromosome 13
  JOURNAL   Genomics 75 (1-3), 9-16 (2001)
   PUBMED   11472062
REFERENCE   7  (bases 1 to 1780)
  AUTHORS   Lee,C.S., Buttitta,L.A., May,N.R., Kispert,A. and Fan,C.M.
  TITLE     SHH-N upregulates Sfrp2 to mediate its competitive interaction with
            WNT1 and WNT4 in the somitic mesoderm
  JOURNAL   Development 127 (1), 109-118 (2000)
   PUBMED   10654605
REFERENCE   8  (bases 1 to 1780)
  AUTHORS   Chang,J.T., Esumi,N., Moore,K., Li,Y., Zhang,S., Chew,C.,
            Goodman,B., Rattner,A., Moody,S., Stetten,G., Campochiaro,P.A. and
            Zack,D.J.
  TITLE     Cloning and characterization of a secreted frizzled-related protein
            that is expressed by the retinal pigment epithelium
  JOURNAL   Hum Mol Genet 8 (4), 575-583 (1999)
   PUBMED   10072424
REFERENCE   9  (bases 1 to 1780)
  AUTHORS   Leimeister,C., Bach,A. and Gessler,M.
  TITLE     Developmental expression patterns of mouse sFRP genes encoding
            members of the secreted frizzled related protein family
  JOURNAL   Mech Dev 75 (1-2), 29-42 (1998)
   PUBMED   9739103
REFERENCE   10 (bases 1 to 1780)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080766.1 and BC034853.1.
            
            [WARNING] On Mar 6, 2025 this sequence was replaced by NM_016687.4.
            
            On Jul 10, 2009 this sequence version replaced NM_016687.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034853.1, AF117709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1679              AK080766.1         2-1680
            1680-1780           BC034853.1         1639-1739
FEATURES             Location/Qualifiers
     source          1..1780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.99 cM"
     gene            1..1780
                     /gene="Sfrp4"
                     /note="secreted frizzled-related protein 4"
                     /db_xref="GeneID:20379"
                     /db_xref="MGI:MGI:892010"
     exon            1..703
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1314
                     /gene="Sfrp4"
                     /note="FRP-4; sFRP-4; frizzled-related protein 4; secreted
                     frizzled-related sequence protein 4"
                     /codon_start=1
                     /product="secreted frizzled-related sequence protein 4
                     precursor"
                     /protein_id="NP_057896.1"
                     /db_xref="CCDS:CCDS26261.1"
                     /db_xref="GeneID:20379"
                     /db_xref="MGI:MGI:892010"
                     /translation="MLRSILVALCLWLRLALGVRGAPCEAVRIPMCRHMPWNITRMPN
                     HLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQ
                     RARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMM
                     VQERSFDADCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVV
                     DVKEIFKSLSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKW
                     RDQLSRRSIQWEERLQEQQRTIQDKKQIASRTSRTSRSNPPKSKGRPPAPKPASPKKN
                     IKARSAPKKSNLKKSAS"
     exon            704..784
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            785..850
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1049
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1113
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1760
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfrp4"
                     /note="hexamer: ATTAAA"
     polyA_site      1724
                     /gene="Sfrp4"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfrp4"
                     /note="hexamer: GATAAA"
     polyA_site      1760
                     /gene="Sfrp4"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgctcc gagctgcggg actcgagact ggagcttccc gcgggggtcg ttgctctgga
       61 ggctgagtgc tggcgctgcc agtgccggtg cgcccagggg tgatcgacgg ccaacccccc
      121 agaactcctc atcagtgcag actggagctc cagcaggaaa gctcactcca ctgcccctag
      181 gtaaagagat aaggaggtca acggggctgg aagaaaaggg tcctcccagc agagactgca
      241 gcccaggagg acagtgccat gctccgctcc atcctggtgg cgttatgcct gtggctgcgc
      301 ctggcgctgg gagttcgcgg agcgccctgc gaagctgtgc gcatccccat gtgcaggcac
      361 atgccctgga acatcacccg gatgcccaac cacctgcacc acagcactca ggagaacgcc
      421 atcctggcca tcgaacagta tgaagagcta gtggacgtga actgcagctc tgtgctgcgc
      481 ttcttccttt gtgccatgta cgcacccatc tgtaccctgg agttcctgca cgatcccatc
      541 aagccctgca agtctgtgtg ccagcgcgca cgtgacgact gcgagcccct catgaagatg
      601 tataaccaca gctggccaga gagcctggcc tgcgatgagc tgccggtcta tgaccgtgga
      661 gtttgtatct ctccagaggc aatagtcact gaccttccag aagatgtgaa gtggatagac
      721 atcacaccag atatgatggt gcaagaaagg tcctttgatg ctgactgtaa acgtctgagc
      781 cctgatcggt gcaagtgcaa aaaggtgaag ccgaccctgg caacatacct gagcaaaaac
      841 tacagctatg ttattcatgc caaaataaaa gccgtccaga ggagtggttg caatgaggtc
      901 acaactgtgg tagatgtaaa agagatcttc aagtctttgt cacctatccc tcgaacacaa
      961 gtccctctca tcaccaattc ctcctgccag tgtccacata tcctgcccca tcaagatgtc
     1021 ctaatcatgt gttatgagtg gcgttcaagg atgatgcttc ttgaaaattg cttagttgaa
     1081 aagtggagag atcaactcag tagaaggtcc atacagtggg aagagaggct tcaggaacag
     1141 cagagaacaa ttcaggacaa gaagcagata gccagccgca ccagtcgcac cagtcgcagt
     1201 aaccccccaa agtcaaaggg aaggccacct gctcccaaac ctgccagtcc taagaagaac
     1261 atcaaagcta gaagtgcccc caaaaagtca aacctgaaga aaagcgcaag ctaattactt
     1321 tctgtgatgg agccaccctt acaggataag gtggtgctgc ctgggacagc ctacagaagg
     1381 ccacatacca cttgccttaa ggacccactg tggttctctt tatagacact tcttgcagca
     1441 tgtctcgtaa tgatagcttc agtgttttgc tttaagccac agagccctgt tacttgttgg
     1501 ttttctggta tggaaagtac aagagggaag gcttgtggaa gggtacctga attcacagtt
     1561 gtctgtgtgc atactgtgta agacctcctg ttttaagagt ttgacctaaa atgtacatta
     1621 taaagttcac atactatgtc aagcaaaact ttttgacaaa aaatattgga tatcctttga
     1681 cttgtgttaa gaagttggtg atatattaaa tgttattgaa aacatgtttt tgataaaggc
     1741 aggggaaatg atacttaaaa aaaaaaaaaa aaaaaaaaaa
//
