LOCUS       NM_009144               2001 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus secreted frizzled-related protein 2 (Sfrp2), mRNA.
ACCESSION   NM_009144
VERSION     NM_009144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2001)
  AUTHORS   Lv,D., Lin,Z., Liao,X., Peng,R., Liu,H., Wu,T., Wu,K., Sun,Y. and
            Zhang,Z.
  TITLE     Sfrp2 promotes renal dysfunction of diabetic kidney disease via
            modulating Fzd5-induced cytosolic calcium ion concentration and
            CaMKII/Mek/Erk pathway in mesangial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166933 (2024)
   PUBMED   37951508
  REMARK    GeneRIF: Sfrp2 promotes renal dysfunction of diabetic kidney
            disease via modulating Fzd5-induced cytosolic calcium ion
            concentration and CaMKII/Mek/Erk pathway in mesangial cells.
REFERENCE   3  (bases 1 to 2001)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2001)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   5  (bases 1 to 2001)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2001)
  AUTHORS   Leimeister,C., Bach,A. and Gessler,M.
  TITLE     Developmental expression patterns of mouse sFRP genes encoding
            members of the secreted frizzled related protein family
  JOURNAL   Mech Dev 75 (1-2), 29-42 (1998)
   PUBMED   9739103
REFERENCE   7  (bases 1 to 2001)
  AUTHORS   Melkonyan,H.S., Chang,W.C., Shapiro,J.P., Mahadevappa,M.,
            Fitzpatrick,P.A., Kiefer,M.C., Tomei,L.D. and Umansky,S.R.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   8  (bases 1 to 2001)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   9  (bases 1 to 2001)
  AUTHORS   Roy,K., Mitsugi,K. and Sirotnak,F.M.
  TITLE     Additional organizational features of the murine folylpolyglutamate
            synthetase gene. Two remotely situated exons encoding an alternate
            5' end and proximal open reading frame under the control of a
            second promoter
  JOURNAL   J Biol Chem 272 (9), 5587-5593 (1997)
   PUBMED   9038166
REFERENCE   10 (bases 1 to 2001)
  AUTHORS   Shirozu,M., Tada,H., Tashiro,K., Nakamura,T., Lopez,N.D.,
            Nazarea,M., Hamada,T., Sato,T., Nakano,T. and Honjo,T.
  TITLE     Characterization of novel secreted and membrane proteins isolated
            by the signal sequence trap method
  JOURNAL   Genomics 37 (3), 273-280 (1996)
   PUBMED   8938438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141473.4.
            
            On Nov 25, 2008 this sequence version replaced NM_009144.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014722.1, U88567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               AC141473.4         118178-118900
            724-804             AC141473.4         121183-121263
            805-2001            AC141473.4         124975-126171
FEATURES             Location/Qualifiers
     source          1..2001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.37 cM"
     gene            1..2001
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /note="secreted frizzled-related protein 2"
                     /db_xref="GeneID:20319"
                     /db_xref="MGI:MGI:108078"
     exon            1..723
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..804
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2001
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /note="hexamer: TATAAA"
     polyA_site      2001
                     /gene="Sfrp2"
                     /gene_synonym="Sdf5"
                     /note="major polyA site"
ORIGIN      
        1 gctcactctg ctcccccggg tcggagcccc ccggagctgc gcgcgggctt gcagtgcctt
       61 gcccgcgccg acctcccggc gcccggcttc gcgcgttcgc gccgcccgct gtccagagcc
      121 cccacgagca gagcgaggga gtcccggacg agctcgagct ccggccgcct ctcgcttccc
      181 ccgctcggct ccctccgccc cccgggggtc gctagtccac gatgccgcgg ggccctgcct
      241 cgctgctgct gctagtcctc gcctcgcact gctgcctggg ctcggcgcgt gggctcttcc
      301 tcttcggcca gcccgacttc tcctacaagc gcagcaactg caagcccatc cccgccaacc
      361 tgcagctgtg ccacggcatc gagtaccaga acatgcggct gcccaacctg ctgggccacg
      421 agaccatgaa ggaggtgctg gagcaggcgg gcgcctggat tccgctggtc atgaagcagt
      481 gccacccgga caccaagaag ttcctgtgct cgctcttcgc ccctgtctgt ctcgacgacc
      541 tagatgagac catccagccg tgtcactcgc tctgcgtgca ggtgaaggac cgctgcgccc
      601 cggtcatgtc cgccttcggc ttcccctggc cagacatgct ggagtgcgac cgtttcccgc
      661 aggacaacga cctctgcatc cccctcgcta gtagcgacca cctcctgccg gccacagagg
      721 aagctcccaa ggtgtgtgaa gcctgcaaaa ccaagaatga ggacgacaac gacatcatgg
      781 aaaccctttg taaaaatgac ttcgcactga aaatcaaagt gaaggagata acgtacatca
      841 acagagacac caagatcatc ctggagacaa agagcaagac catttacaag ctgaacggcg
      901 tgtccgaaag ggacctgaag aaatccgtgc tgtggctcaa agacagcctg cagtgcacct
      961 gtgaggagat gaacgacatc aacgctccgt atctggtcat gggacagaag cagggcggcg
     1021 agctggtgat cacctccgtg aaacggtggc agaagggcca gagagagttc aagcgcatct
     1081 cccgcagcat ccgcaagctg caatgctagt ttcccagtgg ggtggcttct ctccatccag
     1141 gccctgagct ctgtagacca cttccgctcc gcgacctcat ttccggtttc ccaagcacag
     1201 tccgggaaag ctacagcccc agcttggagc cgcttgccct gcctcctgca tgtgtgtatc
     1261 cctaacatgt cctgagttat aaggccctag gaggccttgg aaacccatag ctgttttcac
     1321 ggaaagcgaa aagcccatcc agatcttgta caaatattca aactaataaa atcatgacta
     1381 tttttatgaa gttttagaac agctcgtttt aaggttagtt ttgaatagct gtagtacttt
     1441 gacccgaggg gcattttctc tctttggtca gtctgttggc ttataccgtg cacttaggtt
     1501 gccatgtcag gcgaattgtt tctttttttt tttttttttc cctctgtggt ctaagcttgt
     1561 gggtcccaga cttagttgag ataaagctgg ctgttatctc aaagtcttcc tcagttccag
     1621 cctgagaatc ggcatctaag tcttcaaaca tttcgttgct cgttttatgc cctcatgagc
     1681 tctgaccatt gcatgcgttc ccatcccagc tacagaactt cagtttataa gcacacagta
     1741 accattcctc attgcatgat gccctcaaat aaaaagtgaa tacagtctat aaattgacga
     1801 gtattttaag ctttgtttaa aacatctttt aattcaattt tttaatcatt ttttttgcaa
     1861 actaaatcat tgtagcttac ctgtaatata cgtagtagtt gacctggaaa agttgtaaaa
     1921 atattgcttt aaccgacact gtaaatattt cagataaaca ttatattctt tgtatataaa
     1981 ctttacatct tgttgtacct a
//
