LOCUS       NM_013834               4389 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus secreted frizzled-related protein 1 (Sfrp1), mRNA.
ACCESSION   NM_013834
VERSION     NM_013834.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4389)
  AUTHORS   Zhang,D.F., Jin,X.N., Ma,X., Qiu,Y.S., Ma,W., Dai,X. and Zhang,Z.
  TITLE     Tumour necrosis factor alpha regulates the miR-27a-3p-Sfrp1 axis in
            a mouse model of osteoporosis
  JOURNAL   Exp Physiol 109 (7), 1109-1123 (2024)
   PUBMED   38748896
  REMARK    GeneRIF: Tumour necrosis factor alpha regulates the
            miR-27a-3p-Sfrp1 axis in a mouse model of osteoporosis.
REFERENCE   2  (bases 1 to 4389)
  AUTHORS   Wrynn,T., Min,S., Horeth,E., Osinski,J., Sinha,S. and Romano,R.A.
  TITLE     DeltaNp63 regulates Sfrp1 expression to direct salivary gland
            branching morphogenesis
  JOURNAL   PLoS One 19 (5), e0301082 (2024)
   PUBMED   38722977
  REMARK    GeneRIF: DeltaNp63 regulates Sfrp1 expression to direct salivary
            gland branching morphogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4389)
  AUTHORS   Gregory,K.J., Mason,H., Casaubon,J. and Schneider,S.S.
  TITLE     SFRP1 decreases WNT-Mediated M2 macrophage marker expression in
            breast tissue
  JOURNAL   Cancer Immunol Immunother 73 (5), 86 (2024)
   PUBMED   38554160
  REMARK    GeneRIF: SFRP1 decreases WNT-Mediated M2 macrophage marker
            expression in breast tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4389)
  AUTHORS   Mayr,C.H., Sengupta,A., Asgharpour,S., Ansari,M., Pestoni,J.C.,
            Ogar,P., Angelidis,I., Liontos,A., Rodriguez-Castillo,J.A.,
            Lang,N.J., Strunz,M., Porras-Gonzalez,D., Gerckens,M., De
            Sadeleer,L.J., Oehrle,B., Viteri-Alvarez,V., Fernandez,I.E.,
            Tallquist,M., Irmler,M., Beckers,J., Eickelberg,O., Stoleriu,G.M.,
            Behr,J., Kneidinger,N., Wuyts,W.A., Wasnick,R.M., Yildirim,A.O.,
            Ahlbrecht,K., Morty,R.E., Samakovlis,C., Theis,F.J., Burgstaller,G.
            and Schiller,H.B.
  TITLE     Sfrp1 inhibits lung fibroblast invasion during transition to
            injury-induced myofibroblasts
  JOURNAL   Eur Respir J 63 (2), 2301326 (2024)
   PUBMED   38212077
  REMARK    GeneRIF: Sfrp1 inhibits lung fibroblast invasion during transition
            to injury-induced myofibroblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4389)
  AUTHORS   Lescher,B., Haenig,B. and Kispert,A.
  TITLE     sFRP-2 is a target of the Wnt-4 signaling pathway in the developing
            metanephric kidney
  JOURNAL   Dev Dyn 213 (4), 440-451 (1998)
   PUBMED   9853965
REFERENCE   7  (bases 1 to 4389)
  AUTHORS   Leimeister,C., Bach,A. and Gessler,M.
  TITLE     Developmental expression patterns of mouse sFRP genes encoding
            members of the secreted frizzled related protein family
  JOURNAL   Mech Dev 75 (1-2), 29-42 (1998)
   PUBMED   9739103
REFERENCE   8  (bases 1 to 4389)
  AUTHORS   Hoang,B.H., Thomas,J.T., Abdul-Karim,F.W., Correia,K.M.,
            Conlon,R.A., Luyten,F.P. and Ballock,R.T.
  TITLE     Expression pattern of two Frizzled-related genes, Frzb-1 and
            Sfrp-1, during mouse embryogenesis suggests a role for modulating
            action of Wnt family members
  JOURNAL   Dev Dyn 212 (3), 364-372 (1998)
   PUBMED   9671940
REFERENCE   9  (bases 1 to 4389)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
REFERENCE   10 (bases 1 to 4389)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB620977.1, AK081052.1 and BC094662.1.
            
            On Apr 28, 2009 this sequence version replaced NM_013834.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094662.1, AK088868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               BB620977.1         1-554
            555-1448            AK081052.1         146-1039
            1449-4389           BC094662.1         1435-4375
FEATURES             Location/Qualifiers
     source          1..4389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.48 cM"
     gene            1..4389
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /note="secreted frizzled-related protein 1"
                     /db_xref="GeneID:20377"
                     /db_xref="MGI:MGI:892014"
     exon            1..827
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..4372
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4351..4356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /note="hexamer: ACTAAA"
     polyA_site      4372
                     /gene="Sfrp1"
                     /gene_synonym="2210415K03Rik; sFRP-1"
                     /note="major polyA site"
ORIGIN      
        1 attcgagctg cagcgtcgca agtaggtgca gcagcccgca gcccgccgcg cctctgcgag
       61 ccgggacagc actcggcccc gcgcgctccc cgccccgcgc cagccccgcc gcggcgacct
      121 gctgcagcgg aggaccccat cgatcggaga cccggggagc agcgcgcagc cgccgagccg
      181 gacggggccc ggcactgcgc ctttgtcccc ggaggctccg ggaagtttgc agcgggacgc
      241 gcgcgtgaag gcagcgtggg cagccccgac gtcgccgagc aacatgggcg tcgggcgcag
      301 cgcgcggggt cgcggcgggg ccgcctcggg agtgctgctg gcgttggccg ccgctctgct
      361 ggccgcgggt tcggccagcg agtacgacta cgtgagcttc cagtccgaca tcggctcgta
      421 tcagagcggg cgcttctaca ccaagccccc gcagtgcgtg gacatcccgg tggacctgag
      481 gctgtgccac aacgtgggct acaagaagat ggtgctgccc aacctgctgg agcacgagac
      541 catggcagag gtgaagcagc aggccagcag ctgggtgccg ctgctcaaca agaactgcca
      601 catgggcacc caggtcttcc tctgttcgct cttcgcgccc gtctgtctgg accggcccat
      661 ctacccgtgt cgctggctct gcgaggccgt gcgcgactcg tgcgagccgg tcatgcagtt
      721 cttcggcttc tactggcccg agatgctcaa atgtgacaag ttccccgagg gcgacgtctg
      781 catcgccatg accccgccca ataccacgga agcctctaag ccccaaggta caaccgtgtg
      841 tcctccatgc gacaacgagt tgaagtcaga ggccatcatt gaacatctct gtgcaagcga
      901 gtttgcactg aggatgaaaa tcaaagaagt gaagaaggaa aacggtgaca agaagattgt
      961 ccccaagaag aagaaaccct tgaagctggg gcccatcaag aagaaggagc tgaagcggct
     1021 tgtgctgttc ctgaagaacg gtgccgactg tccctgccac cagctggaca acctcagcca
     1081 caactttctc atcatgggcc gcaaggtgaa gagccagtac ctgctgacag ccattcacaa
     1141 gtgggacaag aaaaacaagg agttcaaaaa cttcatgaag agaatgaaaa accacgagtg
     1201 tcccaccttc cagtctgttt ttaagtgata ctggggcgga ctggggaagg ggagtgtggc
     1261 ttggggtgag ggtgggggcg cgtggatgac cctggctctt gggggctcac atattgctct
     1321 cacccattac agttgtggct tttgcattgc acctggctct gttcctacag cgaaccctct
     1381 cccttccctc catagccaca tccagctaag gccacggccc tttagattag gaaggctttt
     1441 ttttttttaa gggctgcagc agggccagca ggcacggtgc aaaaggagag gcagaatcct
     1501 ttcactgagc ctcgggcaca aaaaacagaa aatgttggcc ggtttggaaa aacaaaacaa
     1561 aacggattgt aaagaactgc agacggacag ctgctcagct caacgttgtt cgggacatca
     1621 ttaccaattg cttgtggagt ctaagcctct acaggtagaa gagtctgatc attgccaagc
     1681 caggctgctt tcagtttatt attaatcccc ctctttctgc cttagataga ccatcgccac
     1741 cttcaaaaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     1801 cacttctgaa agtagccagg gtatcccagt atagaacggg atagctaagg gtttgggtgg
     1861 gaggccactg cctactctac cttcagcttt tgaactggcc acctttgata ggaaactgta
     1921 ggtctcagat ggacacttct accagtccat cgggatacaa ggatgccagg caagggtctg
     1981 cttttgtatg aaggaggtac gtgggcatga agagacatga ggcatttcag gctgagaagc
     2041 caacagctac tagttttcaa caatagagtg gaagaaatga gcaaaggtag aaatgtcaag
     2101 caggtcacaa gtcagggtga ttgggggaat cctgtgccaa cagcctcact ttgtaattcc
     2161 atctgtcaca tttcaaaaga acagcagcat aagacaggga taaaagccca cataccctcc
     2221 aaggcttgag taaaagtcca cactcagcat ttcaaagact aacgtcgttg actgcccaag
     2281 gctgccctct taatacaccg cctatgcatg tgctgtggaa ggcaactctg tgcatgtgct
     2341 gtggaggaga tgggcctcat ggctgtgcct ggctgcccag gaatcagtat agctgtggaa
     2401 ggagacagta tccatagact ctgcttttct gcaaggaaag cccttttcct tatacatgat
     2461 tgcctataat tcagacaaat ttaaaatcgc tgcctgcctg agccctccac ctttactttt
     2521 gcattcctcc ggtcatattc ttttgaggct aaagtgccct atccgaggag atggtttcaa
     2581 aggctaacta atctgcagct ttcccaagtg cccagaggta tttctcaaag ttggtatgct
     2641 taataagtga tgtaaatatt ccagttctct taggcagcct tactcctgtt gtccctgtag
     2701 ttctgaaaaa aaaaaaaagt taatttcttc caccaaagtc tgataattcc ccaccgcatc
     2761 catggggcta cagtgactgt ccctttggca tactcaatcc agaggtagga atgattttga
     2821 agaatcatct agtggccttg gattgaccca gaaacaggaa aactctggtt acttctgaaa
     2881 gactccagcc tgaaaactca ccatgccaac ttagttactg acctgagtgg ggtagtgacc
     2941 taattaactt catgtttagt agtcctatta tcttaaccct tttaagaata cttccaacct
     3001 taatcacaat gttatgagga accttaggtg atttgcctat cattgtggat gatttaaaaa
     3061 tatgtatgtg cattagtaat tagaaatagt ctaacctcat tgtccataac tgaaatgcaa
     3121 agtctcctga gtgtgtagat ctgggccttg agccactact agttcagtgc ttggtgaggg
     3181 gtctgctcat tttgggaaag tgtatcatgt ggcagggccc tctccgagtg gcgggagact
     3241 gcctacatga tttttttttt tccctgggga tgttagcagt ttcacagcat aaaagggagg
     3301 acatgttctg gggggctcca gattgggaac cctcaggaag taacttcctc aggaaggatt
     3361 cataaccaat tgatcgatca attgatcatg tgaactgcag cagctgtctg tccccttact
     3421 tcagagtccc cagcttcaga gttttgttgc ggacctgtga ggatttcaga cacacacaca
     3481 cacacacaca gaccagtttt gtctatacta catcagcagt tccagacaaa aagggaggct
     3541 atctaggggc ccgaaagctg catgatcagc agcctttgtc cttttcaaca aaaggtgtaa
     3601 caaaccaatg tgcagactca ttagctttgt ccctggcttc caatggaggt ggtccatgtg
     3661 cgctctgacc agcgttgcca atgaaaaggt cagatttgga aagctttaaa atagtcattc
     3721 cggagagtca gggaaagcta aacccaccaa acttttggga actatcaata gctatcttag
     3781 aaaatagact tgagaggcaa gaattgtaag aatatgtttg ctttttaaaa cattctgtat
     3841 cctcagagct catggttggt gggttagcac taggtcctcc ctggggctga gtctaagccc
     3901 agttccaggc ttcctaagaa tgtgtaaatt acagaaatca catttcccaa agctagaacc
     3961 tgttttatct tgttagcctc cctgtaacca gatgctctgt tggaccttca tagccggacg
     4021 tggttcaaga tgtgctccag aagcagaccc ggggtcacat ctccaggatg gcatgttggc
     4081 tgctctgacc tggcgctgtg ggtcctaagc gcagagacgg aattcctgtt ggccctggtt
     4141 cccccctcct cgcaccccct gaggactcca ctttatagcc taagcctttt atacaaaagc
     4201 tttgaatact gtgaagatgt tttacattcc ttctcattcc tgttgtttct taactacatt
     4261 tgaccagatg ttttgatgtt atcacgtatg ttaatagtga ttcccaggtg tgttttgttt
     4321 tcatgctttc cctgccaatg tattcacttc actaaaatca ctcgatcaat aaaaaaaaaa
     4381 aaaaaaaaa
//
