LOCUS       NM_026377               1583 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SWI5 dependent recombination repair 1 (Sfr1), mRNA.
ACCESSION   NM_026377 XM_918031 XM_925443
VERSION     NM_026377.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Lu,C.H., Yeh,H.Y., Su,G.C., Ito,K., Kurokawa,Y., Iwasaki,H., Chi,P.
            and Li,H.W.
  TITLE     Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by
            modulating Rad51 dissociation
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10059-E10068 (2018)
   PUBMED   30297419
  REMARK    GeneRIF: Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous
            recombination.
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Su,G.C., Yeh,H.Y., Lin,S.W., Chung,C.I., Huang,Y.S., Liu,Y.C.,
            Lyu,P.C. and Chi,P.
  TITLE     Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination
  JOURNAL   Nucleic Acids Res 44 (13), 6242-6251 (2016)
   PUBMED   27131790
  REMARK    GeneRIF: Our results thus help establish the functional relevance
            of the trimeric RAD51-SWI5-SFR1 complex and provide insights into
            the mechanistic underpinnings of homology-directed DNA repair in
            mammalian cells.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Rousseaux,M.W., Marcogliese,P.C., Qu,D., Hewitt,S.J., Seang,S.,
            Kim,R.H., Slack,R.S., Schlossmacher,M.G., Lagace,D.C., Mak,T.W. and
            Park,D.S.
  TITLE     Progressive dopaminergic cell loss with unilateral-to-bilateral
            progression in a genetic model of Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15918-15923 (2012)
   PUBMED   23019375
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11212]
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Tsai,S.P., Su,G.C., Lin,S.W., Chung,C.I., Xue,X., Dunlop,M.H.,
            Akamatsu,Y., Jasin,M., Sung,P. and Chi,P.
  TITLE     Rad51 presynaptic filament stabilization function of the mouse
            Swi5-Sfr1 heterodimeric complex
  JOURNAL   Nucleic Acids Res 40 (14), 6558-6569 (2012)
   PUBMED   22492707
  REMARK    GeneRIF: Biophysical evidence that the mouse Swi5-Sfr1 complex has
            a 1:1 stoichiometry.
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Akamatsu,Y. and Jasin,M.
  TITLE     Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
            through homologous recombination
  JOURNAL   PLoS Genet 6 (10), e1001160 (2010)
   PUBMED   20976249
  REMARK    GeneRIF: Data show that Swi5-Sfr1 is a newly identified complex
            required for genomic integrity in mammalian cells with a specific
            role in the repair of DNA strand breaks.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011531.1, AK146810.1 and AV335878.2.
            
            On Feb 14, 2007 this sequence version replaced NM_026377.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078147.1, SRR1660817.23805.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK011531.1         2-4
            4-7                 AK146810.1         1-4
            8-921               AK011531.1         9-922
            922-1533            AK146810.1         918-1529
            1534-1583           AV335878.2         917-966
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 40.41 cM"
     gene            1..1583
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /note="SWI5 dependent recombination repair 1"
                     /db_xref="GeneID:67788"
                     /db_xref="MGI:MGI:1915038"
     exon            1..66
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1013
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /note="DNA repair protein Sfr1; meiosis protein 5 homolog"
                     /codon_start=1
                     /product="swi5-dependent recombination DNA repair protein
                     1 homolog"
                     /protein_id="NP_080653.2"
                     /db_xref="CCDS:CCDS38019.1"
                     /db_xref="GeneID:67788"
                     /db_xref="MGI:MGI:1915038"
                     /translation="MAEEGNQEFTSKMENSSDSASTSPDAPQPSENPPSPPTSPAAPQ
                     TSENPPSPPTSPAVPQTRENPPSPPTSPAAPQPRENPPSPPTSPAAPQPRENPPSPPT
                     SPAAPQPRENPPSPHSNSSGKQPLSGTPKERLKKARSSSHSFCSVVKRMKVENDENNE
                     TLSEPGESSKEENCSKAQESLKNKDSEPGEKSSEEKNTCESKSSDTGSSNALPKESEN
                     AIIREKLKQEKIRLIRQVEEKEDLLRRLKLVKMYRIKNDVTELENLIKKWRKCGQRLL
                     CELQSIMSEDEDEKLTLTELIDFYGIDDNLLHYNRSEEEFTGV"
     exon            67..425
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /inference="alignment:Splign:2.1.0"
     exon            426..818
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1583
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /note="hexamer: ATTAAA"
     polyA_site      1535
                     /gene="Sfr1"
                     /gene_synonym="6330577E15Rik; Meir5"
                     /note="major polyA site"
ORIGIN      
        1 gtgggctgcg ggcgctccgc tggctgtgtg tacggtgtgt cgccgctgtg agcatggctg
       61 aggaaggaaa tcaggagttc acttccaaga tggaaaactc atcagattca gcatcgactt
      121 cacctgatgc tcctcagccc agtgagaatc caccatcacc accgacttca cctgccgctc
      181 ctcagaccag tgagaatcca ccatcaccac cgacttcacc tgccgttcct cagaccaggg
      241 agaatccacc atcaccaccg acttcacctg ccgctcctca gcccagggag aatccaccat
      301 caccaccgac ttcacctgcc gctcctcagc ccagggagaa tccaccatca cccccgactt
      361 cacctgccgc tcctcagccc agggagaatc caccatcacc ccattcgaat agttcaggaa
      421 aacaacctct gagtggaaca cctaaagaaa ggttaaagaa agcaagatct tcatctcatt
      481 cattttgtag tgtggtgaag cgtatgaagg tagagaatga cgaaaataat gagacccttt
      541 cagaaccagg agaatcttca aaggaagaaa attgttcaaa ggcccaagaa agcttgaaaa
      601 acaaagacag tgagcctgga gaaaagagct cagaggagaa aaacacgtgt gaatctaagt
      661 cgtcggatac tgggtcatct aatgccctcc caaaggagtc tgagaatgcg atcattagag
      721 aaaaattaaa acaagaaaaa ataagattga ttaggcaggt tgaagagaag gaagaccttc
      781 ttcggaggtt aaagttagtc aagatgtata gaataaagaa cgacgtgact gagttagaga
      841 atctaataaa gaagtggagg aagtgtggtc agcggctgct gtgtgagctg cagtctatca
      901 tgtcggagga cgaggacgag aagctgacgc tcaccgagct gatcgacttc tacgggatag
      961 atgacaactt gctgcactac aatcgaagtg aagaagagtt tacaggggtg tgatacattt
     1021 tccaggctat tttctccctc tcttctttgg gtgatgtgat catacctagg gcctcaaaac
     1081 atgtgctctg ttcctgagct atacacttgg cccatttaca gattgtcttt gagaatggca
     1141 atgcaaagag aaatgtttta aaggggaaaa aaaagatcta agctgttgtg gcttagaggg
     1201 aggaatgttg aacagtttgg gatattctga caaaattata agacgaagct tagtattttg
     1261 gatatgtttg ctaaagaaaa tatttaagta taaaaaaatt aaaattgtgt ttaaaaggaa
     1321 gtttggatag ttctagaaac cagggttaat tcattgattt ggggggcaaa aagtttatat
     1381 tcagtattag aaagtagtat gttgaatgtc taaatctcaa gtggcataaa tgtagcctgc
     1441 ccttcctaag tttatggacc tatgctcatc tgcttaacat atctgtttgc taatctagca
     1501 actaattaaa cttaaatgtc tacagttttc tccaatttgt tttcattttc ctcatgtact
     1561 aaaatgaaca tctgtttctt ggg
//
