LOCUS       NM_023603               3500 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus splicing factor proline/glutamine rich (polypyrimidine
            tract binding protein associated) (Sfpq), transcript variant 1,
            mRNA.
ACCESSION   NM_023603 XM_909578
VERSION     NM_023603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3500)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3500)
  AUTHORS   Petit,F.G., Jamin,S.P., Kernanec,P.Y., Becker,E., Halet,G. and
            Primig,M.
  TITLE     EXOSC10/Rrp6 is essential for the eight-cell embryo/morula
            transition
  JOURNAL   Dev Biol 483, 58-65 (2022)
   PUBMED   34965385
REFERENCE   3  (bases 1 to 3500)
  AUTHORS   Hu,X., Li,F., He,J., Yang,J., Jiang,Y., Jiang,M., Wei,D., Chang,L.,
            Hejtmancik,J.F., Hou,L. and Ma,X.
  TITLE     LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control
            RPE Cell Proliferation
  JOURNAL   Invest Ophthalmol Vis Sci 62 (14), 18 (2021)
   PUBMED   34787639
  REMARK    GeneRIF: LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and
            Control RPE Cell Proliferation.
REFERENCE   4  (bases 1 to 3500)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3500)
  AUTHORS   Katano-Toki,A., Yoshino,S., Nakajima,Y., Tomaru,T., Nishikido,A.,
            Ishida,E., Horiguchi,K., Saito,T., Ozawa,A., Satoh,T. and Yamada,M.
  TITLE     SFPQ associated with a co-activator for PPARgamma, HELZ2, regulates
            key nuclear factors for adipocyte differentiation
  JOURNAL   Biochem Biophys Res Commun 562, 139-145 (2021)
   PUBMED   34052659
  REMARK    GeneRIF: SFPQ associated with a co-activator for PPARgamma, HELZ2,
            regulates key nuclear factors for adipocyte differentiation.
REFERENCE   6  (bases 1 to 3500)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3500)
  AUTHORS   Rosenberger,U., Lehmann,I., Weise,C., Franke,P., Hucho,F. and
            Buchner,K.
  TITLE     Identification of PSF as a protein kinase Calpha-binding protein in
            the cell nucleus
  JOURNAL   J Cell Biochem 86 (2), 394-402 (2002)
   PUBMED   12112008
  REMARK    GeneRIF: identified as a protein kinase Calpha-binding protein in
            the cell nucleus
REFERENCE   8  (bases 1 to 3500)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3500)
  AUTHORS   Shav-Tal,Y., Cohen,M., Lapter,S., Dye,B., Patton,J.G.,
            Vandekerckhove,J. and Zipori,D.
  TITLE     Nuclear relocalization of the pre-mRNA splicing factor PSF during
            apoptosis involves hyperphosphorylation, masking of antigenic
            epitopes, and changes in protein interactions
  JOURNAL   Mol Biol Cell 12 (8), 2328-2340 (2001)
   PUBMED   11514619
REFERENCE   10 (bases 1 to 3500)
  AUTHORS   Shav-Tal,Y., Lee,B., Bar-Haim,S., Vandekerckhove,J. and Zipori,D.
  TITLE     Enhanced proteolysis of pre-mRNA splicing factors in myeloid cells
  JOURNAL   Exp Hematol 28 (9), 1029-1038 (2000)
   PUBMED   11008015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ067342.1, BC089305.1, AV137948.2 and AW048189.1.
            
            On Dec 8, 2009 this sequence version replaced NM_023603.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089305.1, AY034062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ067342.1         1-34
            35-2976             BC089305.1         1-2942
            2977-3045           BC089305.1         2944-3012
            3046-3484           AV137948.2         105-543
            3485-3500           AW048189.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..3500
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.2 cM"
     gene            1..3500
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="splicing factor proline/glutamine rich
                     (polypyrimidine tract binding protein associated)"
                     /db_xref="GeneID:71514"
                     /db_xref="MGI:MGI:1918764"
     exon            1..920
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2216
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="PTB-associated splicing factor; DNA-binding
                     p52/p100 complex, 100 kDa subunit; polypyrimidine
                     tract-binding protein-associated-splicing factor"
                     /codon_start=1
                     /product="splicing factor, proline- and glutamine-rich"
                     /protein_id="NP_076092.1"
                     /db_xref="CCDS:CCDS18662.1"
                     /db_xref="GeneID:71514"
                     /db_xref="MGI:MGI:1918764"
                     /translation="MSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNR
                     GPMGPGPGGPKPPLPPPPPHQQQQQPPPQQPPPQQPPPHQQPPPHQPPHQQPPPPPQE
                     SKPVVPQGPGSAPGVSSAPPPAVSAPPANPPTTGAPPGPGPTPTPPPAVPSTAPGPPP
                     PSTPSSGVSTTPPQTGGPPPPPAGGAGPGPKPGPGPGGPKGGKMPGGPKPGGGPGMGA
                     PGGHPKPPHRGGGEPRGGRQHHAPYHQQHHQGPPPGGPGPRTEEKISDSEGFKANLSL
                     LRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESR
                     ALAEIAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERA
                     VVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVEPLEQLDDEDG
                     LPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAK
                     DKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHSQEMQKRKEMQLRQEEERRRR
                     EEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGTMNMGDPYGSGGQKFP
                     PLGGGGGIGYEANPGVPPATMSGSMMGSDMRTERFGQGGAGPVGGQGPRGMGPGTPAG
                     YGRGREEYEGPNKKPRF"
     exon            921..1109
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1411
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1507
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1704
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1789
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1907
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1956
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2078
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..3488
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="hexamer: AATAGA"
     polyA_site      2534
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3048
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="major polyA site"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
                     /note="hexamer: AATAAA"
     polyA_site      3484
                     /gene="Sfpq"
                     /gene_synonym="1110004P21Rik; 2810416M14Rik;
                     5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF;
                     REP1"
ORIGIN      
        1 gaggacaaag gcggcgcgca gcttgtgtcg tccgccattt tgtgctcagc aaggtggcaa
       61 ccacgttccc tgagcgactt ctccgcttct gcctcgaccg ccccttgact acagctatgt
      121 ctcgggatcg gttccggagt cgcggtggcg gcggtggagg ctttcaccgg cgtggaggag
      181 gtggcggccg cggcggcctt cacgacttcc gctctccgcc gccgggcatg ggcctcaacc
      241 agaaccgcgg ccccatgggc ccgggccctg gcggcccgaa gccgccgctc ccgcctccac
      301 ctcctcacca gcagcagcag cagccgccgc cgcagcagcc tccgccgcag cagccgccgc
      361 cgcaccagca gccgccgccg caccagccgc cccatcaaca gcccccgcct ccgccgcagg
      421 aatccaagcc cgtcgtcccc caaggccccg gctcggcgcc gggggtgagc agtgcgcctc
      481 cgccggcggt ctcggctccg cccgccaacc ccccgaccac cggcgcccct ccgggccctg
      541 gtccaacccc gactccgccg cccgccgtcc cctccaccgc ccccggaccg cctcccccat
      601 cgacgccgag cagcggagtc tcgaccaccc ctccacagac cggcggccct ccgccaccgc
      661 ccgccggggg cgccgggccg gggcctaagc cggggccagg ccctggcggt ccaaaaggcg
      721 gcaagatgcc cggtgggcct aagcctggag gtggcccggg catgggcgct cctggtggcc
      781 acccgaagcc accacaccga ggtggcggcg agccccgtgg gggccggcag catcatgcgc
      841 cctaccacca gcagcaccac caggggcccc ctcccggcgg accgggaccg cgcacggagg
      901 agaagatctc cgactcggag ggatttaaag ccaacttgtc tctcttgcgg aggcctggag
      961 aaaaaactta cacacagcgc tgtcggttgt ttgtggggaa tctacctgct gatatcacag
     1021 aggatgaatt caaaagactg tttgctaaat acggagaacc cggagaagtt tttatcaaca
     1081 aaggcaaagg gttcgggttc attaagcttg aatctagagc cttggctgaa atcgccaaag
     1141 ctgagcttga tgatactccc atgagaggta gacagcttcg ggttcgattt gccacacacg
     1201 ctgcagccct gtctgttcga aatctctctc cttatgtttc caacgaactt ttggaagagg
     1261 cctttagcca gtttggtcct attgaaaggg ctgttgtaat tgtggatgat cgcggaagat
     1321 ctacagggaa aggcattgtt gagtttgctt ccaagccagc agcaagaaaa gcatttgaaa
     1381 gatgcagtga aggtgttttc ctactgacaa cgactcctcg cccagtcatt gtggaaccac
     1441 ttgaacagtt agatgacgaa gatggtcttc ctgaaaagct ggcccagaag aatccaatgt
     1501 atcaaaagga gagagaaaca ccacctcgtt ttgctcagca tggcacattt gagtatgaat
     1561 attctcaacg atggaagtcc ttggatgaaa tggaaaaaca gcaaagggaa caagttgaaa
     1621 aaaacatgaa ggatgctaaa gacaaattgg aaagtgaaat ggaagatgct taccatgaac
     1681 accaagcaaa tcttttgcgc caagatctga tgagacgcca ggaagaatta aggcgcatgg
     1741 aggaacttca cagtcaagaa atgcagaaac gtaaagaaat gcagttgagg caagaggagg
     1801 aacggcgtag acgagaggaa gagatgatga ttcgccaacg tgagatggaa gaacaaatga
     1861 gacgccaacg agaagaaagt tacagcagga tgggctacat ggatccaaga gaaagagaca
     1921 tgagaatggg tggtggtgga acaatgaaca tgggagatcc ctatggttca ggaggccaga
     1981 aatttccacc actaggtggt ggtggtggca taggttatga agctaatcct ggagttccac
     2041 cagcaaccat gagtggttcc atgatgggaa gcgacatgcg tactgagcgc tttgggcagg
     2101 gaggtgcggg tcctgtgggt ggacagggtc ctagaggaat ggggcctgga actccagcag
     2161 gatatggtag agggagagaa gagtatgaag ggccaaataa aaaaccccga ttttagatat
     2221 ttaggctttc attctagttt ggttttgtct tttcttgttt agataccact taaattcttg
     2281 gcattttagt aagcaagcta cctttttatg gatgttagca gtttattgac ctgatatttg
     2341 taaatggcct gtttgggcag gtaaaattat gtaacgcagt gttcaaaaca ggagaaaaaa
     2401 ttttttcatt tacttttttt tttaactgta taatgtttct caagttaatg gcagtgtacc
     2461 ttgtgccacc gaatttccaa agtgtaccat ttttttttta ctgtgcttca aataaataga
     2521 aaaaatagtt ataatactga tcttcaactt tgctattcat gcttctatgc acattaggct
     2581 aggtatttca cttggaaagc atgagcgtgt gtaggccttt gagtggcata agccatttct
     2641 gggaaatgta acaggaggct aagtactgct ttctacaaat ggtgcccccc cttgttaaaa
     2701 agaaatgcat actgaagtaa ttaggatttg tttggcatta taggaagcag gctggtgctc
     2761 agcattttta aatggttatg ttagaaaagt tgaacttgca agtcttaatt caggaacatg
     2821 tattaagatt atggatgggt gaaaactatt ggtagtgaga gaaagagttt gttattttgg
     2881 ttaaatggat cccttatggc cctatctatg attctttcct tgaaagcttt tgaaaatgga
     2941 aagatcatct tgttgcgttt ctccctgttg ttttttaaaa gaatcccaag ccctacaaat
     3001 ggcttgtact gaacttttgc atttgaatta aagattgtta aacatgaagc cttttcatgt
     3061 attacttcaa gtgatttaaa agatgggact tagtcgggaa ttttaacttg aagagttaag
     3121 ggttagccaa ctataaggac tagccttatg tactctaaca tacaccttcc tgtgttactt
     3181 ctatggagca aagtctgtag tctgaaaata ctggttctct tggagaacta gtggtgactg
     3241 ttaccaagta ggactgtcaa gtagtctcac tatggagttg aactgttttt atatatcagt
     3301 cttacagtgt agcattaaac ctggagatag ttgcttaggc tacatagtaa aaatatgctt
     3361 tcctcccacc ataagcttgg ggatgttttg atgatgtcag ttcattgtta acttcattga
     3421 atttcctttc gttagagcaa gagactttct gacttgatga taataaagta gattggttac
     3481 tgttgggaaa aaaaaaaaaa
//
