LOCUS       NM_001198808            7826 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Scm-like with four mbt domains 2 (Sfmbt2), transcript
            variant 2, mRNA.
ACCESSION   NM_001198808
VERSION     NM_001198808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7826)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7826)
  AUTHORS   Matoba,S., Kozuka,C., Miura,K., Inoue,K., Kumon,M., Hayashi,R.,
            Ohhata,T., Ogura,A. and Inoue,A.
  TITLE     Noncanonical imprinting sustains embryonic development and
            restrains placental overgrowth
  JOURNAL   Genes Dev 36 (7-8), 483-494 (2022)
   PUBMED   35483741
REFERENCE   3  (bases 1 to 7826)
  AUTHORS   Inoue,K., Ogonuki,N., Kamimura,S., Inoue,H., Matoba,S., Hirose,M.,
            Honda,A., Miura,K., Hada,M., Hasegawa,A., Watanabe,N., Dodo,Y.,
            Mochida,K. and Ogura,A.
  TITLE     Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes
            enlargement of cloned mouse placentas
  JOURNAL   Nat Commun 11 (1), 2150 (2020)
   PUBMED   32358519
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7826)
  AUTHORS   Inoue,K., Hirose,M., Inoue,H., Hatanaka,Y., Honda,A., Hasegawa,A.,
            Mochida,K. and Ogura,A.
  TITLE     The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is
            Imprinted and Essential for Placental Development
  JOURNAL   Cell Rep 19 (5), 949-956 (2017)
   PUBMED   28467908
REFERENCE   5  (bases 1 to 7826)
  AUTHORS   Funato,N., Kokubo,H., Nakamura,M., Yanagisawa,H. and Saga,Y.
  TITLE     Specification of jaw identity by the Hand2 transcription factor
  JOURNAL   Sci Rep 6, 28405 (2016)
   PUBMED   27329940
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7826)
  AUTHORS   Kuzmin,A., Han,Z., Golding,M.C., Mann,M.R., Latham,K.E. and
            Varmuza,S.
  TITLE     The PcG gene Sfmbt2 is paternally expressed in extraembryonic
            tissues
  JOURNAL   Gene Expr Patterns 8 (2), 107-116 (2008)
   PUBMED   18024232
REFERENCE   7  (bases 1 to 7826)
  AUTHORS   Frankenberg,S., Smith,L., Greenfield,A. and Zernicka-Goetz,M.
  TITLE     Novel gene expression patterns along the proximo-distal axis of the
            mouse embryo before gastrulation
  JOURNAL   BMC Dev Biol 7, 8 (2007)
   PUBMED   17302988
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7826)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7826)
  AUTHORS   Tanaka,T.S., Kunath,T., Kimber,W.L., Jaradat,S.A., Stagg,C.A.,
            Usuda,M., Yokota,T., Niwa,H., Rossant,J. and Ko,M.S.
  TITLE     Gene expression profiling of embryo-derived stem cells reveals
            candidate genes associated with pluripotency and lineage
            specificity
  JOURNAL   Genome Res 12 (12), 1921-1928 (2002)
   PUBMED   12466296
REFERENCE   10 (bases 1 to 7826)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147557.1, BC145610.1, AK147651.1 and BQ033024.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the presence and absence of exons, compared to variant 1, which
            results in a shorter transcript encoding a longer protein (isoform
            2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AK147557.1         6-138
            134-3230            BC145610.1         1-3097
            3231-7716           AK147651.1         3110-7595
            7717-7826           BQ033024.1         1-110               c
FEATURES             Location/Qualifiers
     source          1..7826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 7.81 cM"
     gene            1..7826
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /note="Scm-like with four mbt domains 2"
                     /db_xref="GeneID:353282"
                     /db_xref="MGI:MGI:2447794"
     exon            1..102
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            103..153
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            154..295
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..3126
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     scm-like with four MBT domains protein 2; Scm-related gene
                     containing four mbt domain 2"
                     /codon_start=1
                     /product="scm-like with four MBT domains protein 2 isoform
                     2"
                     /protein_id="NP_001185737.1"
                     /db_xref="CCDS:CCDS57152.1"
                     /db_xref="GeneID:353282"
                     /db_xref="MGI:MGI:2447794"
                     /translation="MERYLPVSKKRNSSSSLEKITGSANGNGTLYSEEDTNLEENDFS
                     WGDYLEETGTRAVPHVSFRHVEISIRSNFQPGMKLEVANKNNPDTYWVATIITTCGQL
                     LLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKDKYSDWTDFLIRE
                     LTGSRTAPANLLEGPLRGKGPIDLITVDSLIELQDSQNPFQYWIVSVTENVGGRLRLR
                     YVGLEHTESYDRWLFYLDYRLRPIGWCQENKYRMDPPSELYYLKLPFEWKCALEKALV
                     LAAESPLPMEVFKDHADLQSHFFTVGMRLETLHISDPFHIYPASVTKVFNSKFFQVAI
                     DDLRPEADKPTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQDFNWVDYHKQRQAEE
                     APHFCFKNAFSRGFSKNMKLEAVNPVNPGEVCVATVVSVKGRLLWLHLEGLETPMPDI
                     IVDMDSMDIFPVGWCEANSYPLTTPYKASSKSKRKTVHFKMEKQLLSPVPIEKIPHEL
                     CLLPPQMDSPVGAINAKYCCPQLFVNHRCFSGPFLNKGRISELPQSVGPGMCVLVLKE
                     ILTLITNAAYKPGRVLRELQLVEDPEWNSQEEILKAKYGGKTYRAVVKIVRTADQVMN
                     FCRQVCAKLECCPNLLSPVLISETCPENCSVHTKTRYNKREKGSSLSPASELKDDSAS
                     HATKLQKAKIPQTYYYGKRRRVIQSSLRVSNIETPPKSTRRRKRRKSVYVQKRRKSAI
                     VVPAGVPAGVPAGVPEDIPAGIPEGIPASIPESIPEGIPESLPESLPEAIPESIPKGS
                     AQKTEQEKRETLDTARKKTGYHGPAYQTDTSAAQVPFARPRRAVTLRRNSEALKRPPV
                     ERARRVRTVPTTASSNNRVKGPLVRIVKPEDSSQSDEEKLILESNPLEWSVTDVVRFI
                     KLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQ
                     YAS"
     exon            296..390
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..631
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..720
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            721..967
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1065
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1167
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1315
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1398
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1522
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1636
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1679
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1753
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1896
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2006
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2182
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2281
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2598
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2856
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2985
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..7809
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7789..7794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7809
                     /gene="Sfmbt2"
                     /gene_synonym="D2Wsu23e; D330030P06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgcaggttg ggtcttgtgg gtctaagcct ctaaaggtga ctttgagcct ctttcccacc
       61 tctttctgaa ggatcagctg cgagttgaag gagtgagaag agttttattc cctgagaaaa
      121 agagatatca ggctgtgcct tctcagaccc ctgctcccta gaggatgaat taagggacta
      181 ggaggcctac tcatcagcat ggagagatat ttgccagttt cgaagaagcg caactcatcc
      241 tcctctttgg aaaagataac cggctcagca aatgggaatg ggactcttta ctcagaggaa
      301 gataccaacc tggaggaaaa tgacttcagc tggggagact atttggaaga gacaggtacc
      361 agagcggtgc cacacgtgtc cttcagacat gtggagatca gcattcggag taacttccag
      421 ccaggaatga agttggaggt ggccaacaag aacaatccag acacttactg ggtggccaca
      481 atcatcacca cctgtggaca gctgctgctc ctgcgttact gtggttacgg ggaagaccga
      541 agggctgact tctggtgtga cgtgatcata gcggatctgc accctgtggg gtggtgcacg
      601 cagaacaaca aggtgttgag gcctccggat gctatcaaag acaagtactc agactggaca
      661 gacttcctca tccgtgaatt gactggttct cggacagccc ctgcaaacct tctggaaggt
      721 cctctgcgag ggaaaggccc tatagacctc attacagttg attccttaat agagctgcag
      781 gactcccaga atccctttca gtactggata gttagtgtga ctgagaatgt cggtggaaga
      841 ttacgccttc gctatgtggg actggagcac accgaatcct atgaccggtg gttattttac
      901 ttggattaca gacttcgacc aattggttgg tgtcaagaaa ataaatacag aatggatcca
      961 ccttcagaac tttattatct gaagttgcct ttcgagtgga aatgtgctct ggaaaaagcc
     1021 ctagttcttg ctgcagagtc tcctcttcca atggaagtat ttaaggacca tgcagacttg
     1081 caaagccatt tctttacagt tgggatgcgg ctggagacat tgcatataag cgatcctttt
     1141 catatctacc ctgcatcagt gaccaaggtt tttaatagta aatttttcca agtggccatt
     1201 gatgacctaa gacctgaagc tgataaaccc acgatgctgt gccatgcaga ttctttgggg
     1261 attttgccag tacagtggtg ccttaaaaac ggagtcaacc tcgctcctcc caaaggttac
     1321 tcaggccagg attttaactg ggtggattac cacaagcagc gtcaggcaga agaagcacct
     1381 catttctgct tcaaaaatgc attttctcgg ggcttctcaa agaacatgaa gcttgaagct
     1441 gtgaaccctg tgaatccagg agaggtgtgc gtggccactg tggtcagtgt gaaagggcgg
     1501 ttgttatggc tccatttaga aggtctggag accccaatgc cagatatcat cgtggacatg
     1561 gactccatgg atatcttccc tgtgggctgg tgtgaggcca attcttaccc tctgaccaca
     1621 ccatataaag catcctccaa aagcaagaga aagactgtcc atttcaagat ggaaaaacaa
     1681 ttattatccc cagtgcctat tgagaaaata cctcatgagc tttgcttgct gccgccgcag
     1741 atggacagtc cagtcggagc catcaatgcc aagtactgct gcccacagct gttcgtcaac
     1801 caccggtgtt tctcaggccc attcctgaac aaaggaagga tttcagagct acctcagtca
     1861 gtggggcctg gcatgtgtgt gctggtgctc aaagagattc ttaccctcat taccaatgca
     1921 gcctacaagc ccgggagggt cctgagagaa ttacagctgg tggaagaccc agagtggaac
     1981 tcccaggagg agattctcaa ggcaaaatac gggggcaaaa catacagggc cgtggtcaag
     2041 atcgtgcgaa cagcagacca agtgatgaat ttctgccggc aagtttgtgc caagctggag
     2101 tgctgtccaa atttactgag ccctgtgttg atctctgaaa cctgcccaga gaactgttcc
     2161 gtccacacca aaaccagata caacaaaagg gagaaggggt catcattgtc acctgcaagt
     2221 gaactaaaag atgattctgc atcccatgcc accaaattgc aaaaggctaa gattcctcag
     2281 acctattatt atggaaaaag aagaagggtc attcagtcgt cacttagagt cagcaacatc
     2341 gaaactccac caaaatcaac caggagaagg aaacgacgga aatcagtcta tgtacagaag
     2401 agacggaaat ctgctatagt cgtcccagca ggtgttccag caggcgtccc agcaggtgtc
     2461 ccagaggaca tcccagcggg catcccagag ggcatcccag caagcatccc agagagcatc
     2521 ccagagggca tcccagagag cctcccagag agcctcccag aggccatccc agagagcatc
     2581 ccaaagggct cagcacagaa aactgaacag gagaagcgag aaactctgga cactgcaagg
     2641 aagaaaactg ggtaccatgg tccggcttac cagacagaca cctcagcagc acaggtgccc
     2701 tttgcccggc cacgaagggc tgtaaccctg aggagaaatt ccgaggcttt gaagcgacct
     2761 ccagtggaaa gggcacggag ggtccgcaca gtgccaacta ctgcttcttc taataacaga
     2821 gtcaagggtc cacttgttag aattgtgaaa ccagaggatt cgagccaatc ggatgaggag
     2881 aaactgatac ttgagagcaa tcccctggag tggtcggtga cggatgtggt acgattcatt
     2941 aagctgactg actgtgcacc tttggccagg atcttccagg agcaggacat cgacggccag
     3001 gcactcctcc tgctgactct cccgacagtg caggagtgca tggagctgaa actgggaccc
     3061 gctatcaagt tatgccatca gatcgagaga gtgaaggtgg ctttctatgc ccagtacgcc
     3121 agctaactcg cccttcttgg caggtgtcgc ctgattctga taatgctgtg tttgttgtaa
     3181 aggtttccag gactgagacc ttattccctg ggcttcgtga aatggcacag tcattggtaa
     3241 tcttcaaaaa gccagaagcc caggacctcc tttttgcacc agcctatttg atagtcctat
     3301 atttttaaag cacacggaag gagcaccagc agctctgata gtattgtgaa agttctgaga
     3361 ccttccctgg ctcaggacct ctgagtttcc ttccccctcc ccccaattca aaccaggcag
     3421 tttttttgga agccaggttt ccttacacta aggtaggtct aggttcttcg gaaactaaga
     3481 taaacttagt gtatctgaga agaatacctg tccatcttgc tacccgcttt tgcctgactc
     3541 agactccagc tctcatacag ctctgtctgc cacacacgtg caagcaattg tgatttagag
     3601 tcacctccta tcccatttga tctcacgtaa gctccattct cccacacaac tctgggctct
     3661 gttcagcact gtcttctgtc agaggtgcct tttcacaagt atggcggctt accacgagat
     3721 agctactggg taagcaaagc ctgggacatt tgcaatagca agcaccctct gtagtctcct
     3781 gcagagccat agcttcaatg ttctaagatc actgtgactg gtcaggagga caggacgctg
     3841 ctttagggaa gtatcaaatt ccgtattgaa gaaaagcttt cagagggcat gtataggaag
     3901 tgattttggg gaagtcgttt tttgtttgtt ttttgttttg ttttgttttg ttttgttttt
     3961 ttgtttgtga actagctgta tccgcttaga atggtaacac agatggtcgc tgcaagcaga
     4021 tccctctgag cctctcttct gctagtgcct ggcttgccac atggaaagca agcacaaggg
     4081 agcagtattc cgtagcatat gatagcagag caaataccgg atctggatct agctgatttc
     4141 catccattgg ctaatggcca acttcatgtc cttgggtaac ttgccaccac cctggatcca
     4201 agttcccatg gaggggaaaa ttaggacatt tagtagtgag gcactggtac cttctccctg
     4261 ctcctgttat agaggaggct acgtagacca aaatgagaaa aggaatgtgg ccacagaatg
     4321 taaccgtcca gtttctgcct ttcactttct tgggggttgc ttgtgaaatt aggctaagtc
     4381 atttgtagac taatcagtga ttgtaagttt gcctgatact cagcacacat ctatgttttc
     4441 ctatgagcag ttcaacctgt gcctgcaaag ccaaaggggc tgaggtacat tagagcatgg
     4501 aggacacctc cacatctttt gaaatccagg caaggagacc aaaactttcg ctctgttcac
     4561 ttgtgcctca ctttggaagc ttaacttccc acctatctgg gccttactgg tttacttgtg
     4621 gttttccata gttttccata attacattca tcttctttct ttgactagaa tcacaaccat
     4681 cccagagcat gtatgacaag cttgtgtttt ggcagcattt taaggcatgg tggtccctca
     4741 ggctttgaaa acgcctcttg cctatgttag ttacccattc tcaacactgg gccatggctg
     4801 cagatggaat tggaaagtaa aatatttgtg gctgagcctc tttagtcttc cctgaagctg
     4861 gctttctatg gtcaagctat aattctttgg tgaataggta tgcctaggaa caactggtgg
     4921 ttagtctgtg tcctgtgtgg aactgtaagg atggagctgc ccctgatagg ctctgtggag
     4981 ttggcttgca tttggatttc tctcttctaa ggtacatgtt aaaccttcct ctgccttctc
     5041 agccacatgc ttttggccat aaatactcaa tctaccagtt ggaaagggta tctatttcaa
     5101 gatggggtgg cgtttttccc atactcactc cttcttgatt cttcactgtg gtcttttcca
     5161 gataagttac ttcttttgca tctgaaatgg gatgtggcca tggcattgct agaatatggt
     5221 gtgcttttag aacaaatgtg gccttctcat gccatttcca gtaatgacgc agaggaggac
     5281 gtgttgcctc agaacatggg gacttcctag aggtctgctg agcccacaga aagagccagg
     5341 aaagcattaa cagaaaagcc tgtcaggaca tgtccaccac tggtcagaaa ctcttcttcc
     5401 cgtggaacca aatgtcccag actctcttca tgcctcagcc ttgcagtgta gcataggtct
     5461 ctctctgcac agtgttggtt cctccagcct aacctttggc tttgggaagg aagagatgac
     5521 cgtaatcttg caacaagagt gcccaaccag ggaccactgt catcatagtg gctctcaatg
     5581 tgcatgtcac accccccctc agtagacttg agtattttga tgaccaaaga ggatgatttt
     5641 cctcagagag aagtgccagc gccctccaga gctgtgatcc aggatggcat gctcacgtgc
     5701 ggaatgcaat tttgccaccg gtttgtaatg tgggttttgt ttctctctag acttgcctct
     5761 cactgctttt tgtctgaaac acagagttga tttccgagaa tgattgggaa gaaaagaaat
     5821 ggatttttat acacatacac caaaaatatt ttaatgattc acttgccaaa ttacttcctg
     5881 ggtggtatca tttccttatc tctctgatta tcttctggga cccacgtcct ttcctccaca
     5941 tacctacacc ttgggtgcat cactccattc atggcctcct gttaccaact gcgcagacat
     6001 cacacaatcc gtgccatgtg attgagaaat ggaaatgcca cctcaactta aataatcaca
     6061 gttggtcatt tatgcccact ttaaaatgta gggagtctgt ttcggcccct tttctggagt
     6121 atatttgtac catattgtaa caaaatgatc ctggccacaa aataaaacac acactgatca
     6181 aagccggcta tactggcatt gcatatcttt gctattcaac aatggtgtcc ttcaccacag
     6241 tttctaatct agagcacgga gaactggtct gtcactttta aaattagatg cctttgatca
     6301 gagtttgact cacagacagc atttgagctc tacagctatt tgagtcccta gaccttattt
     6361 gatcatattc aaaagatcat ttcccatgct tgctttgatt tggtcctcaa taaattaaaa
     6421 tgatccacac tttcacactg ccacttctga ccttcactgc catcttcaga cggttccttt
     6481 tgatcagccc ctggaagatg ggtccctcct aatctatgtc atagaatttt gcatgctgta
     6541 tgattggctt tgtcttctat ctcccaccaa ataccacttc ctgagattca tctctgagtt
     6601 ttgcaagcgc tcagggtttt catacttatt tcatataaca cccatttcta ttcatttctg
     6661 tataaagaac agtacagaac agtatcggga tctttgttgg tttgacattg ctgttttggg
     6721 ttaagatatt gagtctaggc tccaattact ctctatcctg tctttagaga gctgtgattg
     6781 agtgtgctat tatttggaag gagaaaatgt aaattgagat agctgtagtg tttatgccag
     6841 aagtctctgg ggacatctac tgcttgtgtc tctttggtgc aataattaaa atggaaggag
     6901 gagctgaact gggaacccta cagcctagtg attcttctac ttgctcgcta tagctttctg
     6961 ttggcaaatt ttctcaaaag cactctcttt aatcagatta acttcttaaa ctgcttaatt
     7021 ctcatcgctt cttaaaacta gggtggtttg caggtatcca aaaatatgct atgacagaac
     7081 aaaattgtgg tattcatgac ccatttaatt tactgaaaaa tcataactgc tgtcctgcct
     7141 gctctccttg ggtttcggtt ttaaaagcct ttgtggttga aatgaataac gattcggttt
     7201 tctgaactgt acacatcctt gttcagtttt cttttgatga ctaaggctca gtaccagcga
     7261 gctgtaggcc atgtcacaga accgaggcag agcagtgctt tgagtaggac aacaaggaac
     7321 attaaagaag gaaagttcta gaacaatctt ttgctaaaaa aaaaaaaaaa gaaagaaatt
     7381 gctttatggt gaaaactgtg ggaagggttt ttttttttaa tttcaacaaa agaaaaagtg
     7441 accatcttac ctgtcattca gaatgcaagc taacatcatc cctgtaagca gagagaaccc
     7501 tagtcactaa aggtgggagc cctttacctc tcatgttcca ctttgaaaag tttgtattga
     7561 catttggttc atatcttgtg tattggtgca taaaagaaaa aaaaacagtg tttttacgtt
     7621 ttcagtttaa aggacaaagg gcgtgctctc tcagtttgct gtaagattgt attctgtaga
     7681 tatgtttcca tgtacataaa ggaaaatata tatcagagtt atattttaat ttttattcta
     7741 aatggaaaaa aaaccctttt tacttgaaaa catgaacgcc acattgctaa taaagttaaa
     7801 aaaaatctaa aaaaaaaaaa aaaaaa
//
