LOCUS       NP_084483               1216 aa            linear   ROD 27-APR-2025
DEFINITION  protein SFI1 homolog isoform 1 [Mus musculus].
ACCESSION   NP_084483 XP_911516 XP_991952
VERSION     NP_084483.2
DBSOURCE    REFSEQ: accession NM_030207.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1216)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   2  (residues 1 to 1216)
  AUTHORS   Pezer,Z., Harr,B., Teschke,M., Babiker,H. and Tautz,D.
  TITLE     Divergence patterns of genic copy number variation in natural
            populations of the house mouse (Mus musculus domesticus) reveal
            three conserved genes with major population-specific expansions
  JOURNAL   Genome Res 25 (8), 1114-1124 (2015)
   PUBMED   26149421
  REMARK    GeneRIF: Study showed major differences in gene copy number in
            natural populations. CWC22, SFI1, and HJURP are highly conserved
            genes with the most copy-number variation. They all exhibit
            population-specific expansion patterns, perhaps for local
            adaptations.
REFERENCE   3  (residues 1 to 1216)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   4  (residues 1 to 1216)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (residues 1 to 1216)
  AUTHORS   Park,C.S., Rehrauer,H. and Mansuy,I.M.
  TITLE     Genome-wide analysis of H4K5 acetylation associated with fear
            memory in mice
  JOURNAL   BMC Genomics 14, 539 (2013)
   PUBMED   23927422
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1216)
  AUTHORS   Gendrel,A.V., Tang,Y.A., Suzuki,M., Godwin,J., Nesterova,T.B.,
            Greally,J.M., Heard,E. and Brockdorff,N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   7  (residues 1 to 1216)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK639032.1, BY303229.1 and AK133558.1.
            
            On or before Feb 2, 2007 this sequence version replaced
            XP_911516.2, XP_991952.1, NP_084483.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133558.1, SRR13948564.3588558.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.19 cM"
     Protein         1..1216
                     /product="protein SFI1 homolog isoform 1"
                     /note="protein SFI1 homolog"
                     /calculated_mol_wt=143903
     Region          87..106
                     /region_name="Interaction with CETN2.
                     /evidence=ECO:0000250|UniProtKB:A8K8P3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          114..146
                     /region_name="HAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          148..177
                     /region_name="HAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          211..822
                     /region_name="Sfi1"
                     /note="Sfi1 spindle body protein; pfam08457"
                     /db_xref="CDD:430007"
     Region          246..278
                     /region_name="HAT 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          375..407
                     /region_name="HAT 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          451..470
                     /region_name="Interaction with CETN2.
                     /evidence=ECO:0000250|UniProtKB:A8K8P3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          617..636
                     /region_name="Interaction with CETN2.
                     /evidence=ECO:0000250|UniProtKB:A8K8P3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          940..967
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          1003..1029
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          1066..1085
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     Region          1122..1154
                     /region_name="HAT 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UZY0.1)"
     CDS             1..1216
                     /gene="Sfi1"
                     /coded_by="NM_030207.3:338..3988"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36094.1"
                     /db_xref="GeneID:78887"
                     /db_xref="MGI:MGI:1926137"
ORIGIN      
        1 mekkigsrsf rdgvvkkpcs pktlplkkss afsgiqreps rschsiyyha sqnwtryrlq
       61 elrircvark flylwirvtf grvtpsrari fheqkilqkv fgewreewwv sqrewklcvr
      121 adchyryyly nlifqnwktf vhqqremrkr friaehhdtk qkmcqawksw liymvsrrtk
      181 lhmkttalef rrqsvlcfww skwrwrlgqa haehalhava vkhralslql qgwlrwqeql
      241 lisqrdrrke atavqhyqhw qkqrslkawl kylqicrvkr wqnemavqfh ratvlqihfc
      301 dwqwawewrq slsahqalvv klagrmvlrr afthwkhyml lqaeeaaqre aaaehrqhyl
      361 lyscfrafkd nvtqarlqqt rkklaqqlrd ttllhrfwnl wqsrieqree rvqtpslhaa
      421 lshyrvtvlh kcvrvwlryv hkrqwqqllr aradghfqqr alpaafytwy rgwlwhqqrr
      481 ilhtkavrfh rgtlekqvfa lwrqkmsqhr enclaermai lqaeqqllrr fwfvwhqqaa
      541 vcqlerqqqa maiahhhsgl lrrafciwke stqgfrierm graqaahfhs aqllsrawsm
      601 wreclalrle eqqklkcaal hsqcillrra lqkwlvyqnr vrsvlrevaa rerqhnrqll
      661 wwalhlwren tmarldgakk tsqarvhysr tlcskvlvqw revtsvqiyy rqkeaaalre
      721 arkaldrgrl qnwfqhwrfc sqraaqqrfq lgqaaqhhhw qllmeamarw kahhlgcirk
      781 kflqrqaaql laqrlsracf cqwrkqlavr kqeqwgtara lwlwafslqa kvwtawlgfv
      841 lerrrkkarl eramqayqqq llqegatrll rftagtkafr qqlqaqqqvq aahslhcavr
      901 hcaelwkkkv lgpgktsqpp apttfskrvt fkdsflsgha aeagdatqet kklrappsqg
      961 vlgslagaag epchldlnaa rssrkqprrp sfllerlgsq rspewyslge qqlekppeee
     1021 stallggssl trpflpgvlp nvpgpklppt aspglellpp ssimphaagg tarvsakpsi
     1081 pgpqpwgcps lprdldpqll pgdsistrte pvygseatgh teleaelegi qqqlqhyqtt
     1141 kqnlwscqrq anslrrwlel sqeepksedl hleeqvktel eevelqvqql akeleaqrqp
     1201 vgtciarvra lrralc
//
