LOCUS       NM_153053               1741 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus splicing factor 3b, subunit 4 (Sf3b4), mRNA.
ACCESSION   NM_153053 XM_907915 XM_920633 XM_920648
VERSION     NM_153053.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
  REMARK    GeneRIF: Sf3b4 regulates chromatin remodeler splicing and Hox
            expression.
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Yamada,T., Takechi,M., Yokoyama,N., Hiraoka,Y., Ishikubo,H.,
            Usami,T., Furutera,T., Taga,Y., Hirate,Y., Kanai-Azuma,M., Yoda,T.,
            Ogawa-Goto,K. and Iseki,S.
  TITLE     Heterozygous mutation of the splicing factor Sf3b4 affects
            development of the axial skeleton and forebrain in mouse
  JOURNAL   Dev Dyn 249 (5), 622-635 (2020)
   PUBMED   31900962
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Isono,K., Mizutani-Koseki,Y., Komori,T., Schmidt-Zachmann,M.S. and
            Koseki,H.
  TITLE     Mammalian polycomb-mediated repression of Hox genes requires the
            essential spliceosomal protein Sf3b1
  JOURNAL   Genes Dev 19 (5), 536-541 (2005)
   PUBMED   15741318
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Ruiz-Lozano,P., Doevendans,P., Brown,A., Gruber,P.J. and Chien,K.R.
  TITLE     Developmental expression of the murine spliceosome-associated
            protein mSAP49
  JOURNAL   Dev Dyn 208 (4), 482-490 (1997)
   PUBMED   9097020
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ060196.1 and AK047751.1.
            
            On May 7, 2015 this sequence version replaced NM_153053.3.
            
            Summary: This gene encodes one of the subunits of splicing factor
            3B. A similar gene in human encodes a protein that cross-links to a
            region in the pre-mRNA immediately upstream of the branchpoint
            sequence in pre-mRNA in the prespliceosomal complex A. It also may
            be involved in the assembly of the B, C and E spliceosomal
            complexes, and also belongs with the minor U12-dependent
            spliceosome. [provided by RefSeq, May 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047751.1, BC026567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                CJ060196.1         1-44
            45-1741             AK047751.1         1-1697
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.65 cM"
     gene            1..1741
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /note="splicing factor 3b, subunit 4"
                     /db_xref="GeneID:107701"
                     /db_xref="MGI:MGI:109580"
     exon            1..102
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     exon            103..231
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     exon            232..774
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     exon            775..981
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1155
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1741
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /note="hexamer: AATAAA"
     polyA_site      1566
                     /gene="Sf3b4"
                     /gene_synonym="Sap49; SF3b49; SF3b50"
                     /note="major polyA site"
ORIGIN      
        1 gaagtggaag ttgtaactga ggtcaggggg cggtgctgct gcttagagac ggcgggagcc
       61 ccttcgccat ggctgccgga ccgatctccg aacggaatca ggatgccacg gtgtacgtgg
      121 gcggtctgga cgagaaagtg agtgagccgc tgctgtggga gctctttctc caggcagggc
      181 cagtggtcaa cacccacatg cccaaggaca gagtcactgg ccagcaccag ggctatggct
      241 ttgttgaatt cctgagcgag gaagatgccg actatgccat taagattatg aacatgatca
      301 aactctatgg aaagccaata cgggtgaaca aggcctcagc tcacaacaaa aacctggatg
      361 tgggagccaa cattttcatt ggaaatctgg acccagaaat tgatgaaaag ctgctttacg
      421 atactttcag cgcctttgga gtcatcctac agacccccaa gatcatgcgg gaccctgaca
      481 caggcaactc caagggttac gccttcatta attttgcctc cttcgatgct tcggatgcag
      541 caattgaggc catgaacggg cagtacctgt gtaaccgtcc tatcactgtg tcttatgcct
      601 tcaagaagga ctctaagggt gaacgccatg gctcagcagc tgaaagactc ctggcagccc
      661 agaacccgct gtcccaggct gaccgccctc accagctgtt tgccgatgca ccccctccgc
      721 cctctgcccc caatcccgtg gtttcatccc tgggttctgg gcttcctcca ccaggcatgc
      781 cgcctcctgg ctcttttcca cctccagtgc cacctcctgg ggccctccct cctgggattc
      841 ccccagccat gcccccacca cctatgccac ctggggctgg aggacatggc cccccagcag
      901 cagggactcc aggggctgga catcccggtc acggacactc acatcctcac ccgttcccac
      961 caggtgggat gccccatcca gggatgtccc agatgcagct ggcccaccat ggcccccatg
     1021 gcctaggaca cccccatgct gggcctccgg gctctggggg gcagccacca cctcggccac
     1081 ctcctggaat gcctcatcct ggacctcctc caatgggcat gcccccccga gggcctcctt
     1141 ttggatctcc catgggtcac ccaggtccca tgcctccaca cggcatgcgt gggcctcctc
     1201 cattgatgcc ccctcatgga tacacgggtc ctccaagacc ccctccctat ggctaccagc
     1261 gggggcccct cccgccaccc agacccactc cacggccccc agttccacct cgtggtcctc
     1321 ttcggggccc acttcctcag taaattgcca tcctttgtct cctcctttta tcctcccttt
     1381 atcttcattt cttggaccaa tcagagatgc tgtagcttgt caaggctaat gtactgaccc
     1441 ttctcagtaa ctctgtcccc attccaatgt catgttttcc actggggatt ttcttcattt
     1501 ttattttaaa atgttggtcc taatttcttt acacatgtat agaaaaataa aactatgctt
     1561 cttgtttgtt ctctggtgaa gtaactttta ggaggagtct gggtttgtgg gaggaacagt
     1621 atgaaaaagg gaaggtgttt acattgtaag gatttatctt gcatgtactt ggaatagagc
     1681 ttatcttgtt atagtatgga ggcattagca acagaaataa aatgtctggt gatgtgctag
     1741 c
//
