LOCUS       NM_133953               4299 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus splicing factor 3b, subunit 3 (Sf3b3), mRNA.
ACCESSION   NM_133953 NM_027443
VERSION     NM_133953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4299)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4299)
  AUTHORS   Guidi,R., Wedeles,C., Xu,D., Kolmus,K., Headland,S.E., Teng,G.,
            Guillory,J., Zeng,Y.J., Cheung,T.K., Chaudhuri,S., Modrusan,Z.,
            Liang,Y., Horswell,S., Haley,B., Rutz,S., Rose,C., Franke,Y.,
            Kirkpatrick,D.S., Hackney,J.A. and Wilson,M.S.
  TITLE     Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain
            type 2 immunity
  JOURNAL   Cell Rep 42 (12), 113515 (2023)
   PUBMED   38096048
  REMARK    GeneRIF: Argonaute3-SF3B3 complex controls pre-mRNA splicing to
            restrain type 2 immunity.
REFERENCE   3  (bases 1 to 4299)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 4299)
  AUTHORS   Li,J., Wang,C., Feng,G., Zhang,L., Chen,G., Sun,H., Wang,J.,
            Zhang,Y., Zhou,Q. and Li,W.
  TITLE     Rbm14 maintains the integrity of genomic DNA during early mouse
            embryogenesis via mediating alternative splicing
  JOURNAL   Cell Prolif 53 (1), e12724 (2020)
   PUBMED   31794640
REFERENCE   5  (bases 1 to 4299)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   6  (bases 1 to 4299)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   7  (bases 1 to 4299)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4299)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 4299)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4299)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126146.1, AK128988.1 and BC042580.1.
            
            On Nov 30, 2006 this sequence version replaced NM_133953.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164199.1, AK128988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY126146.1         1-10
            11-2206             AK128988.1         1-2196
            2207-4299           BC042580.1         2134-4226
FEATURES             Location/Qualifiers
     source          1..4299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.73 cM"
     gene            1..4299
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /note="splicing factor 3b, subunit 3"
                     /db_xref="GeneID:101943"
                     /db_xref="MGI:MGI:1289341"
     exon            1..129
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            130..266
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3850
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /note="SAP 130; spliceosome-associated protein 130;
                     pre-mRNA-splicing factor SF3b 130 kDa subunit"
                     /codon_start=1
                     /product="splicing factor 3B subunit 3"
                     /protein_id="NP_598714.1"
                     /db_xref="CCDS:CCDS22665.1"
                     /db_xref="GeneID:101943"
                     /db_xref="MGI:MGI:1289341"
                     /translation="MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPD
                     PNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKI
                     HQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEA
                     HKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLN
                     HVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRN
                     DLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVP
                     VAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPL
                     KNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVS
                     ELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSC
                     SLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYF
                     EMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDC
                     LQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPV
                     TGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLE
                     FASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLI
                     IIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPK
                     AGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLI
                     LSPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDL
                     GKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYP
                     RWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQK
                     AEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEM
                     HLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEV
                     SKKLEDIRTRYAF"
     exon            267..593
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            594..766
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            767..908
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1021
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1159
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1263
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1429
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1525
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1598
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1750
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1906
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2062
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2206
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2329
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2484
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2659
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2865
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3022
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3148
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3361
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3460
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3604
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3709
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..4299
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4278..4283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /note="hexamer: TATAAA"
     polyA_site      4299
                     /gene="Sf3b3"
                     /gene_synonym="1810061H24Rik; 5730409A01Rik; D8Ertd633e;
                     mKIAA0017; RSE1; SAP130; SF3b130"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgcggc acccgaaggc ccgtcttgaa ggctaatggc ggacgccggc ggatcggcag
       61 tggcggtggc ttaggccttg aagcgattca gcatccgtcg ggtaccgaag ccatccttct
      121 tgcagcaggt ctgctttgcc ttgaaaccgt tgctgtaacc aagagttgac tgagggtcac
      181 agctttgctt gtcaccatgt ttctgtacaa cctgacctta cagcgggcca ctggcatcag
      241 ctttgccatc catggcaact tctctggaac caagcaacag gaaattgttg tttcccgtgg
      301 gaagattttg gagttactac gcccagaccc taacactggc aaagtacata ccctcctcac
      361 tgttgaagta tttggtgtta tccggtcact tatggcgttt aggctaacag gtggcaccaa
      421 agactacatt gtagttggca gtgactcagg ccggattgtt atcttggaat accagccatc
      481 aaagaatatg tttgagaaaa ttcaccaaga aacttttggc aaaagcggat gtcgccgtat
      541 tgttcctggc cagttcttag ctgtggatcc caaaggaaga gctgttatga ttagtgcaat
      601 tgagaagcag aaattggtat atatcttgaa cagagacgct gcagcccgac ttaccatttc
      661 ctctcccctg gaggcccaca aagcgaacac tctggtgtat cacgtggttg gcgtagacgt
      721 gggatttgag aatcctatgt ttgcttgtct ggaaatggat tatgaggagg cagacaatga
      781 tccaacaggg gaagcagcag ccaataccca gcagacactt actttctatg aactggacct
      841 tggcttaaat catgtggttc ggaaatacag tgaacccttg gaggaacatg gcaacttcct
      901 tattacagtt cctggagggt cagatggtcc aagtggagtg ctaatctgct ctgagaatta
      961 tatcacctac aagaactttg gtgaccagcc agacatccga tgtccaattc ccaggagacg
     1021 gaatgacctg gatgaccctg aacgaggaat gatttttgtt tgctctgcca cccataagac
     1081 caagtccatg ttcttctttc tggcccaaac ggagcaggga gatatcttta agatcacttt
     1141 agagacagat gaagatatgg taaccgagat ccgcctcaag tattttgata ctgtgcctgt
     1201 tgctgctgct atgtgtgtgc ttaaaacagg cttccttttt gtggcgtcag aatttggaaa
     1261 tcattacttg tatcaaattg cccatctcgg agatgatgat gaagaacctg agttttcgtc
     1321 tgccatgcct ctagaagaag gagacacatt cttctttcag ccgagaccac tcaaaaatct
     1381 cgtgctggtg gatgaactgg acagcctctc tcctattctg ttttgccaga tagctgattt
     1441 ggccaatgaa gacaccccac agctgtatgt agcctgtggt aggggacccc ggtcctccct
     1501 gagagtctta aggcatggac ttgaggtgtc ggaaatggct gtttctgagc tccctggtaa
     1561 ccccaatgct gtctggacag tccgtcggca cattgaagat gagtttgatg cctacatcat
     1621 tgtgtctttc gtgaatgcca cacttgtgct atctatcgga gagactgtgg aagaagtgac
     1681 tgactctggc ttcttgggca ccactccaac cttgtcctgc tccttgttag gagatgatgc
     1741 actggtgcag gtgtatccag atggcatccg acacatacga gcagataaaa gagttaatga
     1801 gtggaagact cccggcaaga aaacgattgt gaagtgtgca gtgaaccagc gacaagtggt
     1861 gatcgccctg actgggggag agctggtcta tttcgagatg gatccttcag gacagttgaa
     1921 tgagtacacg gagcggaaag agatgtcagc agatgtggtg tgcatgagtc tggccaacgt
     1981 gccccctgga gaacagcgat ctcggttcct ggctgtgggg ctggtggaca acactgtcag
     2041 aatcatctcc ctcgacccat cagactgttt acagcctctg agtatgcagg ctctcccagc
     2101 ccagcctgag tctctatgta ttgtggaaat gggtgggact gagaaacaag atgagctggg
     2161 tgagagaggc tctattggct tcctgtacct gaacattgga ctacagaacg gtgtactgct
     2221 gaggactgtc ctagaccctg ttactgggga cctgtctgac acccgcacta ggtatctggg
     2281 gtcccgtcct gtgaaactct tccgggtccg gatgcaaggc caggaggctg ttctggctat
     2341 gtccagtcgc tcatggctga gctactctta ccagtctcgc ttccatctca cccctctgtc
     2401 ttatgagacc ctggaatttg catcgggctt tgcctctgaa cagtgtcccg agggcattgt
     2461 tgccatctcc accaacactt tgaggatttt ggctttagag aagcttggtg ctgtcttcaa
     2521 tcaagtagcc ttcccattgc agtacacacc caggaagttt gtcatccacc ctgagagtaa
     2581 caaccttatc atcattgaga cggatcacaa tgcctacact gaggccacaa aagctcagag
     2641 aaagcagcag atggctgagg aaatggtaga agcagcaggg gaggatgagc gggagttggc
     2701 tgcagaaatg gcagcagcat tcctcaatga aaacctccca gaatccattt ttggagctcc
     2761 caaggctggc aatgggcagt gggcctctgt gattcgggtg atgaacccta tccaggggaa
     2821 tacactagac cttgtccagt tggagcaaaa cgaggcagcc tttagtgtgg cagtgtgtag
     2881 gttctccaac actggtgaag attggtatgt gctggtgggt gttgccaagg acttgatact
     2941 gagccctcga tctgtggcag ggggctttgt gtatacgtac aagcttgtga acaacgggga
     3001 gaagttggag tttctgcaca agactccagt ggaagaggtc cctgctgcca ttgccccatt
     3061 ccaggggagg gtactgattg gtgtcgggaa gcttttacga gtttatgacc tggggaagaa
     3121 gaagttactt cgaaagtgtg agaataagca tattgccaat tacatatctg ggatccagac
     3181 aattggtcac agggtaattg tgtctgatgt ccaagaaagt ttcatctggg ttcgatacaa
     3241 gcgtaacgag aaccagctca ttatctttgc tgatgacacc tatcccagat gggtcaccac
     3301 agccagcctt ctcgactatg acactgtggc tggggcagac aagtttggca acatttgtgt
     3361 ggtgaggctc ccacctaaca ccaacgatga ggtggatgaa gatcccactg gaaacaaagc
     3421 cctgtgggac cggggcttgc tcaatggggc ttcacagaag gcagaggtca tcatgaacta
     3481 ccacgttgga gagaccgtgc tgtcgctaca gaagaccaca ctgatccctg gaggctcaga
     3541 gtcccttgtc tataccactt tatctggagg aattggcatc cttgtccctt tcacgtctca
     3601 cgaggaccat gacttcttcc agcatgttga aatgcacctg cggtctgagc atccccctct
     3661 ttgtggacgg gaccacctga gctttcgttc ttactatttc cctgttaaga atgtgattga
     3721 tggagacctt tgtgagcagt tcaactccat ggaacccaac aagcagaaga acgtctctga
     3781 ggagctggac cgaaccccac ctgaagtgtc caagaagctt gaggacatta ggacccgcta
     3841 tgccttctga acccgtcttt atctggggcc ttgccagaga gcccctcttt tgttcccatt
     3901 gccagtgtct ggcttttgcc acacagcaga agtgatgtgg tatttaagac tgcattgtta
     3961 aagccagtag ctctgcaccc tcaactctcc cctttgaatg actggttccc tacagttgac
     4021 actgaagtct gctccttgaa catagtgtgt ggccctgagc ttcggtgtgg aacacagttt
     4081 tccttattcc caaagccacc cctgcattgt gtaatttctg gctcttgtct acttttgtac
     4141 acattcttaa ttttcattgt tttcctgtaa atacagtttt gtacaatgtt gctttgagag
     4201 atgaagggag gcaagcaaag gtgcagccag gctgattgca gtgtggctca gttctgccct
     4261 cggaaccctc ctgaatatat aaaactagtt tttaaggtg
//
