LOCUS       NM_030109               3249 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus splicing factor 3b, subunit 2 (Sf3b2), transcript
            variant 1, mRNA.
ACCESSION   NM_030109
VERSION     NM_030109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Jeong,Y.E., Rajbhandari,L., Kim,B.W., Venkatesan,A. and Hoke,A.
  TITLE     Downregulation of SF3B2 protects CNS neurons in models of multiple
            sclerosis
  JOURNAL   Ann Clin Transl Neurol 10 (2), 246-265 (2023)
   PUBMED   36574260
  REMARK    GeneRIF: Downregulation of SF3B2 protects CNS neurons in models of
            multiple sclerosis.
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Murphy,S.A., Miyamoto,M., Kervadec,A., Kannan,S., Tampakakis,E.,
            Kambhampati,S., Lin,B.L., Paek,S., Andersen,P., Lee,D.I., Zhu,R.,
            An,S.S., Kass,D.A., Uosaki,H., Colas,A.R. and Kwon,C.
  TITLE     PGC1/PPAR drive cardiomyocyte maturation at single cell level via
            YAP1 and SF3B2
  JOURNAL   Nat Commun 12 (1), 1648 (2021)
   PUBMED   33712605
  REMARK    GeneRIF: PGC1/PPAR drive cardiomyocyte maturation at single cell
            level via YAP1 and SF3B2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
REFERENCE   5  (bases 1 to 3249)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   6  (bases 1 to 3249)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY785284.1, AK146063.1 and BI134679.1.
            
            On Nov 19, 2009 this sequence version replaced NM_030109.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049118.1, AK146063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY785284.1         1-31
            32-3219             AK146063.1         2-3189
            3220-3249           BI134679.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.29 cM"
     gene            1..3249
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /note="splicing factor 3b, subunit 2"
                     /db_xref="GeneID:319322"
                     /db_xref="MGI:MGI:2441856"
     exon            1..194
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2698
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="splicing factor 3B subunit 2 isoform 1"
                     /protein_id="NP_084385.2"
                     /db_xref="CCDS:CCDS29454.1"
                     /db_xref="GeneID:319322"
                     /db_xref="MGI:MGI:2441856"
                     /translation="MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQARLAEIGAPIQ
                     GSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPMGLPPL
                     QPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQ
                     EERAKQAAVLMEQERQQEIAKMGTAVPRPPQDMGQLGVRTPLGPRVAAPVGPVVPTPT
                     VLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEE
                     EEMETDTRSSLGQSASETEEDTVSISKKEKNRKRRNRKKKKKPQRVRAASSESSGDRE
                     KDSGRSRGSDPPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEK
                     LDKMESSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQ
                     LVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELP
                     DFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPK
                     LTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGP
                     PPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTE
                     EEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAG
                     METPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRK
                     GPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQ
                     KKRKAQPQDSRGGSKKYKEFKF"
     exon            195..241
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            242..319
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            320..559
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            560..677
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            678..787
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            788..884
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            885..976
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1192
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1330
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1411
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1639
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1789
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1879
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1987
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2095
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2238
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2340
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2440
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2626
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..3233
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /note="hexamer: AATAAA"
     polyA_site      3222
                     /gene="Sf3b2"
                     /gene_synonym="145kDa; 2610311M13Rik; 2810441F20Rik;
                     B230398H18Rik; SAP145; SF3b1; SF3b145; SF3b150"
                     /note="major polyA site"
ORIGIN      
        1 gaagtaggcc cggcggctga cccgagcttc cgtgttggtc tcgcgccttc ttgtggctaa
       61 gatggcggcg gagcatcccg aacctcccaa aggagagttg cagttgccac cgcctccacc
      121 tccaggccac tatggagcct gggctgcgca ggagcttcag gccagattgg cagagatagg
      181 agcgccgatc caggggagtc gcgaggagtt agtagagcgg ctgcagacct acacccgtca
      241 gacgggcatt gtcctgaatc gaccagtttt gagaggagaa gatggggaca aagcggctcc
      301 tcctcctatg tcagcacagc tgtctgggat tcctatgcca ccaccaccta tgggacttcc
      361 ccctctacag cctcctccac cacctccacc acctccacca ggccttggcc ttggctttcc
      421 tatggctcac ccaccaaatc tggggccccc accacctctt cgagtgggtg agcctgtggc
      481 gctgtcagaa gaagaacggc tgaagctggc acagcagcag gcagctttgc tgatgcagca
      541 agaggagcgt gccaagcagg cagctgtgtt aatggagcag gaacggcagc aggagatcgc
      601 caagatgggc actgcagtcc ctcggccgcc tcaggatatg gggcagctgg gtgtccgtac
      661 tcctctgggg cctcgcgtag ctgctccagt aggccctgtg gttcccacgc ctacggtttt
      721 gcccatgggg gcacctgttc ctcgccctcg gggtcccccc ccaccccctg gagatgagaa
      781 cagagagatg gatgatcctt ctgtgggccc caagatcccc caggctttgg aaaagattct
      841 tcagctgaag gagagccggc aggaagagat gaactctcag caggaggagg aggaaatgga
      901 gacagatact cgctcatctc tgggacagtc agcatcagag actgaggagg acacggtgtc
      961 catatccaaa aaagagaaaa accgaaagcg tcggaaccga aagaagaaga aaaagccaca
     1021 gcgggtgcgg gcagcctcat cagagagctc tggggaccga gagaaggact ccggtcggtc
     1081 ccgcggctcg gacccccctg ctgctgacgt ggagattgag tatgtgaccg aggagcctga
     1141 gatctacgag cccaatttca tcttcttcaa gaggattttt gaggctttca agctaactga
     1201 tgatgtgaag aaggaaaaag aaaaggagcc agagaagctt gacaagatgg agagctctgc
     1261 agtccccaag aagaagggct ttgaggagga gcacaaggac agtgacgatg acagcagtga
     1321 tgatgagcag gaaaagaagc cggaagcccc taaactgtcg aagaagaagt tgcgccgaat
     1381 gaatcgtttt actgtggcag aactcaagca gctggtggcc cggcctgatg ttgtggagat
     1441 gcatgacgtg acggcacagg accccaagct cttggtccac ctcaaggcca cccggaactc
     1501 cgtccctgtg ccacgccact ggtgttttaa gcgcaagtac cttcaaggca aacggggcat
     1561 tgagaagccc ccctttgagc tgccagactt catcaaacgc acaggcattc aggaaatgag
     1621 agaggccctg caggagaagg aagaacaaaa aaccatgaag tcaaaaatga gagagaaggt
     1681 tcggccgaag atggggaaga tcgacattga ctaccagaag ctacacgatg ccttcttcaa
     1741 gtggcagacc aagccgaaac tcaccatcca tggggacctt tattatgagg ggaaggagtt
     1801 tgagacacgg ctgaaggaga agaagcctgg agatttatct gatgagctaa ggatttcctt
     1861 aggaatgcca gtaggaccta atgcccacaa agtccctcct ccgtggctga ttgccatgca
     1921 gcgatacggg ccacccccat cctacccaaa cctgaaaatc cctggactga attcacctat
     1981 ccctgagagc tgctcctttg gataccatgc tggtggctgg ggcaaacccc cagtggatga
     2041 gactgggaag ccgctctatg gggacgtgtt tggaaccaat gctgctgagt ttcagaccaa
     2101 aacggaagaa gaagaaattg accggacccc gtggggggaa ctggaaccat ctgatgaaga
     2161 atcctcagaa gaggaggagg aggaggaaag cgatgaagac aagccagatg agactggctt
     2221 catcacacct gcagacagcg gcctcatcac tcccggagga ttctcatccg tgccagctgg
     2281 gatggagacc cctgaactca ttgagctgag gaagaagaag atcgaagagg cgatggatgg
     2341 aagtgagaca cctcagttat tcactgtatt gccagagaag agaacagcca ctgttggggg
     2401 agccatgatg ggatccaccc acatttatga catgtccacg gttatgagcc ggaagggccc
     2461 agcccctgaa ttgcaaggtg tggaagtagc gctggcgcct gaggaattgg agttggaccc
     2521 catggccatg acgcagaagt acgaggagca cgttcgggag cagcaggcac aagtagagaa
     2581 ggaagacttc agcgacatgg tggctgagca tgctgctaag cagaagcaaa agaaacggaa
     2641 agctcagccc caggacagcc gtgggggcag caagaaatac aaggagttca aattttaggt
     2701 cctgctcgca tagctggcct gcctttaggc tctttgtatg tctgggcttt ctctgtggct
     2761 ccctaaagct agatctggac tccctaggct cgtcacttcc tgttcttatt ttagacttgt
     2821 tttgtaaata aagctgtttc ccaaggaagg atgaatacag gcgctcttga acctctctct
     2881 cttttagctt ctgcaaaagc atctacttct tgcctgtaat cacagatggc ccataggact
     2941 atgggactgt agttctgaac tgaacttgtg ggtagttcac tatccctacc cctcctgtgt
     3001 gtgaaggctc tgctgaaggt acctttgggt ctggtctgac cttactgctt tgtccgtggg
     3061 gaataaaaat agccagctta gcaccgtggc taggctggga agtaactgta ggctagggaa
     3121 gtaggccagg tcaggccttc ctcattgacc ttgtggcaga aaggccgatt tcttacctat
     3181 tggagaacat ctgtctctaa ataaaatctc aattgttcca gagtactggc taaaaaaaaa
     3241 aaaaaaaaa
//
