LOCUS       NM_031179               6192 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus splicing factor 3b, subunit 1 (Sf3b1), mRNA.
ACCESSION   NM_031179
VERSION     NM_031179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6192)
  AUTHORS   Shi,Y., Zhang,W., Jia,Q., Zhong,X., Iyer,P., Wu,H., Yuan,Y.C.,
            Zhao,Y., Zhang,L., Wang,L., Jia,Z., Kuo,Y.H. and Sun,Z.
  TITLE     Cancer-associated SF3B1-K700E mutation controls immune responses by
            regulating Treg function via aberrant Anapc13 splicing
  JOURNAL   Sci Adv 10 (38), eado4274 (2024)
   PUBMED   39303038
REFERENCE   2  (bases 1 to 6192)
  AUTHORS   Chaudhry,S., Beckedorff,F., Jasdanwala,S.S., Totiger,T.M.,
            Affer,M., Lawal,A.E., Montoya,S., Tamiro,F., Tonini,O., Chirino,A.,
            Adams,A., Sondhi,A.K., Noudali,S., Cornista,A.M., Nicholls,M.,
            Afaghani,J., Robayo,P., Bilbao,D., Nimer,S.D., Rodriguez,J.A.,
            Bhatt,S., Wang,E. and Taylor,J.
  TITLE     Altered RNA export by SF3B1 mutants confers sensitivity to nuclear
            export inhibition
  JOURNAL   Leukemia 38 (9), 1894-1905 (2024)
   PUBMED   38997434
REFERENCE   3  (bases 1 to 6192)
  AUTHORS   Benbarche,S., Pineda,J.M.B., Galvis,L.B., Biswas,J., Liu,B.,
            Wang,E., Zhang,Q., Hogg,S.J., Lyttle,K., Dahi,A., Lewis,A.M.,
            Sarchi,M., Rahman,J., Fox,N., Ai,Y., Mehta,S., Garippa,R.,
            Ortiz-Pacheco,J., Li,Z., Monetti,M., Stanley,R.F., Doulatov,S.,
            Bradley,R.K. and Abdel-Wahab,O.
  TITLE     GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in
            hematologic malignancies
  JOURNAL   Mol Cell 84 (10), 1886-1903 (2024)
   PUBMED   38688280
  REMARK    GeneRIF: GPATCH8 modulates mutant SF3B1 mis-splicing and
            pathogenicity in hematologic malignancies.
REFERENCE   4  (bases 1 to 6192)
  AUTHORS   Boddu,P.C., Gupta,A.K., Roy,R., De La Pena Avalos,B.,
            Olazabal-Herrero,A., Neuenkirchen,N., Zimmer,J.T., Chandhok,N.S.,
            King,D., Nannya,Y., Ogawa,S., Lin,H., Simon,M.D., Dray,E.,
            Kupfer,G.M., Verma,A., Neugebauer,K.M. and Pillai,M.M.
  TITLE     Transcription elongation defects link oncogenic SF3B1 mutations to
            targetable alterations in chromatin landscape
  JOURNAL   Mol Cell 84 (8), 1475-1495 (2024)
   PUBMED   38521065
  REMARK    GeneRIF: Transcription elongation defects link oncogenic SF3B1
            mutations to targetable alterations in chromatin landscape.
REFERENCE   5  (bases 1 to 6192)
  AUTHORS   Simmler,P., Ioannidi,E.I., Mengis,T., Marquart,K.F., Asawa,S.,
            Van-Lehmann,K., Kahles,A., Thomas,T., Schwerdel,C., Aceto,N.,
            Ratsch,G., Stoffel,M. and Schwank,G.
  TITLE     Mutant SF3B1 promotes malignancy in PDAC
  JOURNAL   Elife 12, e80683 (2023)
   PUBMED   37823551
  REMARK    GeneRIF: Mutant SF3B1 promotes malignancy in PDAC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6192)
  AUTHORS   Fan,H.Y., He,X., Kingston,R.E. and Narlikar,G.J.
  TITLE     Distinct strategies to make nucleosomal DNA accessible
  JOURNAL   Mol Cell 11 (5), 1311-1322 (2003)
   PUBMED   12769854
REFERENCE   7  (bases 1 to 6192)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6192)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   9  (bases 1 to 6192)
  AUTHORS   Isono,K., Abe,K., Tomaru,Y., Okazaki,Y., Hayashizaki,Y. and
            Koseki,H.
  TITLE     Molecular cloning, genetic mapping, and expression of the mouse
            Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome
  JOURNAL   Mamm Genome 12 (3), 192-198 (2001)
   PUBMED   11252167
REFERENCE   10 (bases 1 to 6192)
  AUTHORS   Babalola,G.O. and Schultz,R.M.
  TITLE     Modulation of gene expression in the preimplantation mouse embryo
            by TGF-alpha and TGF-beta
  JOURNAL   Mol Reprod Dev 41 (2), 133-139 (1995)
   PUBMED   7654366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK331410.1, AK140982.1, CN526934.1, CF952155.1, AK048521.1,
            AK087700.1 and AK077993.1.
            
            On Jul 25, 2007 this sequence version replaced NM_031179.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037890.1, SRR1660815.221636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                CK331410.1         1-83
            84-2456             AK140982.1         2-2374
            2457-2935           CN526934.1         64-542
            2936-3378           CF952155.1         1-443
            3379-4163           AK048521.1         542-1326
            4164-4336           AK087700.1         256-428
            4337-6188           AK048521.1         1500-3351
            6189-6192           AK077993.1         2222-2225
FEATURES             Location/Qualifiers
     source          1..6192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 27.98 cM"
     gene            1..6192
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /note="splicing factor 3b, subunit 1"
                     /db_xref="GeneID:81898"
                     /db_xref="MGI:MGI:1932339"
     exon            1..140
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4027
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /note="SAP 155; spliceosome-associated protein 155;
                     pre-mRNA-splicing factor SF3b 155 kDa subunit;
                     transforming growth factor alpha regulated gene 4;
                     splicing factor 3b, subunit 1, 155 kDa"
                     /codon_start=1
                     /product="splicing factor 3B subunit 1"
                     /protein_id="NP_112456.2"
                     /db_xref="CCDS:CCDS35567.1"
                     /db_xref="GeneID:81898"
                     /db_xref="MGI:MGI:1932339"
                     /translation="MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIY
                     GGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYD
                     PFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQH
                     LTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSW
                     DQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGH
                     ATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKR
                     KSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREI
                     DERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTED
                     RTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGT
                     PPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDL
                     VRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYV
                     RNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPH
                     LRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRG
                     KGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGT
                     DGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDD
                     LKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGF
                     GTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMG
                     HLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEK
                     VQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAI
                     GPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNG
                     VLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGC
                     EDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVR
                     DVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL"
     exon            141..307
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            308..412
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..527
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..607
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            608..778
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1016
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1229
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1351
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1549
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1651
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1831
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1918
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2189
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2335
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2482
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2608
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2830
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3013
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3125
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3246
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3378
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3651
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3868
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..6192
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4312..4317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /note="hexamer: AATAAA"
     polyA_site      4338
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /note="major polyA site"
     regulatory      6171..6176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
                     /note="hexamer: AATAAA"
     polyA_site      6192
                     /gene="Sf3b1"
                     /gene_synonym="155kDa; 2810001M05Rik; Prp10; SAP155;
                     SF3b155; TA-8; Targ4"
ORIGIN      
        1 gtgcggcgcg cgctcccggg tgcgcacgct cagagagcgg cctctgtttc tggcggcggc
       61 gagcggaagt ccttgggagc gccagttccg tctgtgtgtt cgagtggaca aaatggcgaa
      121 gatcgccaag actcacgaag atatcgaagc acagattcga gaaattcaag gcaagaaggc
      181 agctcttgat gaagcccaag gagtgggcct tgattccaca ggttattatg accaagaaat
      241 ttatggtgga agtgatagca gatttgctgg atatgtgaca tcaattgctg caactgaact
      301 tgaagatgat gacgatgact actcatcatc cacgagcttg ctcggtcaga agaagcctgg
      361 atatcatgcc cccgtggcgt tgcttaatga tataccacag tcaacagagc agtatgatcc
      421 atttgctgag catcgtcctc caaagattgc cgatcgggaa gatgaataca aaaagcatag
      481 gcggaccatg ataatttccc cagagcgtct tgatcctttt gcagatggag ggaagactcc
      541 cgatcctaaa atgaatgcta gaacctacat ggatgttatg cgagaacaac atttgactaa
      601 ggaagagaga gaaattaggc aacaactagc agaaaaagct aaagctggag aactaaaagt
      661 cgtcaatgga gcagcagcat cccagcctcc ctcaaaacga aaacggcgct gggatcagac
      721 cgctgaccag actcctggtg ccactcccaa aaagctatcg agttgggatc aggcagagac
      781 ccctgggcat accccatctt taagatggga tgagacaccg ggtcgtgcaa aaggaagtga
      841 aacacctggc gcaaccccag gctcaaaaat atgggaccct acaccgagtc atacacctgc
      901 gggagctgct actcctgggc gaggcgacac accaggccat gcaaccccgg gccatggtgg
      961 tgcaacttcc agtgctcgta aaaacagatg ggatgagacc cccaaaacag aaagagatac
     1021 tcctgggcat ggaagtggat gggctgagac tcctcgaaca gatcgaggtg gagactctat
     1081 tggtgaaaca ccaactcctg gagcaagtaa aagaaagtct cgttgggatg aaacgccggc
     1141 gagtcaaatg ggtggaagca ctcctgttct gactccagga aaaacaccaa ttggcacacc
     1201 agccatgaac atggctaccc cgactccagg tcacataatg agcatgacac ctgaacagct
     1261 tcaggcgtgg cggtgggaga gagaaattga tgaacgaaac cgcccacttt ctgatgaaga
     1321 attagatgct atgttcccag aaggatataa ggtacttccc cctccagctg gttatgttcc
     1381 tattcgaact ccagctcgaa agctgacagc aactcctaca cctttgggtg gtatgactgg
     1441 tttccacatg caaactgaag acagaactat gaaaagtgtc aatgaccagc catctgggaa
     1501 tcttccattt ttaaaacctg atgacattca gtactttgat aaactattgg ttgatgtaga
     1561 tgaatcaaca cttagtccag aagaacaaaa agaaagaaaa ataatgaagt tgcttttaaa
     1621 aattaagaat ggtacacctc caatgagaaa ggctgcctta cgtcagatta ctgataaagc
     1681 tcgagaattt ggagctggac cactgtttaa ccagattctt cctctgttga tgtcccctac
     1741 acttgaggat caagagcgac atttacttgt gaaagttatt gatagaatat tgtataaact
     1801 tgatgacttg gtgcggccgt atgtgcacaa gattcttgtg gttatcgagc cactgttgat
     1861 tgatgaagat tactatgcta gagtggaagg ccgagagatt atttctaatt tggcaaaggc
     1921 tgctggtctg gctactatga tttctaccat gagacctgat atagataaca tggatgaata
     1981 tgtccgaaac acaacagcta gagcttttgc tgtcgtagcc tctgccctgg gcatcccttc
     2041 tttattgcct ttcttaaaag ctgtgtgcaa aagcaagaag tcttggcaag cgaggcacac
     2101 tggtattaag attgtacaac agatagccat tctcatgggc tgtgctatct tgccacatct
     2161 cagaagtttg gttgaaatca ttgaacatgg tctcgtggat gagcagcaga aagttcggac
     2221 catcagtgct ctggccattg ctgctttggc tgaggcagca actccttatg gtattgagtc
     2281 ttttgattct gtgctcaagc ccctatggaa gggtatccgc caacacagag gaaagggtct
     2341 ggctgctttc ttgaaggcta ttgggtatct tattcctctt atggatgcag aatatgccaa
     2401 ctactatact agagaagtga tgttaatcct cattcgagaa tttcagtctc ctgatgaaga
     2461 aatgaagaaa attgttttga aggtggtgaa acagtgttgt ggaactgatg gtgtagaagc
     2521 aaactacatt aaaacagaga ttcttccacc tttctttaaa cacttttggc aacacagaat
     2581 ggctttggat agaagaaatt accgacagtt agttgataca actgtggagt tggcaaacaa
     2641 agtaggtgca gcagagatca tatctaggat tgttgatgat ctgaaggatg aagctgagca
     2701 gtacaggaaa atggtgatgg aaacaattga gaaaattatg ggtaatctag gcgcagcaga
     2761 tattgaccat aaacttgagg aacaactgat tgatggtatt ctctatgctt tccaagaaca
     2821 gactacagag gattcagtaa tgttgaatgg ctttggcaca gtagttaatg ctcttggcaa
     2881 acgagtcaaa ccatacttgc ctcagatctg tggtacagtt ttatggcgtt taaataacaa
     2941 atcagcaaaa gttaggcaac aagcagctga cttgatttct cgaactgctg ttgttatgaa
     3001 gacttgtcaa gaggaaaaac tgatggggca cttgggtgtg gtgctgtatg aatatttggg
     3061 tgaagagtac cctgaagtat tgggcagcat tcttggagca ctgaaggcta ttgtaaacgt
     3121 aataggtatg cataagatga caccaccaat taaagatctc ctgcctagac tcacccccat
     3181 tttaaagaac agacatgaaa aagtacaaga gaattgtatt gatcttgttg gacgcattgc
     3241 tgacagggga gctgaatatg tatctgcaag agaatggatg aggatttgct ttgagctttt
     3301 agagctctta aaagctcaca aaaaagctat tcgaagagct accgtcaata catttggtta
     3361 tatcgcaaag gctattggcc ctcatgatgt attggctaca cttttaaaca acctcaaagt
     3421 tcaggaaagg cagaacaggg tttgtacgac tgtagccata gccattgttg ctgaaacatg
     3481 ctcccccttc acagtactgc ctgccttaat gaatgaatac agagttcctg aacttaatgt
     3541 gcaaaatgga gtgttaaaat cactctcctt cttgtttgag tatatcggcg aaatggggaa
     3601 agactacatc tatgctgtga cgcctttact tgaggatgcg ttaatggaca gggaccttgt
     3661 tcacagacag acagcgagtg cagtggtgca gcacatgtca cttggtgttt acggatttgg
     3721 ctgtgaggat tctctgaatc acttactgaa ctatgtgtgg cctaatgtgt ttgagacatc
     3781 tccccatgta atccaggcag ttatgggagc tctggagggc ctgagggttg ctattggacc
     3841 atgcagaatg ttgcagtatt gcttacaggg tctgttccac ccagctcgga aagtcagaga
     3901 cgtatattgg aaaatttaca actccatcta cattggctcc caggatgctc tcatagcaca
     3961 ttacccacga atctacaatg acgataagaa cacctatatt cgttacgaac ttgactatat
     4021 cttgtaactt tgtgtctaat acagctgttt cacaccttaa acctgcttca atctgatgat
     4081 ataaacttgt aaaacattgc cgatcagtgt agagctggtc atagtggagg gatagaaatc
     4141 cagtagcatg atttttaaat aacttttgtt tttttgatgt taaacagtaa atggcagtag
     4201 tgaccaagga cagtgcttat acacactata ctggagggat atcatttttt attcatcttt
     4261 atgaagattt agaattcatt ccttgtgttt aaagggaatg tttaattgag aaataaacat
     4321 tcgtgtacaa aatgctaatt tgtgtgtgtt ttttgaatat gacttgtaaa atgcaaaact
     4381 ttggtaaagt actggtttgt gtagaataag tggattaatt tcatcttttg tcacctagtt
     4441 tattatggaa cacagcagca cgcaaactat atagtgatgg cctgtttgtc aaaagcccat
     4501 tgttttgttg gtaatgaaga gtagcttggg gtgcccctcc cctcagtgta gcataacagt
     4561 tccagcacca tagaaaagta gcactctgac tgagctgtct taagtattat tttgtactta
     4621 catagcacct ttcaccttga tttctcaaaa tgctttatga gcagacatga aggatatatt
     4681 ttacttcttg tccaactttg gcctgtgctt ataaagtgga gaagctgtct gtaacttaga
     4741 atagtgtatt tcctgttggg agtgaggcta tctaagaaat aattatatag taggacagtc
     4801 tttgggcttt tgtgtgatgc ctctaatcag tttatttata agcagctatt gaacacctgt
     4861 tgaatgctag ccactgtctg ttgaagaagg ggcttcgaag gtgcacatga tccggccttt
     4921 catgtaacgg aagggtgggc gcagatcctt aggtaccagg gtgctgtgca atggaagatg
     4981 cagagatgcc tagatttgct tagcttgtat gtagcagtca gatactgtat tggcttaagt
     5041 gtgagcataa gccaaaatgc cgttcagttt atgaagaaca agcattaagg ggctatttta
     5101 atgttttggg tcaactaatg aatcagcttt tttttgttgt tgtttattgt tttttaattt
     5161 tatgccccaa atttcttgtt tttaaaactt ttctagccat cactgttttg tctccctctg
     5221 tacttgtgtg gactctaaaa ggaaataaat tctgccatca gtgtgactgg catgtgactc
     5281 taccaccctc agactgtcag gagtgctagg cagcttgtgc ttctgactgt taacaaggaa
     5341 gactctggtg gaagatcaga ttagattaga gacagcttct gctctgcttt ctcagaatgg
     5401 atactgagca ttaaccgtcc ccatgcagga cgcacggatt cttgttcttt gtatgtggtc
     5461 tgactatcat tgtgtagtaa accatttccc tgttcttaga aaattcctag ccatacctaa
     5521 gcacttttaa atgttttgta tagttgattt caaataaccc ttggtaatta caatcttgaa
     5581 ttgagtatat ttctcaaagt taaaatttga ctttaaacca cttgggaaca ttttattgta
     5641 ttattaatta aaatacttaa gtttgtttaa cttcttgctt tttatttaaa aattaaattt
     5701 tgcagtagaa ctacagctca caggagactg cttacccctt aagtgacatt ttcctgatgg
     5761 aggtaatctg agaatggata aggggaaaaa atgctgaagg ctgcaatctc aagattagga
     5821 ccaaaataga tactcaaaga tgtttggatt gtgaaatgct cttattgaat aaggaaagca
     5881 ttttgggata aacccttgtg aaagatgcta tgtcacgttt taacacttct caactaagac
     5941 cttttcttta gcactttgat gtttcttaag gtgaaactta ggcaggagga attcatgttc
     6001 ttaaggggac agaggggtgg gtttttctct gggctttggt tttttttttc tctgggcatt
     6061 gccctctgat ggaattgata tttctttggc tgtttgattt tatttttttt tatattgtat
     6121 ttttaatatt tgttgtatgg tgccctgtga gcatcaagta ccaccagata aataaaactt
     6181 atcacatcta aa
//
