LOCUS       NP_083433                501 aa            linear   ROD 14-JUN-2024
DEFINITION  splicing factor 3A subunit 3 [Mus musculus].
ACCESSION   NP_083433 XP_620099 XP_901227 XP_916384 XP_927057 XP_979451
            XP_988666 XP_997661 XP_997684 XP_997700
VERSION     NP_083433.1
DBSOURCE    REFSEQ: accession NM_029157.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Jin,L., Chen,Y., Crossman,D.K., Datta,A., Vu,T., Mobley,J.A.,
            Basu,M.K., Scarduzio,M., Wang,H., Chang,C. and Datta,P.K.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Cao,H., Wu,J., Lam,S., Duan,R., Newnham,C., Molday,R.S.,
            Graziotto,J.J., Pierce,E.A. and Hu,J.
  TITLE     Temporal and tissue specific regulation of RP-associated splicing
            factor genes PRPF3, PRPF31 and PRPC8--implications in the
            pathogenesis of RP
  JOURNAL   PLoS One 6 (1), e15860 (2011)
   PUBMED   21283520
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 501)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606907.10.
            
            On or before Jan 29, 2007 this sequence version replaced
            XP_916384.1, XP_988666.1, XP_927057.1, XP_620099.1, XP_979451.1,
            XP_901227.1, XP_997700.1, XP_997684.1, XP_997661.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.21250.1, AK030743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.88 cM"
     Protein         1..501
                     /product="splicing factor 3A subunit 3"
                     /note="SAP 61; SF3a60; spliceosome-associated protein 61"
                     /calculated_mol_wt=58711
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Region          2..501
                     /region_name="PRP9"
                     /note="Splicing factor 3a, subunit 3 [RNA processing and
                     modification]; COG5188"
                     /db_xref="CDD:227515"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Region          175..179
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q12874"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            299
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Region          342..374
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Site            369
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     Region          382..501
                     /region_name="SF3a60_Prp9_C"
                     /note="SF3a60/Prp9 C-terminal; pfam11931"
                     /db_xref="CDD:432197"
     Site            475
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12874; propagated from
                     UniProtKB/Swiss-Prot (Q9D554.2)"
     CDS             1..501
                     /gene="Sf3a3"
                     /gene_synonym="4930512K19Rik; 60kDa"
                     /coded_by="NM_029157.4:80..1585"
                     /db_xref="CCDS:CCDS38875.1"
                     /db_xref="GeneID:75062"
                     /db_xref="MGI:MGI:1922312"
ORIGIN      
        1 metileqqrr yheekerlmd vmakemltkk stlrdqinsd hrtramqdry mevsgnlrdl
       61 yddkdglrke elnaisgpne faefynrlkq ikefhrkhpn eicvpmsvef eellkarenp
      121 seeaqnlvef tdeegygryl dlhdcylkyi nlkasekldy itylsifdql fdipkerkna
      181 eykrylemll eylqdytdrv kplqdqnelf gkiqtdfekk wdngtfpgwp ketssaltha
      241 gahldlsafs sweelaslgl drlksallal glkcggtlee raqrlfstkg kslesldtsl
      301 faknpkskgt krdternkdi afleaqiyey veilgeqrql thenvqrkqa rtgeereeee
      361 eeqisesese deeneiiynp knlplgwdgk pipywlyklh glninyncei cgnytyrgpk
      421 afqrhfaewr hahgmrclgi pntahfanvt qiedavslwa klklqkaser wqpdteeeye
      481 dssgnvvnkk tyedlkrqgl l
//
