LOCUS       NM_021286               4219 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus seizure related gene 6 (Sez6), transcript variant 1,
            mRNA.
ACCESSION   NM_021286
VERSION     NM_021286.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4219)
  AUTHORS   Hidaka C, Mitsui S, Osako Y, Takahashi K, Tanaka K and Yuri K.
  TITLE     Differential brain expression pattern of Sez6 alternative splicing
            isoform with deleted transmembrane domain
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 2), 128-132 (2022)
   PUBMED   36368155
  REMARK    GeneRIF: Differential brain expression pattern of Sez6 alternative
            splicing isoform with deleted transmembrane domain.
REFERENCE   2  (bases 1 to 4219)
  AUTHORS   Nash A, Gijsen HJM, Hrupka BJ, Teng KS, Lichtenthaler SF, Takeshima
            H, Gunnersen JM and Munro KM.
  TITLE     BACE inhibitor treatment of mice induces hyperactivity in a
            Seizure-related gene 6 family dependent manner without altering
            learning and memory
  JOURNAL   Sci Rep 11 (1), 15084 (2021)
   PUBMED   34302009
  REMARK    GeneRIF: BACE inhibitor treatment of mice induces hyperactivity in
            a Seizure-related gene 6 family dependent manner without altering
            learning and memory.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4219)
  AUTHORS   Pigoni M, Hsia HE, Hartmann J, Rudan Njavro J, Shmueli MD, Muller
            SA, Guner G, Tushaus J, Kuhn PH, Kumar R, Gao P, Tran ML, Ramazanov
            B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen
            JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T and Lichtenthaler
            SF.
  TITLE     Seizure protein 6 controls glycosylation and trafficking of kainate
            receptor subunits GluK2 and GluK3
  JOURNAL   EMBO J 39 (15), e103457 (2020)
   PUBMED   32567721
  REMARK    GeneRIF: Seizure protein 6 controls glycosylation and trafficking
            of kainate receptor subunits GluK2 and GluK3.
REFERENCE   4  (bases 1 to 4219)
  AUTHORS   Nash A, Aumann TD, Pigoni M, Lichtenthaler SF, Takeshima H, Munro
            KM and Gunnersen JM.
  TITLE     Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term
            Memory, and Cognitive Flexibility and Alters Dendritic Spine
            Properties
  JOURNAL   Cereb Cortex 30 (4), 2167-2184 (2020)
   PUBMED   31711114
  REMARK    GeneRIF: Lack of Sez6 Family Proteins Impairs Motor Functions,
            Short-Term Memory, and Cognitive Flexibility and Alters Dendritic
            Spine Properties.
REFERENCE   5  (bases 1 to 4219)
  AUTHORS   Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M,
            Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM,
            Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF
            and Hecimovic S.
  TITLE     BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C
            disease mouse brains
  JOURNAL   PLoS One 13 (7), e0200344 (2018)
   PUBMED   29979789
  REMARK    GeneRIF: Results show that NPC1 loss-of-function in a mouse model
            of Niemann-Pick type C disease leads to enhanced cleavage of BACE1
            substrates Sez6 and Sez6L, in addition to APP, and that this effect
            most likely involves altered trafficking of BACE1 and of its
            substrates within the endolysosomal system. Efficacy of Sez6
            cleavage by BACE1 may be spatiotemporally differently regulated in
            contrast to the cleavage of Sez6L.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4219)
  AUTHORS   Herbst R and Nicklin MJ.
  TITLE     SEZ-6: promoter selectivity, genomic structure and localized
            expression in the brain
  JOURNAL   Brain Res Mol Brain Res 44 (2), 309-322 (1997)
   PUBMED   9073173
REFERENCE   7  (bases 1 to 4219)
  AUTHORS   Kajiwara K, Nagawawa H, Shimizu-Nishikawa S, Ookuri T, Kimura M and
            Sugaya E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   8  (bases 1 to 4219)
  AUTHORS   Shimizu-Nishikawa K, Kajiwara K and Sugaya E.
  TITLE     Cloning and characterization of seizure-related gene, SEZ-6
  JOURNAL   Biochem Biophys Res Commun 216 (1), 382-389 (1995)
   PUBMED   7488116
REFERENCE   9  (bases 1 to 4219)
  AUTHORS   Nehls M, Luno K, Schorpp M, Pfeifer D, Krause S, Matysiak-Scholze
            U, Dierbach H and Boehm T.
  TITLE     YAC/P1 contigs defining the location of 56 microsatellite markers
            and several genes across a 3.4-cM interval on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (5), 321-331 (1995)
   PUBMED   7626882
REFERENCE   10 (bases 1 to 4219)
  AUTHORS   Shimizu-Nishikawa K, Kajiwara K, Kimura M, Katsuki M and Sugaya E.
  TITLE     Cloning and expression of SEZ-6, a brain-specific and
            seizure-related cDNA
  JOURNAL   Brain Res Mol Brain Res 28 (2), 201-210 (1995)
   PUBMED   7723619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055345.1, BC053011.1, BU612140.1 and AW122777.1.
            
            [WARNING] On Nov 15, 2023 this sequence was replaced by
            NM_021286.5.
            
            On Mar 29, 2014 this sequence version replaced NM_021286.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053011.1, AB206791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               BC055345.1         1-246
            247-3597            BC053011.1         143-3493
            3598-4200           BU612140.1         51-653              c
            4201-4219           AW122777.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..4219
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /note="seizure related gene 6"
                     /db_xref="GeneID:20370"
                     /db_xref="MGI:MGI:104745"
     exon            1..276
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3197
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; seizure protein 6; brain-specific receptor-like
                     protein C"
                     /codon_start=1
                     /product="seizure protein 6 isoform 1 precursor"
                     /protein_id="NP_067261.2"
                     /db_xref="CCDS:CCDS25087.1"
                     /db_xref="GeneID:20370"
                     /db_xref="MGI:MGI:104745"
                     /translation="MRPAALLLLPSLLALLAHGLSSEAPITGEGHATGIRETDGELTA
                     APTPEQSDRGVHFVTTAPTLKLLNHHPLLEEFLQEGLEREEAPQPALPFQPDSPTHFT
                     PSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPGPSM
                     AVPTLLPEDRPSTTPPSQAWTPTQEGPGDMDRPWVPEVMSKTTGLGVEGTIATSTASG
                     DDEETTTTIITTTVTTVQPPGPCSWNFSGPEGSLDSPTAPSSPSDVGLDCFYYISVYP
                     GYGVEIKVENISLQEGETITVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSL
                     PLPAGPGTFHFRYQAYLLSCHFPRRPAYGDVTVTSLHPGGSAHFHCATGYQLKGARFL
                     TCLNATQPFWDSQEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQ
                     RLHLHFEKVSLAEDDDRLIIRNGNNVEAPPVYDSYEVEYLPIEGLLSSGRHFFVEFST
                     DSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLEQGS
                     IIIECVDLHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEE
                     DKRIMLDIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMADVTIQFQSD
                     PGTSALGYQQGFVIHFFEVPRNDTCPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQ
                     VVGSSILMCQWDLSWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYVCDQ
                     GFVLTGSAILTCHDRQAGSPKWSDRAPKCLLEQFKPCHGLSAPENGARSPEKRLHPAG
                     ATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNGRSLDVAKAPAA
                     SSALDAAHLAAAIFLPLVAMVLLVGGVYLYFSRFQGKSPLQLPRTHPRPYNRITVESA
                     FDNPTYETGSLSFAGDERI"
     exon            277..936
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1070
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1266
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1452
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1621
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1788
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1983
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2122
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2319
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2514
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2706
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2904
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2943
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3061
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3164
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..4204
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagccgct cctcctgcgc ccccgccccc agccccgcgc ggcgatcccg ggcgccgacg
       61 ccaggcgctg gccgtggtgc tgattctgtc aggcgctggc ggcggcggcg gcggccccgc
      121 tgctctcccc gggaccggct ctgccccccg cgcccacgcc tctcccagtc cccagttccc
      181 ctaccgcggc cccgacccgg ggcgcggccg caagcagcac catgcgccca gcagccctgc
      241 tgctcctgcc ctcgctgctg gcgctcctgg ctcacggact ctcctcagag gctccgatca
      301 cgggggaagg tcatgccacg ggcatcaggg agacggatgg ggagctgacc gcagccccta
      361 cacctgagca gtcagaccga ggcgtccact tcgtcaccac agcccctacc ctcaagctgc
      421 tcaaccacca cccacttctg gaagaatttc ttcaagaggg gctagaaaga gaggaagcgc
      481 cgcagcctgc actgcccttc cagccggact cacctacaca ctttactcca agccccctcc
      541 cccgcctcac caaccaggac aaccgccccg tctttaccag tccgactcca gccgtggctg
      601 cagcacccac ccagccccac tccagggaga aaccttggaa cctagaatcc aaaccccctg
      661 agctttctat cacatcgtcc cttcctccag ggccgagtat ggcagtgccc acactgctcc
      721 cagaggacag acccagtact acacccccta gccaagcatg gactccaact caggagggtc
      781 ctggagacat ggacagacct tgggttccag aggtcatgtc taagaccaca gggcttggtg
      841 tcgagggaac cattgccacc tccacagctt caggggatga cgaagagacc actaccacca
      901 tcattaccac tactgtcacc acagttcagc caccaggccc ctgtagctgg aatttctcag
      961 gcccagaggg ctctctggat tcccccacgg cccccagctc accctctgat gttggcctgg
     1021 actgtttcta ctatatctct gtctaccctg gatatggagt agagatcaag gtggagaaca
     1081 tcagccttca ggaaggggag accatcaccg tggagggcct ggggggcccc gatccactgc
     1141 ccttggctaa ccagtcgttc ctgctgaggg gccaggtcat ccgcagcccc acccaccaag
     1201 cagccctgag gttccagagc ctcccgctac ccgctgggcc tggcactttc catttccgct
     1261 accaagccta tctcctgagc tgccactttc cccgacgtcc agcgtatgga gatgtgactg
     1321 tcaccagtct ccacccagga ggcagcgccc acttccattg tgccactggc taccagctca
     1381 agggtgccag gttcctcacc tgtctcaatg ccacccagcc cttttgggat tcccaagagc
     1441 ctgtttgcat tgctgcttgt ggtggagtga ttcggaatgc caccactggc cgcattgtct
     1501 ctcctggctt cccggggaac tacagcaaca acctcacctg ccactggttg ctagaggctc
     1561 cagagagcca gcggctgcac ctgcactttg aaaaggtctc cctggcagaa gacgacgaca
     1621 ggctcatcat ccgcaatgga aataacgtgg aggccccgcc ggtgtacgac tcctatgagg
     1681 tggaatacct gcccattgag ggcctgctca gctctggcag acacttcttc gtggagttca
     1741 gtactgacag cagtggggca gctgcaggca tggccctgcg ctatgaggcc ttccagcaag
     1801 gacattgcta tgagcccttt gtcaaatacg gcaacttcag cagcagtgca ccgtcctacc
     1861 ctgtgggtac aactgtggag ttcagctgtg accctggcta caccctggag cagggctcca
     1921 tcatcatcga atgcgtcgac ctccacgacc cccagtggaa tgagacagag ccagcctgcc
     1981 gagccgtgtg cagcggggag atcacagact ctgcaggcgt ggtgctctct ccaaactggc
     2041 cggagcctta tggccgaggg caggactgca tctggggtgt gcatgtggag gaggacaagc
     2101 gcatcatgct ggacatccga gtgctgcgca taggctctgg ggatgtactg accttctacg
     2161 atggggatga cctcacagcc cgggtcctgg gccaatactc agggccccgt ggccacttca
     2221 agctctttac ctccatggcc gatgtcacca tccagttcca gtcagaccct gggacctcgg
     2281 cgctgggtta ccagcaagga tttgtcatcc acttctttga ggttccccgc aacgacacat
     2341 gtccagagct acccgagatc cccaacggct ggaagaaccc atcacagcct gagctggtgc
     2401 acggcacggt ggtcacctat cagtgctacc ctggttacca ggtggtggga tccagtattc
     2461 tcatgtgcca gtgggaccta agctggagtg aggacctgcc ttcatgccag agagtgacat
     2521 cttgccatga cccaggggat gtggagcaca gccgacgcct catatccagc cccaagtttc
     2581 ccgtgggagc aactgtgcaa tatgtctgtg accagggttt tgtgctgacg gggagtgcca
     2641 ttctcacctg ccatgatcgg caagcaggca gtcccaagtg gagtgacagg gcccccaagt
     2701 gtctcttgga acaattcaag ccgtgccatg gcctcagcgc cccggagaat ggtgcccgca
     2761 gccctgagaa gcggcttcac ccagcagggg ccaccatcca cttctcctgt gcccctggtt
     2821 atgtgctgaa gggccaggcc agcatcaaat gcgtgcctgg acacccctcg cattggagtg
     2881 acccaccacc catctgtagg gctgcctctc tggatgggtt ctacaacggc cgtagcctgg
     2941 atgttgccaa ggcacctgcc gcctccagtg ccctggacgc tgctcacctg gctgctgcca
     3001 tcttcctacc attggtggcc atggtgttgc tggtgggagg agtgtacctc tatttttcca
     3061 gattccaggg gaaaagtccc ctgcaacttc cccgaactca tcctcgcccc tataaccgca
     3121 tcacggtaga gtcagcattt gacaatccaa cttatgagac tggatctctt tcctttgcag
     3181 gagacgagag aatatgaagt ttccatctag gtgggagcag cctggggatg cacacgcagt
     3241 cctgcatcgc aggccagcgg cagggctccc ggctctctgc tgtccctcac ctcctgtaca
     3301 tactgcctgg gaagagacac caccaacccc ttccccgcct gcaatgccca cagtgaccta
     3361 ttttcttggc accgctgtgc ccacttcggg cccttctttg gattcagggg catctgcctc
     3421 gggtagaacg tagctgggac acattaccag cagccatcat tctcctgctt ctcttttgcc
     3481 ctggacctcc agcctggaag ttgcaggctg actgaggagg ggcacttgtt acacatggcc
     3541 accatcctgc ctggcatgtg aggactccag gagagctgac ttgacagcag ggtgcccctc
     3601 acagggccag ctaccagagg ccaaaattgt tctcaactgt gacctcttgg tagtcctggc
     3661 gtgccaacac cagcccctca gggaggtttc tagtccctct ctaaaggctc agaattggac
     3721 agttaagcct tctgccctgt cctgggaggt gatgatttaa gaatcctaaa aggttcaggg
     3781 actctattcc aagctcaggc tgggccccac tggatggata ctcacgctcc acaccaaagc
     3841 aggacaccct acggctctcc ggcatccctc tactctgagg agggagagcc cttccttgaa
     3901 gtttatctgg ctgttacaaa tgtctccttc cccaccagtc cctcctctga gccacttacc
     3961 atgttccccc ttcctgccac tgtgttatgg catgccagga gagggcagct acattctgga
     4021 gaggagcaga tgtccaagga cccaggaatg tggcagaagt caagaacccc caggagcaat
     4081 ctcagtccgg accgaggcca ctttgtacat atgatgtatt atatggggtc tgggctccag
     4141 ccagagaaca atcttttatt tctgttgttt ccttattaaa atggtgtttt ggaaaaaaaa
     4201 tcaaaaaaaa aaaaaaaaa
//
