LOCUS       NP_067261                991 aa            linear   ROD 01-MAY-2025
DEFINITION  seizure protein 6 isoform 1 precursor [Mus musculus].
ACCESSION   NP_067261
VERSION     NP_067261.2
DBSOURCE    REFSEQ: accession NM_021286.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 991)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 991)
  AUTHORS   Hidaka,C., Mitsui,S., Osako,Y., Takahashi,K., Tanaka,K. and Yuri,K.
  TITLE     Differential brain expression pattern of Sez6 alternative splicing
            isoform with deleted transmembrane domain
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 2), 128-132 (2022)
   PUBMED   36368155
  REMARK    GeneRIF: Differential brain expression pattern of Sez6 alternative
            splicing isoform with deleted transmembrane domain.
REFERENCE   3  (residues 1 to 991)
  AUTHORS   Nash,A., Gijsen,H.J.M., Hrupka,B.J., Teng,K.S., Lichtenthaler,S.F.,
            Takeshima,H., Gunnersen,J.M. and Munro,K.M.
  TITLE     BACE inhibitor treatment of mice induces hyperactivity in a
            Seizure-related gene 6 family dependent manner without altering
            learning and memory
  JOURNAL   Sci Rep 11 (1), 15084 (2021)
   PUBMED   34302009
  REMARK    GeneRIF: BACE inhibitor treatment of mice induces hyperactivity in
            a Seizure-related gene 6 family dependent manner without altering
            learning and memory.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 991)
  AUTHORS   Pigoni,M., Hsia,H.E., Hartmann,J., Rudan Njavro,J., Shmueli,M.D.,
            Muller,S.A., Guner,G., Tushaus,J., Kuhn,P.H., Kumar,R., Gao,P.,
            Tran,M.L., Ramazanov,B., Blank,B., Hipgrave Ederveen,A.L., Von
            Blume,J., Mulle,C., Gunnersen,J.M., Wuhrer,M., Rammes,G.,
            Busche,M.A., Koeglsperger,T. and Lichtenthaler,S.F.
  TITLE     Seizure protein 6 controls glycosylation and trafficking of kainate
            receptor subunits GluK2 and GluK3
  JOURNAL   EMBO J 39 (15), e103457 (2020)
   PUBMED   32567721
  REMARK    GeneRIF: Seizure protein 6 controls glycosylation and trafficking
            of kainate receptor subunits GluK2 and GluK3.
REFERENCE   5  (residues 1 to 991)
  AUTHORS   Nash,A., Aumann,T.D., Pigoni,M., Lichtenthaler,S.F., Takeshima,H.,
            Munro,K.M. and Gunnersen,J.M.
  TITLE     Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term
            Memory, and Cognitive Flexibility and Alters Dendritic Spine
            Properties
  JOURNAL   Cereb Cortex 30 (4), 2167-2184 (2020)
   PUBMED   31711114
  REMARK    GeneRIF: Lack of Sez6 Family Proteins Impairs Motor Functions,
            Short-Term Memory, and Cognitive Flexibility and Alters Dendritic
            Spine Properties.
REFERENCE   6  (residues 1 to 991)
  AUTHORS   Herbst,R. and Nicklin,M.J.
  TITLE     SEZ-6: promoter selectivity, genomic structure and localized
            expression in the brain
  JOURNAL   Brain Res Mol Brain Res 44 (2), 309-322 (1997)
   PUBMED   9073173
REFERENCE   7  (residues 1 to 991)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   8  (residues 1 to 991)
  AUTHORS   Shimizu-Nishikawa,K., Kajiwara,K. and Sugaya,E.
  TITLE     Cloning and characterization of seizure-related gene, SEZ-6
  JOURNAL   Biochem Biophys Res Commun 216 (1), 382-389 (1995)
   PUBMED   7488116
REFERENCE   9  (residues 1 to 991)
  AUTHORS   Nehls,M., Luno,K., Schorpp,M., Pfeifer,D., Krause,S.,
            Matysiak-Scholze,U., Dierbach,H. and Boehm,T.
  TITLE     YAC/P1 contigs defining the location of 56 microsatellite markers
            and several genes across a 3.4-cM interval on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (5), 321-331 (1995)
   PUBMED   7626882
REFERENCE   10 (residues 1 to 991)
  AUTHORS   Shimizu-Nishikawa,K., Kajiwara,K., Kimura,M., Katsuki,M. and
            Sugaya,E.
  TITLE     Cloning and expression of SEZ-6, a brain-specific and
            seizure-related cDNA
  JOURNAL   Brain Res Mol Brain Res 28 (2), 201-210 (1995)
   PUBMED   7723619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591065.17 and AL845484.9.
            
            On Jun 19, 2003 this sequence version replaced NP_067261.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053011.1, AB206791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     Protein         1..991
                     /product="seizure protein 6 isoform 1 precursor"
                     /note="seizure protein 6; brain-specific receptor-like
                     protein C"
                     /calculated_mol_wt=105481
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1971
     mat_peptide     20..991
                     /product="Seizure protein 6. /id=PRO_0000341348"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSK2.1)"
                     /calculated_mol_wt=105481
     Region          <78..182
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          79..193
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSK2.1)"
     Region          241..349
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(249,251,253,281,286,319,344,346,348..349)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            286
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSK2.1)"
     Region          354..410
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(364,381)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Site            396
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSK2.1)"
     Region          413..523
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(422,424,426,453,458,493,518,520,522..523)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            433
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSK2.1)"
     Region          529..586
                     /region_name="Sushi"
                     /note="Sushi repeat (SCR repeat); pfam00084"
                     /db_xref="CDD:459664"
     Site            538
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSK2.1)"
     Region          590..699
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(600,602,629,634,667,695,697,699)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          <707..892
                     /region_name="PHA02927"
                     /note="secreted complement-binding protein; Provisional"
                     /db_xref="CDD:222943"
     Region          707..763
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(717,736)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Site            923..943
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSK2.1)"
     CDS             1..991
                     /gene="Sez6"
                     /gene_synonym="BSRP-C; D11Bhm177e; sez-6"
                     /coded_by="NM_021286.5:144..3119"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS25087.1"
                     /db_xref="GeneID:20370"
                     /db_xref="MGI:MGI:104745"
ORIGIN      
        1 mrpaallllp sllallahgl sseapitgeg hatgiretdg eltaaptpeq sdrgvhfvtt
       61 aptlkllnhh plleeflqeg lereeapqpa lpfqpdspth ftpsplprlt nqdnrpvfts
      121 ptpavaaapt qphsrekpwn leskppelsi tsslppgpsm avptllpedr psttppsqaw
      181 tptqegpgdm drpwvpevms kttglgvegt iatstasgdd eettttiitt tvttvqppgp
      241 cswnfsgpeg sldsptapss psdvgldcfy yisvypgygv eikvenislq egetitvegl
      301 ggpdplplan qsfllrgqvi rspthqaalr fqslplpagp gtfhfryqay llschfprrp
      361 aygdvtvtsl hpggsahfhc atgyqlkgar fltclnatqp fwdsqepvci aacggvirna
      421 ttgrivspgf pgnysnnltc hwlleapesq rlhlhfekvs laedddrlii rngnnveapp
      481 vydsyeveyl piegllssgr hffvefstds sgaaagmalr yeafqqghcy epfvkygnfs
      541 ssapsypvgt tvefscdpgy tleqgsiiie cvdlhdpqwn etepacravc sgeitdsagv
      601 vlspnwpepy grgqdciwgv hveedkriml dirvlrigsg dvltfydgdd ltarvlgqys
      661 gprghfklft smadvtiqfq sdpgtsalgy qqgfvihffe vprndtcpel peipngwknp
      721 sqpelvhgtv vtyqcypgyq vvgssilmcq wdlswsedlp scqrvtschd pgdvehsrrl
      781 isspkfpvga tvqyvcdqgf vltgsailtc hdrqagspkw sdrapkclle qfkpchglsa
      841 pengarspek rlhpagatih fscapgyvlk gqasikcvpg hpshwsdppp icraasldgf
      901 yngrsldvak apaassalda ahlaaaiflp lvamvllvgg vylyfsrfqg ksplqlprth
      961 prpynritve safdnptyet gslsfagder i
//
