LOCUS       NM_198033              10970 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus senataxin (Setx), mRNA.
ACCESSION   NM_198033
VERSION     NM_198033.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10970)
  AUTHORS   Fujiwara,Y., Saito,K., Sun,F., Petri,S., Inoue,E., Schimenti,J.,
            Okada,Y. and Handel,M.A.
  TITLE     New allele of mouse DNA/RNA helicase senataxin causes meiotic
            arrest and infertility
  JOURNAL   Reproduction 166 (6), 437-450 (2023)
   PUBMED   37801077
  REMARK    GeneRIF: New allele of mouse DNA/RNA helicase senataxin causes
            meiotic arrest and infertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10970)
  AUTHORS   Zhao,H., Hartono,S.R., de Vera,K.M.F., Yu,Z., Satchi,K., Zhao,T.,
            Sciammas,R., Sanz,L., Chedin,F. and Barlow,J.
  TITLE     Senataxin and RNase H2 act redundantly to suppress genome
            instability during class switch recombination
  JOURNAL   Elife 11, e78917 (2022)
   PUBMED   36542058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10970)
  AUTHORS   Campisi,L., Chizari,S., Ho,J.S.Y., Gromova,A., Arnold,F.J.,
            Mosca,L., Mei,X., Fstkchyan,Y., Torre,D., Beharry,C.,
            Garcia-Forn,M., Jimenez-Alcazar,M., Korobeynikov,V.A., Prazich,J.,
            Fayad,Z.A., Seldin,M.M., De Rubeis,S., Bennett,C.L., Ostrow,L.W.,
            Lunetta,C., Squatrito,M., Byun,M., Shneider,N.A., Jiang,N., La
            Spada,A.R. and Marazzi,I.
  TITLE     Clonally expanded CD8 T cells characterize amyotrophic lateral
            sclerosis-4
  JOURNAL   Nature 606 (7916), 945-952 (2022)
   PUBMED   35732742
  REMARK    Erratum:[Nature. 2022 Aug;608(7924):E34. doi:
            10.1038/s41586-022-05184-0. PMID: 35945277]
REFERENCE   5  (bases 1 to 10970)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10970)
  AUTHORS   Becherel,O.J., Yeo,A.J., Stellati,A., Heng,E.Y., Luff,J.,
            Suraweera,A.M., Woods,R., Fleming,J., Carrie,D., McKinney,K.,
            Xu,X., Deng,C. and Lavin,M.F.
  TITLE     Senataxin plays an essential role with DNA damage response proteins
            in meiotic recombination and gene silencing
  JOURNAL   PLoS Genet 9 (4), e1003435 (2013)
   PUBMED   23593030
  REMARK    GeneRIF: These data support key roles for senataxin in coordinating
            meiotic crossing-over with transcription and in gene silencing to
            protect the integrity of the genome.
REFERENCE   7  (bases 1 to 10970)
  AUTHORS   Padmanabhan,K., Robles,M.S., Westerling,T. and Weitz,C.J.
  TITLE     Feedback regulation of transcriptional termination by the mammalian
            circadian clock PERIOD complex
  JOURNAL   Science 337 (6094), 599-602 (2012)
   PUBMED   22767893
REFERENCE   8  (bases 1 to 10970)
  AUTHORS   Moreira,M.C., Klur,S., Watanabe,M., Nemeth,A.H., Le Ber,I.,
            Moniz,J.C., Tranchant,C., Aubourg,P., Tazir,M., Schols,L.,
            Pandolfo,M., Schulz,J.B., Pouget,J., Calvas,P., Shizuka-Ikeda,M.,
            Shoji,M., Tanaka,M., Izatt,L., Shaw,C.E., M'Zahem,A., Dunne,E.,
            Bomont,P., Benhassine,T., Bouslam,N., Stevanin,G., Brice,A.,
            Guimaraes,J., Mendonca,P., Barbot,C., Coutinho,P., Sequeiros,J.,
            Durr,A., Warter,J.M. and Koenig,M.
  TITLE     Senataxin, the ortholog of a yeast RNA helicase, is mutant in
            ataxia-ocular apraxia 2
  JOURNAL   Nat Genet 36 (3), 225-227 (2004)
   PUBMED   14770181
REFERENCE   9  (bases 1 to 10970)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 10970)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BK001523.1, AL845267.2, AL772379.11 and BC058109.1.
            
            On Aug 31, 2006 this sequence version replaced NM_198033.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               BK001523.1         2-629
            629-670             AL845267.2         190361-190402
            671-2613            BK001523.1         672-2614
            2614-5900           AL845267.2         209874-213160
            5901-6000           AL845267.2         214447-214546
            6001-6159           AL772379.11        3780-3938
            6160-8662           BK001523.1         6161-8663
            8663-10970          BC058109.1         2517-4824
FEATURES             Location/Qualifiers
     source          1..10970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.45 cM"
     gene            1..10970
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /note="senataxin"
                     /db_xref="GeneID:269254"
                     /db_xref="MGI:MGI:2443480"
     exon            1..558
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..670
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..860
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1071
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1181
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1401
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1521
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1693
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1781
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..5900
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..6000
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6001..6159
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6160..6392
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6393..6560
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6561..6717
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6718..6819
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6820..6935
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            6936..7007
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7008..7157
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7158..7265
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7266..7453
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7454..7546
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7547..7711
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7712..7810
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7811..7898
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     exon            7899..10970
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10948..10953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /note="hexamer: AATAAA"
     polyA_site      10962
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
     polyA_site      10970
                     /gene="Setx"
                     /gene_synonym="A130090N03; A930037J23Rik; Als4; AOA2;
                     mKIAA0625; SCAR1; Sen1"
                     /note="major polyA site"
ORIGIN      
        1 gccactcagc ggtcaggccg gttgttcccc gctgctgcac tttccacctc ccgtccgccc
       61 ccatggtccg cccccttggt gtaccacaac aagccggctc tggcgggggc gggctgaggg
      121 cggggtccgc tctcgcggca gcggcgggtt gggcgttggg cgtcgccttg cccttccgtc
      181 tgctgttcta gcggggggca tggaggtggg ttagcgcgct gcagccgggc ctagccgggg
      241 tgagacgcgc cgcggacaag ccgcgagcgg gcgaacgagc aggagaggag agcgcgtgcg
      301 cggtgagggg cgcgcggctt actgccgttg ggaacttgcg cgcggcctgc gggagcgggc
      361 gcctgctgtg acccttctgg agagctgcgt ttggtgagag cggcggcttg ccgctgctac
      421 caagggcggg cagcgcttgg tgtttcctgc aagcgaggcc cgcccccgga tctctgctgt
      481 tctggcatca gcaccgccgg ccctgggcaa cgatgtacag cgaggaccct tagcttcggg
      541 gcgagggagg cctcccggaa atgttctttt tgggggccaa agtgtgaatc tgtctgaatg
      601 cagagccaca tctcacagat aagcccagca atcacaaaga gcatcacttc tctgtaggac
      661 cttggtcaag ctacaggtgc agcatgagca catgctgttg gtgtactcca ggtgggtctt
      721 ccaccattga tgtcctaaag cgctatgcat ctagcactgg gtcaagtgaa tttcagacag
      781 ctgatgaaga cctctgctac tgcttagagt gtgtggctga gtaccaccga gccagagatg
      841 aggtgccgtt cttgcacgag gttttatggg agctagaaac cttacgcctc gtaagtcact
      901 ttgagaagtc catgaaggca gaagctgaag atgacgatga tttatatata gtagacaaca
      961 atggagagga acagctgttt gactgtagtg gccaagattt tgaaaataag cttcgagttc
     1021 ctctttttga aatactgaag tacccttact tgcttctgca tgagcgtgtt aatgaactgt
     1081 gtgtggaagc gctttgccga atggaacaaa acaattgctc ctttcaggtt tttgacaaat
     1141 atccaggcat ctatttgttt ttggttcatc ccaatgaaat ggttcggcga tgggctattc
     1201 tgactgcaag aaacctgggg aaggtggaca gagatgacta ttatgactta caggaagttt
     1261 taacttgcct ttttaaagtc attgagctgg ggcttttgga aagtccagac atttacacat
     1321 cttctgtgct tgaaaaaggc aaactgatcc ttttgcctgc acacatgtat gatactacca
     1381 actacaaaaa ctattggcta ggtatttgca tgttgttgac tattcttgag gagcaagcca
     1441 tggattcact gttgctgggc tcagacaagc aaaatgattt tatgcaatca attcttcaca
     1501 ccatggagaa gcaatcggat gatgatagca tggatccttt ttggccagca ttacactgtt
     1561 tcatggtgat tcttgatcgc cttggatcta aggtatgggg tcaacttatt gaccctattg
     1621 aagcatttca aaccatcatt aacaacgaga gctacaacag agagatccag aatatacgga
     1681 acagctccat aaggaccaag ttagaaccgg agccacattt tgatgatatg gtgacgtgca
     1741 gccagattgt ttataacttt aatcctgaaa agaccaaaaa ggattctggg tggagatcag
     1801 ccatttgtcc agattattgt ccaaacatgt atgaagaaat ggaaacatta gccaatgtac
     1861 ttcagtcaga tattggtcaa gatatgcgtg ttcataacag cacctttctg tggttcatac
     1921 cttttgttca gtcactcatg gatcttaagg atttgggtgt ggcttacata gtagaagtta
     1981 ttcatcatct atactcagaa gtcaaagatg tcctcaacca gacagatgct gtgtgtgaca
     2041 aagtcactga attttttatt ctgattttaa tatcagtgat tgagctgcat agaaataaaa
     2101 aatgcttgca tctgctgtgg gtgagttctc agcagtgggt agaagctgtt gtgaagtgtg
     2161 ccaagcttcc tactaccgca tttgtccgga gttgtgagaa gtcacctgga agtacctcca
     2221 gaggagcagc aataatgtcg tccttggcgt tgcattcggt gcagtctaac tctgtccagc
     2281 ttgcttgtgt acagttgatt agaggtctcc tcaaagaagg ttatcagctt ggtcagcaaa
     2341 cactttgtaa gcggttctgg gataagctta acttattcct tcgaggaaat ttgtctctgg
     2401 gttggcaatt gactggtcaa gaaacccatg agttacaaat gtgtttgaaa caaataatta
     2461 gaaacataaa attcaaaatg ccccaatata gcacttttgg ggattcaact tctacattta
     2521 aaacccctcc atcttttaaa gaagaaagtg ataaaataga caggaagcat aaaaaaaaca
     2581 tttattgttt ggaaaattgc agtccagtgt cttctaaaga gccaatgaaa gctgacaccc
     2641 atcgagtatt gatgaaagta aatactacag aagaggagaa cttcaagcag cattacattg
     2701 atttgaatga agaagagcaa gagcctcttc cagctgagtt gtgcttgaag cagaaaagtg
     2761 aggccctttt ttctgaaagt gctcaagagc aagttaaaat tagcgcagag aagtctggga
     2821 aagaaagctc ttcatatgca ccatcaaata gtacttcaag aaatggtcca gaatggggat
     2881 gtgacagagg agtgataatg tcagcacatt cattgactga ttctagcagt gattttatgg
     2941 aacaggtatc tacatcaaat gaagatgtct cattaaagga tggctctgtt ggtaaaactt
     3001 caaaaccaag tttcaaatta cagaaagatg aaatttgtgc aaagttatca catgtcataa
     3061 agaagcaaat caggaaaagt actttggtag ataatattat cgatctagag gaaaatacag
     3121 ctatatctga ccttgagaac tgttcaggaa cagatggagg agctctaaag gaagatagta
     3181 ttggacacaa tgtcccttca gaccctgttc tggatgacaa gcatgaagag caaaaatctc
     3241 aaaacagttc attattcaag aaagagataa agagtgagga gttggataat agtagttctg
     3301 atgatgaaga caagcttcaa atccaggaag gccgtgctga cgatgatttg gtatcattta
     3361 cagaagttac tgatacactg gtgaaagctc catgtgaggg tcatgtaaag atggtagttg
     3421 aatcaagaga taaggaaatg agagagagta cagcgttgac ttctaacttg gtagaaggac
     3481 aggtgcctca tgacagtagc aagcctttgg ttgcaggtcg tcaaatagac ctctgtaaca
     3541 taactttaat atctcaaacc actgttattc aatttccatc aggtttaagt aaacagaatt
     3601 catttcagct acaaaaaggt gataaaagat gtttgacagc taaccaaaac agtgctgcca
     3661 cctgccgtgg acaagttatt gtgatttcag attctgacga agaagaggat gaggatgaag
     3721 atgaaagaag tagtagtgag gaaaacatca aacagagtaa agcatgcata gggaaagact
     3781 gctcagagca tcgtagcttg gcagttaatg ccagtgtgga gaagcagctt gtaaaagagg
     3841 aagaaaggta ccctgtagaa tttgaagact ctgaatctca ggtttttgag tttgaaagct
     3901 catctgaagt cttttcagtt tggcaagatc ataaaataga cagcaaaaac tcccttcaag
     3961 gggaacagaa gagctatgta actcatgtag ctgatagtac aaacaataac ttgggttgtg
     4021 gtgactctgt gtctgaagag gttgttagaa acaaagcaga gggagttaaa gagcatgcag
     4081 gaccacatag tagtgtttct gctgaggaat tttgtaaaac tggagtaaaa aaacctaaga
     4141 ggaaacgcta tgacaaagtt acagctgaag atcctcagag gccttcctct tctgttggaa
     4201 ctgatcaatt gcctgatcgc agagatctta ctgaaagtga tttaaagagt gcagacatgg
     4261 ggatggcaac tcccagttca agtgttgaga gagattctac aattttacag aagtctacaa
     4321 aatctcgaac tcactcaaaa cctgttagga aagttccagc ctctaaggca actaagaaaa
     4381 cacattcaga caccagaaga ggacagtcta agagttcatg ttacataagt tgtagaactt
     4441 ctcctgctat tgtgccacca aagaagcttc gtcagtgtcc agagccaact tcaacagttg
     4501 aaaaacttgg tctgaaaaaa gcccctagga aggcatttga gttgtcccag aggtctctgg
     4561 agtgtatagt ccaattacgt gaccacggga agactgttgg agtagttgac gcccccaaga
     4621 aagctaaatt aatttctcct cagactcttt ctatcaaaaa taataagaag cttctgacaa
     4681 gccaggatct tcaatttcaa aggcttatga gatccagatc acataaaaaa cgagactttg
     4741 attacaaaaa tactgatact gtaagagtgt cacgcatagt acagggatca gatgtacttg
     4801 aagcagactc tgatgagcca gatgatcata gagtaagtga gccacttgcc atcagtaatg
     4861 aaaaacagtt agcaaaatgc atgctttcca aaacagaagt ggcagaagcc tcttctgatc
     4921 cttgggtgac aggtataact tgtcttgtga accagtgtga atctagagtg ttaagtggag
     4981 gagtgccaac agatgtggtg atggtctctg cttcagagga ccctgtggat ggaggtgctg
     5041 tcacagttca agttggggag gtggcatctg tgaaagctgc agagccagcg tctagtagtg
     5101 atacagatga tgatgacaac ttattcctaa cacaacatga tcctcaagat atggatctgt
     5161 gctcacagtt ggaaaataaa accattatcg tggctcataa aaaagataca gttcagagag
     5221 aagattcttt aagtcggcct cagttggagt ctttgagtat cacaaagtgt aaatacaaag
     5281 actgtgtcga aactacaaaa aaccagggtg aatactgccc aagacactct gaagctaaag
     5341 cagcagatga cggcctgttc cgtaaacctg gcttgcctct ttctgtagcc aggcccttga
     5401 gacctactac taccaagata tttagctcaa gcagcgcttc acgaactgcc aatctttcca
     5461 agtctttgga aagtactaca cttcagcagt cagcactaaa aaataagtca agtggagcgc
     5521 agcctaattt gaaggtgaca ccaccctctt ccatgggttc tcagaagcca gtggctgagg
     5581 tgaaaagtct atgcaatatt tttcattttc agactccaag cagttccagc aaacagagtt
     5641 gcaagcttac atttagtgag aacaggccta catcagctgc ttctccagtg aatattctct
     5701 tgccatcgca gtctatcttt gacaccttca ttaaagaggt cttaaaatgg aaataccaaa
     5761 tgtttttgaa ctttgataag tgtggtgctc caacaagtct ctgtcagtct atctcaagac
     5821 ctgtgcctgt ccgatttcaa gattgtgcag aatattttaa tgtttttcta cctttgatta
     5881 tattgaatgc ttttgaaaca gtggcacagg aatggctgag ctctccaaat aaagagaatt
     5941 tctatcagtt gcaattacga aaatttccag ctgactataa aaaatactgg gagtttctga
     6001 tttacttgaa cgaatctgaa cttgctaaac agcttcaccc aaaggaaaat gatctggtgt
     6061 ttctggctcc tgagaagagt tatatggaca ggcatggcat gcaagattgc agtcactatt
     6121 actgtggcta tgttcataag tttcgtcgca cttcagttat gcgcagtggg aaagctgagt
     6181 gttcattatg catacagaca caagatacct tgccagccag tgtaaaaaat cttacaagat
     6241 gcattgtgat cagttctctg gtaactacac agaggaaatt gaaagccatg tctctgttga
     6301 gtagtcggaa ccagttggcc agagctgttc taaatccaaa ccccatggac ttctgtacca
     6361 aagatctact aactacaact tctgaaagaa ttgttgccta cttaaaagac tttaatgaag
     6421 accaaaagaa agccatagaa actgcatatg ccatggtgaa acactcacca tccgttgcca
     6481 aaatctgtct gattcatgga ccacctggaa caggaaaatc caaaactatt gttggtctct
     6541 tgtaccgctt actgacagag aaccagagga agggccattc agatgaaaat ttcaatgcca
     6601 aaatcaaaca aaatcgagtc ctcgtgtgtg caccttccaa tgcggcggtt gatgaactta
     6661 tgaaaaaaat tatcctcgaa tttaaagaaa aatgtaaaga caagaagaat cctttgggaa
     6721 actgtggaga tataaattta gtacgactag gtccagaaaa gtctattaat acagaggtct
     6781 taaaattcag tttggacagc caagtcaacc atagaatgaa aaaagacttg ccttctcata
     6841 ttcaagaaat gcttagaaga aaagaaattc tagatgctca acttgatgag ctttctcgtc
     6901 agcgagctct gtgccgaggt gggcgggaga tgcagaggca agaattagat gaacacattg
     6961 ccatagtctc aaaagaaagg caagaacttg cttcgaaaat taaagaggtt cagggacgcc
     7021 cacagagagc acagaatacc atcatcttgg agtcccatgt catctgctgc acattgagca
     7081 ctagtggtgg tttattgctt gagtctgctt ttcgagggca agggggtgtc cccttcagtt
     7141 gtgtcatcgt agatgaggct gggcagtctt gtgaagttga gacactttct ccactcatcc
     7201 accgctgcaa taaacttatc ctagtaggag accccaaaca gctccctccc acagtcatct
     7261 ctatgaaagc acaggagtat ggctatgacc agtcgatgat ggcccgattc tgcaagctgc
     7321 tggaagagaa tgtggagcag aacatgattg gcaggctgcc ggtgttacag cttaccattc
     7381 agtacaggat gcatccagac atatgtcttt tcccttctaa ttacgtttat aacaaaaacc
     7441 tgaagacaaa tagattgact gaatccattc gatgttcatc agagtggcca tttcagccct
     7501 acctcgtgtt tgatgttgga gatggttcag aacgacggga taatgactca tatataaatg
     7561 ttcaagaaat aaagttggtg atggaaataa ttaaacttat taaagagaaa agaaaagata
     7621 tttccttccg aaatattggc ataataaccc attacaaggc tcagaagacg atgatccaga
     7681 aggatttgga gaaagaattt gataagaaag gacctgcaga agtggacaca gtagatgcct
     7741 tccagggccg gcagaaagac tgtatcatcg ttacctgtgt cagggcaagt gctgtgcaag
     7801 gctcaatagg attcctggca agtttgcaga gattgaatgt caccattaca cgagccaagt
     7861 atagcctctt tatccttgga catttgagga ctctgatgga aaaccagcat tggtatgaac
     7921 tgattcagga tgctcagaag cgtggggcca ttattaagac cagtgaccca aactatagac
     7981 atgacgcaat gaagattctg aaactgaagc ctgtgctaca gaggagtctg acccatcccc
     8041 cagccactgc cccggaggca cccagacccc agggtggctt gcccagcaac agactggaca
     8101 gtggacttgc cacaacatct tttgctgctt ctttgtatca cacaccctct gatactgtca
     8161 cttcaaaggg acctgaaagg ccacttcttc aagaccgact tcgagatcca cgactactca
     8221 ggagattgga tgctgaagcc aagggaacat tcctgaagga tccacagccc gttagccccc
     8281 agctccccgg ggtagttcat ctcttgggag agcctggctt ccctgtggtt ttccaggacc
     8341 taggttttgt tgtgccgcca tccactgcca ttgttgctcc tctgggcagc cacaggtcac
     8401 ctatgcaggc tgagccacca cctgctcacc ctgctgctgc cgcctccaca agtaagagga
     8461 agtacagtga cccagatgct gggctcagcc acaaaagaga acccagggcc ttcagtggag
     8521 agcaggggag gcatggctct gtgactcatc acgtgctgag aagcactgac tgggacagga
     8581 ggaggctgga tgacagcagt gccaagagga gacaatttct atagtagcac ctcgtgagga
     8641 gactgttgtc cacaggccag ctagtggtac cctactgaga agttgggttt tggttttgtt
     8701 tcccttgaag ggtcgctgtt agaggatgga agtaacttct aattcttgat ctgtttgttg
     8761 gtcttgtttt cagtactttt tgccagttgt atacacttgg agagggaatt tgtatgcctg
     8821 taatcttgtt cttgaggtca gaaattcaaa acattgggag cttttgttgt aaaggttaaa
     8881 ctgtgaatcc atatagcaaa tgcagatcct tttacagtgt aaaccacatt tcctgcctca
     8941 gcctaaagca ctggtcattt tccaacagaa caaacttcca atttaaagag agagaggagg
     9001 acagatcctt tcaaccattg tgtggtagat gaatttaaca gcctcagtac tgggagttag
     9061 tcaagtttga acaagtagct agtgtcttca gctggggttt cgtgggcctt tagaaagcag
     9121 cacgttggga gttgtgctca taagtgcact ttgaaacaag gcagcttggc acagggcatg
     9181 actgtgacaa gttcatttac ctatattggt gtataggttt tctggctaaa aatctttccc
     9241 ttctcaaaac ggaagaccaa ttcttgaatg gtcattcatg cttgcaaagt tttgtgaggt
     9301 tgatgtaact ggggaattgt agacagctta gcaaatggag gatttgtgct ggcttggttg
     9361 gtctggcctg gaagagtcca tttaggatgc ttgtgaaggc ttgagagttg cccggaaaat
     9421 taaaaaggat gcattttaag ggatcccatg ggagctacac aggggcagac cagatagcat
     9481 atctcaggca ggagagaaac tccatgagaa agaagagcag ccgtctgggc tgcaggacca
     9541 tccagtaggt aggtgaaagt gcagtctatg ttgggtcact gcaggcactg gactccatca
     9601 gacctggtgt ggttgtgaga ggaaagcaga ggggcctgga agtcaagtcg ggacaaggga
     9661 gggagggctg tttaaccagt ctctatgtag aagggcatgt gagtgtgagg tctctggtaa
     9721 ctactgtgtg cacagcccgt tagctgcctt ggggcaggaa gacagcccta aaacttagtg
     9781 tttgctgtta ggagggattt ttgccatctg ttcttacaca agggttttgt gttagaaatt
     9841 ctgctgaagg aggttttgtt tgttaagagc tttgaaaaaa tgcattttgc caagtttcaa
     9901 cacttgagtt tcctgatctc tttctgctag tgcccagaca tgaaccctaa tatctgctga
     9961 atacttgtaa agctggggag taggcacctt ctcagagccc ttcagcctcc tggatgtccc
    10021 cagctaagtg ggaaagaaat cctgctctgg ctagggcagg ggttcagtaa gctcctgcat
    10081 atgacattgg caggaaacct cactgtcact tgaaattttc tttcctagta tctgtgagaa
    10141 gtgctcagtt tagccaaaag tgtgcttctg agaggggaat aacaacagca atagccagga
    10201 cgtttccttc tctaaagacc caagaagtac atttgtaaaa agaagatttt ccaaaacatg
    10261 tagttggctg ctctccaatg agtatgttgt aggacattgt gtgttcatct gctggctcat
    10321 ggctagccac atccgagtat tggaatttgt attgcagcct gcttattttg tgaatgtaag
    10381 ggctgctggg attagactct ggccaaggga tcttccttct cagcaagcag acttgcctta
    10441 gaactgtctc acagcagaat gtagttgcat tatattagat ctgaaacctt atttattcca
    10501 gttggtaaag gtatttgcag aaagtgtttg ctgtgtcaag gggcctttcc tgacagtgct
    10561 gtcagaaatg gtcaaccctg acaagatgaa aaggtcactt tgtccttgct gtggttaaaa
    10621 gaacatgccc tgactacttt caaatgttat ttcaaggtga atatattata cctgtcttac
    10681 tttgcttctc tcttgattta ccacagtttg tccagttatg ttttcatgaa ttatcaggag
    10741 taaatttgaa caaaaacatg tgaataatct cctgtaaatg tgttttataa caagagtgtg
    10801 ctaaactatt ttctaaaaat tacttgtgca ttttgggaat ctttctgtag ctttgtgttt
    10861 tgtatgctct ggattcataa ctggattttg gcaaatagta aacctattat ctttgttaaa
    10921 acctaaaatt taagagaaaa tggcagaaat aaaaacaaac aagaaaactg
//
