LOCUS       NM_178391               1617 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SET domain without mariner transposase fusion
            (Setmar), transcript variant 1, mRNA.
ACCESSION   NM_178391 XM_001001353 XM_982623
VERSION     NM_178391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Apostolou,P., Toloudi,M., Ioannou,E., Kourtidou,E.,
            Chatziioannou,M., Kopic,A., Komiotis,D., Kiritsis,C., Manta,S. and
            Papasotiriou,I.
  TITLE     Study of the interaction among Notch pathway receptors, correlation
            with stemness, as well as their interaction with CD44, dipeptidyl
            peptidase-IV, hepatocyte growth factor receptor and the SETMAR
            transferase, in colon cancer stem cells
  JOURNAL   J Recept Signal Transduct Res 33 (6), 353-358 (2013)
   PUBMED   23964856
  REMARK    GeneRIF: The suppression of Notch-1 led to increased expression of
            Oct4 and Sox2, but in decreased gene expression of cMET, Setmar and
            CD44.
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   Wray,J., Williamson,E.A., Chester,S., Farrington,J., Sterk,R.,
            Weinstock,D.M., Jasin,M., Lee,S.H., Nickoloff,J.A. and Hromas,R.
  TITLE     The transposase domain protein Metnase/SETMAR suppresses
            chromosomal translocations
  JOURNAL   Cancer Genet Cytogenet 200 (2), 184-190 (2010)
   PUBMED   20620605
  REMARK    GeneRIF: Metnase may have been selected for because it has a
            function opposing transposases and may thus play a key role in
            suppressing translocations that underlie oncogenicity.
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Cordaux,R., Udit,S., Batzer,M.A. and Feschotte,C.
  TITLE     Birth of a chimeric primate gene by capture of the transposase gene
            from a mobile element
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8101-8106 (2006)
   PUBMED   16672366
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   Siddiqui,J., Haqqi,T., Bickers,D. and Mukhtar,H.
  TITLE     Identification and partial characterization of novel genes by
            differential display of mRNAs in squamous papillomas induced in
            skin of SENCAR mice
  JOURNAL   Int J Oncol 9 (2), 211-216 (1996)
   PUBMED   21541502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153916.2 and AK017895.1.
            
            On Feb 1, 2013 this sequence version replaced NM_178391.3.
            
            Summary: This gene encodes a histone-lysine N-methyltransferase
            that may be involved in the methylation of histone H3. In
            anthropoid primates this gene is a fusion gene of a SET
            histone-lysine N-methyltransferase and a mariner (MAR) family
            transposase. In all other species this gene contains only the SET
            domain. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045208.1, AK017895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC153916.2         186068-186068
            2-173               AK017895.1         2-173
            174-179             AC153916.2         186241-186246
            180-421             AK017895.1         180-421
            422-423             AC153916.2         196955-196956
            424-1424            AK017895.1         425-1425
            1425-1617           AC153916.2         197958-198150
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.71 cM"
     gene            1..1617
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /note="SET domain without mariner transposase fusion"
                     /db_xref="GeneID:74729"
                     /db_xref="MGI:MGI:1921979"
     exon            1..195
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..966
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /EC_number="2.1.1.357"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase SETMAR; SET domain and
                     mariner transposase fusion gene-containing protein
                     homolog; epidermal tumor expressed transcript 2; SET
                     domain without mariner transposase fusion protein"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETMAR
                     isoform 1"
                     /protein_id="NP_848478.2"
                     /db_xref="CCDS:CCDS51867.1"
                     /db_xref="GeneID:74729"
                     /db_xref="MGI:MGI:1921979"
                     /translation="MSAEGVEKLSLEIAASEEESVAPTEQQDVACGLENLPVSLWPLG
                     AEPRPKPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHENNYDDNLC
                     LRDVGSEGKYAKPVFECNVLCQCGMRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFI
                     PKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIMETFVDPTYIGN
                     IGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDK
                     EKIDCSPPRKPCYCGAQSCTTFLPYDSSLYMAP"
     exon            196..1617
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1592..1597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /note="hexamer: AATAAA"
     polyA_site      1617
                     /gene="Setmar"
                     /gene_synonym="5830404F24Rik; Etet2"
                     /note="major polyA site"
ORIGIN      
        1 aaaatggtca ggcgagtagt cgaagcgaga ccataaatgt ctgcggaagg tgtggagaag
       61 ctttctctcg agatagcagc atctgaggag gaatctgtag ccccgacaga acaacaagat
      121 gtagcgtgcg gcctggagaa cttgcctgtg agcttgtggc ctttgggggc ggagcccagg
      181 cctaaacctt tccagtatac tcctgatcat gttgctggac ctggagcaga cattgacccc
      241 acacaaataa ccttccctgg atgtgcttgc atcgaaactc catgtgtccc tggcacttgc
      301 tcttgtcttc gccatgagaa taactacgat gacaatttat gccttaggga tgtgggatcc
      361 gaaggaaagt acgccaagcc agtttttgaa tgcaatgttc tgtgccagtg tggcatgcgc
      421 tgcagaaata gggtggtcca gaatggccta cacttccttc tccaggtgtt ccagacagag
      481 aaaaaaggct ggggacttcg gactttggaa tttataccca agggaagatt tgtctgtgag
      541 tatgctgggg aggtgttagg attctctgaa gtgcaaagaa gaattcacct acaaacatca
      601 catgactcaa attacatcat cgctgtcaga gaacacattt acagtggaca gatcatggaa
      661 acatttgtcg accctaccta cataggaaat attgggagat tcctcaacca ttcttgtgaa
      721 ccaaatctgt tgatgattcc tgtccgaatt gactcaatgg tacccaagct ggcacttttc
      781 gcagccaaag atattttgcc aggagaagaa ctctcttacg actattcagg aagattcctt
      841 aaccaagtaa gtagtaaaga caaagaaaag atagactgta gcccaccacg aaagccttgt
      901 tactgtgggg cccagtcatg caccactttc ctgccctatg acagttcact atatatggcc
      961 ccttagaaaa tccaggcacc agttaggaaa ggagatccta cctgccggcc cctttgcaga
     1021 cagaaatcag agggagccaa gcattaagtg ataaaatacc atctgggttc gtctcctaca
     1081 agcaaactac tctcaaggga aggctacctc atagtccgca tcttgttcat ccctgtaaga
     1141 caaggggttg cccagccctg ccaggttccc acattcaact cagcaatttg gcccagatag
     1201 aatgtccatc aatacactct ctcccagaat acttgtcttt gtagctaagt gtgggtaagt
     1261 gggtatgttg taactaacag gatacaagca aacaggatga atccttgggc atcgtccttg
     1321 tatttcttct tggaaaccag aagtcagacc tgatggctgg agttggaaca gccatcctaa
     1381 agccaggacg accctggcaa agggtcattc agagcaaatc aacaaggtat ctggcactgg
     1441 agaaaaatac tgctagtcct gactggatgg atgcctctgc acttgtaggt gaggagccta
     1501 caatgttaag ctactgctgc ctcacatttg agcaaacctc atgtatgatt cagcaagacc
     1561 tcagccttgc tttttggcta gtcttgccgg caataaagct gtcttctatc tatttga
//
