LOCUS       NM_001320720            3000 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus SET domain, bifurcated 2 (Setdb2), transcript variant
            1, mRNA.
ACCESSION   NM_001320720
VERSION     NM_001320720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Mangum,K.D., denDekker,A., Li,Q., Tsoi,L.C., Joshi,A.D.,
            Melvin,W.J., Wolf,S.J., Moon,J.Y., Audu,C.O., Shadiow,J., Obi,A.T.,
            Wasikowski,R., Barrett,E.C., Bauer,T.M., Boyer,K., Ahmed,Z.,
            Davis,F.M., Gudjonsson,J. and Gallagher,K.A.
  TITLE     The STAT3/SETDB2 axis dictates NF-kappaB-mediated inflammation in
            macrophages during wound repair
  JOURNAL   JCI Insight 9 (20), e179017 (2024)
   PUBMED   39435663
  REMARK    GeneRIF: The STAT3/SETDB2 axis dictates NF-kappaB-mediated
            inflammation in macrophages during wound repair.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Davis,F.M., Melvin,W.J., Mangum,K., Tsoi,L.C., Joshi,A.D., Cai,Q.,
            Henke,P.K., Gudjonsson,J.E. and Gallagher,K.A.
  TITLE     The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of
            Metalloproteinase-Matrix Metalloproteinase Activity During
            Abdominal Aortic Aneurysm Development
  JOURNAL   Ann Surg 278 (3), 426-440 (2023)
   PUBMED   37325923
  REMARK    GeneRIF: The Histone Methyltransferase SETDB2 Modulates Tissue
            Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity
            During Abdominal Aortic Aneurysm Development.
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Sonobe,S., Kitabatake,M., Hara,A., Konda,M., Ouji-Sageshima,N.,
            Terada-Ikeda,C., Furukawa,R., Imakita,N., Oda,A., Takeda,M.,
            Takamura,S., Inoue,S., Kunkel,S.L., Kawaguchi,M. and Ito,T.
  TITLE     THE CRITICAL ROLE OF THE HISTONE MODIFICATION ENZYME SETDB2 IN THE
            PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME
  JOURNAL   Shock 60 (1), 137-145 (2023)
   PUBMED   37195726
  REMARK    GeneRIF: THE CRITICAL ROLE OF THE HISTONE MODIFICATION ENZYME
            SETDB2 IN THE PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME.
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Melvin,W.J., Audu,C.O., Davis,F.M., Sharma,S.B., Joshi,A.,
            DenDekker,A., Wolf,S., Barrett,E., Mangum,K., Zhou,X., Bame,M.,
            Ruan,A., Obi,A., Kunkel,S.L., Moore,B.B. and Gallagher,K.A.
  TITLE     Coronavirus induces diabetic macrophage-mediated inflammation via
            SETDB2
  JOURNAL   Proc Natl Acad Sci U S A 118 (38) (2021)
   PUBMED   34479991
  REMARK    GeneRIF: Coronavirus induces diabetic macrophage-mediated
            inflammation via SETDB2.
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Roqueta-Rivera,M., Esquejo,R.M., Phelan,P.E., Sandor,K., Daniel,B.,
            Foufelle,F., Ding,J., Li,X., Khorasanizadeh,S. and Osborne,T.F.
  TITLE     SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a
            Regulation
  JOURNAL   Cell Metab 24 (3), 474-484 (2016)
   PUBMED   27568546
  REMARK    GeneRIF: INSIG2 is a negative regulator of SREBP, and acute
            glucocorticoid treatment decreased active SREBP during refeeding or
            in livers of Ob/Ob mice, both systems of elevated SREBP-1c-driven
            lipogenesis.
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Kroetz,D.N., Allen,R.M., Schaller,M.A., Cavallaro,C., Ito,T. and
            Kunkel,S.L.
  TITLE     Type I Interferon Induced Epigenetic Regulation of Macrophages
            Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral
            Infection
  JOURNAL   PLoS Pathog 11 (12), e1005338 (2015)
   PUBMED   26709698
  REMARK    GeneRIF: these findings identify Setdb2 as a novel regulator of the
            immune system in acute respiratory viral infection.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Schliehe,C., Flynn,E.K., Vilagos,B., Richson,U., Swaminanthan,S.,
            Bosnjak,B., Bauer,L., Kandasamy,R.K., Griesshammer,I.M., Kosack,L.,
            Schmitz,F., Litvak,V., Sissons,J., Lercher,A., Bhattacharya,A.,
            Khamina,K., Trivett,A.L., Tessarollo,L., Mesteri,I., Hladik,A.,
            Merkler,D., Kubicek,S., Knapp,S., Epstein,M.M., Symer,D.E.,
            Aderem,A. and Bergthaler,A.
  TITLE     The methyltransferase Setdb2 mediates virus-induced susceptibility
            to bacterial superinfection
  JOURNAL   Nat Immunol 16 (1), 67-74 (2015)
   PUBMED   25419628
  REMARK    GeneRIF: Results suggest that a Setdb2-mediated regulatory
            crosstalk between the type I interferons and NF-kappaB pathways is
            a mechanism for virus-induced susceptibility to bacterial
            superinfection.
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Hogarth,C.A., Mitchell,D., Evanoff,R., Small,C. and Griswold,M.
  TITLE     Identification and expression of potential regulators of the
            mammalian mitotic-to-meiotic transition
  JOURNAL   Biol Reprod 84 (1), 34-42 (2011)
   PUBMED   20826732
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114007.6, BC172021.1 and AI428348.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU155090.1, EU155092.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC114007.6         45296-45428
            134-2736            BC172021.1         1-2603
            2737-3000           AI428348.1         1-264               c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.48 cM"
     gene            1..3000
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /note="SET domain, bifurcated 2"
                     /db_xref="GeneID:239122"
                     /db_xref="MGI:MGI:2685139"
     exon            1..294
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            295..623
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..2701
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /EC_number="2.1.1.366"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase SETDB2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETDB2
                     isoform 1"
                     /protein_id="NP_001307649.1"
                     /db_xref="CCDS:CCDS84142.1"
                     /db_xref="GeneID:239122"
                     /db_xref="MGI:MGI:2685139"
                     /translation="MEEKNGDAKTFWMELQDDGKVDLMFEKTQNVLHSLKQKIKDGSA
                     TNGDYVQAMNLVNEATLSNTQTLEKDHTPVTQSEQENKSSAVPSASCDNSCPKGCTIP
                     SPGKKVFLPVKNKADNLVKKEAPLHISFHRHICSRTCLMETPLSLKGENPLQLPIRCH
                     FQRRHAKTNSHSSALHVNYKTPCGRNLRNMEEVFHYLLETECNFLFTDNFSFNTYVQL
                     TRNHPKQNEVVSDVDISNGVESVSIPFCNEIDNSKLPRFKYRNTVWPRIYHLNFSNMF
                     SDSCDCSEGCIDIKKCACLQLTAKNAKACPLSSDGECAGYKYKRLQRLIPTGIYECNL
                     LCKCNKQMCQNRVIQHGVRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLRRAT
                     PEKTNIGENGREQQHIVKNSFSKKRKLEVVCSDCDAHCDSPKAEDCPPKLSGDLKEPA
                     VEMNHRNISRTQHHSVIRRTKSKTTVFHYSEKNMGFVCSDSAAPEDKNGFKPAQEHVN
                     SEARRAHEDLSSNPAGDSEDTQLTESDVIDITASREDSAPAYRCKHATIVDRKDTKQV
                     LEVPGKKSQEEEPAASQSQQALCDEELPSERTKIPSASLMQLSKESLFLLDASKEGNV
                     GRFLNHSCCPNLWVQNVFVETHDRNFPLVAFFTNRYVKARTELTWDYGYEAGATPAKE
                     ILCQCGFNKCRKKLI"
     exon            624..749
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            750..815
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            816..912
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1473
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1590
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1760
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1959
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2059
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2153
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2494
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2583
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2991
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /note="hexamer: AATATA"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /note="hexamer: TATAAA"
     polyA_site      2988
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
     polyA_site      2991
                     /gene="Setdb2"
                     /gene_synonym="Clld8; Gm293; KMT1F"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggggc cgcggaaact gtgtggagct cccttggggc tgatgtctcc cccgctgagg
       61 tgaagccgcc tcgggactgc agactctggt gcggacagtg caaggcgcgc ggggtgccag
      121 gccgcctcaa cccgctgtct cagtagcggg ggtggccggg gctctcagtc gcgtttcccc
      181 caccgtcttg cggcgctcac tttcgtggct ggtgatttct gagtaatttg gctatcatgg
      241 gctgtagaca gcggagcaca gacaagatct tcaggacact ggtccattcc acagagtgtt
      301 tcatgcattt gtggaccaaa acatgggatg aactttaatt ttaaaaagac attgtcagta
      361 gtcctgatcc ggctttcaac ctggccttga agaagatgct gtgcctgttt ttcttggact
      421 agtagtcatt ctgaaagtct attcaagcac agtttctatt tgcaaattca aatactaaag
      481 actattagga agtggcctaa cgagatactc tctttgggga ctacagattt catagagact
      541 gcagttggag cccatttagt tttgattaac ttcattttga agaattttat ataagcaaca
      601 ccaaaagatg gaagaaaaaa atggtgatgc aaagactttc tggatggagc tacaagatga
      661 tggtaaagtt gacttaatgt ttgagaaaac acaaaatgtc ctacattcac tgaaacagaa
      721 gataaaggat gggtctgcca caaatggaga ctatgtccaa gcaatgaatc tagtaaatga
      781 agccactctg agtaacacgc aaacactgga aaaggatcat acacctgtga ctcagagtga
      841 acaggaaaac aaatcaagtg cggttccctc tgcatcatgt gacaactcct gtcctaaggg
      901 ctgtactatc ccatctccag gaaaaaaagt attcctccct gtgaagaata aagctgacaa
      961 tttagtgaaa aaggaagccc cactgcatat atctttccat cgccatatct gctccaggac
     1021 ttgtctaatg gaaaccccac tgtccttgaa gggagaaaac cccctgcagc taccaatcag
     1081 atgtcacttc caaagacgac atgcaaagac aaactctcat tcttctgccc tccatgtgaa
     1141 ttataaaacg ccctgtggac ggaatctacg aaacatggag gaagttttcc attacctgct
     1201 tgaaacagag tgtaactttt tattcacaga caacttctct ttcaatactt atgtccagtt
     1261 gactcggaat cacccaaagc aaaatgaagt tgtttctgac gtggatatta gtaatggagt
     1321 ggaatcagtg tcgattcctt tctgtaatga aattgacaac agtaaacttc cacggtttaa
     1381 gtatagaaat acagtatggc cccgaatata tcatctgaac ttttccaaca tgttttctga
     1441 ttcatgtgac tgttctgagg gctgcataga cataaaaaaa tgtgcatgtc ttcagttgac
     1501 agcaaagaat gccaaggcat gtcccttgtc atcggatgga gaatgtgctg gatataaata
     1561 caaaagactg cagaggctca tacctactgg catttatgaa tgcaacctgc tctgcaagtg
     1621 taacaaacag atgtgtcaaa accgagttat ccagcatggt gtccgggtga ggctacaggt
     1681 gttcaaaagt gagaagaagg gctggggagt acgctgcctg gatgacattg acaaagggac
     1741 atttgtgtgc atttattcag gaaggttact gcgcagagcc actcctgaga aaactaatat
     1801 aggtgaaaat ggaagagagc aacagcacat tgtgaaaaat tcattttcca aaaagaggaa
     1861 actagaagtt gtgtgttcag attgtgacgc acactgtgac agtcctaagg ctgaggactg
     1921 ccctcccaag cttagtggtg atctcaaaga gcccgctgtg gaaatgaacc atagaaatat
     1981 ttcaagaact cagcatcatt cagtcattag aagaactaaa tccaagacaa ctgtttttca
     2041 ttacagtgag aaaaacatgg gatttgtttg ctcagattct gccgccccag aagataagaa
     2101 tggatttaaa ccagctcaag aacacgtgaa ctctgaagct aggagagctc acgaggactt
     2161 aagttcaaac ccagctggag attctgaaga cacacagctg actgaatcag acgtgataga
     2221 tataactgca agtagagaag actctgcccc agcatacagg tgtaagcacg caaccatagt
     2281 ggatcgtaag gacactaaac aggtgcttga agtcccagga aagaagtccc aagaggaaga
     2341 gcctgcagcc tctcaaagcc agcaggcctt gtgtgatgag gagctgccaa gtgagaggac
     2401 aaagattcca tctgcttccc tgatgcagct cagtaaggag agtctgtttc tattggatgc
     2461 ttcaaaagaa ggaaatgtgg gccgtttcct caatcatagt tgctgtccaa atctctgggt
     2521 gcagaatgtt tttgtagaaa cacatgacag gaatttccca ttggtggcct tcttcaccaa
     2581 caggtatgtg aaagcaagga cagaactaac gtgggattat ggttatgaag ctggggccac
     2641 gcctgcaaag gaaatcctct gccaatgtgg gtttaataag tgtcggaaaa aattaatata
     2701 actttatatc tgatatccat ccgtgaactg agctgctcaa tgtataacaa tatcagttgt
     2761 caaagagatt atggttaata cttctgtttc ctttgttcag ggtattgatg ttttatgtct
     2821 aattttgtat cttaggttag aagcaaaata agggcactca tcaagtatca cagtgttatt
     2881 acagttaatt aactttacat gagtagaata taaataatat attttatgta catatcattg
     2941 tataatttgt aacttttgta ttttatatat taatataaaa ttatactaga aaaaaaaaaa
//
