LOCUS       NM_018877               4644 bp    mRNA    linear   ROD 02-NOV-2024
DEFINITION  Mus musculus SET domain, bifurcated 1 (Setdb1), transcript variant
            2, mRNA.
ACCESSION   NM_018877
VERSION     NM_018877.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4644)
  AUTHORS   Garcia,P., Jarassier,W., Brun,C., Giordani,L., Agostini,F.,
            Kung,W.H., Peccate,C., Ravent,J., Fall,S., Petit,V., Cheung,T.H.,
            Ait-Si-Ali,S. and Le Grand,F.
  TITLE     Setdb1 protects genome integrity in murine muscle stem cells to
            allow for regenerative myogenesis and inflammation
  JOURNAL   Dev Cell 59 (17), 2375-2392 (2024)
   PUBMED   38848717
  REMARK    GeneRIF: Setdb1 protects genome integrity in murine muscle stem
            cells to allow for regenerative myogenesis and inflammation.
REFERENCE   2  (bases 1 to 4644)
  AUTHORS   Takagiwa,Y., Higashihori,N., Kano,S. and Moriyama,K.
  TITLE     Roles of the histone methyltransferase SET domain bifurcated 1 in
            epithelial cells during tooth development
  JOURNAL   Arch Oral Biol 165, 106026 (2024)
   PUBMED   38875772
  REMARK    GeneRIF: Roles of the histone methyltransferase SET domain
            bifurcated 1 in epithelial cells during tooth development.
REFERENCE   3  (bases 1 to 4644)
  AUTHORS   Chang,Y.H., Yamamoto,K., Fujino,T., Wang,T.W., Sugimoto,E.,
            Zhang,W., Yabushita,T., Suzaki,K., Pietsch,E.C., Weir,B.A.,
            Crescenzo,R., Cowley,G.S., Attar,R., Philippar,U., Wunderlich,M.,
            Mizukawa,B., Zheng,Y., Enomoto,Y., Imai,Y., Kitamura,T. and
            Goyama,S.
  TITLE     SETDB1 suppresses NK cell-mediated immunosurveillance in acute
            myeloid leukemia with granulo-monocytic differentiation
  JOURNAL   Cell Rep 43 (8), 114536 (2024)
   PUBMED   39096901
  REMARK    GeneRIF: SETDB1 suppresses NK cell-mediated immunosurveillance in
            acute myeloid leukemia with granulo-monocytic differentiation.
REFERENCE   4  (bases 1 to 4644)
  AUTHORS   Sun,D., Zhu,Y., Peng,W., Zheng,S., Weng,J., Dong,S., Li,J.,
            Chen,Q., Ge,C., Liao,L., Dong,Y., Liu,Y., Meng,W. and Jiang,Y.
  TITLE     SETDB1 regulates short interspersed nuclear elements and chromatin
            loop organization in mouse neural precursor cells
  JOURNAL   Genome Biol 25 (1), 175 (2024)
   PUBMED   38961490
  REMARK    GeneRIF: SETDB1 regulates short interspersed nuclear elements and
            chromatin loop organization in mouse neural precursor cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4644)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
REFERENCE   7  (bases 1 to 4644)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 4644)
  AUTHORS   Yang,L., Mei,Q., Zielinska-Kwiatkowska,A., Matsui,Y.,
            Blackburn,M.L., Benedetti,D., Krumm,A.A., Taborsky,G.J. Jr. and
            Chansky,H.A.
  TITLE     An ERG (ets-related gene)-associated histone methyltransferase
            interacts with histone deacetylases 1/2 and transcription
            co-repressors mSin3A/B
  JOURNAL   Biochem J 369 (Pt 3), 651-657 (2003)
   PUBMED   12398767
REFERENCE   9  (bases 1 to 4644)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4644)
  AUTHORS   Yang,L., Xia,L., Wu,D.Y., Wang,H., Chansky,H.A., Schubach,W.H.,
            Hickstein,D.D. and Zhang,Y.
  TITLE     Molecular cloning of ESET, a novel histone H3-specific
            methyltransferase that interacts with ERG transcription factor
  JOURNAL   Oncogene 21 (1), 148-152 (2002)
   PUBMED   11791185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY074856.1, AK132202.1 and BC060173.1.
            
            On Jul 25, 2009 this sequence version replaced NM_018877.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132202.1, SRR9219383.2322.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY074856.1         1-29
            30-1546             AK132202.1         2-1518
            1547-4618           AK132202.1         1520-4591
            4619-4644           BC060173.1         4611-4636
FEATURES             Location/Qualifiers
     source          1..4644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..4644
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /note="SET domain, bifurcated 1"
                     /db_xref="GeneID:84505"
                     /db_xref="MGI:MGI:1934229"
     exon            1..138
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            139..407
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..4074
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /EC_number="2.1.1.366"
                     /note="isoform a is encoded by transcript variant 2;
                     histone-lysine N-methyltransferase SETDB1; SET domain
                     ERG-associated histone methyltransferase; ERG-associated
                     protein with SET domain"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETDB1
                     isoform a"
                     /protein_id="NP_061365.3"
                     /db_xref="CCDS:CCDS17613.1"
                     /db_xref="GeneID:84505"
                     /db_xref="MGI:MGI:1934229"
                     /translation="MSSLPGCMSLAAAPAAADSAEIAELQQAVVEELGISMEELRQYI
                     DEELEKMDCIQQRKKQLAELETWVLQKESEVAYVDRLFDDASREVTNCESLVKDFYSK
                     LGLQYHDSSSEDEASRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKS
                     AQDVQKFMDAVNKKSSSQDLHKGTLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTL
                     IAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQVWL
                     YAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIE
                     EYITAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGS
                     TRLEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQYTQDLTGTGIQFKPME
                     PLQPIAPPAPLPIPPLSPQAADTESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTS
                     STLSENVSAGKLGINQTYRSPLASVTSTPASAAPPVPPVPPGPPTPPGPPAPPGPLAP
                     PAFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRNEQYRGKNPLLVPLLY
                     DFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYV
                     LVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTG
                     PEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQVNPNSGYQYKRLEECLPTGVYE
                     CNKRCNCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILT
                     DDFADKEGLEMGDEYFANLDHIESVENFKEGYESDVPTSSDSSGVDMKDQEDGNSGSE
                     DPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENELSEMTSKDSRPPDLGP
                     PHVPIPSSVSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDG
                     RAGGGRGEAERASTSGLSFKDEGDNKQPKKEDPENRNKMPVVTEGSQNHGHNPPMKSE
                     GLRRSASKMSVLQSQRVVTSTQSNPDDILTLSSSTESEGESGTSRKPTAGHTSATAVD
                     SDDIQTISSGSDGDDFEDKKNLSGPTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDK
                     GESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFP
                     WVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL"
     exon            408..559
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            560..594
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            595..694
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            695..820
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1022
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1096
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1287
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1417
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1568
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1727
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..2414
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2531
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2701
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..3330
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3359
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3489
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3655
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3867
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..3956
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4622
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4603..4608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /note="hexamer: ATTAAA"
     polyA_site      4622
                     /gene="Setdb1"
                     /gene_synonym="ESET; KMT1E; mKIAA0067"
                     /note="major polyA site"
ORIGIN      
        1 tgtttcccct cccccgccgt ctctccttca gtttgcctgg gtttggcaag gcggagccct
       61 ggagtaaaac ctggggtcgg ggttgtgaga cgcggccctt gcggtcgggc gccagagttg
      121 tggggaggac ggactgaggg ccaaagcatg tcctccctcc ctgggtgcat gagtttggct
      181 gcagcgccag ctgcagctga ctctgcagag attgctgagc tgcagcaggc ggtggttgaa
      241 gagctgggta tctctatgga ggaacttcgt cagtacattg atgaggaact ggaaaagatg
      301 gactgcatac agcagcgcaa gaagcagctc gcagagctgg agacgtgggt actacagaaa
      361 gagtctgaag tggcttatgt tgatcggctg tttgatgatg catccaggga agtgactaac
      421 tgtgagtctt tggtgaagga tttctactct aagctgggac tacagtatca tgacagtagc
      481 tctgaggatg aagcttcccg gcccacagag atcattgaga ttcctgatga agatgatgat
      541 gtcctcagta ttgattcagg tgatgctggg agcagaactc caaaagacca gaagcttcgt
      601 gaagctatgg ctgccttaag aaaatcagct caagatgtcc agaagttcat ggatgctgtc
      661 aacaagaaaa gcagttctca agatctacat aaaggaacct tgggtcaggt gtctggagaa
      721 ctgagcaaag atggggacct gatagtcagc atgcggattc tgggcaagaa gaggactaag
      781 acatggcaca aaggcaccct tattgccatc cagactgttg ggctaggaaa aaaatacaaa
      841 gtgaaatttg acaacaaagg aaagagtctg ctatctggga accatattgc ctatgattac
      901 caccctcccg ctgacaagct gtttgtgggc agtcgagtgg tggccaagta caaagatgga
      961 aatcaggtct ggctttatgc tggcattgta gctgagaccc ctaacgtcaa gaacaagctc
     1021 agatttttaa ttttttttga tgatggctat gcttcctatg tcactcagtc agagctttat
     1081 cccatttgcc gaccactaaa aaagacttgg gaggacatag aagatagctc ctgccgagac
     1141 ttcatagagg aatatatcac tgcctatcca aaccgcccaa tggtacttct caagagtggg
     1201 cagcttatca agactgagtg ggaaggcaca tggtggaagt ctcgagttga agaggtggat
     1261 ggcagcctag tcaggatcct ctttctggat gacaaaagat gtgagtggat atatcgaggc
     1321 tctacacgcc tggaacctat gtttagtatg aagacatcct cagcctctgc aatggagaag
     1381 aagcaagggg ggcaactcag aacccgtcct aatatgggtg ctgtgaggag caaaggtcct
     1441 gttgttcagt atacacagga tctaactggt actggaatcc agtttaagcc catggagccc
     1501 ctacagccta tagctccacc ggccccactt cctatacctc ctctttcccc ccaagcagct
     1561 gacactgaaa gcttagaaag ccaacttgca caatcacgga aacaagtagc caagaagagc
     1621 acatcattcc gaccaggatc tgtgggctcc ggccattcct cccctacttc atccacactc
     1681 agtgaaaatg tgtctgctgg gaaacttggg ataaaccaga catatcggtc acctttggcc
     1741 tcagtaacat ctaccccagc atctgcagcc cctccagtcc ctccagtccc accagggcct
     1801 ccaacccctc cagggcctcc agctcctcca gggcctctag ctcctccagc cttccatggc
     1861 atgttagagc gggcaccagc tgagccctcc taccgagccc ccatggagaa gcttttctat
     1921 ttacctcatg tctgcagtta cacttgtttg tcccggatca gacccatgag aaacgaacag
     1981 tatcggggca agaaccctct attagttcca cttctgtatg acttccggag gatgacagca
     2041 cggcgcagag ttaaccgcaa aatgggcttt catgtaatct ataagacacc ctgtggtctc
     2101 tgccttcgga cgatgcagga gatagagcgc tacctttttg agactggctg tgactttctg
     2161 ttcctggaga tgttctgttt ggatccatat gttcttgttg acagaaagtt tcaacccttt
     2221 aagccttttt actatatttt ggacatcacc tatggcaagg aagatgttcc cctgtcctgt
     2281 gttaatgaga ttgacacaac tcccccaccc caggtggcct acagcaagga acgcattcct
     2341 ggcaagggtg ttttcattaa cacaggccct gaatttctgg ttggctgtga ctgcaaggat
     2401 gggtgtcggg ataaatccaa atgtgcctgc caccagctaa ctatccaggc cacagcctgt
     2461 accccagggg gccaagtcaa ccctaactct ggctaccagt ataaaagact agaagagtgt
     2521 ctgcccacag gggtttatga gtgtaacaaa cgctgcaatt gtgacccaaa catgtgcaca
     2581 aatcggttgg tgcagcatgg tctgcaggtt cgactacagc tgtttaagac acagaacaag
     2641 ggctggggta tccgctgctt ggatgatatt gccaaaggct cttttgtctg catttatgca
     2701 ggcaaaatcc tgacagatga ctttgcagac aaagaaggcc tggagatggg tgatgagtac
     2761 tttgcaaatc tggaccacat tgaaagtgtg gagaacttca aggaaggata tgagagtgat
     2821 gtccccactt cctctgacag cagtggggta gatatgaagg accaggaaga tggcaacagc
     2881 ggttcagagg accctgaaga atccaatgat gacagctctg atgataactt ctgtaaggat
     2941 gaggacttca gcaccagttc agtgtggcgt agctatgcta cccggaggca gactcggggt
     3001 caaaaggaga atgaattgtc tgagatgact tccaaggact cccgcccccc agacctcggg
     3061 cctccacatg ttcctatccc ttcctcagta tctgtagggg gctgcaatcc accttcctct
     3121 gaagagacac ccaagaacaa ggtggcctcg tggttgagtt gcaatagtgt cagtgaaggt
     3181 ggatttgctg actctgacag ccgttcttcc ttcaagacta gtgaaggtgg agatggccgt
     3241 gctgggggag gccggggaga ggctgaaagg gcctctacct caggattgag cttcaaggat
     3301 gaaggagaca ataagcagcc taaaaaagag gaccctgaga accgaaacaa gatgccagta
     3361 gttactgaag gctctcagaa tcatggacat aatcctccca tgaagtctga agggcttcgc
     3421 cgatcagcta gtaaaatgtc tgtgctccag agccagcgag ttgtgacttc tactcagtca
     3481 aaccctgatg acatcctgac actgtccagc agcacagaga gtgaggggga aagtggaacc
     3541 agccgaaagc ccactgctgg tcacacttca gccacagctg ttgatagtga tgacatccag
     3601 accatctctt ctggctctga cggtgatgac tttgaggaca agaagaactt gtcaggacca
     3661 acaaagcgcc aggtggcagt aaaatcaacc cgaggctttg ctcttaaatc aacccatggt
     3721 attgccatta aatcaaccaa catggcttcc gtggacaagg gggagagtgc accagttcgt
     3781 aagaacacac gccagttcta tgatggtgaa gagtcttgct acatcattga tgccaaactt
     3841 gaaggcaacc taggccgcta cctcaatcac agttgcagcc ccaacctgtt tgtccagaat
     3901 gtgtttgtgg atacccatga tcttcgcttc ccttgggtgg ccttctttgc cagcaagaga
     3961 atccgggctg gaacagaact cacttgggac tacaactacg aagtgggcag tgtggaaggc
     4021 aaggagctgc tgtgctgctg tggggccatt gaatgcagag ggagacttct ttagaggaag
     4081 acttcctcac tttgagaacg cttgaactat ccttttcccc aggaactggg tcttcctgac
     4141 tgttgaactc tgaccccaag tctctgatct agcttcttcc cagctcctag tagatagaga
     4201 tggggattct caatcaggac tttcccagcg tggtgctagc aggcactagg gtgggtagac
     4261 atgaccactc tagcatcagc ctgaggtcct tctcatcttg tatgcattca tgattcacat
     4321 gggctgtgta tctgccatcc ctgatttgta tggtttcttg aaagtcttct aacaagatgg
     4381 taaagtagag attgtggttt gtcttatctc ctgccttgat cttccatgtc atttcccagt
     4441 gggcaactat cattagttta tacctcgatt ttatttgccc tgtgtaattt ttaactaaaa
     4501 atgttacata accacaaggg aggcctaaga aaaaaactaa ccctttctca agtcttaata
     4561 gtctgacaca gtcatgtttt atttaacctt taatatactt taattaaaaa aaattaacag
     4621 taaaaaaaaa aaaaaaaaaa aaaa
//
