LOCUS       NM_001035123            1672 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SET domain containing 6 (Setd6), transcript variant 1,
            mRNA.
ACCESSION   NM_001035123
VERSION     NM_001035123.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Carmona-Mora,P., Widagdo,J., Tomasetig,F., Canales,C.P., Cha,Y.,
            Lee,W., Alshawaf,A., Dottori,M., Whan,R.M., Hardeman,E.C. and
            Palmer,S.J.
  TITLE     The nuclear localization pattern and interaction partners of
            GTF2IRD1 demonstrate a role in chromatin regulation
  JOURNAL   Hum Genet 134 (10), 1099-1115 (2015)
   PUBMED   26275350
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Binda,O., Sevilla,A., LeRoy,G., Lemischka,I.R., Garcia,B.A. and
            Richard,S.
  TITLE     SETD6 monomethylates H2AZ on lysine 7 and is required for the
            maintenance of embryonic stem cell self-renewal
  JOURNAL   Epigenetics 8 (2), 177-183 (2013)
   PUBMED   23324626
  REMARK    GeneRIF: SETD6 monomethylates H2AZ on lysine 7 and is required for
            the maintenance of embryonic stem cell self-renewal.
REFERENCE   7  (bases 1 to 1672)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1672)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113951.13.
            
            On Feb 7, 2019 this sequence version replaced NM_001035123.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010304.1, BC139199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC113951.13        43757-44114         c
            359-500             AC113951.13        43533-43674         c
            501-695             AC113951.13        43226-43420         c
            696-816             AC113951.13        42986-43106         c
            817-997             AC113951.13        41926-42106         c
            998-1140            AC113951.13        41692-41834         c
            1141-1672           AC113951.13        41020-41551         c
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.17 cM"
     gene            1..1672
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /note="SET domain containing 6"
                     /db_xref="GeneID:66083"
                     /db_xref="MGI:MGI:1913333"
     exon            1..358
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1446
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 6; N-lysine methyltransferase
                     SETD6"
                     /codon_start=1
                     /product="N-lysine methyltransferase SETD6 isoform 1"
                     /protein_id="NP_001030295.1"
                     /db_xref="CCDS:CCDS22566.1"
                     /db_xref="GeneID:66083"
                     /db_xref="MGI:MGI:1913333"
                     /translation="MAAPAKRARVSGGSPLVAPCPSPRAARAPLPLPAGSSGGEPEGD
                     AVAGFLRWCRRVGLELSPKVTVSRQGTVAGYGMVARESVRAGELLFAVPRSALLSPHT
                     CSISGLLERERGALQSLSGWVPLLLALLHELQAPASPWSPYFALWPELGRLEHPMFWP
                     EEERLRLLKGTGVPEAVEKDLVNIRSEYYSIVLPFMEAHSDLFSPSVRSLELYQQLVA
                     LVMAYSFQEPLEEDDDEKEPNSPLMVPAADILNHIANHNANLEYSADYLRMVATQPIL
                     EGHEIFNTYGQMANWQLIHMYGFAEPYPNNTDDTADIQMVTVRDAALQGTKDETEKLL
                     VCERWDFLCKQEMVGEEGAFVIGCEEVLTEEELATTLKVLCMPAEEFRDYKERAGWGE
                     EETEDDSLAITDIPKLQESWKRLLRNSVLLTLQTYTTDLKTDQDLLSNKEAYATLSWR
                     EQQALQVRYGQKMILHRVLELTN"
     exon            359..500
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            501..695
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..816
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..997
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1140
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1672
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1672
                     /gene="Setd6"
                     /gene_synonym="0610039J04Rik; 3110004G14Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggacc cggctgctcg cagcatggcg gcccccgcca agcgcgcgcg ggtaagtggc
       61 gggtcgcccc tcgtcgcgcc ctgtccctcc ccgagagctg cccgcgcgcc cctgccgctc
      121 cctgcggggt ccagcggcgg cgagcccgag ggcgacgcgg tggccggctt cctgcgctgg
      181 tgcaggcgag tggggctgga gctgagtcct aaggtgacgg tgagccggca gggcacggtg
      241 gccggctatg gcatggtggc gcgggagagc gtgcgggccg gggagctcct tttcgcagtg
      301 ccgcggtccg cgcttctgtc cccccacacc tgttccatca gcggcctgct ggagcgagag
      361 cgaggcgcgc tgcagagcct gtctgggtgg gtgccgctgc tgctggcgct gctccacgag
      421 ctccaggccc cagcatcacc ctggagccct tacttcgcgc tctggccaga gctggggcgt
      481 ttggagcatc ccatgttttg gccggaggaa gagcggttgc gactcctaaa gggtacaggt
      541 gtccccgaag ccgtggagaa ggatttggtg aacatccgta gcgaatacta ttccatcgtc
      601 ctgcccttca tggaggctca ctcggatctc ttcagcccct ctgttcgctc cctggaactc
      661 tatcagcagc tcgtggccct cgtgatggct tatagctttc aagaaccgct ggaggaagat
      721 gatgatgaaa aggagcccaa ctcacccttg atggtgcctg ctgcagacat actaaaccac
      781 atagccaatc ataatgccaa tctagagtac tcggcagatt atctccggat ggtggctact
      841 cagcccattc ttgaaggtca tgaaatcttc aacacatatg ggcaaatggc taactggcaa
      901 ctgattcata tgtatggttt tgctgagccc tatcctaaca acacagacga cacggctgac
      961 attcagatgg tgacagtccg agatgctgca ctgcagggaa caaaggatga aactgaaaag
     1021 ctgctcgtgt gtgaacgctg ggatttcctg tgcaaacagg agatggtagg ggaagaggga
     1081 gcctttgtga taggttgtga ggaggtgctg actgaagagg agctagccac cacactgaag
     1141 gtactgtgca tgcctgctga ggagttcaga gactataaag agcgggctgg atggggagag
     1201 gaggagacag aagacgacag tttggcaatc acagatatcc ccaagctcca agaatcatgg
     1261 aaacggcttc ttcgaaacag tgttctgttg accctacaga cctacaccac agacttaaaa
     1321 acagaccagg acttactcag taataaggag gcctatgcca cgctgagctg gcgcgaacaa
     1381 caagccttac aggtccgcta tggtcagaag atgatcttac atcgggtgtt ggaactcaca
     1441 aattaagcag gcttcctgag aaccttttaa ggtcatgttc tgttgcttgg agaggaggga
     1501 aatttgggac ttttgctatt tggcagttag aatcaaagga aaaatagcta aaaagtaaac
     1561 ttacatgtcg gcacgtttgg attgatgtca gcagatttag gagcatgcta tttttactaa
     1621 tgccatcaga tttttttaga acttaataaa catgggctga gttcaacttt ga
//
