LOCUS       NM_028385               6470 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus SET domain containing 5 (Setd5), transcript variant 1,
            mRNA.
ACCESSION   NM_028385
VERSION     NM_028385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6470)
  AUTHORS   Burnett,L.E., Koppensteiner,P., Symonova,O., Masson,T.,
            Vega-Zuniga,T., Contreras,X., Rulicke,T., Shigemoto,R., Novarino,G.
            and Joesch,M.
  TITLE     Shared behavioural impairments in visual perception and place
            avoidance across different autism models are driven by
            periaqueductal grey hypoexcitability in Setd5 haploinsufficient
            mice
  JOURNAL   PLoS Biol 22 (6), e3002668 (2024)
   PUBMED   38857283
  REMARK    GeneRIF: Shared behavioural impairments in visual perception and
            place avoidance across different autism models are driven by
            periaqueductal grey hypoexcitability in Setd5 haploinsufficient
            mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6470)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6470)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6470)
  AUTHORS   Zaghi,M., Longo,F., Massimino,L., Rubio,A., Bido,S., Mazzara,P.G.,
            Bellini,E., Banfi,F., Podini,P., Maltecca,F., Zippo,A., Broccoli,V.
            and Sessa,A.
  TITLE     SETD5 haploinsufficiency affects mitochondrial compartment in
            neural cells
  JOURNAL   Mol Autism 14 (1), 20 (2023)
   PUBMED   37264456
  REMARK    GeneRIF: SETD5 haploinsufficiency affects mitochondrial compartment
            in neural cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6470)
  AUTHORS   Iwagawa,T., Kawabata,R., Fukushima,M., Kuribayashi,H. and
            Watanabe,S.
  TITLE     Setd5, but not Setd2, is indispensable for retinal cell survival
            and proliferation
  JOURNAL   FEBS Lett 597 (3), 427-436 (2023)
   PUBMED   36349512
  REMARK    GeneRIF: Setd5, but not Setd2, is indispensable for retinal cell
            survival and proliferation.
REFERENCE   6  (bases 1 to 6470)
  AUTHORS   Poissonnier,L., Villain,G., Soncin,F. and Mattot,V.
  TITLE     miR126-5p repression of ALCAM and SetD5 in endothelial cells
            regulates leucocyte adhesion and transmigration
  JOURNAL   Cardiovasc Res 102 (3), 436-447 (2014)
   PUBMED   24562769
REFERENCE   7  (bases 1 to 6470)
  AUTHORS   Pinheiro,I., Margueron,R., Shukeir,N., Eisold,M., Fritzsch,C.,
            Richter,F.M., Mittler,G., Genoud,C., Goyama,S., Kurokawa,M.,
            Son,J., Reinberg,D., Lachner,M. and Jenuwein,T.
  TITLE     Prdm3 and Prdm16 are H3K9me1 methyltransferases required for
            mammalian heterochromatin integrity
  JOURNAL   Cell 150 (5), 948-960 (2012)
   PUBMED   22939622
REFERENCE   8  (bases 1 to 6470)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 6470)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6470)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122551.1.
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122551.1, SRR11927936.2105446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.73 cM"
     gene            1..6470
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /note="SET domain containing 5"
                     /db_xref="GeneID:72895"
                     /db_xref="MGI:MGI:1920145"
     exon            1..74
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            75..261
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..4516
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /EC_number="2.1.1.359"
                     /EC_number="2.1.1.367"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 5; histone-lysine
                     N-methyltransferase SETD5"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD5 isoform
                     1"
                     /protein_id="NP_082661.1"
                     /db_xref="CCDS:CCDS20411.1"
                     /db_xref="GeneID:72895"
                     /db_xref="MGI:MGI:1920145"
                     /translation="MSIAIPLGVTTPDTSYSDMAAGSDPESVEASPAVNEKSVYSTHN
                     YGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGF
                     LLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSI
                     TLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYE
                     EAFTNQYSADVQNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQLGRV
                     TRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGV
                     EMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYE
                     YSNCNYKVDCACHKGNRNCPIQKRNPNAAELPLPPPPSFPTIGAETRRRKARRKELEL
                     EQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPEEEEKEEATDDQENSAHSRR
                     TREDRKVEAIMHAFESLEKRKKRRDQPVEQSSSDIEITTSSSEIVVGEETKTAAPESE
                     VSSPVSNVAIPSTPQSTGVNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPKSRISRYRT
                     SSAQRLKRQKQAIAQQAELSQAALEEGGSNNSVTPPEAGNTDSSGENRQLTGSDPTVI
                     SVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLP
                     GLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSS
                     VPQETRTQHLYQSNETSNSSSICKDNADLLSPLKKWKSRYLMEQNITKLLQPLSPVTP
                     PPPSSGSKSPQLTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKD
                     LDLTKVGFPDSSTHSCADRPSLLNCNHPDLASHPSVVPTSEAGFPSRSGDGPQTLLRN
                     SDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYE
                     HGFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSGGGNDS
                     SQSKSKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSSPHKKFSPSHSSASHLEAVSPSD
                     SRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNI
                     TEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFR
                     GHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYPSPAHPVSTDSLAPFTGTPGYY
                     SSQPHSGNSTGSNLPRRSCSSSAASPTPQGPSDSPTSDSVSQSSTGTLSSTSFPQNSR
                     SSLPSDLRTISLPNAGQSAAYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVKT
                     QTGLS"
     exon            262..367
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            368..519
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            520..578
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            579..757
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1000
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1149
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1267
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1377
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1627
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1714
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1972
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2293
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2536
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2666
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2914
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3385
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3684
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3818
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3907
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..6470
                     /gene="Setd5"
                     /gene_synonym="2900045N06Rik; C330007C20; mKIAA1757"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgagtctc gctgcctccc gggagtgccg tgcgccgcag cccgggccca ggccccggca
       61 gcgcctgggt caaggattcc tcatgtccgt aacatgttgg ctgaggctct gcagttcacc
      121 cccactcttt gagtggtcag tctccattaa ttggaccccg tgattcccac cttctgctgt
      181 cttggacgtc atgagcattg caatccctct gggagtcacc acaccagata cttcctactc
      241 agatatggct gctggatcag accctgaatc tgtggaggct agtccagcag ttaatgagaa
      301 gagcgtgtat tccactcata attatgggac cactcagagg catgggtgtc gaggactgcc
      361 ttatgctacg atcatccctc gttctgacct gaatggcctg ccgtcgcccg tagaggaacg
      421 ctgtggagac agcccgaact ctgaaggaga gactgttcct acctggtgtc cttgtggtct
      481 ttctcaggat ggcttccttc tcaactgtga caagtgcagg ggaatgagca gggggaaggt
      541 tattagactt catcggcgga agcaggacaa catatcaggt ggggatagca gtgcaacaga
      601 aagctgggat gaggagcttt ctccttccac tgtgttgtac acagcaacac agcacacacc
      661 tacaagcatc accttaactg ttagaagaac caaacccaag aagcggaaaa agagtccaga
      721 aaagggtcgt gcagcaccaa agacgaagaa gatcaagaat tctccctcgg aagcacagaa
      781 tttagatgaa aataccactg agggctggga aaatcggata agactatgga ctgatcaata
      841 tgaagaagct ttcactaatc agtacagtgc agatgtacag aatgcccttg agcaacatct
      901 ccattctaac aaggaatttg tgggcaaacc tgcaatttta gacactatta ataaaactga
      961 actggcctgt aataatacag taatcggttc ccaaatgcag ttacagctgg gaagagtcac
     1021 tcgtgttcaa aagcaccgga aaatcctgag ggctgcaaga gatttggctt tggacactct
     1081 tataatagaa tatcgtggga aagtcatgtt acgacaacaa tttgaggtca atgggcattt
     1141 ctttaaaaaa ccatatccct ttgtgctctt ctactcaaaa ttcaatggtg tagagatgtg
     1201 tgtcgatgct cgtactttcg gtaatgatgc tcggttcatc agaagatcat gtacaccaaa
     1261 tgcagaggtg agacacatga ttgcagatgg gatgattcac ttgtgtatct atgccgtatc
     1321 tgctatcacc aaggatgcag aagtcaccat tgcatttgat tatgaatata gtaactgtaa
     1381 ttacaaagtg gactgtgctt gtcacaaggg aaaccggaat tgccctatac agaaaagaaa
     1441 tcccaatgct gcagaattgc cactcccacc tcctcctagc tttcccacca ttggagcaga
     1501 gaccagacgt agaaaagcac ggcggaaaga gctggagctg gagcagcaaa atgaggttcc
     1561 agaagagaat cctgacccgc aaccacaaga agttccagaa aaagtaactg tatccaatga
     1621 gcatgaggaa gttgacaatc cagaagaaaa accagaagaa gaagaaaaag aagaggctac
     1681 agatgaccag gagaactctg ctcatagcag aaggactcga gaagaccgaa aggttgaagc
     1741 catcatgcat gcttttgaat ctttagagaa gagaaagaaa cggcgggatc agcctgtaga
     1801 acagagcagc tcggacatag agattactac tagcagttca gagatagtag ttggagaaga
     1861 gacaaaaact gcagcccctg agtctgaagt tagcagccct gtttcaaatg ttgctatccc
     1921 aagcacccca cagagcactg gtgtgaatac tcggaggtcc tcccatgctg gggatgtagc
     1981 tgcagaaaag ccaatcccta aaccacctcc agctaagcct tctagacccc gaccgaaaag
     2041 tagaatttct cggtaccgga ccagttcagc ccaaagacta aaacgccaga agcaggccat
     2101 tgcacaacag gcagaactgt cgcaagctgc cttggaagaa ggaggaagta acaactcagt
     2161 aactcctcct gaagctggaa atacagacag ttcaggagag aacagacagc taacagggtc
     2221 tgacccaact gtgatatcag ttactggatc ccatgtcaac cgtgctgcat ctaaataccc
     2281 caaaaccaaa aagtatctag ttacagaatg gttaaatgac aaggcagaga agcaagaatg
     2341 ccctgttgag tgtcctttgc gtatcaccac tgacccaact gtgttggcaa caaccctgaa
     2401 catgctacca ggtcttattc attccccatt aatttgtacc acccccaaac actacattcg
     2461 ctttggctca ccctttatgc ctgagaggcg tcgaaggccc cttctgcctg atggcacatt
     2521 cagctcctgt aagaagcgct ggataaagca agccttggaa gaagggatga ctcagacttc
     2581 atctgtgccc caagagacta gaacacagca cctataccaa agtaatgaga ctagtaattc
     2641 ttctagtatc tgtaaagaca atgcagactt actgagccca ttaaagaaat ggaagtctcg
     2701 ctatctgatg gagcagaata tcaccaagtt gcttcagcct ctgtctccag ttacaccacc
     2761 cccacccagc tcaggctcaa agagtcccca gctgaccaca cctggccaga ctcacccagg
     2821 agaagaggag tgtcgaaatg gatacagcct catgttctca ccaatcacat ctcttactac
     2881 tgctagtcgt tccaacactc ctctgcagtt tgagctttgt caccgaaaag acctagattt
     2941 gacaaaagtg ggattcccag actccagcac tcacagctgc gctgataggc cctccctgct
     3001 taactgcaat catcctgacc tggcttctca tccctctgtt gttcccacct ccgaggctgg
     3061 cttcccaagc aggagtggag atggtcctca gaccttgctg agaaactcag accaggcgtt
     3121 taggacagag ttcaatttga tgtacgccta ctcccctttg aatgctatgc ctcgagcaga
     3181 tggactgtat agagggtctc ccttggtggg agacaggaag cctttacatt tagatggagg
     3241 atattgttcc cctgctgaag gcttttccag cagatatgaa catggcttta tgaaagacct
     3301 ctctcgggga tccatgtcac ctggtggtga aaggacctgt gaaggagtcc catctgctcc
     3361 tcagaaccca ccgcaaagga aaaaggtatc cttgctagag taccgcaaaa gaaaacaaga
     3421 agctaaggag aattctggtg ggggaaatga ctcttcacag agcaaaagca agtcttcagg
     3481 agctgggcaa ggcagcagta actctgtttc tgacactggt gcccatggtg tgcagggatc
     3541 ctcagccgga accccgtcat cccctcacaa aaaattttcc ccgtctcatt cctctgcatc
     3601 gcatttggag gcggtaagcc cgtcagattc caggggcact tcttcctctc actgcagacc
     3661 tcaagaaaac atcagcagta ggtggatggt tcctacatca gttgaacgac tccgagaagg
     3721 aggtagcatc cctaaggttc ttcgaagcag tgtgagagtt gcccagaagg gagagccttc
     3781 tccaacatgg gagagtaaca tcacagagaa agagtcagac cctgcagatg gagaaggccc
     3841 agagccattg agctcagcac tctctaaagg agcaactgtt tacagccctt ccagatatag
     3901 ctaccagctc ctgcagtgtg acagtccacg gacagaatca caaagcctcc ttcagcagag
     3961 ttcgtccccc tttagaggac atcccaccca atctccagga tacagttatc gaactactgc
     4021 actgagacct ggaaaccctc cctctcacgg ttcttcagaa tcctccctct cttccacgtc
     4081 ctaccccagc cctgcccacc ctgtgtctac agactcgttg gccccattta cggggactcc
     4141 agggtattac agcagccagc cgcattctgg aaacagcact ggcagcaatc ttccaaggag
     4201 gagctgttct tcaagtgctg ctagccctac cccacagggc ccctcagact caccgacctc
     4261 agactcggtt tctcagtcca gcacaggaac tctgagttcc acctcctttc ctcagaactc
     4321 taggtcttca ttgccatcag acttacggac tatcagtctg cccaatgctg ggcagtcagc
     4381 tgcctaccag gcctccaggg tatctgcggt ttccaattca cagcactacc cacatcgtgg
     4441 tagtgggggt gtacaccagt accgactcca gccactgcaa gggtcaggag tcaagactca
     4501 gacaggactt tcctagggct tctggatatg ggcaaactga acttaatgag cccatagctg
     4561 cttccttcca gctgcctctg gaatcaaggc cgagcatatc gctggggaag aggggtacaa
     4621 ggtgccagag gaatgggtct ggtcagcaag aaatgagact tgtggtcatg actggcctcc
     4681 ggccttggag aaagatgtaa atcttgtctg aagcagagac tataaagaag tttctccctg
     4741 ctgttaaggg tacattgtta acaagcaaat ggtgtttcgg ttagtaacgg ttctaagtgc
     4801 aatgacttgt gttgaagcct atgtctccca tccttgcctg tagcctgtag tcacttgtgc
     4861 agtgaggaca tctttttcaa taattttttt ttttttcttt tcaaaagaaa aaagtgggaa
     4921 agagccaatc ttaaagcccc aagccatctg agtagtgtta gggttttatg cacttaaggg
     4981 aaaaaaaggt aggtatgtaa atgtctgctg tgagacaacc attcctaatg cagatgcatg
     5041 gtcaaggtgt gtccacctgg agtgctccct gcctttgtct taaagccacc aggaaatggg
     5101 cagggagagg aatgtgggtg cctactctga ctgaggcttg cccggctctc tgagaggagg
     5161 agctcctggg tatttgggag cagatttggg atggactggg ctccagctgt taccatccac
     5221 tcctccttcc aagttgtttc acagtttaat gatagccctg tgaagtagag aagtgaggca
     5281 ggccagttta ggaaacatcc agtggtctgg gtaatctttg aattttaatt ttcctattcc
     5341 cagttaatca ggagttgctg tcctaagagc aggacggcct ccgtgactga aaagcatgca
     5401 ctcatgactg cagggtaaga atgggacaga tagggttgcg gagtggcacc gacagggctg
     5461 tgattgtgtg tggggcatac ctgccccacg tttctatggg gaatgcttat atgacagtga
     5521 gcaggtgaga gttagcaagt cacccatacc cctaacactg ttctgtagga gagacaaaga
     5581 gcagactggc ttctccccat cagtgcattg tgcctgttgt acacccctgg aggagccctg
     5641 aagccagccc aggtggggta cacaatcttt ttaaattcca tatggttgcc agcttatttc
     5701 tttcacttgt ttactgtaat acctggcgtg tttttattta tctaattttg tattcagcta
     5761 taaccatggt agggtagtga gtgtatgaca gtgtgatccc tggtgctgca gtggaccgta
     5821 cttcttttgg acaagatata ctgtgagtct ccctccttac ctctaattgt tttctttccc
     5881 attccctaga ctctttcatc tccttttcta ccctgaccta caactatcat atgcacagtc
     5941 ttctctcttt gtgtgtgact gttacaaatt ttcacttttc aaaattgaaa tcaggtgttt
     6001 gctcaaatga ggggagaatt ttttttttgt tttggtttta tttgttttta atgctgaacc
     6061 ctcggcatag tactttctgt tgttttcccc acaaacccat cagtctggga gagcattggg
     6121 agtggaaatc atgttgcctg ggatgctggt ttctttgtat attatataaa acgtatgtaa
     6181 atgtctctcc atttgggctg gggtttgcat tctcccattg gctaaaagcc aaggggagag
     6241 gccagcgggc aggcggccct caccctgcct ggcacgtgca gagaccccag ccactctgtg
     6301 tgggcagggt gctgtcaaga ccagacctct gggggggagg gtggggggag gggggactct
     6361 tggaagggaa ggagcaccac ttcttcctca agtggagtgt ttacaccttg ctgtaacatt
     6421 tgaactttca caagagatgt aataattttg ataataaaat tcttaaccat
//
