LOCUS       NM_145482               2074 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus SET domain containing 4 (Setd4), transcript variant 1,
            mRNA.
ACCESSION   NM_145482
VERSION     NM_145482.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Yang,S.H., Zeng,Y.Z., Jia,X.Z., Gu,Y.W., Wood,C., Yang,R.S.,
            Yang,J.S. and Yang,W.J.
  TITLE     Activated dormant stem cells recover spermatogenesis in
            chemoradiotherapy-induced infertility
  JOURNAL   Cell Rep 43 (8), 114582 (2024)
   PUBMED   39096488
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Lana-Elola,E., Aoidi,R., Llorian,M., Gibbins,D.,
            Buechsenschuetz,C., Bussi,C., Flynn,H., Gilmore,T.,
            Watson-Scales,S., Haugsten Hansen,M., Hayward,D., Song,O.R.,
            Brault,V., Herault,Y., Deau,E., Meijer,L., Snijders,A.P.,
            Gutierrez,M.G., Fisher,E.M.C. and Tybulewicz,V.L.J.
  TITLE     Increased dosage of DYRK1A leads to congenital heart defects in a
            mouse model of Down syndrome
  JOURNAL   Sci Transl Med 16 (731), eadd6883 (2024)
   PUBMED   38266108
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Huang,X.T., Li,T., Li,T., Xing,S., Tian,J.Z., Ding,Y.F., Cai,S.L.,
            Yang,Y.S., Wood,C., Yang,J.S. and Yang,W.J.
  TITLE     Embryogenic stem cell-derived intestinal crypt fission directs de
            novo crypt genesis
  JOURNAL   Cell Rep 41 (11), 111796 (2022)
   PUBMED   36516755
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Cai,S.L., Yang,Y.S., Ding,Y.F., Yang,S.H., Jia,X.Z., Gu,Y.W.,
            Wood,C., Huang,X.T., Yang,J.S. and Yang,W.J.
  TITLE     SETD4 cells contribute to brain development and maintain adult stem
            cell reservoir for neurogenesis
  JOURNAL   Stem Cell Reports 17 (9), 2081-2096 (2022)
   PUBMED   36027907
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   Bochkis,I.M., Schug,J., Ye,D.Z., Kurinna,S., Stratton,S.A.,
            Barton,M.C. and Kaestner,K.H.
  TITLE     Genome-wide location analysis reveals distinct transcriptional
            circuitry by paralogous regulators Foxa1 and Foxa2
  JOURNAL   PLoS Genet 8 (6), e1002770 (2012)
   PUBMED   22737085
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160993.5.
            
            On Feb 27, 2023 this sequence version replaced NM_145482.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.150989.1,
                                           SRR17253013.4548060.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AC160993.5         112751-113248       c
            499-573             AC160993.5         112322-112396       c
            574-734             AC160993.5         110823-110983       c
            735-830             AC160993.5         108397-108492       c
            831-868             AC160993.5         105483-105520       c
            869-957             AC160993.5         102432-102520       c
            958-1387            AC160993.5         100059-100488       c
            1388-1562           AC160993.5         99096-99270         c
            1563-1644           AC160993.5         97004-97085         c
            1645-1725           AC160993.5         95422-95502         c
            1726-1849           AC160993.5         94364-94487         c
            1850-2074           AC160993.5         92645-92869         c
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.52 cM"
     gene            1..2074
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /note="SET domain containing 4"
                     /db_xref="GeneID:224440"
                     /db_xref="MGI:MGI:2136890"
     exon            1..498
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            499..573
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            574..734
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             665..1984
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /EC_number="2.1.1.364"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 4"
                     /codon_start=1
                     /product="SET domain-containing protein 4 isoform 1"
                     /protein_id="NP_663457.2"
                     /db_xref="CCDS:CCDS28340.1"
                     /db_xref="GeneID:224440"
                     /db_xref="MGI:MGI:2136890"
                     /translation="MQRRRGRTERARKRRRRSSGSRAVNESYRSEFIELRKWLKERKF
                     EDTDLVPASFPGTGRGLMSKASLQEGQVMISLPESCLLTTDTVIRSSLGPYIKKWKPP
                     VSPLLALCTFLVSEKHAGCRSLWKSYLDILPKSYTCPVCLEPEVVDLLPSPLKAKAEE
                     QRARVQDLFTSARGFFSTLQPLFAEPVDSVFSYRAFLWAWCTVNTRAVYLRSRRQECL
                     SAEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEVFICYGPHDN
                     QRLLLEYGFVSVRNPHACVPVSADMLVKFLPAADKQLHRKITILKDHGFTGNLTFGWD
                     GPSWRLLTALKLLCLEAERFTSWKKVLLGEVISDTNEKTSLGVAQKICSDVIEETHAV
                     LRKVSDMKEGTVSLRSQLSLVEALRMEELRILQASAEILSGLLAPFS"
     exon            735..830
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            831..868
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            869..957
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1387
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1562
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1644
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1725
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1849
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2074
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /note="hexamer: AATAAA"
     polyA_site      2074
                     /gene="Setd4"
                     /gene_synonym="C21orf18; ORF21"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgtag gctcgccgca ccgcagccgc tttctccgta gctggtggag cggtctgcgt
       61 ccgtaccccg gcttcgccgc ggtttctaag gtaagcagga gcacttccgg tgggcctggc
      121 gttgcctggg caacgggagc ggggttccgt tggctttttt gagttctgtg tagctccaga
      181 ccccaatttc ctctgcgcgt gtggaacctc tcccggaacg gaagtcagga ccagagcgac
      241 tactgcgcag gcgtggtgtg cggccagcgg gcctgggttg gttcgctggt gcgggtggca
      301 tggattgatt gatgtccggt ccgtccagga ctgcgagcca ggacggcgct gtggcgtgtg
      361 gccatcactg aggccccggt ggcaagcagg gggcagggct gcggtggaac tgcgcgtcct
      421 tgtgcaccac acgtgggctc caggacggac ctggtgcctg gctccagact gactcgtaaa
      481 gcaagtcttg ctgccgaggg cgttttgtta cagagtcctg gcattctttt tacccagagg
      541 caggacccaa aggggtttat cttatgtata aaggtgccca ggcccgtggt tctcgtccag
      601 ctggaaggga gggctgagct gcgagttgtt ctcagctaaa cacagcacag gctccaggga
      661 tagcatgcag agacgaagag gaagaacaga gagggccagg aagagacggc ggcgaagctc
      721 tggttcaaga gcagtaaatg agagctacag atcagaattt atagagctaa gaaaatggct
      781 gaaagaaagg aagtttgaag acacagactt agtacccgcc agctttccag gaacaggaag
      841 agggctgatg agcaaagcgt cgttgcagga gggccaggtg atgatctcac tgcctgagag
      901 ctgtctgctc accacggaca ctgtgattcg aagctcccta gggccctaca ttaagaagtg
      961 gaagcctcct gtgtctcctc tgctggcctt gtgtactttc ttagtctcag aaaagcatgc
     1021 cggctgtcgg tccctctgga agtcttacct ggacatctta cccaagtcat acacctgccc
     1081 ggtgtgtttg gagccggaag tggtagatct tcttcccagc cctttaaagg cgaaggcgga
     1141 agagcagaga gcccgagtgc aggacctgtt tacctccgct agaggcttct tctctaccct
     1201 gcagcctctg tttgcagagc ctgtggacag cgttttcagc taccgagcct tcctgtgggc
     1261 ctggtgcacg gtgaacacca gggctgtgta cctgaggtcc aggaggcagg agtgcctttc
     1321 cgcagagccg gacacgtgtg cgcttgctcc gttcctggac ctgctgaatc acagcccaca
     1381 tgtgcaggta aaagcggcgt ttaacgagaa aaccaggtgc tatgagatta gaacagcctc
     1441 gcgctgtagg aagcaccagg aggtgttcat ctgctacggc ccccatgata accagaggct
     1501 gctcctggag tatggctttg tctccgtccg caatcctcac gcctgcgttc ctgtctcggc
     1561 agacatgctg gttaagttcc tccctgcagc agataagcag ctccacagga agataaccat
     1621 tttgaaggat catggcttta caggaaatct gacgtttgga tgggatgggc cgtcctggag
     1681 gctactcacg gctctcaagt tgctgtgtct ggaagccgag cgcttcacat cctggaaaaa
     1741 ggtgctcctt ggcgaagtca tctccgatac aaacgagaag acaagcttgg gcgtggccca
     1801 gaaaatatgc tctgacgtca tcgaggagac gcacgctgtg ctgcgcaagg tttctgacat
     1861 gaaggaaggg acagtgtcac tgagaagcca gctctccttg gtggaagcct tgaggatgga
     1921 agagcttagg attctccagg cttctgctga gatcctgagt ggcttgctag cccccttttc
     1981 ctgacctccc ggggtcacgt ggttccctcc tatggaggat gtaccagcgg ctgcgtcttt
     2041 actgaggttg gaataaacag acttttatat gaaa
//
