LOCUS       NM_028262               2725 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SET domain containing 3 (Setd3), transcript variant 2,
            mRNA.
ACCESSION   NM_028262
VERSION     NM_028262.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Alganatay,C., Balbasi,E., Tuncbag,N., Sezginmert,D. and Terzi
            Cizmecioglu,N.
  TITLE     SETD3 regulates endoderm differentiation of mouse embryonic stem
            cells through canonical Wnt signaling pathway
  JOURNAL   FASEB J 38 (4), e23463 (2024)
   PUBMED   38334393
  REMARK    GeneRIF: SETD3 regulates endoderm differentiation of mouse
            embryonic stem cells through canonical Wnt signaling pathway.
REFERENCE   3  (bases 1 to 2725)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2725)
  AUTHORS   Diep,J., Ooi,Y.S., Wilkinson,A.W., Peters,C.E., Foy,E.,
            Johnson,J.R., Zengel,J., Ding,S., Weng,K.F., Laufman,O., Jang,G.,
            Xu,J., Young,T., Verschueren,E., Kobluk,K.J., Elias,J.E.,
            Sarnow,P., Greenberg,H.B., Huttenhain,R., Nagamine,C.M., Andino,R.,
            Krogan,N.J., Gozani,O. and Carette,J.E.
  TITLE     Enterovirus pathogenesis requires the host methyltransferase SETD3
  JOURNAL   Nat Microbiol 4 (12), 2523-2537 (2019)
   PUBMED   31527793
  REMARK    GeneRIF: Enterovirus pathogenesis requires the host
            methyltransferase SETD3. SETD3 is essential for in vivo replication
            and pathogenesis in multiple mouse models for EV infection,
            including CV-A10, EV-A71 and EV-D68.
REFERENCE   5  (bases 1 to 2725)
  AUTHORS   Xu,L., Wang,P., Feng,X., Tang,J., Li,L., Zheng,X., Zhang,J., Hu,Y.,
            Lan,T., Yuan,K., Zhang,Y., Ren,S., Hao,X., Zhang,M. and Xu,M.
  TITLE     SETD3 is regulated by a couple of microRNAs and plays opposing
            roles in proliferation and metastasis of hepatocellular carcinoma
  JOURNAL   Clin Sci (Lond) 133 (20), 2085-2105 (2019)
   PUBMED   31654063
  REMARK    GeneRIF: SETD3 is regulated by a couple of microRNAs and plays
            opposing roles in proliferation and metastasis of hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 2725)
  AUTHORS   Wilkinson,A.W., Diep,J., Dai,S., Liu,S., Ooi,Y.S., Song,D.,
            Li,T.M., Horton,J.R., Zhang,X., Liu,C., Trivedi,D.V., Ruppel,K.M.,
            Vilches-Moure,J.G., Casey,K.M., Mak,J., Cowan,T., Elias,J.E.,
            Nagamine,C.M., Spudich,J.A., Cheng,X., Carette,J.E. and Gozani,O.
  TITLE     SETD3 is an actin histidine methyltransferase that prevents primary
            dystocia
  JOURNAL   Nature 565 (7739), 372-376 (2019)
   PUBMED   30626964
  REMARK    GeneRIF: results identify a mammalian histidine methyltransferase
            and uncover a pivotal role for SETD3 and actin His73 methylation in
            the regulation of smooth muscle contractility; data also support
            the broader hypothesis that protein histidine methylation acts as a
            common regulatory mechanism
REFERENCE   7  (bases 1 to 2725)
  AUTHORS   Eom,G.H., Kim,K.B., Kim,J.H., Kim,J.Y., Kim,J.R., Kee,H.J.,
            Kim,D.W., Choe,N., Park,H.J., Son,H.J., Choi,S.Y., Kook,H. and
            Seo,S.B.
  TITLE     Histone methyltransferase SETD3 regulates muscle differentiation
  JOURNAL   J Biol Chem 286 (40), 34733-34742 (2011)
   PUBMED   21832073
  REMARK    GeneRIF: SETD3 is a H3K4/K36 methyltransferase and plays an
            important role in the transcriptional regulation of muscle cell
            differentiation
REFERENCE   8  (bases 1 to 2725)
  AUTHORS   Ishii,H., Mimori,K., Mori,M. and Vecchione,A.
  TITLE     Differentially expressed genes in endothelial differentiation
  JOURNAL   DNA Cell Biol 24 (7), 432-437 (2005)
   PUBMED   16008511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087049.1, BC016123.1 and AK031371.1.
            
            On Nov 17, 2009 this sequence version replaced NM_028262.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031371.1, BC016123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY087049.1         2-71
            71-2720             BC016123.1         1-2650
            2721-2725           AK031371.1         2684-2688
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.23 cM"
     gene            1..2725
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /note="SET domain containing 3"
                     /db_xref="GeneID:52690"
                     /db_xref="MGI:MGI:1289184"
     exon            1..132
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            133..242
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1924
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /EC_number="2.1.1.85"
                     /note="isoform 2 is encoded by transcript variant 2; SET
                     domain-containing protein 3; histone-lysine
                     N-methyltransferase setd3; endothelial differentiation
                     inhibitory protein D10; actin-histidine
                     N-methyltransferase; protein-L-histidine
                     N-tele-methyltransferase"
                     /codon_start=1
                     /product="actin-histidine N-methyltransferase isoform 2"
                     /protein_id="NP_082538.2"
                     /db_xref="CCDS:CCDS26159.1"
                     /db_xref="GeneID:52690"
                     /db_xref="MGI:MGI:1289184"
                     /translation="MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPSPG
                     KEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFK
                     EEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFH
                     LLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYA
                     YFYKVIQTHPHANKLPLKESFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDM
                     CNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSH
                     DRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHSTEPPISAQLLAFLRVFCMTE
                     EELKEHLLGDSAIDRIFTLGNAEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKI
                     VLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAVNREYYRKHMEERAPLPRYEESDLG
                     LLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGENLIPNGTRSE
                     NESLSPEESENVTGEESSGSMAKVKERL"
     exon            243..335
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            336..484
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            485..557
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            558..814
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            815..873
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            874..988
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1063
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1230
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1316
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1477
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2725
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /note="hexamer: ATTAAA"
     polyA_site      2720
                     /gene="Setd3"
                     /gene_synonym="2610102I01Rik; 2610305M23Rik;
                     6030490B17Rik; D12Ertd771e"
                     /note="major polyA site"
ORIGIN      
        1 ggctgccgtc cagcccctcc cgtccggccg ccgccgccac cgccgccgcc gccgcctggg
       61 ggttggttga ggcggacggt ggggtcccgg ccggagtgtg gcgccgccgc tgcgcgaaga
      121 cgaagcgggc agtcagaaaa tgggtaagaa gagtcgagtg aaaactcaga aatcaggtac
      181 tggggctaca gccactgtgt caccaaagga aattttgaac ctgacaagtg agctgttgca
      241 gaaatgtagc agtcctgcac ccagcccagg gaaagaatgg gaagagtaca cgcagatccg
      301 ggctctggtt gagaaaatac ggaagaagca aaaaggtctg tctgttactt ttgatgggaa
      361 aagagaagat tacttccctg atctaatgaa atgggcctct gaaaacgggg cttctgtcga
      421 gggttttgaa atggttaact tcaaagaaga gggctttggt ttgagagcaa caagagacat
      481 caaggcagaa gaattatttt tatgggttcc acgaaagtta ctaatgactg ttgaatctgc
      541 taagaattca gtattggggc ccctgtattc tcaagaccga attctccaag ctatgggaaa
      601 cattgcactg gcctttcatc tgctgtgcga gcgagccagc cccaactctt tctggcagcc
      661 atacattcag accctcccca gtgaatatga cacccctctc tacttcgaag aagaggaagt
      721 acgctgtctt cagtcaacac aagccatcca tgatgtcttc agccagtata aaaacacagc
      781 acgccagtac gcctatttct ataaagtcat ccagacccat cctcatgcca acaaactgcc
      841 cttgaaggag tctttcactt acgaggacta caggtgggcc gtctcatcag ttatgacacg
      901 gcaaaaccaa attcctacag aggatggttc ccgggtgacc ttggctctga ttcctttatg
      961 ggacatgtgc aatcatacca atggcctgat cacaactggc tataacctgg aagatgaccg
     1021 ctgtgagtgt gtggctctgc aggactttca ggctggagat cagatttaca ttttttatgg
     1081 cactcggtca aatgcagagt ttgtgatcca cagtggtttt ttctttgaca ataattccca
     1141 cgacagagtg aaaattaagc tgggcgtgag taaaagtgac aggctctacg ccatgaaggc
     1201 tgaggtcctg gctcgggctg gcatcccaac atccagtgtt tttgcgttgc attccactga
     1261 gccgcccatc tctgcccagc ttctagcttt tctccgagta ttctgcatga ccgaagagga
     1321 gctgaaagag catttgctag gggacagcgc cattgacagg atcttcactc tggggaacgc
     1381 agagtttcct gtcagctggg acaatgaggt caaactttgg acatttctgg aagatagagc
     1441 ctcacttctt ttaaaaacat ataagacaac aattgaggaa gataagatcg tcttgaaaaa
     1501 tcctgacctc tctgtccggg ccacaatggc catcaaattg cgcttgggtg aaaaggagat
     1561 tttggaaaaa gcagtgaaga gtgcggccgt gaaccgggag tactaccgta aacacatgga
     1621 ggagagggca ccactgccca gatacgagga gagtgacctg gggctcttgg agggtggtgt
     1681 gggggactca aggctccctc tggtcctgag aaagttggag gaggaagcag gtgtgcagga
     1741 gtctctgagc ctcacagaga ctgtcagcaa agtcaaggct gctgaaaatg ggcttgtcaa
     1801 tggggaaaac ttgatcccta atgggaccag gtctgaaaat gaaagcttaa gcccagaaga
     1861 aagtgaaaac gtgactggag aagagtcttc aggcagcatg gccaaggtga aggagcgact
     1921 ttgagatgct catggaatcc agtcgagcag aagtttcgga cagcccacca catcaccatg
     1981 ttccttgtta acatttttct tttcgcagag aggaaaatat gtttttgctg ctttatataa
     2041 aagtgatttt taagttattt taaagatcta gcttccctat ttgattaaga ttgccatctt
     2101 gcttttgggc agaaaaaagt agtgaatagc agcggagaaa agaggaggca cccttgaatg
     2161 actgcagacc agctgtgggc actcgctgct cctccaggaa agggtgaggt ccgtgctcag
     2221 ctatgcttgc aggcctgctg tcctcactcc agaatgagtg ctggctctgc ctctggctgc
     2281 agagttgagg ttggactctg gagtggatgg tggagatgag gcacagtgga gagaaagctg
     2341 ggctaggcca ttgaaataga ggctgggttt tttaataaga atatccccag taccaaaaga
     2401 aaaggtgagg tggcaacctg atttctaatg gcttaaaatg ttgatgatga tcctaattac
     2461 ataaacacac acatatatct agtgatttct aaggatttgt ttactttttg tgttctgttt
     2521 tgctgtatta aaaacttgtc cttttcctta aatcaaagta ggactcgagt cctcgttttt
     2581 cacgctggct ttgtttcaga ggtatactga ctccagtggt gtcaggatga ggtggcccct
     2641 ggctttctgg ttcacaacaa gctagagatt ttcaaagcta cccttttgag taaaacccct
     2701 tattaaaaga gaaaccatga ctggt
//
