LOCUS       NM_001081340            8410 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus SET domain containing 2 (Setd2), mRNA.
ACCESSION   NM_001081340 XM_895138
VERSION     NM_001081340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8410)
  AUTHORS   Mitome,T., Wakui,H., Azushima,K., Uehara,T., Jikuya,R., Ohtake,S.,
            Noguchi,G., Kawaura,S., Iribe,Y., Aomori,K., Tatenuma,T., Ito,H.,
            Kawahara,T., Komeya,M., Ito,Y., Muraoka,K., Furuya,M., Kato,I.,
            Fujii,S., Nagahama,K., Nishiyama,A., Tamura,T., Kimura,Y.,
            Kawagoe,T., Mizuki,N., Huang,G., Uemura,H., Yao,M., Makiyama,K.,
            Tamura,K. and Hasumi,H.
  TITLE     SETD2 regulates SLC family transporter-mediated sodium and glucose
            reabsorptions in renal tubule
  JOURNAL   Biochem Biophys Res Commun 734, 150730 (2024)
   PUBMED   39366177
  REMARK    GeneRIF: SETD2 regulates SLC family transporter-mediated sodium and
            glucose reabsorptions in renal tubule.
REFERENCE   2  (bases 1 to 8410)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8410)
  AUTHORS   Chen,S., Liu,D., Chen,B., Li,Z., Chang,B., Xu,C., Li,N., Feng,C.,
            Hu,X., Wang,W., Zhang,Y., Xie,Y., Huang,Q., Wang,Y., Nimer,S.D.,
            Chen,S., Chen,Z., Wang,L. and Sun,X.
  TITLE     Catalytic activity of Setd2 is essential for embryonic development
            in mice: establishment of a mouse model harboring patient-derived
            Setd2 mutation
  JOURNAL   Front Med 18 (5), 831-849 (2024)
   PUBMED   39115793
  REMARK    GeneRIF: Catalytic activity of Setd2 is essential for embryonic
            development in mice: establishment of a mouse model harboring
            patient-derived Setd2 mutation.
REFERENCE   4  (bases 1 to 8410)
  AUTHORS   Chen,L., Liu,J., Chen,K., Su,Y., Chen,Y., Lei,Y., Si,J., Zhang,J.,
            Zhang,Z., Zou,W., Zhang,X., Rondina,M.T., Wang,Q.F. and Li,Y.
  TITLE     SET domain containing 2 promotes megakaryocyte polyploidization and
            platelet generation through methylation of alpha-tubulin
  JOURNAL   J Thromb Haemost 22 (6), 1727-1741 (2024)
   PUBMED   38537781
  REMARK    GeneRIF: SET domain containing 2 promotes megakaryocyte
            polyploidization and platelet generation through methylation of
            alpha-tubulin.
REFERENCE   5  (bases 1 to 8410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 8410)
  AUTHORS   Edmunds,J.W., Mahadevan,L.C. and Clayton,A.L.
  TITLE     Dynamic histone H3 methylation during gene induction: HYPB/Setd2
            mediates all H3K36 trimethylation
  JOURNAL   EMBO J 27 (2), 406-420 (2008)
   PUBMED   18157086
REFERENCE   7  (bases 1 to 8410)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 8410)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 8410)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8410)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132103.3.
            
            On Feb 3, 2022 this sequence version replaced NM_001081340.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC132103.3         113698-113911       c
            215-230             AC132103.3         101135-101150       c
            231-4516            AC132103.3         94956-99241         c
            4517-4648           AC132103.3         93216-93347         c
            4649-4777           AC132103.3         90034-90162         c
            4778-4901           AC132103.3         85211-85334         c
            4902-4979           AC132103.3         83436-83513         c
            4980-5077           AC132103.3         81782-81879         c
            5078-5204           AC132103.3         78616-78742         c
            5205-5339           AC132103.3         76639-76773         c
            5340-5459           AC132103.3         74384-74503         c
            5460-6122           AC132103.3         72176-72838         c
            6123-6171           AC132103.3         56014-56062         c
            6172-6352           AC132103.3         53871-54051         c
            6353-7022           AC132103.3         51690-52359         c
            7023-7157           AC132103.3         47197-47331         c
            7158-7297           AC132103.3         44188-44327         c
            7298-7409           AC132103.3         42219-42330         c
            7410-7490           AC132103.3         31500-31580         c
            7491-7592           AC132103.3         28915-29016         c
            7593-8410           AC132103.3         27815-28632         c
FEATURES             Location/Qualifiers
     source          1..8410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.0 cM"
     gene            1..8410
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /note="SET domain containing 2"
                     /db_xref="GeneID:235626"
                     /db_xref="MGI:MGI:1918177"
     exon            1..214
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..7754
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /EC_number="2.1.1.359"
                     /note="lysine N-methyltransferase 3A; SET
                     domain-containing protein 2; protein-lysine
                     N-methyltransferase SETD2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD2"
                     /protein_id="NP_001074809.2"
                     /db_xref="CCDS:CCDS40781.2"
                     /db_xref="GeneID:235626"
                     /db_xref="MGI:MGI:1918177"
                     /translation="MKPLPSQQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKG
                     PVFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSFTKKTLQNRFLTALSNEKQSDSP
                     NSPAPPLQVDSNPKVKMDAGDTFPATEESSPPKSRVELGRIHFKKHLLHVTSRPQLAA
                     STTAASPLPPTTQLPAVLAESMIDSPPSSPPPPPPPPQASSPSPPAQISEPVALPQPP
                     ATALMTSPPGPLPGDVAVRAQKESPVKSGPEVLEVDTKQDIVSNSLEEHTVQTLKEQA
                     DHLLQKEDSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSS
                     QRSHDLKSSTSIDKERDFKKSSAPSKSEDLGKSSRSKTERDDRYCSYSKLERDTRYVS
                     SRCRSERDRRRSRSRSRSDRASRTSLSYSRSERSHYYDSERRYHRSSPYRERTRYSRP
                     YTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTETSYLEMERRG
                     KYTSKLERESKRTSEHETIKRCCSPPNELGFRRGSSYSKHDNSTSRYKSALSKSISKN
                     DKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKISEREKTGSPTPSNQLNDS
                     PTFKKLDESPVLKPEFIGHDGRESIKELELSKVKNDQLRNFCSIELNVNGSPETEADV
                     ATFCTSKTDAISMTSDDSVTGSEVSPLIKACMLSSNGFQNVGRCRERDSDDTCRQHNT
                     SKSPFREMEPLLSPHHDKLMSLPVKTIDYPKTLIKEPVDKRHSCCKTKDSDIYCSPNE
                     NPEAENAEPSAMTISSHSFVNVHLESKTVICDNREPTDRHSENTCDEYKQSIGSTSSA
                     SHNHFDGLYEPIGSSGISSLQSPPSGIRCEENTSPTLDAVESKKGIDFLKYARKETDV
                     GSALPDSGKGFSWENRHNNVLSGQSLQEAQEEGNSILHERRGRPEIPLDEEQRGHTHI
                     SDDSEVVFPYDLNLTMEDSDGITYTLKCDSSGNAPEIVSTVHEDYSGSSASSSDESDS
                     EDTESDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYKHYSDRWEDGLETRR
                     HAYEEEYESKGCSQTEKYFLHKGTERSAESCYSQFGRKADNHLPDIAHAQSDGVDSTS
                     QTDSRSDHLGHLNPEDTLRAKTSRPQELPVYSDDFEDLPNKSRQQMIFSNRPDSSRLG
                     KTELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQ
                     STEHYGGTHNYWQGNGYWDPRSAGRPPGTGLAYDRIQGQVPDSLTDDREEEEHWDQRS
                     GSHFSSPSNKFFFHQKDKGSVQAPEISSNSIKDALVMNERKDFSKNFEKNDIKERGPP
                     KKRRQELESDSESDGELQARKKVRVEMEQGESSVPQHSELMGPSCAMDDFRDPQRWKE
                     FAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEVACGEDC
                     LNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLE
                     YCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCE
                     TQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENR
                     VSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKL
                     TCLKLIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIP
                     TKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPSTEM
                     DTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVEEDEELQSQ
                     QLLPQQLCESKVESEATIEVSKLPTSEPEADTETEPKDSNGTKLEETIAEETPSQDEE
                     EGVSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVAERGR
                     DAAAFRDQTAPKTPNRSRERDPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDT
                     PTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNA
                     SHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTESL
                     AAPPSVPVVPHVAASVEVSSSQYVAQNESVVHQDSNVPVMPVQAPGPVQGQNYNVWES
                     NQQSVSVQQQYSPAQSQTTIYYQGQTCSTVYSVTSPYSQTTPPIVQSYAQPSLQYIQG
                     QQIFTAHPQGVVVQPTAAVTSIVAPGQPQSLQPPEMVVTNNLLDLPPPSPPKPKTIVL
                     PPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPM
                     KTSKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKH
                     LARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE"
     exon            215..230
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            231..4516
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4648
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..4777
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..4901
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..4979
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5077
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5204
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5339
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5459
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            5460..6122
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            6123..6171
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            6172..6352
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            6353..7022
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7023..7157
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7158..7297
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7298..7409
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7410..7490
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7491..7592
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            7593..8410
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8364..8369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /note="hexamer: AATAAA"
     regulatory      8374..8379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /note="hexamer: ATTAAA"
     polyA_site      8379
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
     polyA_site      8389
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
                     /note="major polyA site"
     polyA_site      8410
                     /gene="Setd2"
                     /gene_synonym="4921524K10Rik; KMT3A"
ORIGIN      
        1 gggccagcca gccagccagc gacgccggcc gcccctgccg ccgccgcgat cggaccagcg
       61 gccgcctccc ctccggtccc ctcccccgca tcggcctgcc gcggggaggg ggctagcgtc
      121 gccgcctcca gccgctcctc atgaagccgc tgccgtcgca gcagccgcca ccgaagatgg
      181 gggatttcta cgatcccgag cacccgaccc ctgaagaaga agaaaatgag gcaaagattg
      241 aaaatgtgca gaaaacaggt ttcatcaaag gaccagtgtt caaaggtgtt gcttcaagtc
      301 gatttttgcc caaaggcacg aagacaaaag ttaatttgga ggaacaggga cggcaaaagg
      361 tgtcattcag cttcagtttt acaaagaaaa ctttacagaa tagatttctc actgcgctta
      421 gcaatgaaaa gcaaagtgat tctccaaact ccccagctcc ccctcttcaa gtagactcaa
      481 accctaaagt taaaatggac gctggagata cttttcctgc tacagaagaa tcttcgccac
      541 caaaatcgag agtggaattg ggcagaattc attttaagaa acatttgctt catgtgacat
      601 ctaggccaca gctggctgca agtacaacag cagcatctcc ccttcctcct acaacacagt
      661 taccagcagt cttagcagag tcgatgatag actcaccacc ttcatctcca cccccacctc
      721 ctccacctcc ccaggcctca tcaccctcac caccagcaca gatatcagag ccagtggcct
      781 tgccgcaacc cccagcaaca gcactaatga catcaccacc aggaccttta ccaggagacg
      841 tagccgtgag agctcagaaa gaatcaccag ttaaaagtgg acccgaagtt ttagaggtgg
      901 atacaaagca agatattgta tctaatagtt tggaagaaca cacagttcaa actttgaagg
      961 aacaagcaga tcatctcctg caaaaagaag attcccatat tgggaaggaa gaagaggttt
     1021 cagatggctc taagataagc ctcagttcta aaaaagcaag ttctaagaag aaatcttcac
     1081 aatttgaagg cacatttctt ggttcagagt ctgatgaaga ttctgtacgg acttcttcca
     1141 gtcaaagatc acatgattta aaatcttcaa caagcattga caaggaaaga gattttaaga
     1201 agagctcagc accttcaaaa agtgaggatt tggggaaatc atcaagatcg aaaacagaga
     1261 gagatgatag atattgtagc tactcaaaac ttgaacgaga tactcggtat gtatcttccc
     1321 gatgtcggtc cgaaagagat cgaaggcgaa gccgatctcg ttctagatct gacagagcct
     1381 ctagaactag tttgtcttat tctcgctcag aaagatctca ttattatgat tctgaacggc
     1441 gctaccatag gagttcccct tatcgtgaga ggacacgcta ttctcggcca tatactgata
     1501 acagggcacg ggagagctca gactctgaag atgagtataa gaagacatac ccacggcgta
     1561 cctcagccca ttcctacaga gacctaagga catcatcatc ttactctaaa tttgatcggg
     1621 actgtaaaac tgagacctct tacttagaga tggagagaag aggaaagtat acttcaaaac
     1681 tagaaagaga atccaaacgg acttcagagc atgaaaccat aaaaagatgt tgttctcccc
     1741 caaatgaact gggattccga cgggggtcat catattccaa gcatgataac agtacttccc
     1801 gttataaatc tgccctttca aaatctatat ccaagaatga taaatttaaa aattctttct
     1861 gttgtacaga attaaatgag gaaaacaaac aatctcattc gtttagtttg cagactcctt
     1921 gttcaaaagg tagtgaatta agaacaatta ataagatttc tgaaagagaa aagactgggt
     1981 ctccaactcc atcaaatcaa ttaaacgatt cacctacttt taaaaagcta gatgaatctc
     2041 ctgttcttaa gcctgaattt ataggacacg atggccgtga aagtattaaa gaattggagt
     2101 tatcaaaagt gaaaaatgat caattaagaa atttttgttc cattgaatta aatgtaaacg
     2161 gatctccaga gacagaagct gatgtggcaa cattttgtac ttctaagaca gatgctatat
     2221 caatgacttc tgatgatagt gtgactggat cagaggtatc ccctttgatc aaggcttgca
     2281 tgctttcatc aaatggattt cagaatgttg gtagatgcag agaaagggac tcagatgata
     2341 cttgtaggca gcataatacg tcaaaaagtc catttaggga aatggaacct ttgttgtcac
     2401 cacaccatga taaactcatg tctttgccag ttaagactat agattatccc aaaacattaa
     2461 ttaaagaacc agttgataag agacattctt gctgcaaaac caaagattca gatatatact
     2521 gttctccaaa tgaaaaccct gaagctgaga acgctgaacc ttcagctatg acgatttctt
     2581 cacatagctt tgtgaatgtg catttggaat ccaagacagt tatatgtgat aatagggagc
     2641 cgacagaccg gcactcagag aatacatgtg atgaatataa gcagagcatt ggtagcacta
     2701 gttcagcttc tcataaccat tttgatggtt tgtatgagcc tatagggagt tcaggtattt
     2761 catctctcca gagtcctccg tcaggaataa gatgtgaaga aaacacatct ccaactctag
     2821 atgcagtgga gagtaaaaaa ggcatagatt ttttaaagta tgcacggaaa gaaacagatg
     2881 ttggtagtgc ccttcctgat tcaggaaaag gattttcttg ggaaaacagg cataataatg
     2941 tgttatctgg gcagtctttg caagaggctc aagaagaagg gaattccata ttgcatgaga
     3001 gaagaggaag accagaaatc cccttagatg aggaacaaag aggccataca catatttctg
     3061 atgattcaga agtggtattt ccttatgatt tgaacttgac catggaagac agtgatggta
     3121 taacctacac cttaaaatgt gatagtagtg gaaatgctcc agagattgta tctactgtcc
     3181 atgaagacta ttctggatct tctgcaagtt caagcgatga aagtgattct gaagatacag
     3241 agtctgatga tagcagtatt ccaagaaacc gactccagtc tgttgtggtt gtgccaaaga
     3301 attctacttt gcccatggaa gagacaagtc cctgttcttc tcggagcagt cagagctaca
     3361 aacattattc tgaccgctgg gaagatggat tagagaccag gagacatgca tatgaggaag
     3421 agtatgagag taaaggctgt tctcaaactg aaaaatactt ccttcataaa ggaacagaga
     3481 gaagtgcaga aagttgttat tcacagtttg gcaggaaagc agataatcac ctgcctgaca
     3541 ttgctcatgc tcagagtgac ggggttgata gtacaagtca gacagactcg agatctgacc
     3601 atctaggtca cctgaatcca gaggacacat taagagccaa aacatctagg ccacaagagc
     3661 taccagttta ttctgacgat tttgaagatc tcccaaataa gtctcggcag cagatgattt
     3721 tctctaatcg gccagatagt agtagactag gaaaaacaga gctgagtttt tcttcctctt
     3781 gtgacatttc ccgaatggat ggcttgcact catcagaaga gctcagaaac ctagggtggg
     3841 acttttccca acaggaaagg cccaccacca cataccagca gcctgacagc agctatggaa
     3901 cctgtggtac acataagtat caacaaagta ctgaacacta tggtgggacc cataattact
     3961 ggcaaggcaa tggctattgg gatccaagat cagcaggtag acctccagga actgggcttg
     4021 cttatgatcg aatccaaggg caagtaccag attctctaac agacgatcgt gaagaagagg
     4081 aacattggga tcaacgaagt ggatcacatt tttcaagccc gtccaataaa tttttcttcc
     4141 atcagaagga caagggatca gtgcaagcac cggaaataag cagcaattca attaaagacg
     4201 ctttagttat gaacgaaagg aaagattttt cgaaaaactt tgaaaaaaat gatataaaag
     4261 agagagggcc tcctaaaaaa cgaaggcaag agttggagag tgattctgaa agtgatggtg
     4321 aactacaggc tagaaagaaa gttagagtgg agatggagca gggagaatca tctgtgcccc
     4381 agcactcaga actgatgggg ccttcgtgtg ctatggatga cttcagggac ccacagcggt
     4441 ggaaagaatt tgccaagctg gggaagatgc catgttactt tgatcttatt gaagaaaatg
     4501 tttatttaac agaaaggaag aagaacaaat cccaccggga tattaagcga atgcagtgtg
     4561 agtgtacacc tctttctaag gatgaaagag ctcaaggtga agtagcatgt ggagaagatt
     4621 gccttaatcg tctcctcatg attgaatgtt cctctcgatg tccaaatgga gattactgtt
     4681 caaacagacg gtttcagaga aaacagcatg cagatgtaga agtcatactt acagaaaaga
     4741 aaggctgggg cttaagggct gctaaggatc ttccttcgaa cacctttgtc ctggaatact
     4801 gtggagaggt acttgatcat aaagagttta aagctcgggt gaaagaatat gcacggaaca
     4861 aaaacatcca ctactacttc atggccctga aaaatgacga gataatagat gccactcaaa
     4921 aagggaattg ctctcgtttc atgaatcata gctgtgaacc aaactgtgaa acccagaaat
     4981 ggactgtgaa tggacagctg agggttggat tttttaccac caaactagtt ccttcaggct
     5041 cagaattaac ttttgactac cagttccaaa gatatggcaa agaagctcag aagtgtttct
     5101 gtgggtcagc caactgccgg ggctacttgg gaggagaaaa cagagtcagt atcagagctg
     5161 caggagggaa gatgaaaaag gaacgctctc gaaagaagga ttcagtggat ggagaacttg
     5221 aagcactgat ggaaaatggt gaaggcctct ctgataagaa ccaggttctt agtttatccc
     5281 ggctcatggt tagaattgaa actttggaac agaaacttac ctgtcttaag ctcattcaga
     5341 acacacactc acagtcctgc ctcaagtcat ttctggaacg tcatgggttg tcactgttgt
     5401 ggatctggat ggcagagctt ggcgacggcc gggaaagtaa ccagaagctt caggaagaga
     5461 ttataaagac tttggagcat ttgcccattc ctactaaaaa tatgttggaa gaaagcaaag
     5521 tacttccaat tattcagcgc tggtctcaaa ctaagactgc tgttcctcag ttaagtgaag
     5581 gagacgggta ttctagtgag aatacatcac gtgctcacac accgcttaat acaccggacc
     5641 cttctgccaa gccgagcacg gaaatggata cagatactcc caagaaactc atattccgca
     5701 gactgaagat tataagtgaa aatagcatgg acagtgcagt ctcggacgtc actagtgagc
     5761 tagaatgcaa ggatggcaaa gaggaccttg atcagttaga gactgtcact gtggaagagg
     5821 atgaagagct gcagtcccag cagctcctcc cacagcagct gtgcgagtcc aaagttgaga
     5881 gtgaagccac tattgaagtc agtaagttac ccacatctga accggaggca gacacggaga
     5941 cagagcccaa agacagcaat ggcacaaaac tagaagaaac tattgctgag gaaacaccat
     6001 cccaagatga agaagaggga gtgtctgatg ttgaaagtga gagaagccag gagccaccag
     6061 ataaaacagt ggatataagt gatttggcta ccaagttact agacagttgg aaagatctaa
     6121 aggaggtgta tcggattcca aagaaaagtc aaactgaaaa ggagagcaca gtagctgaac
     6181 gaggaagaga tgctgctgcc ttcagagatc aaacagctcc aaagactcct aacaggtcta
     6241 gagagagaga cccagacaag cagtctcaaa ataaagagaa aaggaaacga cggggctctc
     6301 tgtcaccacc ctcttctgca tatgagcggg gaacaaaaag gccagatgac agatatgata
     6361 caccaacttc taaaaagaaa gtacgaatta aagaccgaaa caaactttct acagaggagc
     6421 gcaggaagtt gtttgaacaa gaggtggcac agagggaagc tcagaagcaa cagcaacaga
     6481 tgcagaactt ggggatgaca tcaccactcc cctttgactc tctgggatat aatgcctctc
     6541 atcacccctt tgctgggtac ccaccaggtt accccatgca agcctatgtg gatcccagca
     6601 accctaatgc tggaaaggtg cttctgccca cacctagcat ggaccctgtg tgctcccctg
     6661 ctccttatga tcacgctcag cccttggtag gacattctac agaatccctt gctgctcccc
     6721 catctgtgcc agtggtgccg catgtggcag cctctgtgga agtttccagt tctcagtatg
     6781 tagctcagaa tgaaagtgtt gtacaccaag actccaatgt tcctgtaatg ccagtacaag
     6841 ctccaggccc agtccaagga cagaattaca atgtctggga gtcaaaccaa cagtctgtca
     6901 gtgtacaaca gcagtattct cctgcacaat ctcaaacaac catatattat caaggacaga
     6961 catgttcaac tgtctatagt gtgacctcgc cttattcaca gacaactcct ccaattgtgc
     7021 agagttatgc ccagccaagt cttcagtata tccagggaca gcagattttc acagctcacc
     7081 cacaaggagt ggtggtacag ccaactgcag ccgtgacttc aatagttgca ccagggcagc
     7141 ctcagtcctt acagccacct gaaatggttg taacaaataa tctactggac ctgccaccac
     7201 cctcccctcc aaaaccaaaa acgattgttt tacctcccaa ctggaagaca gcccgagacc
     7261 ctgaggggaa gatctactac taccacgtga tcacaagaca gactcagtgg gatcctccta
     7321 cttgggaaag cccaggagat gatgccagcc ttgagcatga agctgaaatg gacctgggaa
     7381 ccccaaccta tgatgaaaac cccatgaaga catcaaaaaa gcccaagaca gcagaagcag
     7441 acacctccag tgagctggca aagaaaagca aagaagtatt cagaaaagag atgtctcagt
     7501 tcattgtcca gtgcctgaat ccttaccgga aacctgactg caaggtgggc aggatcacca
     7561 ccactgaaga tttcaagcac ctcgcccgaa agctgactca tggagttatg aataaggagc
     7621 tgaagtactg taagaacccc gaggacctgg agtgcaatga gaatgtgaaa cacaaaacca
     7681 aggagtacat caagaagtac atgcagaagt ttggggctgt ttacaaacct aaagaggaca
     7741 ctgaactaga gtgacctcag gccagagtgg agtatgagcg gaaaggatga atcctgtggc
     7801 ttctgcccta ccccacggcc aaggctgtgc tactgatgtg atgacccacc atcctgagca
     7861 gttcaaacct gcaggtgtca gctgtaagct gcaaaagtga gctctgtctc caaatgaccc
     7921 ctagttgtga gctgttggtg taacagttac aggccatcag aggcagtagc ctagggaaga
     7981 ccttggccac acgaccccat tctcaaatct gggtctcccc cttggcggtg ctgtcagcgc
     8041 acagacccat gcgcacctcc cccagatcct ttaccctgac aatatgtatt atattttaat
     8101 gtatatgtga agatattgaa aataatttgt ttttcctggt ttttgttctg tttttgtttg
     8161 ctgttagcat ctatgtgctg gaatcaagga aagactttgt gaggatagta taaattctcc
     8221 tgcaaggttg gatttgttat catgtaaata tcccaacgca ggctgccttg tggtttggcc
     8281 gccttgtgct atgttgataa gattgattta ctgcttcaga tcactttact ttatccaatt
     8341 tttactgaac tttttatgta aaaaataaaa tcaattaaag aacttggaat gtgtgctccc
     8401 tcaaaattaa
//
