LOCUS       NM_001040398            8868 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SET domain containing 1B (Setd1b), mRNA.
ACCESSION   NM_001040398 XR_001549 XR_005169
VERSION     NM_001040398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8868)
  AUTHORS   Bilmez,Y., Talibova,G. and Ozturk,S.
  TITLE     Expression of the histone lysine methyltransferases SETD1B, SETDB1,
            SETD2, and CFP1 exhibits significant changes in the oocytes and
            granulosa cells of aged mouse ovaries
  JOURNAL   Histochem Cell Biol 158 (1), 79-95 (2022)
   PUBMED   35445296
  REMARK    GeneRIF: Expression of the histone lysine methyltransferases
            SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the
            oocytes and granulosa cells of aged mouse ovaries.
REFERENCE   2  (bases 1 to 8868)
  AUTHORS   Michurina,A., Sakib,M.S., Kerimoglu,C., Kruger,D.M., Kaurani,L.,
            Islam,M.R., Joshi,P.D., Schroder,S., Centeno,T.P., Zhou,J.,
            Pradhan,R., Cha,J., Xu,X., Eichele,G., Zeisberg,E.M., Kranz,A.,
            Stewart,A.F. and Fischer,A.
  TITLE     Postnatal expression of the lysine methyltransferase SETD1B is
            essential for learning and the regulation of neuron-enriched genes
  JOURNAL   EMBO J 41 (1), e106459 (2022)
   PUBMED   34806773
  REMARK    GeneRIF: Postnatal expression of the lysine methyltransferase
            SETD1B is essential for learning and the regulation of
            neuron-enriched genes.
REFERENCE   3  (bases 1 to 8868)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8868)
  AUTHORS   Greulich,F., Wierer,M., Mechtidou,A., Gonzalez-Garcia,O. and
            Uhlenhaut,N.H.
  TITLE     The glucocorticoid receptor recruits the COMPASS complex to
            regulate inflammatory transcription at macrophage enhancers
  JOURNAL   Cell Rep 34 (6), 108742 (2021)
   PUBMED   33567280
REFERENCE   5  (bases 1 to 8868)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8868)
  AUTHORS   Lee,J.E., Wang,C., Xu,S., Cho,Y.W., Wang,L., Feng,X., Baldridge,A.,
            Sartorelli,V., Zhuang,L., Peng,W. and Ge,K.
  TITLE     H3K4 mono- and di-methyltransferase MLL4 is required for enhancer
            activation during cell differentiation
  JOURNAL   Elife 2, e01503 (2013)
   PUBMED   24368734
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8868)
  AUTHORS   Bi,Y., Lv,Z., Wang,Y., Hai,T., Huo,R., Zhou,Z., Zhou,Q. and Sha,J.
  TITLE     WDR82, a key epigenetics-related factor, plays a crucial role in
            normal early embryonic development in mice
  JOURNAL   Biol Reprod 84 (4), 756-764 (2011)
   PUBMED   21123813
REFERENCE   8  (bases 1 to 8868)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   9  (bases 1 to 8868)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8868)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AK141316.1, CF536496.1,
            AC158114.8, BC038367.1 and AI463740.1.
            
            On Jul 20, 2012 this sequence version replaced NM_001040398.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. There are no
            full-length transcripts supporting this RefSeq in mouse; however,
            it is predicted based on partial transcript alignments and on
            full-length transcript support from the human homolog (GeneID:
            23067, JF813787.1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-972               AK141316.1         1-972
            973-1354            CF536496.1         206-587
            1355-2139           AK141316.1         1355-2139
            2140-2922           AC158114.8         150313-151095
            2923-7663           BC038367.1         1-4741
            7664-8702           AC158114.8         165914-166952
            8703-8868           AI463740.1         361-526
FEATURES             Location/Qualifiers
     source          1..8868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.8 cM"
     gene            1..8868
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /note="SET domain containing 1B"
                     /db_xref="GeneID:208043"
                     /db_xref="MGI:MGI:2652820"
     exon            1..262
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            263..447
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..6234
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /EC_number="2.1.1.364"
                     /note="SET domain-containing protein 1B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD1B"
                     /protein_id="NP_001035488.2"
                     /db_xref="CCDS:CCDS59684.1"
                     /db_xref="GeneID:208043"
                     /db_xref="MGI:MGI:2652820"
                     /translation="MENSHPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHH
                     KLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPK
                     QVTFAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAV
                     QHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQ
                     LSDALKRLKDGSLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPITP
                     RLGTPFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTDAYNRRHEHHYVHNSAV
                     AGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASGFKSAFSPYQ
                     TPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPPGPPPPDS
                     NSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFL
                     REQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSSTGLEDISPT
                     PLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEGQQ
                     SSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLP
                     PPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFP
                     PGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASA
                     GLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYIPRQEDPHKATVDGVL
                     LVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPK
                     PKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRL
                     RPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLELDSGGEEDEKE
                     SLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEEEEEEEEEAEEEEEEGPRSR
                     ISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITT
                     SKAPAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKET
                     AMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPE
                     MQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEH
                     GPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEPPPEDH
                     PPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGL
                     SSGGLPRTPGRDFSFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLP
                     LPLPLPLPLALPVPVLRAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSL
                     DGPLVRPPPGPALGRDLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQP
                     PPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRRPPKKR
                     HEDLVAPSASPEPSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQ
                     DNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYLN
                     SSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLK
                     FRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSS
                     YMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEI
                     TYDYKFPIEDVKIPCLCGSENCRGTLN"
     exon            448..546
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            547..817
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            818..930
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2139
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2964
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3226
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3576
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3691
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..4243
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..5503
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            5504..5670
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5802
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            5803..5922
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            5923..6060
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     exon            6061..8858
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8808..8813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /note="hexamer: ATTATA"
     polyA_site      8832
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
     regulatory      8838..8843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /note="hexamer: AATATA"
     polyA_site      8858
                     /gene="Setd1b"
                     /gene_synonym="KMT2G; mKIAA1076"
                     /note="major polyA site"
ORIGIN      
        1 actcgggtcg ggctccttag cggtgtattg tgggatgtgc ggctactggg agccgagcct
       61 ccgccgccag ccgcctcccg ggcagcagca gcagcagcag cggcggcggc agcagcaagg
      121 gcagcggcag ctcggggccc ggcagccgct aaggcggcgt cccccccatc ccggcccccg
      181 gtccggccgc cccggcctcg gctcccgcgg gggacaccat gtactggctg gcggcgcagg
      241 gaggccggcg cccggcgggg atgttgggtt aacggcatgg agaacagtca cccccaccac
      301 caccaccagc agcccccgcc gcagcccggc ccttcgggcg agaggaggaa ccaccattgg
      361 agaagttaca agttgatgat tgacccggct ctgaaaaagg ggcaccataa actgtaccgc
      421 tacgatgggc agcatttcag cctggccatg tccagcaacc gcccggtgga gatcgtggaa
      481 gatccccggg tggtcggaat ctggaccaaa aacaaggagc tggagctgtc tgtgcccaaa
      541 ttcaagatcg atgagttcta cgtgggccct gtgcctccaa agcaggtgac atttgccaag
      601 ctgaatgaca acgtccgtga aaacttccta agggacatgt gcaaaaagta tggggaggtg
      661 gaggaggtgg agatcttgta taacccgaag accaagaaac acctgggcat tgccaaggtg
      721 gtctttgcca cagtcagggg cgccaaggag gccgtccaac acctgcacag cacttctgtc
      781 atgggcaaca ttatccacgt ggagctggac accaaagggg aaactcgcat gcgcttctac
      841 gagctgttgg tcaccggccg gtacacccct cagaccctcc ctgttggtga gctggatgct
      901 atttctccga ttgtgagcga gaccctgcag ctatcagatg ctctgaagcg cctcaaagat
      961 ggcagcctgt ctgcaggctg cggctctggc tcctcgtcag tcacccccaa tagcggtggg
     1021 acccccttct cccaagacac agcttactcc agctgccgcc tggacacacc caactcctat
     1081 ggacaaggca ccccaatcac gcctcgcctg ggcacccctt tctcccagga ttccagctac
     1141 tccagccgtc agcccacacc ctcctatctc ttcagccagg accccacagc cacattcaag
     1201 gcgaggcggc acgagagcaa gttcacagat gcctacaacc gccgccacga acatcattat
     1261 gtccacaact cagcggtggc tggagccaca gctcctttcc gaggctcctc ggacctctct
     1321 tttgggacag ttggcagcag cgggactccc ttcaaggctc agtcgcagga tgccaccacg
     1381 tttgcccata ctccacctcc tgcccaaaca gccacggctt ctggattcaa atcagctttc
     1441 tctccatatc agactccagc accccccttc ccgccacccc ctgaggagcc caccgccaca
     1501 gcagcctttg ggagccgcga cagtggggag ttccggaggg cacctgcgcc cccgcccctg
     1561 ccacccgctg agcctccagc caaggagaag ccaggcaccc ctcctggtcc cccgccccct
     1621 gacagcaaca gcatggagct gggtggtcgg cctacctttg gctggagtcc tgagccctgt
     1681 gacagccctg gcacccctac tctggagtcc tctccagccg ggccagagaa gccccatgac
     1741 agcctggact cccgcattga gatgctgctg aaggagcaac gcaccaagct gcccttcctt
     1801 cgtgagcagg actcagacac cgagatacag atggaaggca gccccatctc ctcctcctcc
     1861 tcccaactct ccccgctcag ccactttggc actaactcgc agcccggctt ccgcggtccc
     1921 tcgccaccct cctcgcgccc ctccagcaca ggtctagagg acatcagtcc cacaccactg
     1981 cctgactctg atgaagatga ggacttgggc ctgggcctgg ggcctcggcc cccacctgag
     2041 ccaggccccc cagaccctat gggtctgcta ggccagacag ccgaggtgga tttggacctg
     2101 gcaggagaca ggacccccac ctcagagcgg atggatgagg gccagcagtc ctcaggagag
     2161 gacatggaaa tctcagatga tgagatgccc tcggccccca tcaccagcgc tgactgcccc
     2221 aagcccatgg tggtgacccc aggggccggg gctgtggcag cccccaacgt gctggctcca
     2281 aacctgcccc tgcccccacc ccctggcttc cctccattac ccccgccccc tcctccaccc
     2341 ccaccacaac ctggcttccc catgccccca cctctgcctc caccaccacc accaccacca
     2401 ccagcccatc ctgcagtgac agtgcccccg ccacccttgc cagcgccccc gggtgtcccg
     2461 cccccaccca tccttccgcc gctacctccc ttcccaccgg gactgtttcc tgtgatgcag
     2521 gtggacatga gccatgtgct gggtggccag tggggtggca tgcccatgtc cttccagatg
     2581 caaacacaga tgttaagccg gctcatgaca ggccaggggg cttgtcccta cccacctttc
     2641 atggccgctg cggctgccgc cgcttctgct ggactgcagt ttgtcaactt gcccccctac
     2701 cggagcccat tctccctgag caacagtggc ccaggacgtg gacagcattg gccgcccctg
     2761 cccaagtttg acccctccgt gccaccacca ggctacatac cacgtcagga ggacccgcac
     2821 aaggccacgg tggatggggt cttgctggta gtgctcaagg aacttaaggc catcatgaag
     2881 cgtgatctca accgcaagat ggtagaggtg gtggccttcc gggcctttga cgaatggtgg
     2941 gacaagaagg agcggatggc caaggcctca ctgacccccg tgaagtccgg tgagcacaag
     3001 gacgaggaca ggccaaagcc caaagaccga atcgcctcct gtctgctgga gtcgtggggc
     3061 aagggtgagg gcctgggtta cgagggccta ggcctgggca ttggactgcg gggcgccatt
     3121 cgcttgccct ccttcaaggt caagaggaag gagccaccgg acacagcctc ttctggtgac
     3181 cagaagcggc tacggccttc aacctctgtg gatgaggaag atgaagagtc agagcgggag
     3241 cgggaccggg acatagctga tgctccctgc gaactcacca agcgggaccc caaaagcgtg
     3301 ggtgtgcgac gccggccagg acggcccctg gagctggaca gcggcgggga ggaggatgag
     3361 aaggagtcct tgtcagcgtc ctcctcttcc tcagcatcct catcctctgg atcttctacc
     3421 acctcaccct catcctccgc ctcagacaag gaagaggagg accgagaaag caccgaggag
     3481 gaggaggagg aagaggagga ggaagcagag gaagaggagg aggaaggccc caggagccgc
     3541 atatcctcac cctcatcctc ctcaagctcc gacaaggatg acgaagatga caacgaagcc
     3601 gacagcgatg gccagattga ttcagacatc gacgatcagg gtgcacccct gtcggaggcc
     3661 agcgagaaag acaatggaga ttctgaggag gaggagacag agagcatcac cacctcaaag
     3721 gccccagctg agtcgtcctc atcctccagt gaaagttctg gatcttctga gtttgaatcc
     3781 agttccgagt ccgagtcttc atcttcatcc tcagaggacg aggaggagat gaccgtacct
     3841 ggggtggagg aagaagagga ggaggaggaa gaggaggaga aagagactgc aatggctgca
     3901 gccacggtag tggctatggc agaagagagc atgcctccag cgggtggcca ggactttgag
     3961 caggacaggg cagaagtgcc tctgggccca cgaggcccca tgagggagtc cttgggcaca
     4021 gaggaggaag tggacattga ggctgaggac gaagtccctg agatgcaggc tcctgagctg
     4081 gaggagcctc cattgcccat gggtgctcgg aagctggaag ggagcccaga gcccccagaa
     4141 gagccaggcc ccaacacaca aggggacatg ctgctctctc cagagctccc tgcccgggag
     4201 acggaggagg ctcaactccc atcaccgcct gaacatggtc cagagtcaga cctggacatg
     4261 gagcccgagc cccctcctat gctctccttg cccttgcagc cgccattgcc gccccctcga
     4321 ctgctccggc cacccagccc accgcctgag cctgagaccc cagagccccc caaacctccc
     4381 gtccccctgg agcctccccc agaagaccac cctccacgta ccccaggcct ctgtggcagt
     4441 ctggccaagt cacagagcac agagacagtg ccagccaccc caggcgggga gcccccactg
     4501 tcagggagca gcagtggcct gtccctgagc tccccgcagg tgcctggcag cccgttctcc
     4561 tatccatccc cgtcccccgg cttgagcagt gggggacttc cacggacacc tggtcgggac
     4621 ttcagcttca cacctacttt ccctgagccc agtggaccct tgcttctgcc tgtctgtccc
     4681 ctcccaaccg gtcggcgaga tgagcgtacc ggccccctgg cctccccagt gctcctggaa
     4741 actggcctgc ccctcccact tcccctgccc ctgcccttac ctctggcatt gcctgtcccg
     4801 gttctgaggg cccagcctcg gccacctccc cagctgcctc ccctactgcc cgctacccta
     4861 gctccctgcc caacccccat caagaggaag ccaggccggc cccggagatc cccaccgtcc
     4921 atgctgtcct tggatgggcc tttggtccgg ccaccgccag gacctgccct tgggagggac
     4981 cttctcctcc tgccaggcca gccaccggcc cccattttcc ccagcgcaca tgaccctcgg
     5041 gctgtgacct tggacttccg gaacacgggg atcccggccc ccccaccgcc cctcccaccc
     5101 cagcctcccc cacctccacc cccaccaccc gttgaatcca ccaagctacc cttcaaggag
     5161 ctggacaacc agtggccctc tgaagctatc cccccaggac ctcgccgaga tgaggtcact
     5221 gaagagtacg tggacctggc caaggtgcgg ggaccgtggc ggcggccacc caagaagcgg
     5281 cacgaagacc tggtggcccc atcggcctca cctgaaccct caccacccca gcctctcttc
     5341 cggccccgct cagagtttga ggagatgacc atcttgtacg acatctggaa cggtggcatc
     5401 gacgaggagg acatccgctt cctgtgcgtc acctacgagc gcctgctgca gcaggacaat
     5461 ggcatggact ggctgaatga cacactctgg gtctaccatc cctccaccag cctctcctca
     5521 gccaagaaaa agaaacggga ggacggtatc cgtgagcacg tgacaggctg cgcccgaagc
     5581 gagggcttct acaccatcga caagaaggac aagctgagat acctcaacag cagccgtgcc
     5641 agcacagacg agccccccat ggacacccag ggtatgagta tcccagccca gccccatgcc
     5701 tctactcggg caggctcaga gcggcggtct gagcagaggc gcctcttgtc ctccttcacc
     5761 ggcagctgtg acagcgacct gctcaagttc aaccagctca agtttcgaaa gaagaagctc
     5821 aaattctgta agagccacat tcacgactgg ggcctgtttg ccatggagcc aattgctgct
     5881 gacgagatgg tcatcgagta cgtgggccag aacatccgcc aggtgattgc ggacatgagg
     5941 gagaaacggt atgaggatga aggcatcggt agcagctaca tgttcagagt agaccatgac
     6001 accatcatcg acgccaccaa gtgcggcaac tttgcacgct tcattaacca cagctgcaat
     6061 cccaactgct acgccaaggt gatcacggtg gagtcccaga agaagatcgt catctactct
     6121 aagcagcaca tcaacgtcaa cgaggagatc acgtacgact acaagttccc gatcgaagat
     6181 gtcaagatcc cctgcctctg tggctccgag aactgccggg ggaccctcaa ttagtccccg
     6241 cgtgccaaag gccgaggatg tcagccgtag cccaggagaa ccctcgctcg ccctgggcca
     6301 ggctccacac acacccccac ccacttcagg tgctgtcctt atccccagca gccgcactag
     6361 ggcctggcgc ccccaacact atcccaggac ccacccgcag ccccagcccc gcagcgggaa
     6421 agggcttctc tgtctctcca cctgcgtctt tccgttttta tagatgctct tcgcacgcag
     6481 gctttgtatc cttatgtatc tggctttcca ttctccctcc gtccgtctgt ccgtccgtcc
     6541 gtctgtcttc cctccctggc tctggcctca gtcatttccc ccacccctga gaatgctgct
     6601 ctgtggtgtt gtgtctcctc tttattttct tccttgtccg aagaaaagac attttttttt
     6661 aaccgttgaa aatgtgaagg cagaatcaga ggtggagccc tgtggggaat ccggaggcct
     6721 cagtgaaact gggtgtgggc ccagggtcca ggctgacctt ggactaggtg ctgcaggagg
     6781 agggggcctc ccgcggcctc aacctcagaa cactacagac ccgcaaggcc cctacctgcc
     6841 cgtcgatgca gcgagcagac cccacagttt ctcccggcct gttccccagt ccctgacccc
     6901 caccccccgt ggttgagggt gcccctttcc ctttggtaga ccctggggga gccaagctgg
     6961 tcccagacag gaacttcctc cttggggact cccagctgcc ctacctactc ccccccccac
     7021 ccccccaatc cttgggttca atgtttactt tctcattcgg atgccagcaa cgatggagcc
     7081 tcccagggtg tccccagtgc ggtgggggcg ctgggaaggg tgtttccact ctcggcagcc
     7141 ttggccctgc ccaggtgtag agggtgccag ggccctgagg gcctccccca agccctgcca
     7201 ttacgggttt gtccgaccgt acgcatgtga cattttttgt tgttgataag cttcgcccca
     7261 ttaccctaac ccccacaccc atgtcaccct gctggaggcc cccacccagg aggccagggc
     7321 gtatttattt ccatagcgag caggttgttt ctcctagaga aaggaagatg gtcttggaaa
     7381 tgatattaaa attcagatct ccatcttgga cagctcctgc ccccacccca ccccatcctc
     7441 ttcagggtta atttccatga attttttttt ttctcgtgta taaaatcaaa ctgaagggaa
     7501 gaaaattatt attttggcgt tccgaaccaa tccctgtaga tagactgcca taacagacta
     7561 cttttttctt gggaactttg tttcttgtag aaacaagtgg gaagactttt tttttccttc
     7621 tctcatttct ttgtacttaa aaaaaaaaaa aaaaaaaaaa aaagcaaacc aacaacaaca
     7681 aaaagacaca cacagtaaca gcaagtccca tccacccccc caacccccca gaaagcaaag
     7741 cagacatgta aatatttctg gaccgtgact gttgtgaccc agagtcctca ccaagatgaa
     7801 gtgctccggg tgggactgac ctcacccgtg gaccaggtgg caggagcctc ttggtacctc
     7861 agcttgtgtc aagctttctt atcatgtaaa ttctgtacaa agaattgttt tttccctttc
     7921 tctctctctc tctctctttc tctctctctc tctctctctc tctctctctc tctctctctc
     7981 tctgtcgttg gtggttttgt tgtggttttt ctcttttttt ttttcccctt ttttaatttt
     8041 ccacaggccc tctgtgtttg agactgtgcc cacaggccct ctgtgtttga gactgtgccc
     8101 acaggcccgt ctgaaggttg agaggattat ttcgattggc aattaagaca caaggggcac
     8161 ctggtgggca cagcgcccac ctactcttcc atatgcagtt gtctgcataa ttgtgcaaat
     8221 gagaaaaaaa agatttattt ttcacaagaa gaaatgtgta gcgtgtagag atggcttaat
     8281 ttgagttcct cgggcaggcc ggctcgctgg gggctttctt catcttccct actgaccccc
     8341 atcacaaagg gatgaagatg cccagatgcc agggaagggc tgcttggtcc ctggcagggc
     8401 ctcactgagc cccgtcacgg gatccgcatg cattaacctt gacttgagtt tagggtgagg
     8461 tgttgagcta acccttcccc aagcccctgg cttctccacc cccaccccca gcatcccagg
     8521 aagggtatgc aatactcctg atctgtgggc ccatttttct ttgaaagctt ttgttttcat
     8581 tgagtagatc tcttgctttt gaagggtcag gggtttctga tttttttttt tcctccctct
     8641 ccctgcccct gcaaagaaga gaaccaataa attttagggt tgtctgtgcg tatagactct
     8701 gtcatctgta tgtaacttgt ttttgaagag aaatgtttcc gttgtgggtg tgtcttgctg
     8761 taaatatttg ttcatacttt tgtgaattca atactatgta ccattgtatt atagtaactt
     8821 ttataaagca aaccataaat atactgactt ttcttacaaa aaaaaaaa
//
