LOCUS       NM_178029               5934 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus SET domain containing 1A (Setd1a), mRNA.
ACCESSION   NM_178029 XM_894035 XM_985966 XM_994371
VERSION     NM_178029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5934)
  AUTHORS   Bosworth,M.L., Isles,A.R., Wilkinson,L.S. and Humby,T.
  TITLE     Sex-dependent effects of Setd1a haploinsufficiency on development
            and adult behaviour
  JOURNAL   PLoS One 19 (8), e0298717 (2024)
   PUBMED   39141687
  REMARK    GeneRIF: Sex-dependent effects of Setd1a haploinsufficiency on
            development and adult behaviour.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5934)
  AUTHORS   Zhao,T., Hong,Y., Yan,B., Huang,S., Ming,G.L. and Song,H.
  TITLE     Epigenetic maintenance of adult neural stem cell quiescence in the
            mouse hippocampus via Setd1a
  JOURNAL   Nat Commun 15 (1), 5674 (2024)
   PUBMED   38971831
  REMARK    GeneRIF: Epigenetic maintenance of adult neural stem cell
            quiescence in the mouse hippocampus via Setd1a.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5934)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5934)
  AUTHORS   Obi-Nagata,K., Suzuki,N., Miyake,R., MacDonald,M.L., Fish,K.N.,
            Ozawa,K., Nagahama,K., Okimura,T., Tanaka,S., Kano,M., Fukazawa,Y.,
            Sweet,R.A. and Hayashi-Takagi,A.
  TITLE     Distorted neurocomputation by a small number of extra-large spines
            in psychiatric disorders
  JOURNAL   Sci Adv 9 (23), eade5973 (2023)
   PUBMED   37294752
REFERENCE   5  (bases 1 to 5934)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5934)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   7  (bases 1 to 5934)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   8  (bases 1 to 5934)
  AUTHORS   Wilson,C., Goetting-Minesky,P. and Nekrutenko,A.
  TITLE     mNSC1 shows no evidence of protein-coding capacity
  JOURNAL   Gene 370, 83-85 (2006)
   PUBMED   16476528
  REMARK    GeneRIF: mNSC1 lacks protein-coding capacity
REFERENCE   9  (bases 1 to 5934)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5934)
  AUTHORS   Kutsuwada,K., Satoh,J., Ohki,G., Muto,S., Imai,M., Arakawa,M. and
            Suzuki,M.
  TITLE     Cloning and characterization of 5'-flanking region of mouse
            non-selective cation channel 1
  JOURNAL   Biochim Biophys Acta 1444 (1), 92-100 (1999)
   PUBMED   9931454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On or before Dec 17, 2006 this sequence version replaced
            XM_894035.2, XM_994371.1, XM_985966.1, NM_178029.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC149222.4         176549-176673       c
            126-290             AC149222.4         175785-175949       c
            291-386             AC149222.4         175461-175556       c
            387-657             AC149222.4         173407-173677       c
            658-779             AC149222.4         170312-170433       c
            780-1009            AC149222.4         169860-170089       c
            1010-1898           AC149222.4         168326-169214       c
            1899-2690           AC149222.4         167390-168181       c
            2691-2867           AC149222.4         166760-166936       c
            2868-2955           AC149222.4         166476-166563       c
            2956-3113           AC149222.4         165708-165865       c
            3114-3201           AC149222.4         165493-165580       c
            3202-3519           AC149222.4         162530-162847       c
            3520-4575           AC149222.4         157364-158419       c
            4576-4748           AC149222.4         156816-156988       c
            4749-4859           AC149222.4         156625-156735       c
            4860-4979           AC149222.4         156339-156458       c
            4980-5117           AC149222.4         154834-154971       c
            5118-5934           AC149222.4         153940-154756       c
FEATURES             Location/Qualifiers
     source          1..5934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.73 cM"
     gene            1..5934
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /note="SET domain containing 1A"
                     /db_xref="GeneID:233904"
                     /db_xref="MGI:MGI:2446244"
     exon            1..125
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..290
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..5291
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /EC_number="2.1.1.364"
                     /note="non-selective cation channel 1; SET
                     domain-containing protein 1A"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD1A"
                     /protein_id="NP_821172.2"
                     /db_xref="CCDS:CCDS40144.1"
                     /db_xref="GeneID:233904"
                     /db_xref="MGI:MGI:2446244"
                     /translation="MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDG
                     VHFSVSDSKYTPVEDLQDPRCHVRSKARDFSLPVPKFKLDEFYIGQIPLKEVTFARLN
                     DNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSV
                     MGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPTGGKALSEKFQGSGAAAETTEARR
                     RSSSDTAAYPAGTTVGGTPGNGTPCSQDTNFSSSRQDTPSSFGQFTPQSSQGTPYTSR
                     GSTPYSQDSAYSSSTTSTSFKPRRSENSYQDSFSRRHFSTSSAPATTATATSATAAAT
                     AASSSSSSSSSSSSSSSSSSSASQFRGSDSSYPAYYESWNRYQRHTSYPPRRATREDP
                     SGASFAENTAERFPPSYTSYLAPEPNRSTDQDYRPPASEAPPPEPPEPGGGGGGSGGG
                     GGGGGGGGGGAPSPEREEARTPPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEML
                     LKEQRSKFSFLASDTEEEEENSSAGPGARDAGAEVPSGAGHGPCTPPPAPANFEDVAP
                     TGSGEPGAARESPKANGQNQASPCSSGEDMEISDDDRGGSPPPAPTPPQQPPPPPPPP
                     PPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPPHIYDFVNSLELMD
                     RLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAGPPGGAFGEAFLPFPPPQEAA
                     YGLPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSVSGEEARLPHREEAEIAESK
                     VLPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAA
                     KQQAKEEDKEKMKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLRGALRLPSFKVKRKE
                     PSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRDEERGKTQGKHRK
                     SFTLDSEGEEASQESSSEKDEDDDDEDEEDEEQEEAVDATKKEAEASDGEDEDSDSSS
                     QCSLYADSDGENGSTSDSESGSSSSSSSSSSSSSSSSSSESSSEEEEQSAVIPSASPP
                     REVPEPLPAPDEKPETDGLVDSPVMPLSEKETLPTQPAGPAEEPPPSVPQPPAEPPAG
                     PPDAAPRLDERPSSPIPLLPPPKKRRKTVSFSAAEEAPVPEPSTAAPLQAKSSGPVSR
                     KVPRVVERTIRNLPLDHASLVKSWPEEVARGGRNRAGGRVRSTEEEEATESGTEVDLA
                     VLADLALTPARRGLATLPTGDDSEATETSDEAERPSPLLSHILLEHNYALAIKPPPTT
                     PAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPKQQLQQQHPEQEGEEEEEDEE
                     EESESSESSSSSSSDEEGAIRRRSLRSHTRRRRPPLPPPPPPPPSFEPRSEFEQMTIL
                     YDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVQHTITNLSTPKRKRRPQDG
                     PREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGGDTQGTNRVLSERRSEQRRL
                     LSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQN
                     IRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVIT
                     IESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN"
     exon            291..386
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..657
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..779
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1009
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1898
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2690
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2867
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2955
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3113
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3201
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3519
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..4575
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4748
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4859
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..4979
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5117
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5118..5934
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5913..5918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /note="hexamer: ATTAAA"
     polyA_site      5934
                     /gene="Setd1a"
                     /gene_synonym="KMT2F; mKIAA0339; mNSC1; Nsccn1"
                     /note="major polyA site"
ORIGIN      
        1 gggggggcgc cgccgccgcc accgctgcgg ggccgggtct cgcgctgccg ccgccgccgc
       61 cgccgcctca cgccgctgag gtgctgcgcg cggtgggggg agggtgagcc gctcgccacg
      121 agcggtgtaa atgagcaaag atggaccagg aaggtggggg agacgggcag aaagccccga
      181 gcttccagtg gcggaactac aagctcatag tggatcctgc tttggaccct gctttgcgca
      241 ggccttccca gaaggtgtac cgctatgacg gagtccactt cagtgtcagt gactcaaagt
      301 atacccccgt ggaagacctc caggaccccc gctgtcatgt caggtccaaa gccagagact
      361 tttccctccc ggttcctaag tttaagctgg atgagttcta tattggacag ataccactga
      421 aggaagtaac ttttgcgagg ctcaatgaca atgtgaggga aaccttcctg aaggatatgt
      481 gccggaaata tggagaggtg gaagaagtgg agatccttct tcatccccgc actcgaaagc
      541 acctaggcct ggcccgtgtg ctcttcacca gcactcgggg cgccaaggaa actgtcaaaa
      601 acctccacct cacctctgtc atgggcaaca tcattcatgc ccagcttgat atcaaaggcc
      661 aacaacgaat gaagtactat gaattgattg tcaatggctc ttacactcct cagactgtgc
      721 ccactggggg caaggccttg agtgagaagt tccagggttc tggtgcagcc gctgagacga
      781 ctgaagcccg ccgacggtct tcctcggaca cagctgccta tccagcaggc actactgtgg
      841 ggggcacccc tggcaatggc actccctgct cccaagatac aaatttctcc agcagccgac
      901 aagatactcc atcttccttt ggccagttca cccctcagtc ctcccaagga accccctaca
      961 catctcgggg tagcaccccc tactctcagg actctgccta ctccagcagc accacttcaa
     1021 cctccttcaa accccggcgg tcagagaaca gctatcaaga ttctttttct cgccgccatt
     1081 tctctacatc ttcagcccct gcaaccaccg ctactgccac ctcagcaact gctgcagcta
     1141 ctgcagcctc ctcctcatct tcctcctcct cgtcatcgtc ctcctcctcg tcgtcttctt
     1201 cctcagcctc tcagtttcgt ggttctgact ctagctaccc agcatattat gaaagctgga
     1261 atcgttacca gcgccatact tcctatccac ctcgccgggc aactagagag gacccttctg
     1321 gggcttcatt tgccgaaaat acggctgagc gcttcccacc ttcctatacc tcctatttgg
     1381 cccctgagcc taaccgatcc actgaccaag actaccggcc tcctgcctca gaggccccac
     1441 ctccagaacc tccagaacct ggtggtggtg gtggtggtag tggtggtggt ggtggtggtg
     1501 gtggtggtgg tggtggtggg gcacccagcc ctgagagaga agaagcccgg actcccccac
     1561 gcccagcttc ccctgcacgc tctggctccc cagccccaga gaccaccaac gagagtgtgc
     1621 cctttgctca gcacagcagt ttggattccc gtattgaaat gctgctgaag gaacaacgct
     1681 ccaagttttc tttcttggct tctgatacag aggaagagga agagaacagc agtgcaggcc
     1741 ctggggctag agatgcaggg gctgaggtgc cttctggggc aggtcatggg ccctgtacac
     1801 ctcctcctgc accagctaat tttgaagatg tagcacctac agggagtgga gagccagggg
     1861 ctgcccggga gtcaccaaag gccaatggac agaaccaggc ttctccatgt tcttccggag
     1921 aagatatgga gatctctgat gatgacaggg gtggctcacc acctccagcc ccaacacccc
     1981 cccagcagcc gccaccgcca ccacctcccc ctcctccccc ccctcctccc taccttgctt
     2041 cccttcccct tggctatcct ccccaccaac ctgcctacct cctcccaccc cgcccagatg
     2101 gaccaccccc ccctgagtac cctccgccac ctcctccacc accaccccac atctatgact
     2161 ttgtgaactc cctggaactt atggatcgac ttggggcaca gtggggaggg atgcccatgt
     2221 ccttccagat gcagacccag atgttaacac ggctccacca gttacggcag ggcaagggat
     2281 tgactgcagc ctcagctggt cctcctggcg gggcttttgg cgaggccttt ctcccttttc
     2341 cacctccaca agaggcagcc tatggcttgc cctatgctct gtacacacaa gggcaagaag
     2401 gtcgtgggtc gtactcccgg gaggcctacc acctgccctt gcctatggca gccgagcccc
     2461 tgccctcttc ctcagtctcg ggagaggagg cgcggctgcc tcatagggag gaagcagaga
     2521 tagcagaaag caaggtccta ccatcagcag gcacagtggg tcgtgtgctg gctacccttg
     2581 tccaagagat gaagagcatt atgcagcgag accttaatcg aaagatggtc gagaatgtgg
     2641 cctttggagc ctttgaccag tggtgggaga gcaaggaaga gaaggccaag ccattccaga
     2701 atgcagccaa acagcaagcc aaggaagagg acaaagaaaa gatgaagctc aaagagccag
     2761 gcatgctgtc cctcgtagac tgggccaaga gtggcggtat cacaggcatt gaggcctttg
     2821 cctttgggtc agggcttcga ggggccctgc ggttgccttc attcaaggta aaacggaaag
     2881 agccatcaga aatttcagag gcaagtgagg aaaagaggcc caggccctct actccagctg
     2941 aggaagatga agatgatcct gagcgagaga aggaagctgg agaaccagga cgtccaggga
     3001 ccaagcctcc gaagcgagat gaagaacggg gcaagaccca aggcaaacac cgaaaatcct
     3061 ttactctgga cagtgaaggg gaggaggcgt cccaggagtc ttcctcagag aaggatgagg
     3121 atgatgatga tgaagatgag gaagatgaag aacaggagga agctgtggat gccaccaaga
     3181 aggaagcaga ggcatcggat ggtgaggatg aggacagtga ctcgtcctcc cagtgctctc
     3241 tgtatgcgga ttcagatggt gaaaatggca gcacatcaga ctccgagagt ggcagctcgt
     3301 cttcctcttc ctcatcgtct tcctcctctt cctcctcttc ctcatcagag tcctcctctg
     3361 aggaagagga gcagtcagca gtcattccct cagcttcacc ccccagagaa gttccagagc
     3421 cccttccagc tcctgatgag aagcctgaga cagacgggct tgtagattcc cctgtcatgc
     3481 ctctctctga aaaggagaca ttgcccacac agcctgcagg ccctgctgaa gaaccacctc
     3541 ctagtgtacc acagcctcca gcagagccac ccgccggacc gccagacgct gccccccgcc
     3601 tggatgagcg cccctcttct cctatccctc tcctaccccc acccaagaaa cgccggaaaa
     3661 ctgtttcctt ctctgctgca gaggaggcac cagtcccaga accttccaca gctgccccac
     3721 tgcaggccaa gtcttctggt ccagtctctc gaaaagtccc ccgggtcgta gagcggacca
     3781 ttcgtaacct ccccctggac catgcgtctc tggtcaagag ttggcctgag gaggtcgccc
     3841 gagggggtcg gaatcgagct ggaggtcgtg tgcgctctac tgaagaagag gaggccactg
     3901 agtcagggac agaagtagac ctggcagtac tggctgacct ggccctgacc ccagcccgac
     3961 gtgggttggc taccctaccc actggtgacg actcagaggc cacagagacc tcagatgagg
     4021 ctgagcgccc aagccctcta ctcagccaca tcctcttgga acacaactat gccctagcca
     4081 tcaagccccc gcctaccaca ccagcacctc ggcccctgga gccagctcct gcccttgctg
     4141 cactcttcag ctctccagct gatgaagtct tagaggcccc tgaggtggtg gtggctgagg
     4201 cagaggagcc aaagcaacag ctgcagcagc agcatccaga gcaggaagga gaagaggagg
     4261 aggaagatga agaggaggag tccgagtctt cagaaagcag cagcagcagc agcagtgatg
     4321 aggaaggggc aatcaggagg cgtagcctcc gctcccacac tcgaagaaga aggccaccac
     4381 tcccaccccc acccccacct cctccttcct ttgagccgag aagtgaattt gagcagatga
     4441 ccatcttgta tgatatttgg aactcaggcc ttgacttgga agacatgagc tatttgcgac
     4501 tcacatatga acggctgctg cagcaaacca gtggcgctga ctggcttaat gacacccact
     4561 gggtccagca cacaatcacc aacctaagca ctccaaagcg caaaagacgg ccccaagatg
     4621 ggccccggga gcatcagaca ggctctgcac gcagcgaagg ttattacccc attagcaaga
     4681 aggagaaaga taaatacttg gatgtgtgcc ccgtctcggc ccggcagctg gaaggtggag
     4741 acactcaggg gactaatcgg gtgctttctg agcgacggtc agagcagcgg cggttactaa
     4801 gcgctattgg cacctcagcc atcatggaca gtgatctgct aaagctaaac cagctcaagt
     4861 ttcggaagaa gaaactccga tttggccgga gccgtatcca tgagtggggt ctgtttgcca
     4921 tggaacccat tgccgctgat gagatggtga tcgaatatgt tggccagaac atccgccaga
     4981 tggtagcgga catgcgggaa aagcgctacg tgcaggaggg cattggcagc agctaccttt
     5041 tccgggtgga tcacgacacc atcattgatg ccaccaagtg tggcaacctc gccaggttca
     5101 tcaaccactg ctgcacgccc aactgctatg cgaaggtgat caccattgag tctcagaaaa
     5161 agattgtcat ctactcgaag cagcccatcg gcgtggatga ggagatcacc tacgactaca
     5221 agttcccact agaagacaac aagattccgt gtctgtgcgg cactgaaagt tgccgtggct
     5281 ccctcaactg aggtggggca ggaccggtgc cctcacccct atttattccc ccttggtgcc
     5341 ctaagctccc agcaccccag ccttattggg ctcagcaggg cccactgccc ccaccttcac
     5401 gtgggatagg gagcactgag gccaacaagg gagcctcagt cctttgaggc atctgctgcc
     5461 tcccctatgc cccatgccca aacaccctct taattttttt ttctttgcga agaagaagct
     5521 gtaaatgttt tgtagctgcc agcagctgtt tcctgtggaa acctggggta ccagcctgta
     5581 tagatgctat tcttgggggc tgcatagccc tttgcttcat gttaatgggg acttcccctt
     5641 ctgccctatg tgcaccccgc cccagtttag gggtctctgg ggcagtggcc atgttctccc
     5701 cctggggggg cctttggccc ctagtcctgg gaactctgtg cctggaaccc tgcctcatct
     5761 gttcctgcca gaccctgtgg gtcaccctcc caccctggtg tctcagggct ctggctcagt
     5821 gggccaggat ggtggggggc aggcccttct tgttgggctg gattgtacat aatgttaata
     5881 gtgaaaccca acaccacatt tttataattg tgattaaact ttattgtaca aaaa
//
