LOCUS       NM_053099              11008 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SET binding protein 1 (Setbp1), mRNA.
ACCESSION   NM_053099 XM_140508
VERSION     NM_053099.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11008)
  AUTHORS   Whitlock,J.H., Soelter,T.M., Howton,T.C., Wilk,E.J., Oza,V.H. and
            Lasseigne,B.N.
  TITLE     Cell-type-specific gene expression and regulation in the cerebral
            cortex and kidney of atypical Setbp1S858R Schinzel Giedion Syndrome
            mice
  JOURNAL   J Cell Mol Med 27 (22), 3565-3577 (2023)
   PUBMED   37872881
REFERENCE   3  (bases 1 to 11008)
  AUTHORS   Tanaka,A., Nishimura,K., Saika,W., Kon,A., Koike,Y., Tatsumi,H.,
            Takeda,J., Nomura,M., Zang,W., Nakayama,M., Matsuda,M.,
            Yamazaki,H., Fukumoto,M., Ito,H., Hayashi,Y., Kitamura,T.,
            Kawamoto,H., Takaori-Kondo,A., Koseki,H., Ogawa,S. and Inoue,D.
  TITLE     SETBP1 is dispensable for normal and malignant hematopoiesis
  JOURNAL   Leukemia 37 (9), 1802-1811 (2023)
   PUBMED   37464069
  REMARK    GeneRIF: SETBP1 is dispensable for normal and malignant
            hematopoiesis.
REFERENCE   4  (bases 1 to 11008)
  AUTHORS   Nguyen,N., Gudmundsson,K.O., Soltis,A.R., Oakley,K., Roy,K.R.,
            Han,Y., Gurnari,C., Maciejewski,J.P., Crouch,G., Ernst,P.,
            Dalgard,C.L. and Du,Y.
  TITLE     Recruitment of MLL1 complex is essential for SETBP1 to induce
            myeloid transformation
  JOURNAL   iScience 25 (1), 103679 (2021)
   PUBMED   35036869
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11008)
  AUTHORS   Nguyen,N., Oakley,K., Han,Y., Kwok,M., Crouch,G. and Du,Y.
  TITLE     Interaction with XPO1 is essential for SETBP1 to induce myeloid
            transformation
  JOURNAL   Leukemia 33 (11), 2758-2762 (2019)
   PUBMED   31337858
  REMARK    GeneRIF: myeloid transformation requires the interaction of XPO1
            with SETBP1
REFERENCE   6  (bases 1 to 11008)
  AUTHORS   Vishwakarma,B.A., Nguyen,N., Makishima,H., Hosono,N.,
            Gudmundsson,K.O., Negi,V., Oakley,K., Han,Y., Przychodzen,B.,
            Maciejewski,J.P. and Du,Y.
  TITLE     Runx1 repression by histone deacetylation is critical for
            Setbp1-induced mouse myeloid leukemia development
  JOURNAL   Leukemia 30 (1), 200-208 (2016)
   PUBMED   26205084
  REMARK    GeneRIF: Setbp1 overexpression also causes transcriptional
            repression of critical hematopoiesis regulator gene Runx1
REFERENCE   7  (bases 1 to 11008)
  AUTHORS   Oakley,K., Han,Y., Vishwakarma,B.A., Chu,S., Bhatia,R.,
            Gudmundsson,K.O., Keller,J., Chen,X., Vasko,V., Jenkins,N.A.,
            Copeland,N.G. and Du,Y.
  TITLE     Setbp1 promotes the self-renewal of murine myeloid progenitors via
            activation of Hoxa9 and Hoxa10
  JOURNAL   Blood 119 (25), 6099-6108 (2012)
   PUBMED   22566606
  REMARK    GeneRIF: Setbp1 promotes the self-renewal of murine myeloid
            progenitors via activation of Hoxa9 and Hoxa10.
REFERENCE   8  (bases 1 to 11008)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   9  (bases 1 to 11008)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 11008)
  AUTHORS   Minakuchi,M., Kakazu,N., Gorrin-Rivas,M.J., Abe,T., Copeland,T.D.,
            Ueda,K. and Adachi,Y.
  TITLE     Identification and characterization of SEB, a novel protein that
            binds to the acute undifferentiated leukemia-associated protein SET
  JOURNAL   Eur J Biochem 268 (5), 1340-1351 (2001)
   PUBMED   11231286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114924.5, AC146613.3, AC131736.2 and AC140455.2.
            
            On Apr 2, 2020 this sequence version replaced NM_053099.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.585213.1,
                                           SRR10662773.2239403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1257              AC114924.5         34222-35478
            1258-1887           AC114924.5         57486-58115
            1888-1941           AC146613.3         68487-68540         c
            1942-5389           AC131736.2         132833-136280       c
            5390-5560           AC140455.2         236723-236893       c
            5561-11008          AC140455.2         203842-209289       c
FEATURES             Location/Qualifiers
     source          1..11008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.67 cM"
     gene            1..11008
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /note="SET binding protein 1"
                     /db_xref="GeneID:240427"
                     /db_xref="MGI:MGI:1933199"
     exon            1..1257
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1887
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     CDS             1423..6171
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /codon_start=1
                     /product="SET-binding protein"
                     /protein_id="NP_444329.2"
                     /db_xref="CCDS:CCDS29362.2"
                     /db_xref="GeneID:240427"
                     /db_xref="MGI:MGI:1933199"
                     /translation="MEPREMLSSCRQRGSESEFLQGSSSRSPPAPGCSGEPLKGISVG
                     GERMEPEEEDELGSGRDVDCNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQT
                     TKRAKKPPKNLENYICPPEIKITIKQSGDQKVSRTGKNSKATKEDERNHSKKKLLTAG
                     DPTASDLKAFQTQAYERPQKHSTLQYDPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSN
                     SDSGPATQNCFISPEAGRDTASTSKVPALEPVASFAKAQSKKGSTGGAWSQLSSSSKD
                     LLLGSVVPSPSSHNSPATPSSSAECNGLQPLGDQDGGSTKDLPEPPTLSSKKKSSKKD
                     MISQTLPNSDLDWVKSAQKAFETTEGKREAYSADSAQEASPARQSISSVSNPENDSSH
                     VRITIPIKTPSLDPSNHKRKKRQSIKAVVEKIVPEKALASGISMSSEVVNRILSNSEG
                     SKKDPRVPKLGKMIENETPSVGLETGGNAEKIVPGGASKQRKPPMVMTSPTRTEHAPS
                     GKLSEIQHPKFAAKRRCSKAKPPAMLREAVLATAEKLMVEPPSAYPITPSSPLYTNTD
                     SLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRNLAKLA
                     QLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSVALK
                     AKAPPETSPGAASIESKLGKQINVSKRGTIYIGKKRGRKPRTELPPPSEEPKTAIKHP
                     RPVSSQPDVPAVPSSFQSPVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPN
                     LQPISALPTKTQKGIHGGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETI
                     PSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLI
                     VDTFLAHESLKKPKHKRKRKSLQNRDDLQFLAELEELITKFQVFRISHRGYTFYHENP
                     YPSIFRINFDQYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFS
                     YPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPPPQFHA
                     SSHVKISGATKHKAKHGVHLQGTVGMGLGDIQPSLNPPKVGGATLSSSRLHKRKHKHK
                     RKHKEDRILGTHDNLSGLFAGKATGFSSHLLSERLSGSDKELPLVSEKSKHKERQKHQ
                     HGEASHKVSKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPVESCAKRYSGSGGDST
                     RSEGLDVFSEMNPSSDKWDSDMGGSKRRSFEGFGTYREKDIQAFKMNRKERGSYESSM
                     SPGMPSPHLKVDQTAAHSKSEGSISAMMARKKPTAVDSVAIPSAPVLSLLAASAATSD
                     AASSSLKKRFKRREIEAIQCEVRKMCHYTKLLSTKKNLDHVNKILKAKRLQRQSKTGN
                     NFVKKRRGRPRKQPSQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLALEPASGQDAV
                     MATIEAVIHMAREAPPLPPPPPPPLPPPPPPPPPPPPLPKTARGGKRKHRPQPPAQPA
                     QPTPQPLPQEEEVKAKRPRKSRASESDVLP"
     exon            1888..1941
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..5389
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     exon            5390..5560
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     exon            5561..11008
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10984..10989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /note="hexamer: ATTAAA"
     polyA_site      11008
                     /gene="Setbp1"
                     /gene_synonym="C130092E12; mKIAA0437; Seb"
                     /note="major polyA site"
ORIGIN      
        1 agatagtggc agtgttgagc ccgggaaccg gcgcccagcc cgcggcggtc cccgcggccg
       61 cacagtctcc gcggcagaat ccgactcgct ggagctactg ggccgcgagg acactgggga
      121 gcgggagggg ctcgggggag gcgaggggtc cccgatccgc gtccccgaac tgttctcctt
      181 tcccctccgg caagagcccc gctccctcca attgatcgaa attcacccag gggggcggtc
      241 gagggagaga gaggtcgtcg gccgctcgcc ggctgcgcct ccctgggctt cggctgggga
      301 gcggcccggg ctcgcggggc gagcagtgtg ggctcccgca ccccctctga gggagatcgc
      361 ggggtggcag tccccgtcgg ctccgccgcg cggccgcttc aatcctcccc ctcccccgcg
      421 cacgccctcc cccttccttt cagtaggact ccgggactcg ggagagggcg cgggaggcag
      481 gcacacgggc ccgaccccac tccagcgctc gccggggacg cgggcgggcg gcgaggggac
      541 gcggaggggg cgcggggcgg gcgcggccat agagcagagg cggcggcggc ggcggcagca
      601 gtagcgaccg cgggcggacc agcggcggca gggccggcgg gcgccgggga ccgaactgca
      661 cagctcagca aaagcgcccc agccctcggc gcgccgcctc cagcgagccc agccgggcaa
      721 cattttgtaa ccctccaatc catcttttgg agaaaaggga aaaaatagca ttgagcggag
      781 agatggggga aatctaaata atatatatgt acatatgcat atttatgtat atgtacatat
      841 atgtgtatta tatttggttc ctgctaaaat tagccgggct cgccgcgcgc ctgtgtgcga
      901 gtgtgtgcga gtgtgtgtgc gtgcgggcgt gtgtgtgaat gtgattactc caggactcct
      961 cgggctccgg agacgccatt ttcccccttg atatctctct ccgtaaatcg gtggcgcggc
     1021 ggaggcggcc gcggcgggcg ggaagcgcgg ggctggccgg ggcgctcgcc gccgcctgcg
     1081 cgcccggggg ccccggcgcc ccccgagcga gggcggcccg ccccgcgcgt cgccgtttga
     1141 cagatgctcg tcgctatgga gttgccgcag cagcaccttt gggggctcgg acgagcgacc
     1201 ggaggcggaa tctgagcgag cgcccgggcc agcggagccg gagccgccgg gacatggatc
     1261 tgaccccttc tgagggcttc gccacatctc cgttcttggg acgttgaacc ctacagctgg
     1321 acgactttgt tcttggaatt ttgggtttct tctcttttga ccctttctgc tccccttcat
     1381 cccttccctg tcctgagaac tcctgaagac tgtaggatta tcatggagcc cagggaaatg
     1441 ttaagcagct gccggcaaag agggagtgag tcggaattcc ttcagggctc ctcatccaga
     1501 tccccacctg ctcctggctg ttcaggagag cccttgaaag gcatctctgt gggtggagaa
     1561 cgcatggagc cagaggagga ggatgaattg ggctcaggac gagatgtgga ttgcaattct
     1621 aatgcagaca gtgagaaatg ggtggctgga gatggcttgg aggagcagga gttctccatc
     1681 aaggaggcca acttcactga ggggagctta aagctgaaga ttcagaccac aaagcgggct
     1741 aagaaacccc ccaaaaacct ggagaactat atctgcccac ctgagatcaa gatcaccata
     1801 aagcagtctg gggaccagaa ggtgtcccgt actgggaaaa atagcaaagc gactaaggaa
     1861 gatgaaagaa accactccaa aaagaagctc ctcacagccg gtgaccctac agccagcgac
     1921 ctcaaagcat ttcagacaca ggcatacgag aggccccaga aacactcaac acttcagtat
     1981 gacccaggtc actcccaggg cttcaccagt gacaccttaa aaccaaagca ccagcaaaaa
     2041 agcagcagtc agagccacat ggaatggtcc tccaactctg acagtggacc agctactcag
     2101 aattgcttca tcagtccaga ggctggccga gacactgcaa gcaccagcaa ggtcccagct
     2161 cttgaacccg tggcttcctt tgcaaaggcc cagagtaaaa aaggcagtac aggaggggcc
     2221 tggagtcagt tgtccagcag tagcaaagac ctgctcttgg gaagtgtggt accatccccc
     2281 agcagccaca actccccagc gacccctagc agctcggctg agtgcaatgg actccagcca
     2341 ttgggagatc aagatggagg aagtacaaag gacctcccag agccacccac tctcagtagc
     2401 aagaagaagt ccagtaaaaa agatatgata agccaaaccc taccgaactc agatctggat
     2461 tgggtcaaga gtgcccagaa agcatttgaa accacagaag ggaaacggga ggcctactct
     2521 gcagacagtg ctcaagaggc atcgccagcc cggcagagca tcagttccgt cagtaatccg
     2581 gaaaatgatt ccagtcatgt ccggattact atccccataa agacaccttc tctggatcca
     2641 agcaaccata agaggaaaaa gaggcagtct attaaagctg tggtggagaa aatcgttccg
     2701 gagaaagcac tggcttcagg gatttccatg agcagcgagg ttgttaatag aatactttcc
     2761 aactcagagg gaagtaagaa agaccctcga gtcccgaagt tgggtaagat gatagagaac
     2821 gaaaccccct cagttggcct tgaaacaggt gggaacgctg aaaagattgt ccccggaggt
     2881 gcgtccaagc agaggaaacc gcccatggtc atgacgtcac ccacacgcac agagcacgct
     2941 ccatcaggaa agctgtctga gatccagcac cccaagtttg ctgcaaaaag gaggtgtagc
     3001 aaggccaaac ctccggctat gcttcgagag gcagtcttag ctaccgccga aaaactgatg
     3061 gtggagccac cgtctgctta ccccattacc ccatccagcc ctctgtacac caacacggac
     3121 agtcttactg tgatcacacc ggtcaaaaag aagcggggac gaccaaagaa gcaacctctg
     3181 ctcactgtgg agacgattca cgaaggcact tccactagcc ccgtcagccc aatcagcaga
     3241 gagtttcctg gcaccaagaa aaggaagaga cggcgcaatc tggctaaatt ggcccagtta
     3301 gtgcccggag aggacaaacc catgagcgaa atgaagtttc acaaaaaggt tggcaagctt
     3361 ggtgtgctgg ataagaagac catcaaaacg atcaacaaga tgaagacact caagagaaaa
     3421 aatatcttaa atcagatctt gtcctgttcc agcagcgtgg ccctaaaggc caaagctccc
     3481 ccagagacta gtcctggggc agcatctatc gaaagtaaac tgggaaagca gattaatgtc
     3541 agcaagagag gaaccatcta cataggcaag aagaggggca ggaagccaag gacagagctt
     3601 ccacccccat ccgaggaacc caaaacagcc atcaagcacc ccaggcctgt gtctagccag
     3661 ccggacgttc cagccgtgcc ttccagcttc cagtcacccg tggcttcttc accagcagct
     3721 atgcacccac tctcaacaca gttaggtggg tccaatggca acctgagccc cgccagcact
     3781 gaaaccaatt tttcagagtt aaaaactatg ccgaacctcc agcccatcag tgctcttcca
     3841 accaaaaccc agaagggaat ccacggtggg acctggaagc tgtccccacc ccggctgatg
     3901 gccaactccc catcacacct ttgcgagatt ggctcactga aggagataac gttgtcccct
     3961 gtgagtgagt cccacagcga ggagactatc ccgagcgaca gtggcatcgg gacagacaac
     4021 aacagcacct ccgaccaagc agagaagagt tcagaatccc ggcggaggta ctctttcgac
     4081 ttctgttccc ttgacaaccc agaggccatt ccatccgaca ccagcacaaa gaaccggcac
     4141 ggccaccggc agaagcatct cattgtggac acttttctgg cccacgaaag cctcaagaag
     4201 ccaaagcaca agaggaaacg gaagagcctg caaaaccgcg atgatctcca gtttctggca
     4261 gagctggaag aactcatcac caagtttcaa gtgttcagga tctcccaccg gggctacact
     4321 ttctaccatg agaatccgta tcccagcatc tttaggatta actttgatca gtattacccg
     4381 gtgccatata tccagtacga cccattgctc tatcttcgta ggacttcaga cctgaagtca
     4441 aagaagaagc gtggtaggcc tgcaaaaacc aatgacacca tgacaaaggt gcctttttta
     4501 caggggttca gctaccctat ccccagtgga agttactatg caccctatgg aatgccttac
     4561 acatcaatgc ctatgatgaa ccttggttac tatggtcagt acccggctcc tctgtacctg
     4621 tcacacacac tcggagcagc atcccctttc atgaggccga cagtgccacc accccagttc
     4681 cacgcaagtt ctcatgtaaa gatatccggg gcaacgaaac ataaagccaa gcatggcgtc
     4741 cacttgcagg gaaccgtagg catgggcctt ggtgacatac agccatccct gaaccctccc
     4801 aaggtgggcg gggccactct gtccagcagt aggctccaca agaggaaaca caaacataag
     4861 cgtaagcaca aggaagaccg aatcctaggg acccatgaca acctgagtgg tctctttgca
     4921 ggcaaagcca caggcttctc cagccacctc ctgagtgaac ggctcagcgg ttccgacaaa
     4981 gagctgccgc tggtgagcga gaagagcaaa cacaaggaga gacagaagca ccagcacggg
     5041 gaggccagcc acaaggtttc caagaacaac tttgaggtgg acaccctgtc tacgctgtca
     5101 ctttctgacg cccagcactg gacacaggct aaggacaaag gtgacttgag cagtgagcct
     5161 gtggagtcct gtgctaaaag gtactctggc agcggtggag acagcacaag atcggagggt
     5221 ctggatgtgt tcagtgaaat gaatccttcc agcgacaagt gggacagtga catgggtggg
     5281 agtaagagga ggagctttga aggctttggg acgtacaggg agaaggacat ccaagccttc
     5341 aagatgaatc gcaaggagag aggttcttat gagtcctcca tgtctccagg gatgccaagt
     5401 ccccacttaa aagtggacca gacagcagca cacagtaaga gcgagggctc aatatctgcc
     5461 atgatggcca ggaagaagcc aactgcagtg gacagtgttg cgattccctc agcacccgtg
     5521 ttatctctcc ttgctgcatc tgcagcaaca tcggatgcag ccagctcctc cctgaagaag
     5581 agattcaaga gacgggagat cgaagccatc caatgcgaag tgcggaagat gtgccattac
     5641 accaagcttc tgtccaccaa gaagaacctg gaccacgtga acaaaatcct gaaggccaag
     5701 cggctgcaga gacaatcaaa gacgggcaac aactttgtca agaagaggcg aggccggcct
     5761 aggaagcagc cctcacagtt cgatgaggac tccagagacc aaatgccagt gctggaaaag
     5821 tgcattgacc tacccagcaa gagaggccag aagcccagcc tgagtcccct agcgctggaa
     5881 ccggcctcgg gccaggatgc agtgatggcc accatcgagg ctgtcatcca catggctcgg
     5941 gaggcgccgc cgctgccccc gccgccgccc ccaccactgc caccgccccc gcctccacca
     6001 ccgccgcccc cgccgctgcc caagacggct cggggcggga agaggaaaca cagaccgcag
     6061 cccccagcgc agcccgcgca gcccacgccg cagccccttc cccaggaaga ggaggtgaag
     6121 gccaaaaggc cacggaagtc ccgagccagc gagagtgatg tccttcccta gggcgagcct
     6181 gggtggcagg atccgggcag ggactgatgt gggggagcac agcagccagg gtggggctga
     6241 tgcccagcca cagggacacc ccgcccctct ctacagcggg tgggcaggat gggcagaggg
     6301 cagggtggag ctttagggag ctcttggggt agtggaatga gggaaccccc tccaaaaaaa
     6361 gaaaaagtag ctgtcgctgc tgttcattca gtggcgggat ccttgcaggc tgcagaagac
     6421 ggaggaacgc aaagctggtg ctcaaagatg gccacctgat cctcctcatc ccaggtgtgc
     6481 ccttgattcc gatttcattt gctggtcaga aaaaaagata gataaataaa taaataaata
     6541 aataaataaa taaataggaa acaccattag caaacattcc aaggggaagc aaagctgaaa
     6601 atttaccagc tggcttgttt gtaagccact tccgcataat tggtttttat ttcttttggt
     6661 ttgcaaactc cgctaggctt tggggcacca acatcatctt caagtgaccc gagagatgag
     6721 tctttccgtt aacagcacag ttgctcagat ggaaacttgt gatcagaacg tggaattgga
     6781 ctgataggcg accttagatc tgctcgtgtt cctgtctcct acactgattt ttgcattgtc
     6841 tttttcctgc tttttttcct ttgtgttgtg ttttcatgta ctcccgttaa cttgctgcct
     6901 tcaactttgt gatacacatc taaacaaggt gaacttgact cacgtttgta aagtccactc
     6961 ttcgaatcct gcctcaagga accggctttg aatcccaatc attgtgaaac ataactcagt
     7021 acagtttaga agctttttaa taagtgactc agagcagccg atggatatgt cgacccaagt
     7081 gtcagccagg ttatttttat acttaaaaca tatcagtggc gaataggcag gaaaaaaatg
     7141 gtttaatacc cccccccccc ccagcaagtg gaataactgg ataagccacc aaaaatcaaa
     7201 atcccacacc caccagaaag aaaactgtct agcaatgcct tggtatctga ttattttcat
     7261 gcaaagagct gtcataggtt gttaagaaaa agaaacaaag acagtagaag tccattatct
     7321 cttaataatt attccttaaa atcgaagggg agtaagtgtt cttatctaaa attaaaaaaa
     7381 aaaataaaat aaatagaata aagtattcaa agggtaccac cactccaatt gcatcaagcc
     7441 accttggaca aagtatccaa attgtggttg ccttaataca ctaaaacatt gctgtacata
     7501 atgtaattat aaatctatca gtctgcatgg atgcaaactg tgtgtgacaa atcgtctttg
     7561 aaatggtcaa tttcaactgt acatttctca tccaagttgt attctagcct ctggtttaat
     7621 gtggacagat attccgtcta tcatccattc cacagcccaa gtttggactt aacccactgc
     7681 catagatgtt gttaaaagtc agatgtggaa atttcaaaaa gtattctcaa tttcctccct
     7741 tacgcctccc cttcttcaag acatcaaatg cctggcatca tagcttatat aaagagagac
     7801 acattttcta aggggaatta ggatatctgg tttacctcag aattaagatt ctttacagaa
     7861 agttgagacc agctaagaaa ctgcattatc acatcagaac acaggatctc cttctcagag
     7921 agaggtggat cttttggggg aacatagagt gaataagtga gtagtatcta ctgaaggaaa
     7981 tttgaaagtc ccaagttaat atgcttataa atacaccacc gagtcgtggc accaacagtt
     8041 gcttggaatt acagagccat cctgatcttc actgtcgaaa tggacttcat gtcatttgca
     8101 gcctgctcgg tcactctctt atacttctag caatacacac atttaaagga ctgtgcttat
     8161 ttcaagcttt tatcctagat actcagtttg tgacctgggt tgacctatgg catttcacac
     8221 aatttgaaca gcaaaatcta aacagccatt tccaatctgt cactcccaag ccatgtctga
     8281 gtaactccaa agtcacaggg aggaaggtat agatcagccc ccttcccccc aaccattgct
     8341 acgaaagagc agccatttcc attccaatta agccataaaa gggttctctt cctgatggac
     8401 tttaaaaaac catttctttc ctcctccatt cttgtggtgt agagtctccc aacccaatct
     8461 ataagccttc ttacagaagg cttatagaat ctaaaccttc ctacagaagg ctcatagaat
     8521 ctaaaccttc ctacagaagg cttatagaat ctaaaccttc ctacagaagg cttatagaat
     8581 ctaaaccttc ctacagaagg ctcatagaat ctaaaccttc ctacagaaga gagaaatctg
     8641 gtgcttatta aacctcaaga gacatccacc atttgattgg cattaacctg tgatcagtga
     8701 ttagctcaaa agacgtttgg gttagaattt ccaaaagagt aaaaagattc agtagagata
     8761 cactggatct gccacttaac gcgtgaattg gggtgtattg ttatctttga gttaaatgtg
     8821 agtcacacgg aaatccttgc atgcaagctc tgagaactgt ctggaagact agaggaccaa
     8881 agagtgtcac ggtgaacacc agctgacgat gcaagcgagc ccatctgtgt acacggtggc
     8941 tccctactac ccagtgactt cctcactgct gcatctttta tttctcttgt tttgcatgaa
     9001 cctgatcgcc acaactatgt ctgtgtgccc taaccacacc cttaacctct gctttgccgc
     9061 ccaggcccct ccacgaagcc agttgaattt ccacatccaa gtggttttta cagccagaaa
     9121 gagaacccag ctcttgattc aaagtatgga ggttcttatc cacacaacac tgccttctgg
     9181 ggatgcattt ctattccgag aggggttgtt tagcaacctc aagaccccat ttacagacct
     9241 acaaaacgtt ttgtaatgat cccttgcttt taatttcagt cccccccccc ttctttttag
     9301 aatactcctt cagcaagtag gtagagaccc acttacagta taaggagacc aattagagat
     9361 gagaaggtaa acgtaggtac aaaagctcct tagaggtgct gatgggtctg taatccacct
     9421 tactaaggga ctggaaagcc atttgctttt ttgaccccct cgtctcaaat aagagaaaca
     9481 gaagtttaac ttcttccaat agcctagctg tggctatcag ccaaggaaga aaggtcagag
     9541 gaagggaaaa caggagaggt tgctctgtga cttggcaagg ccaggactca gcagtcactg
     9601 gcagcctagc aaaggtgact aagggctggc agtagaacgg tgtataaact tggctgccgt
     9661 ctgaagtggg aggccatgtt caatggcagt ccaaatgtgt gttctgcaca ttgctgtatc
     9721 tataaatatg ataagcaagt ggtgacagaa ttctagtaga ggatgatgta tcataagcag
     9781 atcataaagg atttggtatt aagacttaag tagaaaatct tactcctggc tcattactca
     9841 acactatcca gataatgagt ttgtggagtg cgccttgccc tatcactagg aaggttgacc
     9901 tgggaactgt ctaaaagtct ttacagatat ttccaaagcc tttaaatgcc aactgtagca
     9961 tagaggggga gtggcgggag ctgaaatgcc tcaaaagcca tttaagtgtt atgtctcggg
    10021 attttcagtc ctactcatta tgtaaaagta cataaatata gacatttttc tcaacactac
    10081 cctatcgtat cacaatggtc caaatgccag cgcttacaga taatgtcatc acagtgccta
    10141 gaaactcaaa ctgtaatata ccgtagcatc ttcttggtgt ttcttcacgt ttctttccac
    10201 aaagcaaggc tccctctgcc tcgtgtttct aagagagttc accccactga ggagcctgcc
    10261 ttccctgttg gactctgtca cttgggggaa cagtcataga agcacatatc aaccaaggaa
    10321 ggaacttcct ggatatctgt ctcccacttg cccaggtata ataaacacta aagaggggaa
    10381 aaccgaagag ctgccaactg gtcaatctgg aagggtagtt ctgccctgga ttggtgtctt
    10441 tctttttctt ccttttttaa aaagaaatct atttcttaaa taataataaa tgcacatgat
    10501 gtgttaaata tgtacatata tatttcaaaa aatgggcaca agattgtctt acaagtcctt
    10561 ctggctaatt tttagtttgt attcataagt ggtttttaaa agcctttttt aaagtgtaat
    10621 ttgcatgttc tactttgatt gtatgtaaac atattttaga acaaaaatgt atttgtattt
    10681 tattgaatat agaggcaaga aaattgtaca ttgtttgaaa tgttcttttg taacagtttt
    10741 tattcataaa gcatttttgt acatttaaac gaacatggac ttgctgtcat ttgaggcgta
    10801 gcgacatctg gcatgcttta ctgtcatgct ctcccatggt cttagatgtt gggttttaaa
    10861 catttttttt tctaaaagaa agttcagtct cttttgctac cagatcaggt tagcacagta
    10921 cagagcactt aactattaaa ataaaaaaag ttgatcctat tcatatgtta ttcattgtgt
    10981 gaaattaaag acattcaatt cagtctaa
//
