LOCUS       NM_023871               2615 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus SET nuclear oncogene (Set), transcript variant 1,
            mRNA.
ACCESSION   NM_023871 NM_023189 XM_978154
VERSION     NM_023871.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2615)
  AUTHORS   Zhang,S., Zhou,J., Shang,P., Zhao,G., Wang,A., Mao,J., Tao,Y.,
            Chen,Z., Wang,X. and Guo,C.
  TITLE     SET/PP2A signaling regulates macrophage positioning in hypoxic
            tumor regions by amplifying chemotactic responses
  JOURNAL   Exp Mol Med 54 (10), 1741-1755 (2022)
   PUBMED   36224346
REFERENCE   2  (bases 1 to 2615)
  AUTHORS   Gao,L., Wang,S., Xu,J., Lu,D. and Cui,Y.
  TITLE     SET improved oocyte maturation by serine/threonine protein
            phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes
  JOURNAL   Reprod Biol 22 (3), 100668 (2022)
   PUBMED   35728284
  REMARK    GeneRIF: SET improved oocyte maturation by serine/threonine protein
            phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes.
REFERENCE   3  (bases 1 to 2615)
  AUTHORS   Harikumar,A., Lim,P.S.L., Nissim-Rafinia,M., Park,J.E., Sze,S.K.
            and Meshorer,E.
  TITLE     Embryonic Stem Cell Differentiation Is Regulated by SET through
            Interactions with p53 and beta-Catenin
  JOURNAL   Stem Cell Reports 15 (6), 1260-1274 (2020)
   PUBMED   33296674
  REMARK    GeneRIF: Embryonic Stem Cell Differentiation Is Regulated by SET
            through Interactions with p53 and beta-Catenin.
REFERENCE   4  (bases 1 to 2615)
  AUTHORS   Umata,K., Sakai,Y., Ikeda,S., Tsuji,S., Kawasaki,H., Ohama,T. and
            Sato,K.
  TITLE     Distribution of SET/I2PP2A protein in gastrointestinal tissues
  JOURNAL   PLoS One 14 (9), e0222845 (2019)
   PUBMED   31557212
  REMARK    GeneRIF: co-immunofluorescent staining of mouse gastrointestinal
            tissues revealed that even though the positive rate is much lower
            than epithelial cells, SET protein is also expressed in
            non-epithelial cells, such as monocytes/macrophages, neural cells,
            myofibroblasts, and smooth muscle cells. Results indicate an
            extensive role of SET in a variety of cell types.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2615)
  AUTHORS   Liu,H.B., Muhammad,T., Guo,Y., Li,M.J., Sha,Q.Q., Zhang,C.X.,
            Liu,H., Zhao,S.G., Zhao,H., Zhang,H., Du,Y.Z., Sun,K., Liu,K.,
            Lu,G., Guo,X.J., Sha,J., Fan,H.Y., Gao,F. and Chen,Z.J.
  TITLE     RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator
            in Early Zygotic Genome Activation
  JOURNAL   Adv Sci (Weinh) 6 (15), 1900295 (2019)
   PUBMED   31406667
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2615)
  AUTHORS   Minakuchi,M., Kakazu,N., Gorrin-Rivas,M.J., Abe,T., Copeland,T.D.,
            Ueda,K. and Adachi,Y.
  TITLE     Identification and characterization of SEB, a novel protein that
            binds to the acute undifferentiated leukemia-associated protein SET
  JOURNAL   Eur J Biochem 268 (5), 1340-1351 (2001)
   PUBMED   11231286
REFERENCE   7  (bases 1 to 2615)
  AUTHORS   Fukukawa,C., Shima,H., Tanuma,N., Ogawa,K. and Kikuchi,K.
  TITLE     Up-regulation of I-2(PP2A)/SET gene expression in rat primary
            hepatomas and regenerating livers
  JOURNAL   Cancer Lett 161 (1), 89-95 (2000)
   PUBMED   11078917
REFERENCE   8  (bases 1 to 2615)
  AUTHORS   Compagnone,N.A., Zhang,P., Vigne,J.L. and Mellon,S.H.
  TITLE     Novel role for the nuclear phosphoprotein SET in transcriptional
            activation of P450c17 and initiation of neurosteroidogenesis
  JOURNAL   Mol Endocrinol 14 (6), 875-888 (2000)
   PUBMED   10847589
REFERENCE   9  (bases 1 to 2615)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   10 (bases 1 to 2615)
  AUTHORS   von Lindern,M., van Baal,S., Wiegant,J., Raap,A., Hagemeijer,A. and
            Grosveld,G.
  TITLE     Can, a putative oncogene associated with myeloid leukemogenesis,
            may be activated by fusion of its 3' half to different genes:
            characterization of the set gene
  JOURNAL   Mol Cell Biol 12 (8), 3346-3355 (1992)
   PUBMED   1630450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005298.9.
            
            On Jan 19, 2022 this sequence version replaced NM_023871.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1;
            also known as isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172327.1, BC018255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               BX005298.9         31075-31293
            220-277             BX005298.9         37282-37339
            278-420             BX005298.9         37973-38115
            421-524             BX005298.9         38340-38443
            525-638             BX005298.9         38531-38644
            639-809             BX005298.9         39198-39368
            810-956             BX005298.9         39454-39600
            957-2615            BX005298.9         39932-41590
FEATURES             Location/Qualifiers
     source          1..2615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.09 cM"
     gene            1..2615
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /note="SET nuclear oncogene"
                     /db_xref="GeneID:56086"
                     /db_xref="MGI:MGI:1860267"
     exon            1..219
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..980
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SET; template-activating factor I; phosphatase 2A
                     inhibitor I2PP2A; SET translocation"
                     /codon_start=1
                     /product="protein SET isoform 1"
                     /protein_id="NP_076360.1"
                     /db_xref="CCDS:CCDS15866.1"
                     /db_xref="GeneID:56086"
                     /db_xref="MGI:MGI:1860267"
                     /translation="MAPKRQSAILPQPKKPRPAAAPKLEDKSASPGLPKGEKEQQEAI
                     EHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHP
                     QVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNES
                     GDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGE
                     VIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDED
                     EGEEGEEDEGEDD"
     exon            220..277
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            278..420
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            421..524
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            525..638
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            639..809
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            810..956
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            957..2615
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /note="hexamer: AATAAA"
     polyA_site      2607
                     /gene="Set"
                     /gene_synonym="2610030F17Rik; 5730420M11Rik; I-2PP2A;
                     StF-IT-1; TAF-I"
                     /note="major polyA site"
ORIGIN      
        1 gaggccgact taaatctccc gcacctgagg ccgcctcagt tcctgtgagt ttcttcctgc
       61 tgtgaacatc agggctctgg gctctgtctc ccggtcatct ccctcgcgcc atggccccga
      121 agcggcagtc tgcgatcctg cctcagccca agaaacccag accggctgct gccccgaagc
      181 tggaggacaa gtcggcctct cccggcctgc cgaagggaga aaaagaacag caagaagcaa
      241 ttgaacatat tgatgaagta caaaatgaaa tagacagact taatgaacaa gccagtgagg
      301 aaattttgaa agtagaacaa aaatataaca aactccgcca accatttttt cagaagaggt
      361 cagaattgat cgccaaaatc ccaaattttt gggtaacaac atttgtcaac catccacaag
      421 tgtctgcact gcttggggag gaggacgagg aggctctgca ttatttgacc agagttgaag
      481 tgacagaatt tgaagacatt aaatcaggtt acagaataga tttttatttt gatgaaaatc
      541 cttactttga aaataaagtt ctctccaaag aatttcatct gaacgagagt ggtgacccgt
      601 cttcaaagtc caccgaaatc aaatggaaat ctggaaagga tttgacaaaa cgctcaagtc
      661 aaacgcaaaa taaggccagc aggaagaggc agcacgaaga gccagagagc ttctttacct
      721 ggtttactga ccattctgac gcaggtgctg atgagttagg agaggtcatc aaagatgaca
      781 tctggccaaa tcccttgcag tactacctgg ttcccgacat ggatgatgaa gaaggagagg
      841 cagaagatga tgatgacgac gacgaagagg aggaggggct ggaagatatt gatgaagaag
      901 gagatgagga tgaaggtgaa gaagatgacg atgaggatga aggggaggaa ggagaggagg
      961 acgaaggcga ggatgattag cacagaagac tgatggattc caaccttctt ttttattttc
     1021 tttttatttt ttaattttct ccagtccctg ggagcaagtt gcagtccttt cctccctgtc
     1081 cctctgtgct cagtcgccct gttttgaggt ctcaacatca tggttctcaa ttaatttggg
     1141 gggaagtatc ttgagcaaaa tacaacagga aaagaatctc cgtttctgtt cttaattcat
     1201 tttttatcct ttcttgtcta aatttgtgga ttccacacca ccatgctctg tgggaaaaaa
     1261 gaaaagccct ccagttccct tggctctgct ggagggcgct aggcccctgt gtagtagttt
     1321 atagaatttt agcttttctt cttttctctg tatattgggc tcagagatta cactgtgtct
     1381 ctatgtgaat acagacagtt agcatttacc aacatgtatc tgtctacttt ctcttgttta
     1441 ataaaaagaa aaaaaaaaag aaaaaaaggg ggggtataga cggtgagcaa gggtgggttt
     1501 gaggtgtctg gggtaggtgg gcatctgaca acatggcttc tcctttggca tgtttaattg
     1561 tgtggtttaa cagacatcct tgcaatttaa ggtgacactt aaaataaaat tctctcctga
     1621 tgatgacttg agccctgaca ctcaatggga gaatcagcag aacctgtatg gttttatttg
     1681 gagttgacat tctgttgtaa ttttaatttt tttctttttc tttttctttt tttttttttt
     1741 ttttttggtt ttcactggaa ggaaaaagat gctcatttta aatgttgaag tgtacaagtt
     1801 gctttgttac aataaaatca gtgtgtacac aaaggacctg atgcttttct gtcaacagat
     1861 gctcaacaga ccttccaagt ttgactgcat aatgacatca cgtcaaactt tgtctcccca
     1921 acttcgtatt ttttgatacg cactttgcag gatgacctca gggctgtgca gattgagaaa
     1981 gggatttgaa tcatgtctta acgtctccgt actgagttgt gggcacagct tgctgctgtg
     2041 gacttatacc cttgattttt atctcaattt ggcattttct ttttaaaatg ggcctttacc
     2101 cggacctcac ggcagcacct acctgctccc accgttactg acccgttgct ctgtgccatc
     2161 tatgagggac agccgctgac gtgtcctcat tggcagtgtg aactgtcagg gtcagcagtc
     2221 agtgaggtgg ttggtagtgt ctgtcacagg tatgtagcag aagctctcag atgtgagact
     2281 gacgtaggtg gatgaagagc tgtctgctca gcgccatcgg gcagaggata atgtttggga
     2341 agctacctga tgcgtaagct ttttaatgct gtaaaataga gctaaaattc aatgccactt
     2401 tttcagagat gattaatgga cagcctggtc aaattcaaag ctttctgatg tataaaactt
     2461 tataaatgga actactccat caataggcaa agtgtaacca aaatctgtct agatggatag
     2521 tgtgtaattt ctgcacagga ctctgtttag taaatacatc actgtatacg tcaggaatct
     2581 tgctccaata aaggaacata aagatttttt ttgga
//
