LOCUS       NM_030261               2158 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus sestrin 3 (Sesn3), mRNA.
ACCESSION   NM_030261 XM_973252 XM_973295 XM_973331 XM_973372 XM_973408
VERSION     NM_030261.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Wang,M., Chen,W., Zeng,X., Wang,T., Sun,Y. and Yang,Q.
  TITLE     Sestrin1, 2, and 3 are dispensable for female fertility in mice
  JOURNAL   J Ovarian Res 17 (1), 28 (2024)
   PUBMED   38297375
  REMARK    GeneRIF: Sestrin1, 2, and 3 are dispensable for female fertility in
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Han,X., Yang,Y., Liu,S., Niu,Y., Shao,H. and Fu,L.
  TITLE     Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice
            via activating Sestrin3
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (1), 166568 (2023)
   PUBMED   36220588
  REMARK    GeneRIF: Aerobic exercise ameliorates insulin resistance in C57BL/6
            J mice via activating Sestrin3.
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Lin,W., Zhao,J., Yan,M., Li,X., Yang,K., Wei,W., Zhang,L. and
            Chen,J.
  TITLE     SESN3 Inhibited SMAD3 to Relieve Its Suppression for MiR-124, Thus
            Regulating Pre-Adipocyte Adipogenesis
  JOURNAL   Genes (Basel) 12 (12), 1852 (2021)
   PUBMED   34946801
  REMARK    GeneRIF: SESN3 Inhibited SMAD3 to Relieve Its Suppression for
            MiR-124, Thus Regulating Pre-Adipocyte Adipogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Lee,J.H., Budanov,A.V. and Karin,M.
  TITLE     Sestrins orchestrate cellular metabolism to attenuate aging
  JOURNAL   Cell Metab 18 (6), 792-801 (2013)
   PUBMED   24055102
  REMARK    Review article
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Lee,J.H., Budanov,A.V., Talukdar,S., Park,E.J., Park,H.L.,
            Park,H.W., Bandyopadhyay,G., Li,N., Aghajan,M., Jang,I.,
            Wolfe,A.M., Perkins,G.A., Ellisman,M.H., Bier,E., Scadeng,M.,
            Foretz,M., Viollet,B., Olefsky,J. and Karin,M.
  TITLE     Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3
  JOURNAL   Cell Metab 16 (3), 311-321 (2012)
   PUBMED   22958918
  REMARK    GeneRIF: Concomitant ablation of Sesn2 and Sesn3 provokes hepatic
            mTORC1-S6K activation and insulin resistance even in the absence of
            nutritional overload and obesity.
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Chen,C.C., Jeon,S.M., Bhaskar,P.T., Nogueira,V., Sundararajan,D.,
            Tonic,I., Park,Y. and Hay,N.
  TITLE     FoxOs inhibit mTORC1 and activate Akt by inducing the expression of
            Sestrin3 and Rictor
  JOURNAL   Dev Cell 18 (4), 592-604 (2010)
   PUBMED   20412774
  REMARK    GeneRIF: FoxOs inhibit mTORC1 and activate Akt by inducing the
            expression of Sestrin3 and Rictor
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Peeters,H., Debeer,P., Bairoch,A., Wilquet,V., Huysmans,C.,
            Parthoens,E., Fryns,J.P., Gewillig,M., Nakamura,Y., Niikawa,N., Van
            de Ven,W. and Devriendt,K.
  TITLE     PA26 is a candidate gene for heterotaxia in humans: identification
            of a novel PA26-related gene family in human and mouse
  JOURNAL   Hum Genet 112 (5-6), 573-580 (2003)
   PUBMED   12607115
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK155398.1.
            
            On Apr 6, 2007 this sequence version replaced NM_030261.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155398.1, BC132086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2158              AK155398.1         2-2159
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 3.89 cM"
     gene            1..2158
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /note="sestrin 3"
                     /db_xref="GeneID:75747"
                     /db_xref="MGI:MGI:1922997"
     exon            1..329
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1730
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /codon_start=1
                     /product="sestrin-3"
                     /protein_id="NP_084537.2"
                     /db_xref="CCDS:CCDS22820.1"
                     /db_xref="GeneID:75747"
                     /db_xref="MGI:MGI:1922997"
                     /translation="MNRGGSSASASANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFI
                     PEKEVVQANTADERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGP
                     LPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINK
                     LLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDP
                     GIANGFRLISVSSFCVCDLANDNSIENTSLAGSNFGIVDSLGELEALMERMKRLQEDR
                     EDDETTREEMTTRFEKEKKESLFVVPGETLHAFPHSDFEDDVIVTADVSRYIEDPSFG
                     YEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMAT
                     HEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKR
                     MYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT"
     exon            330..395
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..593
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..776
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1013
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1188
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1307
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1498
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1643
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2158
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
                     /note="hexamer: CATAAA"
     polyA_site      2093
                     /gene="Sesn3"
                     /gene_synonym="5630400E15Rik; SEST3"
ORIGIN      
        1 gaaggcggcg ggcctcgggg gcggggccgc actgagaagc tgagacggcc gcggctgctc
       61 gtcctggctg gcggggcggg ggtctggcga tgggggcggg aggaacaacg ggtcgctgag
      121 tgccgcggct gccgtccccg ccgagctcgc gcgggcagcc gctgcgccgt cgctgccgcc
      181 cgaccccctg agaagagaac gttgaagcag cccttcgcta gcggccgcgg tgacagcccg
      241 gctccggcgc gatgaaccgc ggtggcagca gcgcgtcggc ctcggccaac tacctgctct
      301 gcaccaactg ccggaaagtg ctgcggaagg acaaaagaat ccgagtgtct caacccctga
      361 caagaggacc aagtgccttt attccagaga aggaagttgt ccaagcaaat acggcggatg
      421 aacgaacaaa ctttcttgtg gaagagtact ctacatccgg tcgcctggac aacatcacac
      481 aggtgatgag cttgcacact cagtacctgg aatctttctt gcggagccag ttctacatgc
      541 tgcgtatgga cggccccctt cccctcccag acaggcacta cattgccatc atggctgcag
      601 ccagacacca gtgttcctac ctaataaaca tgcatgtgga tgaattttta aagactggag
      661 ggatcgctga gtggctgaat ggcttggaat atgtaccaca aagactgaga aatcttaatg
      721 aaattaacaa gctgctggca caccggccct ggctgatcac aaaagagcac attcagaaac
      781 ttgtcaaaac tggagaaaat aattggtccc tgcctgagct agtgcacgcc gtggtcctct
      841 tggctcacta tcacgctttg gccagctttg tttttggtag tggcatcaat ccagagagag
      901 acccaggaat cgccaatggg ttcagactaa tctctgtgag cagcttctgt gtgtgtgacc
      961 tggccaatga caacagcatc gagaacacct ccctggcggg cagcaacttt gggattgtgg
     1021 attccctagg cgagctggaa gccttaatgg aaaggatgaa aaggcttcag gaagacaggg
     1081 aagatgacga gaccactcgg gaagaaatga ccacgcgttt tgagaaggaa aagaaagaaa
     1141 gtctctttgt ggtccctgga gaaactttac atgcgtttcc tcactcagat tttgaagatg
     1201 atgtgattgt aacagccgat gtctctcgat acattgaaga cccaagcttt gggtacgaag
     1261 actttgccag gcgaggagaa gaacatttgc caacattccg agcccaggac tacacctggg
     1321 aaaaccatgg gttctcactg gtgaacaggc tttactctga cattggacat ctcctggatg
     1381 agaagtttcg aatggtctac aatctcacct acaacacaat ggccacccat gaggatgttg
     1441 acacgaccac actgcgcaga gctttgttta actatgttca ctgtatgttt ggaatcaggt
     1501 atgatgacta tgactatgga gaagttaacc agttacttga acggagcctg aaggtttaca
     1561 tcaagacagt gacctgctac cctgagagaa ccacgaagcg catgtatgac agctactggc
     1621 gccagttcac tcactcagag aaggtccacg tgaatctgct tctgatggaa gcacggatgc
     1681 aggccgagct gctttatgct ctgcgagcca taactcggca tctgacctga agcacctgga
     1741 ggaaggcgtc agcatgcatc agggcctctc gcccgggact cccatcagaa ctcgtttgtg
     1801 acgcacctca gcagttacca gttactcggt tctctagtgt caaagtatag ctgtcggggt
     1861 tgtttttgtt tttgattttt gttttgtttt gttcttgttg ttagggttac tttgttttgt
     1921 tttgattttt tttttctggc tgtcacgtgc aatggtgtgt tttatatttc tcgatgctta
     1981 acattgctaa caattgcaaa agtaaccctg gcgagtacta ctttacgttg ttagagttgg
     2041 attttcagat ctgaccataa atcatgaact ggtttgttaa tgcttcactt caatactttg
     2101 aagttcatat gtatgtgtat tatttttctt tacttaaaaa aaaataagga aaatgctt
//
