LOCUS       NM_144907               2677 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus sestrin 2 (Sesn2), mRNA.
ACCESSION   NM_144907
VERSION     NM_144907.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   Hu,H., Lu,X., He,Y., Li,J., Wang,S., Luo,Z., Wang,Y., Wei,J.,
            Huang,H., Duan,C. and Sun,N.
  TITLE     Sestrin2 in POMC neurons modulates energy balance and obesity
            related metabolic disorders via mTOR signaling
  JOURNAL   J Nutr Biochem 133, 109703 (2024)
   PUBMED   39025457
  REMARK    GeneRIF: Sestrin2 in POMC neurons modulates energy balance and
            obesity related metabolic disorders via mTOR signaling.
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   De Leonibus,C., Maddaluno,M., Ferriero,R., Besio,R., Cinque,L.,
            Lim,P.J., Palma,A., De Cegli,R., Gagliotta,S., Montefusco,S.,
            Iavazzo,M., Rohrbach,M., Giunta,C., Polishchuk,E., Medina,D.L., Di
            Bernardo,D., Forlino,A., Piccolo,P. and Settembre,C.
  TITLE     Sestrin2 drives ER-phagy in response to protein misfolding
  JOURNAL   Dev Cell 59 (16), 2035-2052 (2024)
   PUBMED   39094564
  REMARK    GeneRIF: Sestrin2 drives ER-phagy in response to protein
            misfolding.
REFERENCE   5  (bases 1 to 2677)
  AUTHORS   Song,Z., Lin,Q., Liang,J. and Zhang,W.
  TITLE     Inhibition of Sesn2 has negative regulatory effects on the myogenic
            differentiation of C2C12 myoblasts
  JOURNAL   Mol Biomed 5 (1), 31 (2024)
   PUBMED   39117956
  REMARK    GeneRIF: Inhibition of Sesn2 has negative regulatory effects on the
            myogenic differentiation of C2C12 myoblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2677)
  AUTHORS   Barkic,M., Crnomarkovic,S., Grabusic,K., Bogetic,I., Panic,L.,
            Tamarut,S., Cokaric,M., Jeric,I., Vidak,S. and Volarevic,S.
  TITLE     The p53 tumor suppressor causes congenital malformations in
            Rpl24-deficient mice and promotes their survival
  JOURNAL   Mol Cell Biol 29 (10), 2489-2504 (2009)
   PUBMED   19273598
REFERENCE   7  (bases 1 to 2677)
  AUTHORS   Budanov,A.V. and Karin,M.
  TITLE     p53 target genes sestrin1 and sestrin2 connect genotoxic stress and
            mTOR signaling
  JOURNAL   Cell 134 (3), 451-460 (2008)
   PUBMED   18692468
  REMARK    GeneRIF: Sestrin1 and Sestrin2 therefore provide an important link
            between genotoxic stress, p53 and the mTOR signaling pathway.
            Erratum:[Cell. 2009 Jan 23;136(2):378]
REFERENCE   8  (bases 1 to 2677)
  AUTHORS   Papadia,S., Soriano,F.X., Leveille,F., Martel,M.A., Dakin,K.A.,
            Hansen,H.H., Kaindl,A., Sifringer,M., Fowler,J., Stefovska,V.,
            McKenzie,G., Craigon,M., Corriveau,R., Ghazal,P., Horsburgh,K.,
            Yankner,B.A., Wyllie,D.J., Ikonomidou,C. and Hardingham,G.E.
  TITLE     Synaptic NMDA receptor activity boosts intrinsic antioxidant
            defenses
  JOURNAL   Nat Neurosci 11 (4), 476-487 (2008)
   PUBMED   18344994
  REMARK    GeneRIF: Synaptic activity upregulated the
            thioredoxin-peroxiredoxin reactivating gene sestrin 2.
REFERENCE   9  (bases 1 to 2677)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   10 (bases 1 to 2677)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC005672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005672.1, AK170228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N-3"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.45 cM"
     gene            1..2677
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /note="sestrin 2"
                     /db_xref="GeneID:230784"
                     /db_xref="MGI:MGI:2651874"
     exon            1..393
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1746
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /EC_number="1.11.1.15"
                     /codon_start=1
                     /product="sestrin-2"
                     /protein_id="NP_659156.1"
                     /db_xref="CCDS:CCDS18726.1"
                     /db_xref="GeneID:230784"
                     /db_xref="MGI:MGI:2651874"
                     /translation="MIVADSECHSEIKGYLPFTRGGVAGPETREEHREGQARRGSRGP
                     SAFIPVEEILREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLH
                     TDGPLASSWRHYIAIMAAARHQCSYLVGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLS
                     EVNKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLLTHCHSLASFVFGCGILP
                     EGDAEGSPASQAPSPPSEQGTPPSGDPLNNSGGFEAARDVEALMERMRQLQESLLRDE
                     GASQEEMENRFELEKSESLLVTPSADILEPSPHPDILCFVEDPAFGYEDFTRRGTQAP
                     PTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVACSLTYNTIAMHSGVDTSMLRRA
                     IWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFRHS
                     EKVHVNLLLLEARMQAALLYALRAITRYMT"
     exon            394..459
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..657
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..840
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1053
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1204
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1323
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1514
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1659
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2658
                     /gene="Sesn2"
                     /gene_synonym="HI95; Ses2; SEST2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatggtga ggagcgccgg cttcccgagc agcgctggcc actgcggact tccgaggcac
       61 tccgggccgt gaaaacctct gcgccgcggc caatctcagg cctccgaggc cggccgcagt
      121 tttccaagct gggctgaaag gagtgtctat cgccgtagcg ccggttctcc taatcccgag
      181 agacagcccg gggatctcga gcttccccgg cgacccctag tcccggcctc ctgtgcgcgc
      241 ccgacctaga cccctcgggt gtcccaggcg cggacgagcc gcggccgggt cctggcgtac
      301 accatgatcg tagcggactc cgagtgccat tccgagatca agggctacct gccgttcacc
      361 aggggtggtg tggccggccc cgagacccga gaggagcatc gggagggcca ggctcggcga
      421 ggctctcgag ggcccagcgc tttcattcca gtggaagaga tccttcggga aggagctgag
      481 agcctggagc agcacctggg gctcgaggcc ctgatgtcct cagggcgggt ggacaacctg
      541 gcggtggtga tgggtctaca cccggactac cttagcagct tctggcgcct gcattacctg
      601 ctgctgcata cggatgggcc cctggccagc tcctggcgcc actacattgc catcatggct
      661 gctgcccgtc accagtgttc ttacctggtg ggttcccaca tgactgagtt cctgcagacc
      721 ggcggtgacc ccgagtggct gctgggcctt caccgggccc ctgagaagct ccgcaagctc
      781 agcgaggtca acaagttact ggcgcatcgg ccgtggctca tcaccaagga gcatatccag
      841 gccttgctga agactggcga gcacagctgg tccctggccg aactcatcca agcactggtc
      901 ctgcttaccc actgccactc tctggcctcc tttgtgtttg gctgtggaat acttcctgag
      961 ggagatgcag agggcagccc tgcctcccag gcaccttcgc ctcccagtga gcaaggcacc
     1021 cccccgagcg gggacccact gaacaactca gggggctttg aagccgctcg tgacgtagaa
     1081 gctctgatgg aacgcatgag gcagcttcag gagagcctgc tgcgggatga gggggcttcg
     1141 caggaggaaa tggagaaccg ttttgagctg gagaagtcag aaagcctgct ggtgaccccc
     1201 tcagcggata tcctggagcc ttctccacac ccagacatcc tatgctttgt ggaggacccc
     1261 gcatttggat atgaagactt cactcgtcga gggactcagg cgcccccaac cttccgtgcc
     1321 caggattata cctgggaaga ccatggctac tcgctgatcc agaggctcta ccctgaggga
     1381 gggcagctgc tggatgagaa gttccaggta gcctgcagcc tcacctataa caccatcgcc
     1441 atgcacagtg gcgtggacac ctccatgctc cgcagggcca tctggaacta catccactgc
     1501 gtctttggca tcagatacga tgactatgat tacggcgagg taaaccagct cctggaacgg
     1561 aacctcaaaa tctatatcaa gacggtggcc tgctaccctg agaagacgac ccgtaggatg
     1621 tacaacctct tttggaggca cttccgccac tcagagaagg ttcatgtgaa cttgctgctc
     1681 cttgaagccc gcatgcaagc ggccctgctc tatgccctgc gcgccatcac ccgctacatg
     1741 acctgactac cccgtacgca ggaccagcac caggagcagc tgaccctggt ccaccgtcct
     1801 ctgtgcaagg acttctgtgt ctggagacag atctgggaag gaccctttct gtctcatgtc
     1861 tatccaccac atgctgggga tgggcatgtc tgtggcccca ggcagccatc agggcaagcc
     1921 acattttcct tttcctcact ggactgaaca ggaccgtcgc actgactttg gggtctgagc
     1981 tctgtacctg gagctggaag aagattcgga aaggccaagg gccacatccc cttttcttcc
     2041 cctgctccta aaagcagagg aaggctacag agctaaggct gggccccagg caccacaaaa
     2101 gctgccttcc tggactggga agcccctggc tgcctgtgtg ggagaggagt aaggacctcc
     2161 agggactagc actccaggaa gtttgccttc ccgccttccc tccttcctca ttctccagtt
     2221 tcatcagccc cccaacctgc ctcccaccca tcaatgtgaa agttggactc acagctggtc
     2281 tgtgtgccca gttcccctag agcctgttct gctgggcagc ctgttctttg gttacctgag
     2341 taggggttca gttcttctgt ctcctttgcc ctcataccct tttctcccat gcctggtggt
     2401 gtggggcctg ggagaggggc caaacatatc caaagaacac actgtctctg gagagttgga
     2461 gcccgtggtg gtctccctgc tgtctgaaga gtaaggagtg gctgttggtg aactctgtat
     2521 ttgggtcttg aggacctcac tgtggagcca gagtcaatct gtccctctag atggtattgc
     2581 cacacggagg ctggcatcct gacctcctta tcccttgggt tctgccaaga atgcttgcca
     2641 aaaacaaaca aacaaaaaaa aaaaaaaaaa aaaaaaa
//
