LOCUS       NM_001038625            5519 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SERTA domain containing 2 (Sertad2), transcript
            variant 2, mRNA.
ACCESSION   NM_001038625
VERSION     NM_001038625.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5519)
  AUTHORS   Chen,C., Deng,Y., Hu,X., Ren,H., Zhu,J., Fu,S., Xie,J. and Peng,Y.
  TITLE     miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting
            Pparg and Sertad2
  JOURNAL   J Physiol Biochem 74 (3), 381-393 (2018)
   PUBMED   29654510
  REMARK    GeneRIF: Data suggest that expression of microRNA-128-3p is
            down-regulated during adipogenesis; an abundance of microRNA-128-3p
            appears to down-regulate adipogenesis and up-regulate lipolysis in
            adipocytes by targeting expression of Pparg (peroxisome
            proliferator-activated receptor gamma) and Sertad2 (SERTA
            domain-containing protein-2).
REFERENCE   2  (bases 1 to 5519)
  AUTHORS   Qiang,G., Whang Kong,H., Gil,V. and Liew,C.W.
  TITLE     Transcription regulator TRIP-Br2 mediates ER stress-induced brown
            adipocytes dysfunction
  JOURNAL   Sci Rep 7, 40215 (2017)
   PUBMED   28067333
  REMARK    GeneRIF: Study demonstrates a role for TRIP-Br2 in endoplasmic
            reticulum stress-induced brown adipose tissue (BAT) dysfunction,
            and inhibiting TRIP-Br2 could be a potential approach for
            counteracting obesity-induced BAT dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5519)
  AUTHORS   Qiang,G., Kong,H.W., Fang,D., McCann,M., Yang,X., Du,G., Bluher,M.,
            Zhu,J. and Liew,C.W.
  TITLE     The obesity-induced transcriptional regulator TRIP-Br2 mediates
            visceral fat endoplasmic reticulum stress-induced inflammation
  JOURNAL   Nat Commun 7, 11378 (2016)
   PUBMED   27109496
  REMARK    GeneRIF: Transcription factor GATA3 is responsible for the ER
            stress-induced TRIP-Br2 expression in visceral fat.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5519)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 5519)
  AUTHORS   Peng,Y., Zhao,S., Song,L., Wang,M. and Jiao,K.
  TITLE     Sertad1 encodes a novel transcriptional co-activator of SMAD1 in
            mouse embryonic hearts
  JOURNAL   Biochem Biophys Res Commun 441 (4), 751-756 (2013)
   PUBMED   24211589
REFERENCE   6  (bases 1 to 5519)
  AUTHORS   Sim,K.G., Cheong,J.K. and Hsu,S.I.
  TITLE     The TRIP-Br family of transcriptional regulators is essential for
            the execution of cyclin E-mediated cell cycle progression
  JOURNAL   Cell Cycle 5 (10), 1111-1115 (2006)
   PUBMED   16721052
REFERENCE   7  (bases 1 to 5519)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   8  (bases 1 to 5519)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5519)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
REFERENCE   10 (bases 1 to 5519)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146621.1 and AL663115.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142018.1, AK132846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1607              AK146621.1         2-1608
            1608-5519           AL663115.11        135360-139271
FEATURES             Location/Qualifiers
     source          1..5519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 13.03 cM"
     gene            1..5519
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /note="SERTA domain containing 2"
                     /db_xref="GeneID:58172"
                     /db_xref="MGI:MGI:1931026"
     exon            1..297
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..5519
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1231
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /note="isoform 1 is encoded by transcript variant 2; SERTA
                     domain-containing protein 2; PHD zinc finger- and
                     bromodomain-interacting protein 2; transcriptional
                     regulator interacting with the PHD-bromodomain 2"
                     /codon_start=1
                     /product="SERTA domain-containing protein 2 isoform 1"
                     /protein_id="NP_001033714.1"
                     /db_xref="CCDS:CCDS24458.1"
                     /db_xref="GeneID:58172"
                     /db_xref="MGI:MGI:1931026"
                     /translation="MLGKGGKRKFDEHEDGLEGKIVSPSDGPSRVSYTLQRQTIFNIS
                     LMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPAFTPSSQPSNSLSDSYQE
                     APPPAPHPCDLGSTTPLEACLTPASLLEDDNDDTFCTLQAVHPAAPTRLSSAALPAEK
                     DSFSSALDEIEELCPTSTSTEAAHTAAPEGPKGTSSESSVQKPEGPEEGRTDDSRFMD
                     SLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSASGTASKMAPVSADDLLK
                     TLAPYSNQPVAPSQPFKMDLTELDHIMEVLVGS"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /note="hexamer: AATAAA"
     polyA_site      5517
                     /gene="Sertad2"
                     /gene_synonym="Kiaa0127; mKIAA0127; MNCb-1504; SEI-2;
                     Sei2; TRIP-Br2"
                     /note="major polyA site"
ORIGIN      
        1 agaggctcgc aggcggacgt cactcccgca cggcgagtgc tggagcacga gctgtacctc
       61 tctcggcccg ggcgtccact ccgcccgcct cctgcttcct ccaggctgcc cgccgcctcc
      121 accattgtat aatgttcccg actcgcaagc agaggacgcc ggagtcgtag ctccggcctc
      181 gccgagctcc ctgctaccgt cggccccgcg gcgggggcgc cccgcatgga gcgggcatag
      241 cttgaggggt gggcggaaac ccctccgatg cgttagctcc tggtggacct gcttgtgata
      301 tatgttgggt aaaggaggaa aacggaagtt tgatgagcat gaagatgggc tggaaggcaa
      361 aatcgtgtcc ccctccgacg gtccatccag ggtgtcttac accttacagc gccagactat
      421 cttcaacatt tcccttatga aactgtataa ccacaggcct ctgacagagc ccagcttgca
      481 gaagactgtc ttaattaaca acatgttgag gcggatccag gaggaactca agcaggaagg
      541 cagcctgagg cctgcattca ccccctcttc ccagccgagc aactcactga gcgacagcta
      601 ccaggaggcc ccgcctcctg ctcctcaccc ctgtgacctc ggaagcacta cacccttgga
      661 ggcctgcctc acccctgcct ccctgctcga ggacgacaac gatgacactt tttgcacttt
      721 gcaggctgtg caccctgcag ctcccactag actctcttct gcagccctcc cagcagagaa
      781 ggacagcttc tcctccgcct tggatgagat cgaggagctc tgtcccacat ctacctccac
      841 agaggctgcc cacacagcag cccctgaggg cccgaaagga acctccagtg agtccagtgt
      901 ccagaaacct gaggggcccg aggaaggccg cacagatgac tcacgattca tggactctct
      961 gcctgggaat tttgaaataa caacgtccac gggtttcctg acagacttga ccctggatga
     1021 catcttgttt gctgacattg atacatccat gtacgatttt gacccctgca catctgcatc
     1081 ggggacagcc tcaaagatgg cccctgtgtc agctgatgac ctcctcaaga ccctggctcc
     1141 ttacagcaat cagcctgttg ccccaagtca gcctttcaaa atggatctca cggagctgga
     1201 ccacatcatg gaggtgcttg ttggctcctg agacctgggc ccacgtgact gcgcccagcc
     1261 aggctctgca cccttgcagc cccgacagtt tctccgcact gtgcatggac ccttgcttgc
     1321 ctttttcaga gaaaaagaaa attttacaaa aggatcacac tagtattttc ttcaagcaga
     1381 gttggagtgc cttcattcga gtatgcccac ttgtaacaca ctcttctgag tgggttcctc
     1441 agagccctgc tgccctggcg taggagagaa gacatttgaa gactgtgttg ctaatgttga
     1501 aaggtgaaca ggaacagttc aagtgaagca caaggattaa gttggaaaag ctgtaaattg
     1561 catgtgcata tttgtctatt ttttctataa gttttattgc aagaggtaaa aaaaaaaaag
     1621 aatatatatc tatattattt ggataatctc agtacctttt ctggcgtttt gccctgtgta
     1681 agttgacttg gcaattcagc ctttttagag gcattaacta ctcgtaagtg ttgcatttac
     1741 atggctgttt agaaaactgc tgcccaaatt tattttatat ttttgtacag attctgcagt
     1801 ttatgatatt gtttttctaa acacaaatgc tgtttatacc tatgaaatag ctattttgat
     1861 aggatttgct cacatagttc ctgcaaacat gagatgtaca agttgcactt gtacttttat
     1921 aggacttgta atgttttata tgtgtgtggt gcaagagaga actggatcac gtcagtctgc
     1981 agttgatgtc cccactgcaa atacacacag cgctttcata aagggccagg tgatctgaca
     2041 cccaaatttc acaagcacca gcccctggca cggtcacccg ccagcactgt gacttccaaa
     2101 gccagagccc tgtctgctca tcaaacatgc attaagcagt tggcggggag atggctgtgt
     2161 ttcttggggt agggagggcg gagttgatgt ggcaggctcc ttagctccct cttttgaaca
     2221 gaggctgcat catcttattt aagagtggac tcagcagggt gtggtggcac acccctgtaa
     2281 ttccagcatt tgggaggcag gggcaggcag atttttgtga gttccagtcc agccagaact
     2341 atacagtgag aaaaccctgt ctcaaggtgg gggtggggag ggagggggaa cagggggata
     2401 aaaaacaaaa caaaactgta tttatgccaa gttgctattt taattgtttt tattttaaat
     2461 ttttgaaatg aaaaccccag tctttgtctt ttggcatagc ttttatgacg agaccacaat
     2521 tttacacaac aaaattttac aacaagcaac tgaccttttg ctggaggtga gccccacttc
     2581 agtacttagt tccccagaag gcatccatcg tgttgctgag ctgcctctcc catgtccttt
     2641 ccctggagct tttgttccct ctgttgctaa gagctgcaaa tggcatcttt ctgatcagca
     2701 cagtgagcta gctctgcgca cctccgccag ccgggacgcg ctcgctcgct ctcctgacat
     2761 ctgtgactag agccgcagtc caccgcctta tgtcatggtg tccaatctgg ttgctttcct
     2821 taattaactg ctaatttaac tacactttac aaagctgtta ttcccaaata catagagagg
     2881 aatttctatg cacgtctctg gccttcccct acccccatgt gctagcccct ccagcggctc
     2941 tttctttagt gatcccccca acacgtgcac tcatgagatg cagtcgtttg ttttagtgta
     3001 tcaggcctgt tgctgaaacc gcctttctgt ttcatggctc gctcttgcag tgtggtattt
     3061 gagctgttga gtgcaggtta caacctatat ggcttcttta gaaataactt ttatatttat
     3121 ttaaaaaaac ttaaattatg ggattttgtt tttgtttttg gttgtctttg ttggtcattt
     3181 gtcaatatac agtcaccaac caactctgct cacttcttgc catggataaa atgggccttt
     3241 ctggccaatt aaaaagataa attttataaa tggcacttta aaacaagcca taaatagatt
     3301 tatttttata atgcacatgg caagcaaatg catttgtgat gaaggaactg ctcatccaag
     3361 cagaagattt gtggatggtg cgattaatat ctttttacct tttcttcact ggaatgtgtc
     3421 tgacaggctg actgtcagct ctggagcagc gggaggctga tccagctgtg ctcctacagg
     3481 cacctccagc ctttcaccag ccccttcacg cgtgtgtctc ctttcttgta gggcagggac
     3541 cacacgtagg ggaggttgtc atgcacactt gcaagtgtct ctgtgcctgt ccatcttaag
     3601 aacttgtctg tcttgtagag agcaggtctg cccgtactct gtgtgtttta gaactggagg
     3661 atcctgtgaa ctggccacat gccacacaca tctgcataca tgtgcatata cagtagtgtt
     3721 gatgattccc agcaaaaatg gcacaaagca gttgattgcc attgtcaaaa actgatttac
     3781 agtaacttag aacaactgta cttttgttgg attagcaaat catgtgttta aacaatccca
     3841 tatgttgggc aacagttcaa ataagcacag agaagcattg cccaaacttg gttctcaaac
     3901 tctagtgcat ttgtaaggct gggcttcaaa atcaaaacac ccacccccaa caccggcagg
     3961 cagagtgcta attcctgaaa catccatggg aagccaatgg ccctgttttc aggaagagca
     4021 agcccaccaa gagttaagac tgtctttgtg tcctatttat actaagccat gtcccaacag
     4081 ggaagagttt ggaaccagag tgagagctcc cagtcccagt ttgagtgggg gaatgtgctt
     4141 ctagacgctt cctggcagta gtggctcacc ttcacaaaga cagtcttgtg gcatccgagc
     4201 caggcagaca gcctggggtg cctgggcctg acaagcttgt tgacaatgac gtgcaatgac
     4261 gtgacaaggt gagagcagaa tcctgagaga cttaaaggga tggttttccc cataagttat
     4321 ttattctttt tttttttctg tgtaaatata tttattttat tgtggcactc taataacatc
     4381 ctggtggtat ggtgcagaat gtatggtagg aatgtatttc ttgtagggat gtagatctgt
     4441 gtgtattaaa agggggagcc aagccagccc ccacctgtct cttcatcaga tacagtccac
     4501 attcattttt aactctcatc tccaatatgg gtctatttaa aatatgcaaa aaggtatgga
     4561 tgaggaatgt tttaatacct ccaaattttt aaaaaaatca agcataaaag agttgataat
     4621 tttttaaagt tttcttagta gcactttctc ttgatgacag aagggcaaca cataggcacc
     4681 caccttcata ccaaagggtg agaaatggcc acagcctcct acaccactcc agtgtcttta
     4741 gcaattgagc tttctatcgc catagcccca accatcctga ggtcaatcaa ggaaaatttc
     4801 tttacgacgt aagctccaaa gagccaaagt atcaactcac ggatcatttt taaagcctaa
     4861 atttcttacc acctttgcag taaacaatga attatgaaca ctgcaagggc agccttctta
     4921 aatgacagac acaaagactg cttgtgcagc aatcgctact ctactctctg aattgtctta
     4981 attgtgaaac cttgctctta cagattgaac ctttttacat ttctgaaaat agcagaaaga
     5041 gcatatttga cttgtcctag ctgtaagtgg ttggttcttg ttgctgcccg gcccctggat
     5101 gccagcaggg tgtgcatccg cccgtgtgca actgtctcca gtgcttccaa gggtgactct
     5161 acatggctct tggccaggat caaacgctct tgcagacaaa gccagtatag attttagact
     5221 tcttttgggg aatttgggag agaagagtag tccatatgta cagctaaagt ggtgacagtg
     5281 tacatgggga cgtgttggtg cgtgggtttt gaggaaggac gtgtgacctt tccccacaga
     5341 cctgagagct gtgccttttc tatgcaatat tacagacgtc acatcagaac ccagagggct
     5401 gtgttcaata tagattcatt caggctgtat tctaaacaat tggacagatt aaatgtacat
     5461 ggaaatgagc agtcttttgt agttttatat tatacaataa acagttaaaa gatgaaaca
//
