LOCUS       NM_001418519            1217 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus SERTA domain containing 1 (Sertad1), transcript
            variant 2, mRNA.
ACCESSION   NM_001418519 XM_006540217
VERSION     NM_001418519.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Ha,J., Kim,M., Park,J.S., Lee,Y., Lee,J.Y., Shin,J.C., Seo,D.,
            Park,S.S., You,J., Jung,S.M., Kim,H.Y., Mizuno,S., Takahashi,S.,
            Kim,S.J. and Park,S.H.
  TITLE     SERTAD1 initiates NLRP3-mediated inflammasome activation through
            restricting NLRP3 polyubiquitination
  JOURNAL   Cell Rep 43 (2), 113752 (2024)
   PUBMED   38341852
  REMARK    GeneRIF: SERTAD1 initiates NLRP3-mediated inflammasome activation
            through restricting NLRP3 polyubiquitination.
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Nguyen,T.N.Q., Jung,S., Nguyen,H.A., Lee,B., Vu,S.H.,
            Myagmarjav,D., Eum,H.H., Lee,H.O., Jo,T., Choi,Y. and Lee,M.S.
  TITLE     The regulation of insulin receptor/insulin-like growth factor 1
            receptor ratio, an important factor for breast cancer prognosis, by
            TRIP-Br1
  JOURNAL   J Hematol Oncol 15 (1), 82 (2022)
   PUBMED   35710446
  REMARK    GeneRIF: The regulation of insulin receptor/insulin-like growth
            factor 1 receptor ratio, an important factor for breast cancer
            prognosis, by TRIP-Br1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Jung,S., Myagmarjav,D., Jo,T., Lee,S., Han,S., Quynh,N.T.N.,
            Anh,N.H., Vu,S.H., Choi,Y. and Lee,M.S.
  TITLE     Inhibitory role of TRIP-Br1 oncoprotein in anticancer drug-mediated
            programmed cell death via mitophagy activation
  JOURNAL   Int J Biol Sci 18 (9), 3859-3873 (2022)
   PUBMED   35813469
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Liu,Y., Zhao,L.W., Shen,J.L., Fan,H.Y. and Jin,Y.
  TITLE     Maternal DCAF13 Regulates Chromatin Tightness to Contribute to
            Embryonic Development
  JOURNAL   Sci Rep 9 (1), 6278 (2019)
   PUBMED   31000741
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Tian,X., Liu,C., Wang,X., Wang,F., Wang,L., Xu,L., Ma,J., Gao,Y.,
            Bao,Y., Wang,F., Sun,L., Wei,J., Lin,C., Zhang,H., Zhu,G., Guan,X.,
            Fu,S. and Zhang,C.
  TITLE     Sei-1 promotes double minute chromosomes formation through
            activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces
            double-strand breaks in NIH-3T3 fibroblasts
  JOURNAL   Cell Death Dis 9 (3), 341 (2018)
   PUBMED   29497033
  REMARK    GeneRIF: Sei-1 promotes double minute chromosomes formation with
            increasing passage number.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Biswas,S.C., Zhang,Y., Iyirhiaro,G., Willett,R.T., Rodriguez
            Gonzalez,Y., Cregan,S.P., Slack,R.S., Park,D.S. and Greene,L.A.
  TITLE     Sertad1 plays an essential role in developmental and pathological
            neuron death
  JOURNAL   J Neurosci 30 (11), 3973-3982 (2010)
   PUBMED   20237268
  REMARK    GeneRIF: Sertad1 expression is required is required for
            developmental neuronal death in the cerebral cortex.
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Fernandez-Marcos,P.J., Pantoja,C., Gonzalez-Rodriguez,A.,
            Martin,N., Flores,J.M., Valverde,A.M., Hara,E. and Serrano,M.
  TITLE     Normal proliferation and tumorigenesis but impaired pancreatic
            function in mice lacking the cell cycle regulator sei1
  JOURNAL   PLoS One 5 (1), e8744 (2010)
   PUBMED   20090907
  REMARK    GeneRIF: conclude that Sei1 plays an important role in pancreatic
            beta-cells, which supports a functional link between Sei1 and the
            core cell cycle regulators specifically in the context of the
            pancreas
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158304.11.
            
            On Mar 21, 2023 this sequence version replaced XM_006540217.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.175281.1,
                                           SRR13862051.1575417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC158304.11        84973-85125         c
            154-1217            AC158304.11        82142-83205         c
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.91 cM"
     gene            1..1217
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /note="SERTA domain containing 1"
                     /db_xref="GeneID:55942"
                     /db_xref="MGI:MGI:1913438"
     exon            1..153
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1217
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..867
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /note="p34SEI-1; PHD zinc finger- and
                     bromodomain-interacting protein 1; CDK4-binding protein
                     p34SEI1; transcriptional regulator interacting with the
                     PHD-bromodomain 1"
                     /codon_start=1
                     /product="SERTA domain-containing protein 1"
                     /protein_id="NP_001405448.1"
                     /db_xref="GeneID:55942"
                     /db_xref="MGI:MGI:1913438"
                     /translation="MLSKGLKRKREEEETMEALSVDSCWLDPSHPAVAQTPPTVASSS
                     LFDLSVVKLHHSLRQSEPDLRHLVLVVNTLRRIQASMEPAPVLPPEPIQPPAPSVADS
                     LLASSDAGLSASMASLLEDLNHIEDLNQAPQPQADEGPPGRSIGGISPNLGALDLLGP
                     ATGCLLDDGLEGLFEDIDTSMYDSELWLPASEGLKPGPENGPAKEEPPELDEAELDYL
                     MDVLVGTQALERPPGPGR"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /note="hexamer: ATTAAA"
     polyA_site      1217
                     /gene="Sertad1"
                     /gene_synonym="1110032C13Rik; Sei-1; Sei1; TRIP-Br1"
                     /note="major polyA site"
ORIGIN      
        1 gcctccgctg ccttccggaa gcgagggaag gccgggctca ctgagcggcc cgcgggggtc
       61 gcggctcgct gtggcccggg agggacaggc ggtaccctgg ggaatctaaa ggatcccggg
      121 gtcactgggg ccggagtccc cgggggagcc cagaggatgc tgagcaaagg tctgaagcgc
      181 aagcgggagg aggaggagac gatggaagcc ctctccgtgg actcgtgctg gttggatccg
      241 agccacccgg cagtggcgca gaccccgccg acggtggctt ctagctccct ctttgacctc
      301 tcagtggtca agctccacca cagcctgcgg cagagcgagc cggacctccg gcacctggtg
      361 cttgtggtga acacactgag gcgcatccag gcgtccatgg aacccgcacc tgtcctgccg
      421 cctgagccca tccagccccc agccccttct gtggcagaca gccttctggc tagctcagat
      481 gctggcctct cagcctccat ggccagcctc ctggaagatc tcaaccacat tgaggacctg
      541 aaccaggccc cccaacccca agcagatgag gggcctccag gccgctccat cggggggatc
      601 tcacccaacc tgggtgcctt ggacttgcta ggcccagcca ctggctgtct gctggacgat
      661 ggactggagg gcctgtttga ggacatcgat acctccatgt acgacagtga actttggtta
      721 ccagcctctg agggtctcaa gcccggccct gagaatggcc cagccaagga ggagcctcca
      781 gagttggatg aggcggagtt ggactacctc atggatgtac tagtaggcac acaggcactg
      841 gaaaggccac cagggcctgg gcgctgaccc ttaggaccca gggagaattg acttggatct
      901 gagttgagcc tggtggtgac accaacccac tttgacacga cacaggtggc gtcccctcac
      961 agaggagagc cagggtcact ttggagagac tgtactgagt cctgggaact tcacatccat
     1021 ccacctgtct tgaccagtga aggagttgga aatgagcccc gagtggtgaa atgacagggc
     1081 ccagtgacag taatggtgtt tgggccaggc tggggttgaa ctgggataat agtttgggct
     1141 atcccatccc attatcccca gtgtgggaag agacctcata attttttgaa attaaaacca
     1201 gctttgggaa ataccaa
//
