LOCUS       NM_026460               1424 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade I,
            member 2 (Serpini2), mRNA.
ACCESSION   NM_026460
VERSION     NM_026460.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Naba A, Clauser KR, Mani DR, Carr SA and Hynes RO.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman
            GA, Nebert DW and Vasiliou V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Ragg H.
  TITLE     The role of serpins in the surveillance of the secretory pathway
  JOURNAL   Cell Mol Life Sci 64 (21), 2763-2770 (2007)
   PUBMED   17668148
  REMARK    Review article
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Loftus SK, Cannons JL, Incao A, Pak E, Chen A, Zerfas PM, Bryant
            MA, Biesecker LG, Schwartzberg PL and Pavan WJ.
  TITLE     Acinar cell apoptosis in Serpini2-deficient mice models pancreatic
            insufficiency
  JOURNAL   PLoS Genet 1 (3), e38 (2005)
   PUBMED   16184191
  REMARK    GeneRIF: The rescue of growth retardation, immunodeficiency, and
            mortality by either Serpini2 bacterial artificial chromosome
            transgenic expression or by pancreatic enzyme supplementation
            demonstrates these phenotypes as secondary to malnutrition.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008931.1, AK007510.1 and AC147152.3.
            
            On Jan 16, 2013 this sequence version replaced NM_026460.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007347.1, BC098466.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AK008931.1         2-449
            449-1381            AK007510.1         424-1356
            1382-1424           AC147152.3         99144-99186         c
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.74 cM"
     gene            1..1424
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /note="serine (or cysteine) peptidase inhibitor, clade I,
                     member 2"
                     /db_xref="GeneID:67931"
                     /db_xref="MGI:MGI:1915181"
     exon            1..40
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            41..302
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1273
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /note="pancreas-specific serpin; serpin I2; serine
                     protease inhibitor 14"
                     /codon_start=1
                     /product="serpin I2 precursor"
                     /protein_id="NP_080736.2"
                     /db_xref="CCDS:CCDS17413.1"
                     /db_xref="GeneID:67931"
                     /db_xref="MGI:MGI:1915181"
                     /translation="MNKTILWSFLLFFSGSQTSRATDQKIADFAVDLYKAISLSHKNN
                     IIFSPLGTTMLLGMVQLGAKGKAQQQILKTLRMRGTPAGEEFSVLKSLFSAISKKKQE
                     FTFNLASALYLQEGFIVKETYLHSNKEFFQSATKLVDFLDAKTSAQAISTWVESKTDG
                     KIKNMFSEEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTEMTDFTKKDGSTVKVPMMKA
                     LLRAQYGYFSQSSMTCQVLELPYKADEFSLVIILPTEDTSIEEVENQVTAPHVRRWFS
                     ELHEEEVEVSLPRFKIEQKLDLKEALYSLNVTEIFSGGCDLSGITDSSEVYVSRVMQK
                     VFFEINEDGSEAAASTGINIPAIMSLTQTQFLANHPFLFILKHIRTESILFMGKVTDP
                     DIQTTKGRDLDSL"
     exon            303..533
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            534..728
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            729..921
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1019
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1106
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1196
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1424
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcacagca ttcaagttaa taatcagaag ttaattttgg tatacagaac gcaagatgaa
       61 taagaccata ttgtggagtt ttctactatt tttttctgga agtcaaactt caagagcgac
      121 tgaccaaaaa attgctgact ttgcagtgga tctttataaa gctatttctt tatcccacaa
      181 gaacaacatt atattttccc ctcttggaac cactatgctt cttggaatgg tccaactagg
      241 tgcaaaagga aaagcacaac agcagatcct gaagacttta aggatgcggg gaaccccagc
      301 aggagaggaa ttttctgtgt tgaagtcact tttttcagcc atctcaaaga agaagcagga
      361 atttacattt aatcttgcca gtgccctcta ccttcaagaa ggattcattg tgaaggaaac
      421 atatctccat agcaacaagg agttttttca gagtgctaca aaactggtgg attttctgga
      481 tgcaaagact tctgcacagg caataagcac ctgggtagaa agcaaaacag atggaaaaat
      541 taaaaatatg ttttcagagg aagaatttgg ccccttgact cgtctggtcc tggtgaatgc
      601 catttatttt aagggggatt ggaaacagaa attcagaaaa gaagacacag agatgacaga
      661 ttttactaag aaagatggct ctacagtaaa ggttccaatg atgaaggctc tgttgcgagc
      721 acaatatggt tatttttctc agtcatccat gacatgtcaa gttttggaat tgccttacaa
      781 ggctgatgag tttagtttag tcatcattct tcccacggaa gacacgagca tcgaagaagt
      841 ggaaaaccaa gttactgctc ctcacgtccg gagatggttc tccgagctgc atgaagagga
      901 ggtggaagtc agcctccctc gatttaaaat agaacaaaaa ttagacctca aagaagcatt
      961 atattcttta aatgtaactg aaatatttag tggtggctgt gacctttctg gaataacaga
     1021 ctcatctgaa gtctatgtct ccagagtcat gcagaaagtt ttctttgaga taaatgaaga
     1081 tggaagcgaa gctgcagcat ccacaggcat aaacattcct gcgatcatga gtttgactca
     1141 gactcaattt ctagcaaatc atccatttct gtttattttg aagcacatcc gaacagaatc
     1201 aattttgttt atgggaaagg tgacagatcc tgacattcaa acaacgaaag gaagagattt
     1261 agattcactg tgaatgaaaa tgatggtctt agaatacaag acacctcctg gaaaatgatt
     1321 gatgggtgga atgtcatcat tctgaaaatt ttctaacatt tttgtttaaa atcatgccta
     1381 taaaataagt aaagacagat ataaatcctt ttttttggct tttc
//
