LOCUS       NP_080736                405 aa            linear   ROD 05-AUG-2023
DEFINITION  serpin I2 precursor [Mus musculus].
ACCESSION   NP_080736
VERSION     NP_080736.2
DBSOURCE    REFSEQ: accession NM_026460.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Naba A, Clauser KR, Mani DR, Carr SA and Hynes RO.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman
            GA, Nebert DW and Vasiliou V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 405)
  AUTHORS   Ragg H.
  TITLE     The role of serpins in the surveillance of the secretory pathway
  JOURNAL   Cell Mol Life Sci 64 (21), 2763-2770 (2007)
   PUBMED   17668148
  REMARK    Review article
REFERENCE   4  (residues 1 to 405)
  AUTHORS   Loftus SK, Cannons JL, Incao A, Pak E, Chen A, Zerfas PM, Bryant
            MA, Biesecker LG, Schwartzberg PL and Pavan WJ.
  TITLE     Acinar cell apoptosis in Serpini2-deficient mice models pancreatic
            insufficiency
  JOURNAL   PLoS Genet 1 (3), e38 (2005)
   PUBMED   16184191
  REMARK    GeneRIF: The rescue of growth retardation, immunodeficiency, and
            mortality by either Serpini2 bacterial artificial chromosome
            transgenic expression or by pancreatic enzyme supplementation
            demonstrates these phenotypes as secondary to malnutrition.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008931.1, AK007510.1 and AC147152.3.
            
            On Sep 8, 2006 this sequence version replaced NP_080736.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007347.1, BC098466.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.74 cM"
     Protein         1..405
                     /product="serpin I2 precursor"
                     /note="pancreas-specific serpin; serpin I2; serine
                     protease inhibitor 14"
                     /calculated_mol_wt=43359
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2435
     Region          23..392
                     /region_name="serpinI2_pancpin"
                     /note="serpin family I member 2, pancpin; cd19576"
                     /db_xref="CDD:381042"
     Site            order(338..354,356..373)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381042"
     CDS             1..405
                     /gene="Serpini2"
                     /gene_synonym="Spi14"
                     /coded_by="NM_026460.3:56..1273"
                     /db_xref="CCDS:CCDS17413.1"
                     /db_xref="GeneID:67931"
                     /db_xref="MGI:MGI:1915181"
ORIGIN      
        1 mnktilwsfl lffsgsqtsr atdqkiadfa vdlykaisls hknniifspl gttmllgmvq
       61 lgakgkaqqq ilktlrmrgt pageefsvlk slfsaiskkk qeftfnlasa lylqegfivk
      121 etylhsnkef fqsatklvdf ldaktsaqai stwvesktdg kiknmfseee fgpltrlvlv
      181 naiyfkgdwk qkfrkedtem tdftkkdgst vkvpmmkall raqygyfsqs smtcqvlelp
      241 ykadefslvi ilptedtsie evenqvtaph vrrwfselhe eevevslprf kieqkldlke
      301 alyslnvtei fsggcdlsgi tdssevyvsr vmqkvffein edgseaaast ginipaimsl
      361 tqtqflanhp flfilkhirt esilfmgkvt dpdiqttkgr dldsl
//
