LOCUS       NM_009250               3173 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade I,
            member 1 (Serpini1), transcript variant 1, mRNA.
ACCESSION   NM_009250
VERSION     NM_009250.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3173)
  AUTHORS   Torrente,D., Su,E.J., Fredriksson,L., Warnock,M., Bushart,D.,
            Mann,K.M., Emal,C.D. and Lawrence,D.A.
  TITLE     Compartmentalized Actions of the Plasminogen Activator Inhibitors,
            PAI-1 and Nsp, in Ischemic Stroke
  JOURNAL   Transl Stroke Res 13 (5), 801-815 (2022)
   PUBMED   35122213
  REMARK    GeneRIF: Compartmentalized Actions of the Plasminogen Activator
            Inhibitors, PAI-1 and Nsp, in Ischemic Stroke.
REFERENCE   2  (bases 1 to 3173)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3173)
  AUTHORS   Hermann,M., Reumann,R., Schostak,K., Kement,D., Gelderblom,M.,
            Bernreuther,C., Frischknecht,R., Schipanski,A., Marik,S.,
            Krasemann,S., Sepulveda-Falla,D., Schweizer,M., Magnus,T.,
            Glatzel,M. and Galliciotti,G.
  TITLE     Deficits in developmental neurogenesis and dendritic spine
            maturation in mice lacking the serine protease inhibitor
            neuroserpin
  JOURNAL   Mol Cell Neurosci 102, 103420 (2020)
   PUBMED   31805346
REFERENCE   4  (bases 1 to 3173)
  AUTHORS   Lee,T.W., Tsang,V.W., Loef,E.J. and Birch,N.P.
  TITLE     Physiological and pathological functions of neuroserpin: Regulation
            of cellular responses through multiple mechanisms
  JOURNAL   Semin Cell Dev Biol 62, 152-159 (2017)
   PUBMED   27639894
  REMARK    Review article
REFERENCE   5  (bases 1 to 3173)
  AUTHORS   Ragg,H.
  TITLE     The role of serpins in the surveillance of the secretory pathway
  JOURNAL   Cell Mol Life Sci 64 (21), 2763-2770 (2007)
   PUBMED   17668148
  REMARK    Review article
REFERENCE   6  (bases 1 to 3173)
  AUTHORS   Belorgey,D., Hagglof,P., Karlsson-Li,S. and Lomas,D.A.
  TITLE     Protein misfolding and the serpinopathies
  JOURNAL   Prion 1 (1), 15-20 (2007)
   PUBMED   19164889
  REMARK    Review article
REFERENCE   7  (bases 1 to 3173)
  AUTHORS   Chang,W.S., Chang,N.T., Lin,S.C., Wu,C.W. and Wu,F.Y.
  TITLE     Tissue-specific cancer-related serpin gene cluster at human
            chromosome band 3q26
  JOURNAL   Genes Chromosomes Cancer 29 (3), 240-255 (2000)
   PUBMED   10992299
REFERENCE   8  (bases 1 to 3173)
  AUTHORS   Berger,P., Kozlov,S.V., Krueger,S.R. and Sonderegger,P.
  TITLE     Structure of the mouse gene for the serine protease inhibitor
            neuroserpin (PI12)
  JOURNAL   Gene 214 (1-2), 25-33 (1998)
   PUBMED   9729122
REFERENCE   9  (bases 1 to 3173)
  AUTHORS   Osterwalder,T., Cinelli,P., Baici,A., Pennella,A., Krueger,S.R.,
            Schrimpf,S.P., Meins,M. and Sonderegger,P.
  TITLE     The axonally secreted serine proteinase inhibitor, neuroserpin,
            inhibits plasminogen activators and plasmin but not thrombin
  JOURNAL   J Biol Chem 273 (4), 2312-2321 (1998)
   PUBMED   9442076
REFERENCE   10 (bases 1 to 3173)
  AUTHORS   Krueger,S.R., Ghisu,G.P., Cinelli,P., Gschwend,T.P.,
            Osterwalder,T., Wolfer,D.P. and Sonderegger,P.
  TITLE     Expression of neuroserpin, an inhibitor of tissue plasminogen
            activator, in the developing and adult nervous system of the mouse
  JOURNAL   J Neurosci 17 (23), 8984-8996 (1997)
   PUBMED   9364046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140430.3 and AK032152.1.
            
            On Nov 4, 2017 this sequence version replaced NM_009250.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032152.1, AK133770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC140430.3         65837-65888
            53-845              AK032152.1         2-794
            846-1049            AC140430.3         127464-127667
            1050-3003           AK032152.1         999-2952
            3004-3173           AC140430.3         150698-150867
FEATURES             Location/Qualifiers
     source          1..3173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.76 cM"
     gene            1..3173
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="serine (or cysteine) peptidase inhibitor, clade I,
                     member 1"
                     /db_xref="GeneID:20713"
                     /db_xref="MGI:MGI:1194506"
     exon            1..150
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            151..418
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1401
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serpin I1; protease inhibitor 17; peptidase
                     inhibitor 12; serine protease inhibitor 17"
                     /codon_start=1
                     /product="neuroserpin isoform 1 precursor"
                     /protein_id="NP_033276.1"
                     /db_xref="CCDS:CCDS17415.1"
                     /db_xref="GeneID:20713"
                     /db_xref="MGI:MGI:1194506"
                     /translation="MTYLELLALLALQSVVTGATFPDETITEWSVNMYNHLRGTGEDE
                     NILFSPLSIALAMGMMELGAQGSTRKEIRHSMGYEGLKGGEEFSFLRDFSNMASAEEN
                     QYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTN
                     SLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMY
                     QQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLI
                     EEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLS
                     KAVHKSCIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFLYLIRNRKSGIILFMG
                     RVMNPETMNTSGHDFEEL"
     exon            419..649
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            650..844
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1049
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1147
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1234
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1324
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..3173
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="hexamer: AATAAA"
     polyA_site      1648
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="major polyA site"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="hexamer: AATAAA"
     polyA_site      3006
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
                     /note="hexamer: AATAGA"
     polyA_site      3058
                     /gene="Serpini1"
                     /gene_synonym="Ns; PI-12; PI12; Spi17"
ORIGIN      
        1 ggggaaggcg gagcttgaat ctcagaagaa gcttcagctc agcctagtct gtagtttccc
       61 tggagagagg caagagcagc atccggagca gtctcagcct gcccagcatc ctctccagca
      121 tcccgagcgg ggattgcagg tgtgaaggag acttgaaacc atcccatcat gacttacctt
      181 gaactgcttg ctttgctggc cttgcaaagt gtggtgacag gggcaacgtt cccagatgaa
      241 accataactg agtggtcagt gaacatgtat aaccaccttc gaggcaccgg ggaagatgaa
      301 aacattctct tctctccact aagcattgcc cttgcgatgg gaatgatgga gcttggggct
      361 caaggatcta ctaggaaaga aatccgccat tcaatgggat atgagggtct gaaaggtggt
      421 gaagaatttt ctttcctgag ggatttttct aatatggcct ctgccgaaga aaaccaatat
      481 gtgatgaaac ttgccaattc gctctttgta caaaatggat ttcatgtcaa tgaggaattc
      541 ttgcaaatgc tgaaaatgta ctttaatgca gaagtcaacc atgtggactt cagtcaaaat
      601 gtggctgtgg ctaactccat caataaatgg gtggagaatt atacaaacag tctgttgaaa
      661 gatctggtgt ctccggagga ctttgatggt gtcactaatt tggccctcat caatgctgta
      721 tatttcaaag gaaactggaa gtctcagttt agacctgaaa ataccagaac tttctccttc
      781 acgaaagatg atgaaagtga agtgcagatt ccaatgatgt atcaacaagg agaattttat
      841 tatggtgaat ttagtgatgg atccaatgag gctggtggta tctaccaagt ccttgagata
      901 ccctatgagg gagatgagat cagcatgatg ctggcactgt ccagacagga agtcccactg
      961 gccacactgg agcctctgct caaagcacag ctgatcgaag aatgggcaaa ctctgtgaag
     1021 aaacaaaagg tggaagtgta cttgcccagg ttcactgtgg aacaggaaat tgatttaaaa
     1081 gacatcttga aagcccttgg ggtcactgaa attttcatca aagatgcaaa tttgactgcc
     1141 atgtcagata agaaagagct gttcctctcc aaagctgttc acaagtcctg cattgaggtt
     1201 aatgaagaag ggtcagaagc cgctgcagcc tccggaatga ttgcgattag taggatggct
     1261 gtgctgtacc ctcaggttat tgtcgaccat ccatttctct atcttatcag gaacaggaaa
     1321 tctggcataa tcttattcat gggacgagtc atgaaccctg aaacaatgaa tacaagtggc
     1381 catgactttg aggaacttta aatgacgacg tttgagtaca aagaaagcag gaacaaagca
     1441 cattatgttt gcaagtggta tatatttagg atttctgttt tatagtgtta cttagggaaa
     1501 tatttaaata gttctggata gtagtaatcc atgtgaccta taagttagcc tgtcaaaagc
     1561 tgttatcagt ataaagagta tggtcccatt gtgtcattgt gtctggtgtg ctgctgttta
     1621 aaataaaagt acatattgaa actgtgaacc actttttttc attttgaaag tagttgtagt
     1681 ctatacaata ctatgtctga gatttgaaac ctatgctgtt tctttaggaa ttgtagtaaa
     1741 atgatcctac aaggcaaaat gtagaaactg ttgtttctga gtttcttcat aatcatgcag
     1801 aatcaaacac caaagtaagc aacatacata tatatatata ataagcaata ctgtgaaggg
     1861 gaggccaaaa ggccagagaa attgagattg ttatttagtg tggcattcca tgacaaaaga
     1921 tttaggagga aatgtgggat atgtaagacc catagatgta tattttgtat atactgtagt
     1981 attatacttt taatttatta aagtataact cttttattta tttttaaaag tttcctgtga
     2041 accaatatgc cacatgactc tactagcaag ttcagatatc tcattagcta ttctggatga
     2101 catcaagagg cctcatggag ggaatcccgt gtaccattta cgttttagtg attttttgtg
     2161 atgttcacac aaagatgaaa tcacattgtt gcacactctc tagactatat ccaagaaagg
     2221 catcaagtgg tacattggtg tgccaggaaa atagatgtaa ttactttatt aaaaaagttc
     2281 ctggtattgt gcatcatatg gaatcagtgc tgcttaaact tagtacgtcc tgctgacacc
     2341 tggtcactta ttacaaatat aggttcttat ccaggatgtc taaggtagag tgggaaccac
     2401 agctttctat cattactgac atccaaatga tgccgcagat atctgaccat agcctttgct
     2461 gagagtccct tgggttgcaa tgtcgtactt gaagtcagcc tcacattttc acagactgag
     2521 attggagaga tgagggtgca gggaggagat aatctacact agtgatacga tgcctttgtc
     2581 aagcactggt gtgatctcga agtatttcta gtacacactc tagataaatt cttctgtaca
     2641 ttacaacact tgaaatgcag tcgttaaaaa tatggagaca tttataggca atacccatga
     2701 aagaatttat gactatccga ggacacagta cttaacaatg aatcttttac agcttatatt
     2761 ttcagaggac ttgtagttta ttcataaatc ttcatgttat tgtacaatag tgctcttgtt
     2821 ttcatttata atttatgaag ctgagatgcc tggtgttaat tcagtgttca cattctctgc
     2881 taagaacagt ctttatctct gtatccttct tgttaatatg acatctatag ctatatctat
     2941 atgttcatta gttaaacaaa tgtatggcct gtaaggaaga ataaacatta ttatgcaatc
     3001 atgtgattat gtgatgtccc aaatgttaat ttttattaaa aatagatata agatttaatt
     3061 cttggaactt ttaatcttaa aatatttcaa tatgtgtata agttaggtgt tacttagttg
     3121 aaaatggatg tcttgtactg gcagaaaagc tagaaaaaat aatttacaat acc
//
