LOCUS       NM_001412219            2318 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade H,
            member 1 (Serpinh1), transcript variant 7, mRNA.
ACCESSION   NM_001412219
VERSION     NM_001412219.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Kot,A., Chun,C., Martin,J.H., Wachtell,D., Hudson,D., Weis,M.,
            Marks,H., Srivastava,S., Eyre,D.R., Duran,I., Zieba,J. and
            Krakow,D.
  TITLE     Loss of the long form of Plod2 phenocopies contractures of Bruck
            syndrome-osteogenesis imperfecta
  JOURNAL   J Bone Miner Res 39 (9), 1240-1252 (2024)
   PUBMED   39088537
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Shin,J., Toyoda,S., Okuno,Y., Hayashi,R., Nishitani,S., Onodera,T.,
            Sakamoto,H., Ito,S., Kobayashi,S., Nagao,H., Kita,S., Otsuki,M.,
            Fukuhara,A., Nagata,K. and Shimomura,I.
  TITLE     HSP47 levels determine the degree of body adiposity
  JOURNAL   Nat Commun 14 (1), 7319 (2023)
   PUBMED   37951979
  REMARK    GeneRIF: HSP47 levels determine the degree of body adiposity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Thienel,M., Muller-Reif,J.B., Zhang,Z., Ehreiser,V., Huth,J.,
            Shchurovska,K., Kilani,B., Schweizer,L., Geyer,P.E., Zwiebel,M.,
            Novotny,J., Lusebrink,E., Little,G., Orban,M., Nicolai,L., El
            Nemr,S., Titova,A., Spannagl,M., Kindberg,J., Evans,A.L., Mach,O.,
            Vogel,M., Tiedt,S., Ormanns,S., Kessler,B., Dueck,A., Friebe,A.,
            Jorgensen,P.G., Majzoub-Altweck,M., Blutke,A., Polzin,A., Stark,K.,
            Kaab,S., Maier,D., Gibbins,J.M., Limper,U., Frobert,O., Mann,M.,
            Massberg,S. and Petzold,T.
  TITLE     Immobility-associated thromboprotection is conserved across
            mammalian species from bear to human
  JOURNAL   Science 380 (6641), 178-187 (2023)
   PUBMED   37053338
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Allegre,N., Chauveau,S., Dennis,C., Renaud,Y., Meistermann,D.,
            Estrella,L.V., Pouchin,P., Cohen-Tannoudji,M., David,L. and
            Chazaud,C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Hu,H., Ma,J., Li,Z., Ding,Z., Chen,W., Peng,Y., Tao,Z., Chen,L.,
            Luo,M., Wang,C., Wang,X., Li,J. and Zhong,M.
  TITLE     CyPA interacts with SERPINH1 to promote extracellular matrix
            production and inhibit epithelial-mesenchymal transition of
            trophoblast via enhancing TGF-beta/Smad3 pathway in preeclampsia
  JOURNAL   Mol Cell Endocrinol 548, 111614 (2022)
   PUBMED   35304192
  REMARK    GeneRIF: CyPA interacts with SERPINH1 to promote extracellular
            matrix production and inhibit epithelial-mesenchymal transition of
            trophoblast via enhancing TGF-beta/Smad3 pathway in preeclampsia.
REFERENCE   6  (bases 1 to 2318)
  AUTHORS   Wang,S.Y.
  TITLE     Structure of the gene and its retinoic acid-regulatory region for
            murine J6 serpin. An F9 teratocarcinoma cell retinoic
            acid-inducible protein
  JOURNAL   J Biol Chem 267 (22), 15362-15366 (1992)
   PUBMED   1639782
REFERENCE   7  (bases 1 to 2318)
  AUTHORS   Takechi,H., Hirayoshi,K., Nakai,A., Kudo,H., Saga,S. and Nagata,K.
  TITLE     Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a
            collagen-binding stress protein, and its expression during the
            differentiation of F9 teratocarcinoma cells
  JOURNAL   Eur J Biochem 206 (2), 323-329 (1992)
   PUBMED   1317794
REFERENCE   8  (bases 1 to 2318)
  AUTHORS   Clarke,E.P. and Sanwal,B.D.
  TITLE     Cloning of a human collagen-binding protein, and its homology with
            rat gp46, chick hsp47 and mouse J6 proteins
  JOURNAL   Biochim Biophys Acta 1129 (2), 246-248 (1992)
   PUBMED   1309665
REFERENCE   9  (bases 1 to 2318)
  AUTHORS   Wang,S.Y. and Gudas,L.J.
  TITLE     A retinoic acid-inducible mRNA from F9 teratocarcinoma cells
            encodes a novel protease inhibitor homolog
  JOURNAL   J Biol Chem 266 (21), 14135 (1991)
   PUBMED   1856236
  REMARK    Correction to:[J Biol Chem. 1990 Sep 15;265(26):15818-22.. PMID:
            2394749]
REFERENCE   10 (bases 1 to 2318)
  AUTHORS   Wang,S.Y. and Gudas,L.J.
  TITLE     A retinoic acid-inducible mRNA from F9 teratocarcinoma cells
            encodes a novel protease inhibitor homologue
  JOURNAL   J Biol Chem 265 (26), 15818-15822 (1990)
   PUBMED   2394749
  REMARK    Erratum:[J Biol Chem. 1991 Jul 25;266(21):14135.. PMID: 1856236]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158748.9.
            
            Transcript Variant: This variant (7) represents the longest
            transcript. All ten variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1515815.1,
                                           SRR12282455.34274964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC158748.9         119170-119402       c
            234-277             AC158748.9         118112-118155       c
            278-939             AC158748.9         115091-115752       c
            940-1038            AC158748.9         113554-113652       c
            1039-1271           AC158748.9         113213-113445       c
            1272-2318           AC158748.9         111664-112710       c
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.07 cM"
     gene            1..2318
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /note="serine (or cysteine) peptidase inhibitor, clade H,
                     member 1"
                     /db_xref="GeneID:12406"
                     /db_xref="MGI:MGI:88283"
     exon            1..233
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..277
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            278..939
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1038
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1271
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2318
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /note="hexamer: AATAAA"
     polyA_site      2266
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /note="major polyA site"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /note="hexamer: ATTAAA"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
                     /note="hexamer: AAGAAA"
     polyA_site      2308
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
     polyA_site      2318
                     /gene="Serpinh1"
                     /gene_synonym="BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6;
                     Serpinh2"
ORIGIN      
        1 gagcagagcc tgtctgagga gcgattgccc tgtcggtccc ggagcagccc agcccggccc
       61 aggtgagggg cgggagcggc cgggcgattt ggggttgcgc attggccaag ggggaacgga
      121 tcgctccaaa gcttggggtc ctgacacagg tgggcagtga aagatcggac ttggaactgt
      181 cacttgcctg ggttccctgg agctgcggtc tagtacgcgg actgcctggt aaaaatgaaa
      241 aaggcaggca atgatctccc tctgaggccc tttcaagccc tcacaggtcc tctgtggtgc
      301 acacagccca cctcccagcc atgcgctctc tccttctggg caccttatgc ctcttggccg
      361 tggccctggc agccgaggtg aagaaacccc tagaggcggc agcccctggt actgcggaga
      421 agctaagttc caaggcgacc acactggcag agcgcagcac aggcctggcc ttcagcctat
      481 atcaggcgat ggccaaagac caggcggtgg agaacatcct cctgtcaccc ttggtggtgg
      541 cctcatccct gggtcttgtg tcactgggtg gtaaagccac cacagcgtcg caggcgaagg
      601 cagtgctgag cgctgagaag ctgcgcgatg aggaggtgca cacggggctg ggtgagctgc
      661 tccgctccct cagcaactcc actgcgcgca acgtgacctg gaaactgggc agccgcctgt
      721 acgggcccag ctccgtgagc ttcgccgatg acttcgtgcg cagcagcaag caacactaca
      781 actgcgaaca ctccaagatc aacttccgag acaagcgcag cgccctgcag tccatcaacg
      841 agtgggcctc gcagaccacg gacggcaagc tgcctgaggt caccaaggat gtggagcgca
      901 cggatggggc actgcttgtg aacgccatgt tctttaagcc acactgggat gagaagtttc
      961 accacaagat ggtggacaac cgtggcttca tggtgacccg ctcctatact gtgggtgtta
     1021 cgatgatgca ccggacaggc ctgtacaact actatgacga cgagaaggag aagctgcaga
     1081 tggtggagat gcccctggct cacaagctct ccagcctcat catcctcatg ccccaccacg
     1141 tggagccgct cgagcgcttg gagaagctgc tgaccaagga gcagctgaag gcctggatgg
     1201 gaaagatgca gaagaaggct gtcgccatct ccctgcccaa gggcgtggtg gaggtgaccc
     1261 atgacctgca gaaacatctg gcaggactgg gcctgaccga ggccatcgac aagaacaagg
     1321 cagacctatc gcgcatgtct ggcaagaagg acctgtacct agccagtgtg ttccatgcca
     1381 ctgccttcga gtgggacacc gagggcaacc cctttgacca agacatctac gggcgcgagg
     1441 agctgcgcag ccccaagctg ttctatgccg accacccctt catcttcctg gtgcgagata
     1501 atcagagcgg ctccttgctc ttcattggcc gcctggtccg gcccaaggga gacaagatgc
     1561 gagatgagtt gtagagtcca agagtgggcg tggcacggca ggaagtagcc aaaggttcct
     1621 gagacacatg ggtgctattg tggggggagg gggaggcacc aaccctggat attccacggg
     1681 tggggggggt tggcagtgca gatcggaatt cccatatgtc tgagtgggta tttttagaca
     1741 gaatccactc ctaagttagg acatggagcc cagatactat gataccaaat tcaggggtgt
     1801 cacagccatt ttgttctgcc ctgcaagttt tagatccaat ctgcctcaac agtcaatcag
     1861 tgttcatatt tatggccagg cattctatct gttagacaat cgagttgggg gtagggcagc
     1921 ctagctcttt ttgtcacctt gccccgagcc ctcttcagtc ttcctgttca cccctcctcc
     1981 actcccttta accgcaaaac taggtgctgt ggccccagac tacccatcct taaaatgatc
     2041 cttgcccagc ggtgggagct gggagacagt gcatgggagg ggctccctgg catgcctgcc
     2101 ctagaattgt tatgttgggc atcacagtca tgaacttttg tttttctccc ttttttagtt
     2161 ttttcaaaga tggggggaag ggaaatatga gcctttgttg ctttcaaaac gagaacagtt
     2221 tgtacaagtt tttttttttg aataaaactt ttccaatgaa atgttatagg tgtgtgaaag
     2281 cagattaaag aaagaggttc ccatatcatt ctttctaa
//
