LOCUS       NM_009776               1837 bp    mRNA    linear   ROD 26-FEB-2023
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade G,
            member 1 (Serping1), mRNA.
ACCESSION   NM_009776
VERSION     NM_009776.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Ni Y, Wu GH, Cai JJ, Zhang R, Zheng Y, Liu JQ, Yang XH, Yang X,
            Shen Y, Lai JM, Ye XM and Mo SJ.
  TITLE     Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to
            instruct anti-septic acute kidney injury efficacy of high-dose
            ascorbate mediated by NRF2 transactivation
  JOURNAL   Int J Biol Sci 18 (13), 5168-5184 (2022)
   PUBMED   35982894
  REMARK    GeneRIF: Tubule-mitophagic secretion of SerpinG1 reprograms
            macrophages to instruct anti-septic acute kidney injury efficacy of
            high-dose ascorbate mediated by NRF2 transactivation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Bupp S, Whittaker M, Lehtimaki M, Park J, Dement-Brown J, Zhou ZH
            and Kozlowski S.
  TITLE     A novel murine in vivo model for acute hereditary angioedema
            attacks
  JOURNAL   Sci Rep 11 (1), 15924 (2021)
   PUBMED   34354123
  REMARK    GeneRIF: A novel murine in vivo model for acute hereditary
            angioedema attacks.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Seo MH and Yeo S.
  TITLE     Association of increase in Serping1 level with dopaminergic cell
            reduction in an MPTP-induced Parkinson's disease mouse model
  JOURNAL   Brain Res Bull 162, 67-72 (2020)
   PUBMED   32485229
  REMARK    GeneRIF: Association of increase in Serping1 level with
            dopaminergic cell reduction in an MPTP-induced Parkinson's disease
            mouse model.
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M,
            Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B,
            Reina M, Soriano FX, Hastie ND, Martinez FO and Martinez-Estrada
            OM.
  TITLE     Epicardial cell shape and maturation are regulated by Wt1 via
            transcriptional control of Bmp4
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31624071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1837)
  AUTHORS   Farfara D, Feierman E, Richards A, Revenko AS, MacLeod RA, Norris
            EH and Strickland S.
  TITLE     Knockdown of circulating C1 inhibitor induces neurovascular
            impairment, glial cell activation, neuroinflammation, and
            behavioral deficits
  JOURNAL   Glia 67 (7), 1359-1373 (2019)
   PUBMED   30882931
  REMARK    GeneRIF: C1INH has an important role as a gatekeeper to the brain
            via the neurovascular system.
REFERENCE   6  (bases 1 to 1837)
  AUTHORS   Vinci G, Lynch NJ, Duponchel C, Lebastard TM, Milon G, Stover C,
            Schwaeble W and Tosi M.
  TITLE     In vivo biosynthesis of endogenous and of human C1 inhibitor in
            transgenic mice: tissue distribution and colocalization of their
            expression
  JOURNAL   J Immunol 169 (10), 5948-5954 (2002)
   PUBMED   12421980
  REMARK    GeneRIF: Transgenic mice have been generated that express human C1
            inhibitor mRNA and protein under the control of the human promoter
            and regulatory elements; C1nh production is demonstrated in mouse
            brain, spleen, liver, heart, kidney, and lung.
REFERENCE   7  (bases 1 to 1837)
  AUTHORS   Han ED, MacFarlane RC, Mulligan AN, Scafidi J and Davis AE 3rd.
  TITLE     Increased vascular permeability in C1 inhibitor-deficient mice
            mediated by the bradykinin type 2 receptor
  JOURNAL   J Clin Invest 109 (8), 1057-1063 (2002)
   PUBMED   11956243
  REMARK    GeneRIF: Increased vascular permeability in C1 inhibitor-deficient
            mice mediated by the bradykinin type 2 receptor.
REFERENCE   8  (bases 1 to 1837)
  AUTHORS   Lener M, Vinci G, Duponchel C, Meo T and Tosi M.
  TITLE     Molecular cloning, gene structure and expression profile of mouse
            C1 inhibitor
  JOURNAL   Eur J Biochem 254 (1), 117-122 (1998)
   PUBMED   9652403
REFERENCE   9  (bases 1 to 1837)
  AUTHORS   Lener M, Fernandes M, Poirier C, Bazzali-Hernandez C, Tosi M and
            Meo T.
  TITLE     The C1 inhibitor encoding gene (C1nh) maps to mouse chromosome 2
  JOURNAL   Mamm Genome 9 (1), 94 (1998)
   PUBMED   9434962
REFERENCE   10 (bases 1 to 1837)
  AUTHORS   Russell JA, Whaley K and Heaphy S.
  TITLE     The sequence of a cDNA encoding functional murine C1-inhibitor
            protein
  JOURNAL   Biochim Biophys Acta 1352 (2), 156-160 (1997)
   PUBMED   9199246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA458230.1, Y10386.1, AA237518.1 and BQ031701.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_009776.4.
            
            On Dec 22, 2007 this sequence version replaced NM_009776.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10386.1, AF010254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                CA458230.1         38-80
            44-1351             Y10386.1           1-1308
            1352-1764           AA237518.1         64-476
            1765-1814           Y10386.1           1722-1771
            1815-1837           BQ031701.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1837
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /note="serine (or cysteine) peptidase inhibitor, clade G,
                     member 1"
                     /db_xref="GeneID:12258"
                     /db_xref="MGI:MGI:894696"
     exon            1..67
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            68..142
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            143..656
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            657..791
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            792..995
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1132
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1352
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1820
                     /gene="Serping1"
                     /gene_synonym="C1 Inh; C1Inh; C1INH.; C1nh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgattctc tgcgactgtc tgctcagtct gtcctgaagc tgcctagtga ccaagaactt
       61 ggaccaggac gcagctgaca tcgctgccca gatggcctcc aggctgaccc cactgaccct
      121 cctgctgctg ctgctggctg gggatagagc cttctcagat cccgaagcta ccagccacag
      181 cacccaggat ccactggagg ctcaagcgaa aagcagagag agcttccctg aaagagatga
      241 ctcctggagt cccccagagc ctacagtact gccctctacc tggccaacaa ccagtgtagc
      301 catcacaata acaaatgaca ccatgggtaa agtagccaac gagtccttca gccagcacag
      361 ccagccagct gctcagctac ccacagattc tccaggacag ccccctctga attcttccag
      421 ccagccctcc actgcctcag atcttcccac ccaggctact actgaaccct tctgcccgga
      481 gccgcttgct cagtgctctg attcagacag agactcctca gaggcaaagc tctcagaggc
      541 tttgacagat ttctctgtga agctctacca cgccttctca gctaccaaga tggctaagac
      601 caacatggcc ttttccccat tcagcattgc cagcctcctc acacaggttc ttcttggggc
      661 tggagacagc accaagagca acttggagag catcctttcc taccccaagg attttgcctg
      721 tgtccaccaa gcactaaagg gcttttcatc caaaggtgtc acttctgtgt ctcagatttt
      781 ccacagccca gatctggcca taagggacac ctatgtgaat gcatctcaga gcctgtatgg
      841 aagcagcccc agagtcctgg gcccagacag tgctgctaac ttagaactca tcaacacctg
      901 ggtggctgag aacaccaacc ataagatccg caagctgctg gacagcctgc cttctgacac
      961 ctgcctcgtc cttctcaatg ctgtctactt gagtgccaag tggaagataa catttgaacc
     1021 aaaaaagatg atggcgcctt tcttctacaa aaactctatg attaaagtgc ccatgatgag
     1081 tagcgtaaag taccctgtgg cccaattcga tgaccatact ttgaaggcca aggtgggaca
     1141 gctgcagctc tctcacaacc tgagctttgt gatcgtggta cccgtgttcc caaagcacca
     1201 acttaaagat gtagaaaagg ctctcaaccc cactgtcttc aaggccatca tgaagaagct
     1261 ggagctgtcc aaattcctgc ccacttacct gacgatgcct catataaaag taaagagcag
     1321 ccaagacatg ctgtcagtca tggagaaact ggaattcttt gacttcactt acgatctcaa
     1381 cctgtgcggg ctgaccgagg acccagatct tcaggtgtct gccatgaaac acgagacagt
     1441 gctggaactg acagagtcag gggtggaagc agctgcagcc tctgccatct cctttggccg
     1501 aagcttaccc atctttgagg tgcagcgacc tttcctcttc ctgctctggg accagcaaca
     1561 caggttccca gtcttcatgg gtcgtgtata tgaccccagg ggttgagaca ggcttgggta
     1621 aacattgtca cccaagcttc agctcctccg gttatttcct tgccactgcc tgcccgagcc
     1681 acttcaagcc ttaggaactg gcagacggaa ctgtttccat ccaccaaccc ccagggtatc
     1741 aaccactttt ttgcagcttt tacggttcaa acctatcaaa ctctacaaat aaaacttgca
     1801 gacattttct tctctcacta aaaaaaaaaa aaaaaaa
//
