LOCUS       NM_008878               2199 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade F,
            member 2 (Serpinf2), mRNA.
ACCESSION   NM_008878
VERSION     NM_008878.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2199)
  AUTHORS   Kanno,Y., Toyama,K., Shibata,H., Matsuo,O. and Ozaki,K.I.
  TITLE     alpha2-Antiplasmin is associated with macrophage activation and
            fibrin deposition in a macrophage activation syndrome mouse model
  JOURNAL   Clin Exp Immunol 216 (3), 272-279 (2024)
   PUBMED   38457368
  REMARK    GeneRIF: alpha2-Antiplasmin is associated with macrophage
            activation and fibrin deposition in a macrophage activation
            syndrome mouse model.
REFERENCE   2  (bases 1 to 2199)
  AUTHORS   Kanno,Y., Hirota,M., Matsuo,O. and Ozaki,K.I.
  TITLE     alpha2-antiplasmin positively regulates endothelial-to-mesenchymal
            transition and fibrosis progression in diabetic nephropathy
  JOURNAL   Mol Biol Rep 49 (1), 205-215 (2022)
   PUBMED   34709571
  REMARK    GeneRIF: alpha2-antiplasmin positively regulates
            endothelial-to-mesenchymal transition and fibrosis progression in
            diabetic nephropathy.
REFERENCE   3  (bases 1 to 2199)
  AUTHORS   Kanno,Y., Tsuchida,K., Maruyama,C., Hori,K., Teramura,H., Asahi,S.,
            Matsuo,O. and Ozaki,K.I.
  TITLE     Alpha2-antiplasmin deficiency affects depression and anxiety-like
            behavior and apoptosis induced by stress in mice
  JOURNAL   J Basic Clin Physiol Pharmacol 33 (5), 633-638 (2021)
   PUBMED   34913624
  REMARK    GeneRIF: Alpha2-antiplasmin deficiency affects depression and
            anxiety-like behavior and apoptosis induced by stress in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2199)
  AUTHORS   Kawashita,E., Ishihara,K., Miyaji,H., Tanishima,Y., Kiriyama,A.,
            Matsuo,O. and Akiba,S.
  TITLE     alpha2-Antiplasmin as a potential regulator of the spatial memory
            process and age-related cognitive decline
  JOURNAL   Mol Brain 13 (1), 140 (2020)
   PUBMED   33059734
  REMARK    GeneRIF: alpha2-Antiplasmin as a potential regulator of the spatial
            memory process and age-related cognitive decline.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2199)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   6  (bases 1 to 2199)
  AUTHORS   Nagai,N., De Mol,M., Lijnen,H.R., Carmeliet,P. and Collen,D.
  TITLE     Role of plasminogen system components in focal cerebral ischemic
            infarction: a gene targeting and gene transfer study in mice
  JOURNAL   Circulation 99 (18), 2440-2444 (1999)
   PUBMED   10318667
REFERENCE   7  (bases 1 to 2199)
  AUTHORS   Lijnen,H.R., Okada,K., Matsuo,O., Collen,D. and Dewerchin,M.
  TITLE     Alpha2-antiplasmin gene deficiency in mice is associated with
            enhanced fibrinolytic potential without overt bleeding
  JOURNAL   Blood 93 (7), 2274-2281 (1999)
   PUBMED   10090937
REFERENCE   8  (bases 1 to 2199)
  AUTHORS   Okada,K., Lijnen,H.R., Dewerchin,M., Belayew,A., Matsuo,O.,
            Collen,D. and Bernaerts,R.
  TITLE     Characterization and targeting of the murine alpha2-antiplasmin
            gene
  JOURNAL   Thromb Haemost 78 (3), 1104-1110 (1997)
   PUBMED   9308761
REFERENCE   9  (bases 1 to 2199)
  AUTHORS   Menoud,P.A., Sappino,N., Boudal-Khoshbeen,M., Vassalli,J.D. and
            Sappino,A.P.
  TITLE     The kidney is a major site of alpha(2)-antiplasmin production
  JOURNAL   J Clin Invest 97 (11), 2478-2484 (1996)
   PUBMED   8647939
REFERENCE   10 (bases 1 to 2199)
  AUTHORS   Lijnen,H.R., van Hoef,B., Beelen,V. and Collen,D.
  TITLE     Characterization of the murine plasma fibrinolytic system
  JOURNAL   Eur J Biochem 224 (3), 863-871 (1994)
   PUBMED   7523120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591496.13, GQ896353.1, AK077563.1 and AA269351.1.
            
            On Apr 1, 2010 this sequence version replaced NM_008878.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026756.1, Z36774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL591496.13        84459-84503         c
            46-49               AL591496.13        83457-83460         c
            50-1525             GQ896353.1         1-1476
            1526-2191           AK077563.1         1528-2193
            2192-2199           AA269351.1         351-358
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.89 cM"
     gene            1..2199
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /note="serine (or cysteine) peptidase inhibitor, clade F,
                     member 2"
                     /db_xref="GeneID:18816"
                     /db_xref="MGI:MGI:107173"
     exon            1..45
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..112
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1525
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /note="serine (or cysteine) proteinase inhibitor, clade F,
                     member 2; alpha-2-antiplasmin; alpha-2-AP; alpha-2-PI;
                     alpha-2-plasmin inhibitor; serpin F2; plasmin inhibitor
                     alpha 2; pigment epithelium derived factor"
                     /codon_start=1
                     /product="alpha-2-antiplasmin precursor"
                     /protein_id="NP_032904.1"
                     /db_xref="CCDS:CCDS25046.1"
                     /db_xref="GeneID:18816"
                     /db_xref="MGI:MGI:107173"
                     /translation="MALLRGLLVLSLSCLQGPCFTFSPVSAVDLPGQQPVSEQAQQKL
                     PLPALFKLDNQDFGDHATLKRSPGHCKSVPTAEETRRLAQAMMAFTTDLFSLVAQTST
                     SSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGSCLPHLLSHFYQNLGPGTI
                     RLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEEDLANINQWVKEATEGKIED
                     FLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLR
                     WFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEVLANLTWDTLYHPSLQERPTKV
                     WLPKLHLQQQLDLVATLSQLGLQELFQGPDLRGISEQNLVVSSVQHQSTMELSEAGVE
                     AAAATSVAMNRMSLSSFTVNRPFLFFIMEDTIGVPLFVGSVRNPNPSALPQLQEQRDS
                     PDNRLIGQNDKADFHGGKTFGPDLKLAPRMEEDYPQFSSPK"
     exon            113..151
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..214
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..416
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..560
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..764
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..907
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1112
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..2192
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /note="hexamer: AATAAA"
     polyA_site      2192
                     /gene="Serpinf2"
                     /gene_synonym="Pli; Serpimf2"
                     /note="major polyA site"
ORIGIN      
        1 gagaacaccg tgtgctgcgt gtgctgcgct aagaagcctg aagaggaaca tggcactgct
       61 ccgggggctc ctcgtactca gcttgtcctg cctgcaaggt ccctgtttca cgttctctcc
      121 ggtgagcgcc gtggatctcc cgggccagca gccagtgagt gagcaggccc agcagaagct
      181 gcccctgcct gccctcttca agttggacaa ccaggatttt ggtgaccatg ctaccctcaa
      241 gaggtcccca ggacactgca agagtgtccc aactgcagag gagactcgca ggctggctca
      301 ggccatgatg gcttttacta ctgacctgtt ctctttggtg gcccaaacat ctaccagctc
      361 caaccttgtc ctgtcacccc ttagtgtggc cctagcactc tctcacctgg cactaggtgc
      421 tcagaaccaa acactacaca gcttgcatcg agtgttgcac atgaacacag gatcctgcct
      481 cccgcatcta ctgagccatt tctaccagaa cctaggccca gggacaatcc gactggctgc
      541 cagaatatac ctgcagaaag gatttcccat caaagacgat ttcctggagc aatcggaaag
      601 gctctttggt gcgaagcccg tgaaactgac tggaaagcag gaggaagacc tggcgaacat
      661 caaccaatgg gtgaaggagg ccacagaggg gaagattgag gatttcctct ctgagctgcc
      721 ggatagcacc gtgctgcttc tcctcaacgc catccacttt cacggtttct ggaggaccaa
      781 gtttgacccg agcctcaccc agaaagattt cttccacctg gatgagcggt tcacagtgtc
      841 ggtggacatg atgcacgcgg tgtcatatcc tcttcgatgg ttcctgctgg agcaacctga
      901 gatacaggtg gctcatttcc cctttaagaa caacatgagc tttgtggtcg tgatgcccac
      961 ttattttgag tggaacgtgt ccgaggtact agccaacctg acctgggata ctctgtacca
     1021 tccctcgctg caggagaggc ccaccaaggt gtggctgcct aaactccatc tgcaacagca
     1081 gctggacctg gtggccaccc tcagccaact gggcctgcag gaattgttcc agggcccaga
     1141 ccttcgtggg atctctgagc agaatctggt ggtgtctagc gtgcaacatc agtctaccat
     1201 ggagctcagc gaggctggtg tggaggcagc cgcagctacc agcgtagcca tgaatcgaat
     1261 gtccctctcc tccttcactg tgaaccgacc cttcctcttc ttcatcatgg aggacaccat
     1321 aggcgtgccc ctctttgtgg gcagtgtgag gaaccctaac cccagcgcgc tgccccagct
     1381 ccaggaacag cgagattccc ctgacaacag gctcataggc cagaatgaca aagctgactt
     1441 ccatggaggc aagacctttg gtcctgactt gaaacttgca ccccgcatgg aggaagacta
     1501 cccccagttc agctccccca agtgaggagg ggccctgggc agcagcatcc tgagtcccca
     1561 cctggatcag cctctcagct cctgtgactc tttctaacca gctttgtggg atagggtggg
     1621 accggaagga ccatcaccag tgtagaagct gttctcttgc agcaggtggg gtggggcctg
     1681 gaggaaggca ggcatgggga atcttcattt cttcccaagg ggctcagggg gtgatctttt
     1741 gtgggctggc acttgtggac acagttttgg ctagaggtag gttaggcaag tccctaactt
     1801 agggtccctc cacatttgta agcagaggct ggagaggcca tctttagaca tattccagac
     1861 accctgggtg ggaaaaggag agacaagtgt tggtctccca agcttagact ggccttggtg
     1921 ttatacttca tggttggagg ctgacctacc ctacaagagt gtcccttgct gaagacattc
     1981 aggtccccaa cctgtgtcct gtcacccaag tcacccctct ggtatttgga gatgccaaca
     2041 ctgccaggag tcttcctcct tcttctctct cttgtcctcc cctgccagga atcttgggga
     2101 ctgaggcaag gaagggaccc tttagctccc aagactcttt tgtaaagttt ttgtagtgat
     2161 ttttatgcca cctgaataaa gaatgaatgg gcaaaaaaa
//
