LOCUS       NM_011340               1497 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade F,
            member 1 (Serpinf1), mRNA.
ACCESSION   NM_011340
VERSION     NM_011340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Xiang,W., Li,L., Zhao,Q., Zeng,Y., Shi,J., Chen,Z., Gao,G. and
            Lai,K.
  TITLE     PEDF protects retinal pigment epithelium from ferroptosis and
            ameliorates dry AMD-like pathology in a murine model
  JOURNAL   Geroscience 46 (2), 2697-2714 (2024)
   PUBMED   38153666
  REMARK    GeneRIF: PEDF protects retinal pigment epithelium from ferroptosis
            and ameliorates dry AMD-like pathology in a murine model.
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Kim,G., Chen,Z., Li,J., Luo,J., Castro-Martinez,F., Wisniewski,J.,
            Cui,K., Wang,Y., Sun,J., Ren,X., Crawford,S.E., Becerra,S.P.,
            Zhu,J., Liu,T., Wang,S., Zhao,K. and Wu,C.
  TITLE     Gut-liver axis calibrates intestinal stem cell fitness
  JOURNAL   Cell 187 (4), 914-930 (2024)
   PUBMED   38280375
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Qi,W., Zhu,D., Yin,P., Gu,X., Zhao,Z., Li,M., Dong,C., Tang,Q.,
            Xie,W., Zhou,T., Xia,H., Qiu,X., Yang,X. and Gao,G.
  TITLE     Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes
            to Gestational Diabetes Mellitus
  JOURNAL   J Clin Endocrinol Metab 109 (1), e356-e369 (2023)
   PUBMED   37440564
  REMARK    GeneRIF: Pigment Epithelium-Derived Factor, a Novel Adipokine,
            Contributes to Gestational Diabetes Mellitus.
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Geng,Z., Tan,J., Xu,J., Chen,Q., Gu,P., Dai,X., Kuang,X., Ji,S.,
            Liu,T. and Li,C.
  TITLE     ADAMTS5 promotes neovascularization via autophagic degradation of
            PEDF in proliferative diabetic retinopathy
  JOURNAL   Exp Eye Res 234, 109597 (2023)
   PUBMED   37490993
  REMARK    GeneRIF: ADAMTS5 promotes neovascularization via autophagic
            degradation of PEDF in proliferative diabetic retinopathy.
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Kozaki,K., Miyaishi,O., Koiwai,O., Yasui,Y., Kashiwai,A.,
            Nishikawa,Y., Shimizu,S. and Saga,S.
  TITLE     Isolation, purification, and characterization of a
            collagen-associated serpin, caspin, produced by murine colon
            adenocarcinoma cells
  JOURNAL   J Biol Chem 273 (24), 15125-15130 (1998)
   PUBMED   9614124
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Singh,V.K., Chader,G.J. and Rodriguez,I.R.
  TITLE     Structural and comparative analysis of the mouse gene for pigment
            epithelium-derived factor (PEDF)
  JOURNAL   Mol Vis 4, 7 (1998)
   PUBMED   9565647
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Shirozu,M., Tada,H., Tashiro,K., Nakamura,T., Lopez,N.D.,
            Nazarea,M., Hamada,T., Sato,T., Nakano,T. and Honjo,T.
  TITLE     Characterization of novel secreted and membrane proteins isolated
            by the signal sequence trap method
  JOURNAL   Genomics 37 (3), 273-280 (1996)
   PUBMED   8938438
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Pignolo,R.J., Rotenberg,M.O. and Cristofalo,V.J.
  TITLE     Analysis of EPC-1 growth state-dependent expression, specificity,
            and conservation of related sequences
  JOURNAL   J Cell Physiol 162 (1), 110-118 (1995)
   PUBMED   7814443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591496.13, D50460.1, AF017057.1 and AA111321.1.
            
            On Nov 8, 2006 this sequence version replaced NM_011340.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019852.1, D50460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AL591496.13        67498-67625         c
            129-918             D50460.1           98-887
            919-1378            AF017057.1         817-1276
            1379-1497           AA111321.1         183-301
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.87 cM"
     gene            1..1497
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /note="serine (or cysteine) peptidase inhibitor, clade F,
                     member 1"
                     /db_xref="GeneID:20317"
                     /db_xref="MGI:MGI:108080"
     exon            1..128
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            129..216
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1389
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /note="serine (or cysteine) proteinase inhibitor, clade F,
                     member 1; serine (or cysteine) proteinase inhibitor, clade
                     F), member 1; SDF-3; caspin; stromal cell-derived factor
                     3; serpin F1; alpha-2 antiplasmin; pigment
                     epithelium-derived factor; serine (or cysteine) proteinase
                     inhibitor, clade F (alpha-2 antiplasmin, pigment
                     epithelium derived factor), member 1"
                     /codon_start=1
                     /product="pigment epithelium-derived factor precursor"
                     /protein_id="NP_035470.3"
                     /db_xref="CCDS:CCDS25045.1"
                     /db_xref="GeneID:20317"
                     /db_xref="MGI:MGI:108080"
                     /translation="MQALVLLLWTGALLGHGSSQNVPSSSEGSPVPDSTGEPVEEEDP
                     FFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESV
                     IHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKS
                     YGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVT
                     KFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFF
                     LPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQ
                     SLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQP
                     FLFVLRDTDTGALLFIGRILDPSST"
     exon            217..415
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            416..571
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..775
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..918
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1129
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1494
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /note="hexamer: AATAAA"
     polyA_site      1494
                     /gene="Serpinf1"
                     /gene_synonym="EPC-1; Pedf; Pedfl; Sdf3"
                     /note="major polyA site"
ORIGIN      
        1 gtcactttaa gaaaagagta gctgtaatct gaagcctgct ggacgctggt tgagaggcag
       61 ctactcccct cactgcttcc tggagcccct cagagtgcag gctgtgagag aagctgccgc
      121 aaccacagtt ccgggatgca ggccctggtg ctactcctct ggactggagc cctgctcggg
      181 cacggcagca gccagaacgt ccccagcagc tctgagggct ccccagtccc ggacagcacg
      241 ggcgagcccg tggaggagga ggaccccttc ttcaaggtcc ctgtgaacaa gctggcagca
      301 gctgtctcca acttcggcta cgatctgtac cgcctgagat ccagtgccag cccaacgggc
      361 aacgtcctgc tgtctccact cagcgtggcc acggccctct ctgccctttc tctgggagct
      421 gaacatcgaa cagagtctgt cattcaccgg gctctctact acgacctgat caccaaccct
      481 gacatccaca gcacctacaa ggagctcctt gcctctgtta ctgcccctga gaagaacctc
      541 aagagtgctt ccagaattgt gtttgagagg aaacttcgag tcaaatccag ctttgttgcc
      601 cctctggaga agtcctatgg gaccaggccc cggatcctca cgggcaaccc tcgagtagac
      661 cttcaggaga ttaacaactg ggtgcaggcc cagatgaaag ggaagattgc ccggtccacg
      721 agggaaatgc ccagtgccct cagcatcctt ctccttggcg tggcttactt caaggggcag
      781 tgggtaacca agtttgactc gagaaagacg accctccagg attttcattt ggacgaggac
      841 aggaccgtga gagtccccat gatgtcagat cctaaggcca tcttacgata cggcttggac
      901 tctgatctca actgcaagat tgcccagctg cccttgacag gaagtatgag catcatcttc
      961 ttcctgcccc tgaccgtgac ccagaacttg accatgatag aagagagcct cacctctgag
     1021 ttcattcatg acatcgaccg agaactgaag actatccaag ctgtgctgac tgtccccaag
     1081 ctgaagctga gcttcgaagg cgaacttacc aagtctctgc aggacatgaa gctacagtcg
     1141 ttgtttgaat cacccgactt cagcaagatt actggcaaac ccgtgaagct cacccaagtg
     1201 gaacacaggg ctgctttcga gtggaatgaa gagggggcag gaagcagccc cagcccaggc
     1261 ctccagcccg tccgcctcac cttcccgcta gactatcacc ttaaccaacc tttcctcttt
     1321 gttctgaggg acacggacac gggggccctc ctcttcatag gcagaatcct ggaccccagt
     1381 agtacttaat gtctcagtgc tctacagaac ccccagaggg aagctgatta tacattccag
     1441 gaaggcggcc ggtagcttca gtgtagcctc tgcaataaaa gagcttttcc ttaaaaa
//
