LOCUS       NM_008871               3024 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade E,
            member 1 (Serpine1), mRNA.
ACCESSION   NM_008871
VERSION     NM_008871.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Kudryashova,T.V., Zaitsev,S.V., Jiang,L., Buckley,B.J.,
            McGuckin,J.P., Goncharov,D., Zhyvylo,I., Lin,D., Newcomb,G.,
            Piper,B., Bogamuwa,S., Saiyed,A., Teos,L., Pena,A., Ranson,M.,
            Greenland,J.R., Wolters,P.J., Kelso,M.J., Poncz,M., DeLisser,H.M.,
            Cines,D.B., Goncharova,E.A., Farkas,L. and Stepanova,V.
  TITLE     PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling
            and pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 327 (3), L319-L326 (2024)
   PUBMED   38860847
  REMARK    GeneRIF: PAI-1 deficiency drives pulmonary vascular smooth muscle
            remodeling and pulmonary hypertension.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Ibrahim,A.A., Fujimura,T., Uno,T., Terada,T., Hirano,K.I.,
            Hosokawa,H., Ohta,A., Miyata,T., Ando,K. and Yahata,T.
  TITLE     Plasminogen activator inhibitor-1 promotes immune evasion in tumors
            by facilitating the expression of programmed cell death-ligand 1
  JOURNAL   Front Immunol 15, 1365894 (2024)
   PUBMED   38779680
  REMARK    GeneRIF: Plasminogen activator inhibitor-1 promotes immune evasion
            in tumors by facilitating the expression of programmed cell
            death-ligand 1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Mizukami,Y., Kawao,N., Ohira,T., Hashimoto,D., Okada,K., Matsuo,O.
            and Kaji,H.
  TITLE     Roles of Plasminogen Activator Inhibitor-1 in Heterotopic
            Ossification Induced by Achilles Tenotomy in Thermal Injured Mice
  JOURNAL   Calcif Tissue Int 114 (5), 535-549 (2024)
   PUBMED   38467838
  REMARK    GeneRIF: Roles of Plasminogen Activator Inhibitor-1 in Heterotopic
            Ossification Induced by Achilles Tenotomy in Thermal Injured Mice.
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Harvey,M.B., Leco,K.J., Arcellana-Panlilio,M.Y., Zhang,X.,
            Edwards,D.R. and Schultz,G.A.
  TITLE     Proteinase expression in early mouse embryos is regulated by
            leukaemia inhibitory factor and epidermal growth factor
  JOURNAL   Development 121 (4), 1005-1014 (1995)
   PUBMED   7743917
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Lijnen,H.R., van Hoef,B., Beelen,V. and Collen,D.
  TITLE     Characterization of the murine plasma fibrinolytic system
  JOURNAL   Eur J Biochem 224 (3), 863-871 (1994)
   PUBMED   7523120
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   Preissner,K.T., Grulich-Henn,J., Ehrlich,H.J., Declerck,P.,
            Justus,C., Collen,D., Pannekoek,H. and Muller-Berghaus,G.
  TITLE     Structural requirements for the extracellular interaction of
            plasminogen activator inhibitor 1 with endothelial cell
            matrix-associated vitronectin
  JOURNAL   J Biol Chem 265 (30), 18490-18498 (1990)
   PUBMED   1698787
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Ehrlich,H.J., Gebbink,R.K., Keijer,J., Linders,M., Preissner,K.T.
            and Pannekoek,H.
  TITLE     Alteration of serpin specificity by a protein cofactor. Vitronectin
            endows plasminogen activator inhibitor 1 with thrombin inhibitory
            properties
  JOURNAL   J Biol Chem 265 (22), 13029-13035 (1990)
   PUBMED   1695900
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Prendergast,G.C., Diamond,L.E., Dahl,D. and Cole,M.D.
  TITLE     The c-myc-regulated gene mrl encodes plasminogen activator
            inhibitor 1
  JOURNAL   Mol Cell Biol 10 (3), 1265-1269 (1990)
   PUBMED   2406566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147986.3.
            
            On Mar 18, 2008 this sequence version replaced NM_008871.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M33960.1, BC054091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC147986.3         70386-70529
            145-416             AC147986.3         71354-71625
            417-650             AC147986.3         73112-73345
            651-845             AC147986.3         74738-74932
            846-1044            AC147986.3         75633-75831
            1045-1145           AC147986.3         77697-77797
            1146-1232           AC147986.3         78225-78311
            1233-1316           AC147986.3         79094-79177
            1317-3024           AC147986.3         79447-81154
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.16 cM"
     gene            1..3024
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /note="serine (or cysteine) peptidase inhibitor, clade E,
                     member 1"
                     /db_xref="GeneID:18787"
                     /db_xref="MGI:MGI:97608"
     exon            1..144
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..416
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1354
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /note="serine (or cysteine) proteinase inhibitor, clade E,
                     member 1; plasminogen activator inhibitor 1; PAI;
                     endothelial plasminogen activator inhibitor; serpin E1;
                     plasminogen activator inhibitor, type I; Plasminogen
                     activator inhibitor-1 precursor (PAI-1) (Endothelial
                     plasminogen activator inhibitor) (PAI); nexin, plasminogen
                     activator inhibitor type 1"
                     /codon_start=1
                     /product="plasminogen activator inhibitor 1 precursor"
                     /protein_id="NP_032897.2"
                     /db_xref="CCDS:CCDS19761.1"
                     /db_xref="GeneID:18787"
                     /db_xref="MGI:MGI:97608"
                     /translation="MQMSSALACLILGLVLVSGKGFTLPLRESHTAHQATDFGVKVFQ
                     QVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLS
                     KELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIIN
                     DWVERHTKGMISDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGS
                     TVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTNI
                     LDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSD
                     QEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTET
                     ILFMGQVMEP"
     exon            417..650
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..845
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1044
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1145
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1232
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1316
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..3024
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /note="hexamer: AATATA"
     polyA_site      3024
                     /gene="Serpine1"
                     /gene_synonym="PAI-1; PAI1; Planh1"
                     /note="major polyA site"
ORIGIN      
        1 gagcacagct ggatcaggct gcagcagagc cccgagagct ttgtgaagga ggaccgccgc
       61 acacccgcct ccggcagcac acagccaacc acagctgagc gacagccaac aagagccaat
      121 cacaaggcac ctttgaatac tcaggatgca gatgtcttca gcccttgctt gcctcatcct
      181 gggcctggtt ctggtctctg ggaaagggtt cactttaccc ctccgagaat cccacacagc
      241 ccatcaggcc accgacttcg gagtaaaagt gtttcagcag gtggtccagg cctccaaaga
      301 ccggaatgtg gtcttctctc cctatggcgt gtcctcggtg ctggctatgc tgcagatgac
      361 cacagcgggg aaaacccggc ggcagatcca agatgctatg ggattcaaag tcaatgagaa
      421 gggcacagct catgccctcc gccagctctc caaggagctc atggggccgt ggaacaagaa
      481 tgagatcagt actgcggatg ccatctttgt ccagcgggac ctagagctgg tccagggctt
      541 catgccccac ttcttcaagc tcttccagac tatggtgaaa caggtggact tctcagaagt
      601 ggaaagagcc agatttatca tcaatgactg ggtggaaagg cataccaaag gtatgatcag
      661 tgacttactg gccaaggggg ctgtagacga gctgacacgc ctggtgctgg tgaatgccct
      721 ctacttcagt ggccaatgga agactccttt cttagaggcc agcacccacc agcgcctctt
      781 ccacaagtct gatggcagca ccgtctctgt gcccatgatg gctcagagca acaagttcaa
      841 ctacactgag ttcaccaccc ccgatgggct cgagtatgac gttgtggaac tgccctacca
      901 gggcgacacc ctcagcatgt tcatcgctgc accctttgag aaagatgtgc acctctccgc
      961 cctcaccaac atcttggatg ctgaactcat cagacaatgg aagggcaaca tgaccaggct
     1021 gccccgcctc ctcatcctgc ctaagttctc tctggagact gaagtggacc tcagagggcc
     1081 cctggagaag ttgggcatgc ctgacatgtt tagtgcaacc ctggccgact tcacaagtct
     1141 ttccgaccaa gagcagctct ctgtagcaca ggcactgcaa aaggtcagga tcgaggtaaa
     1201 cgagagcggc acagtggcgt cttcctccac agcctttgtc atctcagccc gcatggcccc
     1261 cacggagatg gttatagacc gatcctttct ctttgtggtt cggcacaacc cgacagagac
     1321 aatcctcttc atgggccaag tgatggagcc ttgacagtgg gaagagacgc cttcatttgg
     1381 gacgaaactg gagatgttat aagcagaaac tctgaagaaa aggattattt aaaggactct
     1441 atggggagaa agagaaggca actcctcctt accccccaca ctggtaatct ttccaaccag
     1501 catcccagac ctcggactct tgaagggaaa agagtctaac tccctcctcc ctagggattc
     1561 ctaccccaca aaggtctcat ggaccataga actcacagta cctggatctg cccagcatgc
     1621 cctttggacc cagttcccac cgaggcccca gcagagtgga gggcacaaca ctttcattca
     1681 gcaaaatcgt ttgtgttcca gtcacactgt gggcacctct tgcatcgcct gccattgctg
     1741 tggagggtgg ccatgggcca aaggaaaaag cactgtccta tctcaaggtc cactgtggaa
     1801 atgtccacct tgcccacctc caaggggcaa cggatagaca gatcaaatgg tggcccaata
     1861 gcgagccttc tccctgctcc ctcccttgac acagcttgct tatgttattt cagagtgtag
     1921 gtgacttgtt tacacagctt ttttcgaccc acaaactttt ttcatttgga aagggtgtaa
     1981 gaaaagtcgg acgtgtgtgt gcctggctct tcgtccccag tctcccagtg ggggggccct
     2041 ggggagattc caggggtgtg attgaatatt tatctcttgc tcttgtatgt ttgttgggga
     2101 gaagaagcac ttttaaggaa aatgcttctt atttaaaccg tggcatacgg catcccattt
     2161 ggggtctgca tccctgtatg tcaggggtgc atcactccac aaacctgccc ctctgggtag
     2221 cctcgtgatg gggctcacac tgccgcctag tggcagccga acacaccctt acccggtccc
     2281 tccctccctc cccccccccc cccccccccc ccgtggctct tttccttagg gaccttgcca
     2341 aggtgatgct tggcaaccca cgttaaagga aggggggaaa aaagattaga tggaagagag
     2401 agagatttga gagagggcaa agtggtttca aatttttcca aggcattcag aagcagagag
     2461 ggaaaagggg ctgtgtgacc taacaggaca gaactttctc caattactgg gtgagtcaga
     2521 gctgcactgg tgactcactt caatgtgtca tttccggctg ctgtatgtga gcagtggaca
     2581 cgtggggggg cggggggggg atgaaagaga cagcagctcc tggtcaacca ccttagttag
     2641 ataatctttt ttgaaagctt cctagctgga ggtatgatca gaaaaccaat ttactgaaaa
     2701 actgcacaag aaggtaccgt gaatgtaatt tcctagcagg ccactctgca tctgttatgt
     2761 ctccaccgga aaaaaaataa tcatgttggt gtttttgctt ttctctctct ccctctttct
     2821 ctctgatttt tttttcctct cttttcatta tgcactggac agccacacac cgtgtaccca
     2881 tagggcccca aatgtggggt cacatggtct tgaattttgt tggttacata tgcctttttg
     2941 ttgttgtttg tcttcacttt tgatatataa acaggtaaat atgtttttta aaaaatacta
     3001 aatatagaga atatgcaaac aaaa
//
