LOCUS       NM_008223               2201 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade D,
            member 1 (Serpind1), transcript variant 1, mRNA.
ACCESSION   NM_008223
VERSION     NM_008223.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2201)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   2  (bases 1 to 2201)
  AUTHORS   Gould,T.W., Dominguez,B., de Winter,F., Yeo,G.W., Liu,P.,
            Sundararaman,B., Stark,T., Vu,A., Degen,J.L., Lin,W. and Lee,K.F.
  TITLE     Glial cells maintain synapses by inhibiting an activity-dependent
            retrograde protease signal
  JOURNAL   PLoS Genet 15 (3), e1007948 (2019)
   PUBMED   30870413
  REMARK    GeneRIF: Trancriptomic analysis shows that expression of the
            antithrombins serpin C1 and D1 is significantly reduced in Schwann
            cell-deficient mice. In the absence of peripheral neuromuscular
            activity, neurodegeneration is completely blocked, and expression
            of prothrombin in muscle is markedly reduced.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2201)
  AUTHORS   Kurahashi,K., Inoue,S., Yoshida,S., Ikeda,Y., Morimoto,K.,
            Uemoto,R., Ishikawa,K., Kondo,T., Yuasa,T., Endo,I., Miyake,M.,
            Oyadomari,S., Matsumoto,T., Abe,M., Sakaue,H. and Aihara,K.I.
  TITLE     The Role of Heparin Cofactor in the Regulation of Insulin
            Sensitivity and Maintenance of Glucose Homeostasis in Humans and
            Mice
  JOURNAL   J Atheroscler Thromb 24 (12), 1215-1230 (2017)
   PUBMED   28502917
  REMARK    GeneRIF: Loss of Heparin Cofactor is associated with insulin
            resistance .
REFERENCE   4  (bases 1 to 2201)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2201)
  AUTHORS   Kalle,M., Papareddy,P., Kasetty,G., Tollefsen,D.M., Malmsten,M.,
            Morgelin,M. and Schmidtchen,A.
  TITLE     Proteolytic activation transforms heparin cofactor II into a host
            defense molecule
  JOURNAL   J Immunol 190 (12), 6303-6310 (2013)
   PUBMED   23656734
  REMARK    GeneRIF: In this study, we demonstrate a previously unknown role
            for HCII in host defense
REFERENCE   6  (bases 1 to 2201)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   7  (bases 1 to 2201)
  AUTHORS   Ben-Porath,I., Kozak,C.A. and Benvenisty,N.
  TITLE     Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3),
            genes encoding membrane proteins related to Pmp22
  JOURNAL   Genomics 49 (3), 443-447 (1998)
   PUBMED   9615230
REFERENCE   8  (bases 1 to 2201)
  AUTHORS   Sinha,D., Esumi,N., Jaworski,C., Kozak,C.A., Pierce,E. and
            Wistow,G.
  TITLE     Cloning and mapping the mouse Crygs gene and non-lens expression of
            [gamma]S-crystallin
  JOURNAL   Mol Vis 4, 8 (1998)
   PUBMED   9565648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2201)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   10 (bases 1 to 2201)
  AUTHORS   Zhang,G.S., Mehringer,J.H., Van Deerlin,V.M., Kozak,C.A. and
            Tollefsen,D.M.
  TITLE     Murine heparin cofactor II: purification, cDNA sequence,
            expression, and gene structure
  JOURNAL   Biochemistry 33 (12), 3632-3642 (1994)
   PUBMED   7908224
  REMARK    Erratum:[Biochemistry 1994 Jun 21;33(24):7744]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110573.11, CJ067925.1, AI529123.1, AI196697.1, AA253694.1,
            AI529613.1, CJ238471.1 and AI195091.1.
            
            On Sep 5, 2016 this sequence version replaced NM_008223.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089610.1, SRR5189673.105168.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC110573.11        81943-81958         c
            17-300              CJ067925.1         3-286
            301-507             AI529123.1         259-465
            508-847             AI196697.1         68-407
            848-1140            AA253694.1         54-346
            1141-1312           AI529613.1         183-354
            1313-1323           AC110573.11        73288-73298         c
            1324-1468           AC110573.11        70844-70988         c
            1469-1500           AC110573.11        70445-70476         c
            1501-2189           CJ238471.1         1-689
            2190-2201           AI195091.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.74 cM"
     gene            1..2201
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /note="serine (or cysteine) peptidase inhibitor, clade D,
                     member 1"
                     /db_xref="GeneID:15160"
                     /db_xref="MGI:MGI:96051"
     exon            1..77
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1049
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1660
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /note="heparin cofactor 2; protease inhibitor leuserpin-2;
                     serpin D1; serine (or cysteine) proteinase inhibitor,
                     clade D (heparin cofactor), member 1; heparin cofactor II"
                     /codon_start=1
                     /product="heparin cofactor 2 precursor"
                     /protein_id="NP_032249.3"
                     /db_xref="CCDS:CCDS28000.1"
                     /db_xref="GeneID:15160"
                     /db_xref="MGI:MGI:96051"
                     /translation="MKHPLCTLLSLITFMCIGSKGLAEQLTNENLTTSFLPANFHKEN
                     TVTNDWIPEGEEDEDYLDLEKLLGEDDDYIYIIDAVSPTDSESSAGNILQLFQGKSRI
                     QRLNILNAKFAFNLYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVL
                     HFRDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAA
                     MREFYFAEAQEANFPDPAFISKANNHILKLTKGLIKEALENIDPATQMLILNCIYFKG
                     TWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISM
                     LIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMG
                     ITKLFNKNGNMSGISDQRIAIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVRFTV
                     DRPFLFLVYEHRTSCLLFMGKVTNPAKS"
     exon            1050..1323
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1468
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..2190
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Serpind1"
                     /gene_synonym="HC-II; Hcf2; HCII"
                     /note="major polyA site"
ORIGIN      
        1 accaaagttc acattgaaac ctgctgctga ccttctctgg tctcatctct gccacaccac
       61 tgctcagagg tacagagata gctggtgtga gcattggtgc tgtgaaggct tcttgctgtg
      121 ttaagagaat ctgctgtctg cacattccag tgggggtggt gtcagccagg ctccctgcca
      181 ttccttgttg tctgtttttc acagcagctt tagctctgca gaaatgaaac atccactctg
      241 cactcttctt tctctcatca catttatgtg tattgggagc aaaggccttg ctgagcagct
      301 aactaatgaa aacctgacca cgtccttcct gcctgctaac ttccacaaag aaaacacagt
      361 caccaatgac tggatcccag agggggaaga ggatgaggac tacctggacc tggagaagct
      421 gcttggtgaa gatgacgact acatttatat catcgatgcc gtttccccga cagactcaga
      481 atcaagtgct ggcaacatcc tgcagctttt ccaaggcaag agccggatcc agcgtcttaa
      541 tatcctcaat gcaaagtttg ccttcaacct ttaccgagtc ctgaaggacc aggctaccac
      601 atctgataac ctcttcatag cacctgttgg catttctact gccatgggga tgatctcctt
      661 aggtctgagg ggagagaccc atgaagaagt acactcagtt ctacacttca gagactttgt
      721 caatgctagc agcaagtacg aggttaccac cattcacaat ctctttcgaa agctgaccca
      781 tcgtctattc aggaggaatt ttgggtacac acttcggtca gttaatggcc tttatattca
      841 gaagcagttt cccatacggg aggacttcaa agctgctatg agagagtttt actttgctga
      901 ggcccaggag gctaacttcc cagatcctgc cttcatatca aaggcaaaca accacattct
      961 gaaactcacc aagggcctta taaaagaagc tctggagaat atagatcctg ctactcagat
     1021 gctgattctg aactgcatct acttcaaagg aacttgggtg aataaattcc cagtagaaat
     1081 gacgcacaac cacaacttcc ggctgaatga gagagaagta gtcaaagtct ccatgatgca
     1141 aactaaaggg aatttccttg cggcaaatga ccaggagcta gactgtgaca ttctccagct
     1201 ggagtacgta gggggcatca gcatgcttat tgtagttcca cggaagctat cgggaatgaa
     1261 gactcttgaa gcacagctta caccccaggt ggtggagaga tggcaaaaaa gcatgacaaa
     1321 cagaactcga gaggtacttc tgccaaagtt taagcttgag aagaattaca acctggtgga
     1381 ggtccttaag tccatgggaa tcacaaagct cttcaacaag aatggcaata tgtcaggcat
     1441 ctcagaccag aggatcgcca ttgacctgtt caagcaccaa agtaccatca cagtgaatga
     1501 agagggtacc caagctgcag ctgtaactac agtggggttc atgccgctgt ctacccaagt
     1561 ccgattcact gtcgaccgtc ccttcctgtt cctagtgtat gagcaccgaa ccagctgtct
     1621 gctcttcatg ggaaaagtga ccaaccctgc caagtcttaa tggcagtggt ctgggcacct
     1681 gatgtagttt ggggacactc tgtattcctg ttttcattct aacaaagagg acagagctat
     1741 tttgctatga taatctctgt ggtttatgat aataatctga acagcaaaca gtgccattaa
     1801 gtgcacagat gttaatgcaa ctaatggttg tgccagctat tccctagagg tcctagacac
     1861 acagactgcc ttagccccca cacctctgtc cctaggagaa tgaatgggca gagtggagct
     1921 gacactctct cctcaggcag cctcctcagc ctttattcgt caacggcctc tgctcagcca
     1981 ggcccttcca gacaaaaggc actgaggaac ttgcacccct tccagggagg gtgtccaagt
     2041 agcaccgttc ctgcccagtg ggaaagcaat cccaacatgt ctgagatgtt cggactttta
     2101 aattcatgta aatatctcct cttctgctgt gtgtacatag gactacatag tctatcctag
     2161 agataaataa acaaccatat ttaccatgta aaaaaaaaaa a
//
